Linshang Chemical
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1-(Bromomethyl)-3-Chlorobenzene
Linshang Chemical
|
HS Code |
585051 |
| Chemical Formula | C7H6BrCl |
| Molar Mass | 205.48 g/mol |
| Appearance | Colorless to light - yellow liquid |
| Boiling Point | Approximately 220 - 225 °C |
| Density | Approx. 1.67 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Odor | Pungent |
As an accredited 1-(Bromomethyl)-3-Chlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1-(bromomethyl)-3-chlorobenzene packaged in a sealed glass bottle. |
| Storage | 1-(Bromomethyl)-3-chlorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics. Store it separately from oxidizing agents, strong bases, and reactive chemicals to prevent unwanted reactions. |
| Shipping | 1-(Bromomethyl)-3-chlorobenzene is shipped in tightly - sealed, corrosion - resistant containers. Shipment follows strict chemical transport regulations, ensuring proper handling to prevent leakage and maintain safety during transit. |
Competitive 1-(Bromomethyl)-3-Chlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-(Bromomethyl)-3-Chlorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 1- (bromomethyl) -3-chlorobenzene?
1 - (bromomethyl) - 3 - chlorobenzene, organic compounds are also. Its physical properties are quite important, let me tell you one by one.
Looking at its properties, under room temperature, this substance is mostly liquid, but it also depends on the specific environmental conditions. Its color may be colorless and transparent, or slightly yellowish, depending on the presence and amount of impurities.
As for its smell, it often has a special aromatic smell, but this aroma is not pleasant and fragrant, but it has the unique irritation of organic compounds, and its chemical characteristics can be detected by smelling.
When it comes to the melting point, the melting point is relatively low, which is due to the force between molecules. When the ambient temperature gradually rises to a certain temperature, that is, its melting point is reached, and the solid state of 1- (bromomethyl) -3-chlorobenzene is converted into a liquid state. The boiling point is higher, and more energy is required from the outside world to make its molecules break free from the liquid phase and transform into a gaseous state. This melting boiling point characteristic is a key consideration when separating, purifying and storing.
In terms of solubility, this compound is insoluble in water because it is an organic molecule, and the force between it and water molecules is weak, making it difficult to blend with each other. However, in organic solvents, such as ethanol, ether, benzene, etc., it has good solubility. This is because of the "similarity and miscibility" principle. Organic molecules and organic solvents have similar molecular structures and matching forces, so they are miscible.
Density is also one of its important physical properties. The density of 1- (bromomethyl) -3-chlorobenzene is greater than that of water. If it is mixed with water and left to stand, it can be seen to sink to the bottom of the water. This property is also instructive when it comes to the treatment of mixed systems of water and this compound.
In summary, the physical properties of 1- (bromomethyl) -3-chlorobenzene, such as properties, odor, melting point, solubility and density, are crucial in chemical research, industrial production and related application fields, helping us to understand and properly use this compound.
Looking at its properties, under room temperature, this substance is mostly liquid, but it also depends on the specific environmental conditions. Its color may be colorless and transparent, or slightly yellowish, depending on the presence and amount of impurities.
As for its smell, it often has a special aromatic smell, but this aroma is not pleasant and fragrant, but it has the unique irritation of organic compounds, and its chemical characteristics can be detected by smelling.
When it comes to the melting point, the melting point is relatively low, which is due to the force between molecules. When the ambient temperature gradually rises to a certain temperature, that is, its melting point is reached, and the solid state of 1- (bromomethyl) -3-chlorobenzene is converted into a liquid state. The boiling point is higher, and more energy is required from the outside world to make its molecules break free from the liquid phase and transform into a gaseous state. This melting boiling point characteristic is a key consideration when separating, purifying and storing.
In terms of solubility, this compound is insoluble in water because it is an organic molecule, and the force between it and water molecules is weak, making it difficult to blend with each other. However, in organic solvents, such as ethanol, ether, benzene, etc., it has good solubility. This is because of the "similarity and miscibility" principle. Organic molecules and organic solvents have similar molecular structures and matching forces, so they are miscible.
Density is also one of its important physical properties. The density of 1- (bromomethyl) -3-chlorobenzene is greater than that of water. If it is mixed with water and left to stand, it can be seen to sink to the bottom of the water. This property is also instructive when it comes to the treatment of mixed systems of water and this compound.
In summary, the physical properties of 1- (bromomethyl) -3-chlorobenzene, such as properties, odor, melting point, solubility and density, are crucial in chemical research, industrial production and related application fields, helping us to understand and properly use this compound.
What are the chemical properties of 1- (bromomethyl) -3-chlorobenzene
1 - (bromomethyl) - 3 - chlorobenzene is one of the organic compounds. It has unique chemical properties and has a wide range of uses in the field of organic synthesis.
In this compound, bromomethyl and chlorine atoms are attached to the benzene ring. In bromomethyl, the bromine atom has strong electronegativity, which makes the carbon-bromine bond have a certain polarity, making it prone to nucleophilic substitution reactions. Nucleophilic reagents can attack the carbon atoms of bromomethyl, and the bromide ions leave to form new organic compounds. This reaction is of great significance in the construction of carbon-carbon bonds, carbon-heteroatomic bonds, etc.
Furthermore, the chlorine atom on the benzene ring also affects its chemical properties. Although the nucleophilic substitution activity of chlorine atom is slightly lower than that of bromomethyl, it can also participate in the substitution reaction under suitable conditions. The electron cloud distribution of the benzene ring changes due to the presence of chlorine atom and bromomethyl, which affects the electrophilic substitution activity and regioselectivity of the benzene ring.
1- (bromomethyl) -3 -chlorobenzene can also participate in the reduction reaction. In case of suitable reducing agents, bromomethyl or chlorine atoms can be reduced to form corresponding hydrocarbon compounds, or other reduction transformations can occur to meet the needs of different organic synthesis.
In addition, due to the halogen atoms in its structure, elimination reactions can occur under certain conditions, dehalogenation of hydrogen, formation of unsaturated bonds, and then participation in subsequent addition, cyclization and other reactions, providing a basis for the synthesis of complex organic molecules.
In summary, the properties of bromomethyl and chlorine atoms in the 1- (bromomethyl) -3-chlorobenzene structure present diverse reactivity in the field of organic synthetic chemistry, providing many possibilities for the construction of organic compounds.
In this compound, bromomethyl and chlorine atoms are attached to the benzene ring. In bromomethyl, the bromine atom has strong electronegativity, which makes the carbon-bromine bond have a certain polarity, making it prone to nucleophilic substitution reactions. Nucleophilic reagents can attack the carbon atoms of bromomethyl, and the bromide ions leave to form new organic compounds. This reaction is of great significance in the construction of carbon-carbon bonds, carbon-heteroatomic bonds, etc.
Furthermore, the chlorine atom on the benzene ring also affects its chemical properties. Although the nucleophilic substitution activity of chlorine atom is slightly lower than that of bromomethyl, it can also participate in the substitution reaction under suitable conditions. The electron cloud distribution of the benzene ring changes due to the presence of chlorine atom and bromomethyl, which affects the electrophilic substitution activity and regioselectivity of the benzene ring.
1- (bromomethyl) -3 -chlorobenzene can also participate in the reduction reaction. In case of suitable reducing agents, bromomethyl or chlorine atoms can be reduced to form corresponding hydrocarbon compounds, or other reduction transformations can occur to meet the needs of different organic synthesis.
In addition, due to the halogen atoms in its structure, elimination reactions can occur under certain conditions, dehalogenation of hydrogen, formation of unsaturated bonds, and then participation in subsequent addition, cyclization and other reactions, providing a basis for the synthesis of complex organic molecules.
In summary, the properties of bromomethyl and chlorine atoms in the 1- (bromomethyl) -3-chlorobenzene structure present diverse reactivity in the field of organic synthetic chemistry, providing many possibilities for the construction of organic compounds.
What are the common synthesis methods of 1- (bromomethyl) -3-chlorobenzene?
1 - (bromomethyl) -3 -chlorobenzene is also an organic compound. The common synthesis methods generally have the following numbers.
First, m-chlorotoluene is used as the starting material. First, m-chlorotoluene reacts with N-bromosuccinimide (NBS) under the action of an initiator. This initiator is often benzoyl peroxide. Under light or heating conditions, the bromine atom in the NBS will replace the hydrogen atom at the benzyl position of m-chlorotoluene, resulting in 1 - (bromomethyl) -3 -chlorobenzene. The key to this reaction lies in controlling the reaction temperature, the amount of NBS, and the reaction time. If the temperature is too high, it is easy to produce side reactions, resulting in impure products; improper dosage of NBS also affects the yield.
Second, isochlorobenzoic acid is used as the starting material. First, isochlorobenzoic acid is reduced to isochlorobenzyl alcohol. Commonly used reducing agents include lithium aluminum hydride. Isochlorobenzyl alcohol reacts with hydrobromic acid, and the hydroxyl group is replaced by a bromine atom to obtain 1- (bromomethyl) -3 -chlorobenzene. However, lithium aluminum hydride is active in nature, and it needs to be handled with caution when using it, and the post-reaction treatment needs to be fine to prevent product loss or the introduction of impurities
Third, the coupling reaction of 3-chloro-1-methylphenylboronic acid with bromine-containing halogenated hydrocarbons is carried out under palladium catalysis. The reaction conditions are relatively mild and the selectivity is good. However, palladium catalysts are expensive and expensive, and the reaction system has strict requirements for anhydrous and anaerobic, and the operation is complicated.
All these methods have advantages and disadvantages. When actually synthesizing, it is necessary to choose carefully according to the availability of raw materials, cost, yield and product purity to achieve the best synthetic effect.
First, m-chlorotoluene is used as the starting material. First, m-chlorotoluene reacts with N-bromosuccinimide (NBS) under the action of an initiator. This initiator is often benzoyl peroxide. Under light or heating conditions, the bromine atom in the NBS will replace the hydrogen atom at the benzyl position of m-chlorotoluene, resulting in 1 - (bromomethyl) -3 -chlorobenzene. The key to this reaction lies in controlling the reaction temperature, the amount of NBS, and the reaction time. If the temperature is too high, it is easy to produce side reactions, resulting in impure products; improper dosage of NBS also affects the yield.
Second, isochlorobenzoic acid is used as the starting material. First, isochlorobenzoic acid is reduced to isochlorobenzyl alcohol. Commonly used reducing agents include lithium aluminum hydride. Isochlorobenzyl alcohol reacts with hydrobromic acid, and the hydroxyl group is replaced by a bromine atom to obtain 1- (bromomethyl) -3 -chlorobenzene. However, lithium aluminum hydride is active in nature, and it needs to be handled with caution when using it, and the post-reaction treatment needs to be fine to prevent product loss or the introduction of impurities
Third, the coupling reaction of 3-chloro-1-methylphenylboronic acid with bromine-containing halogenated hydrocarbons is carried out under palladium catalysis. The reaction conditions are relatively mild and the selectivity is good. However, palladium catalysts are expensive and expensive, and the reaction system has strict requirements for anhydrous and anaerobic, and the operation is complicated.
All these methods have advantages and disadvantages. When actually synthesizing, it is necessary to choose carefully according to the availability of raw materials, cost, yield and product purity to achieve the best synthetic effect.
In which fields is 1- (bromomethyl) -3-chlorobenzene used?
1 - (bromomethyl) -3 -chlorobenzene is widely used in the field of organic synthesis. It can be used as a key intermediate to prepare a variety of organic compounds.
In pharmaceutical chemistry, this compound may participate in the construction of drug molecules. Due to its activity of bromomethyl and chlorine atoms, it can combine with other molecules containing active groups through many reactions, such as nucleophilic substitution reactions, to generate drug precursors or end products with specific biological activities.
In the field of materials science, 1 - (bromomethyl) -3 -chlorobenzene is also useful. For example, it can be used to prepare functional polymer materials. Through chemical reaction, it is connected to the polymer chain to give the material unique properties, such as improving the solubility and thermal stability of the material, or introducing special functional groups to meet specific application requirements.
Furthermore, in the field of fine chemistry, it can be used to synthesize special fine chemicals. Such as the preparation of high-performance dyes, fragrances, etc. Due to its structural characteristics, it can bring unique color, odor and other properties to the product. By ingeniously designing the reaction route and using its activity check point, the synthesis of complex fine chemicals can be realized, and the quality and added value of the product can be improved. From this perspective, 1 - (bromomethyl) - 3 - chlorobenzene has important uses in many fields such as organic synthesis, medicinal chemistry, materials science, and fine chemicals, and plays an indispensable role in promoting the development of related fields.
In pharmaceutical chemistry, this compound may participate in the construction of drug molecules. Due to its activity of bromomethyl and chlorine atoms, it can combine with other molecules containing active groups through many reactions, such as nucleophilic substitution reactions, to generate drug precursors or end products with specific biological activities.
In the field of materials science, 1 - (bromomethyl) -3 -chlorobenzene is also useful. For example, it can be used to prepare functional polymer materials. Through chemical reaction, it is connected to the polymer chain to give the material unique properties, such as improving the solubility and thermal stability of the material, or introducing special functional groups to meet specific application requirements.
Furthermore, in the field of fine chemistry, it can be used to synthesize special fine chemicals. Such as the preparation of high-performance dyes, fragrances, etc. Due to its structural characteristics, it can bring unique color, odor and other properties to the product. By ingeniously designing the reaction route and using its activity check point, the synthesis of complex fine chemicals can be realized, and the quality and added value of the product can be improved. From this perspective, 1 - (bromomethyl) - 3 - chlorobenzene has important uses in many fields such as organic synthesis, medicinal chemistry, materials science, and fine chemicals, and plays an indispensable role in promoting the development of related fields.
What are the precautions in the preparation of 1- (bromomethyl) -3-chlorobenzene?
When preparing 1- (bromomethyl) -3 -chlorobenzene, there are many precautions that should not be ignored.
First, the selection of raw materials is extremely critical. The starting materials used need to be very high in purity. If there are many impurities, the reaction will be complicated and the product will be impure. For example, halogenated hydrocarbons, aromatics, etc. should be strictly purified and the purity should be carefully tested before they can be used in the reaction.
Second, the control of the reaction conditions is crucial. The temperature has a great impact on the reaction rate and product selectivity. If the temperature is too high, it is easy to produce side reactions and reduce the yield of the product; if the temperature is too low, the reaction will be slow and take a long time. Therefore, it is necessary to precisely control the temperature, and choose the appropriate heating method and temperature control equipment according to the reaction characteristics. And the pH of the reaction system also needs to be paid attention to. Some reactions can proceed smoothly under specific pH conditions, otherwise the reaction will be blocked.
Third, the operation process needs to be rigorous and meticulous. The wrong order of adding reagents or insufficient stirring can affect the reaction effect. The addition of reagents should be added slowly in sequence according to the reaction mechanism and characteristics, and at the same time, sufficient stirring should be done to make the reactants mix evenly and promote the reaction to proceed fully. The construction of the reaction device should not be ignored to ensure good air tightness to prevent the escape of reactants or the intrusion of external impurities.
Fourth, the separation and purification of the product should not be underestimated. After the reaction, the product is often mixed with impurities such as unreacted raw materials It is necessary to choose a suitable separation method according to the properties of the product and the impurities, such as extraction, distillation, recrystallization, etc. The purification process should be careful to avoid product loss and strive to obtain high-purity products.
Preparation of 1- (bromomethyl) -3 -chlorobenzene, from the raw material to the product, all links are closely linked, and all need to be treated carefully before it can be achieved.
First, the selection of raw materials is extremely critical. The starting materials used need to be very high in purity. If there are many impurities, the reaction will be complicated and the product will be impure. For example, halogenated hydrocarbons, aromatics, etc. should be strictly purified and the purity should be carefully tested before they can be used in the reaction.
Second, the control of the reaction conditions is crucial. The temperature has a great impact on the reaction rate and product selectivity. If the temperature is too high, it is easy to produce side reactions and reduce the yield of the product; if the temperature is too low, the reaction will be slow and take a long time. Therefore, it is necessary to precisely control the temperature, and choose the appropriate heating method and temperature control equipment according to the reaction characteristics. And the pH of the reaction system also needs to be paid attention to. Some reactions can proceed smoothly under specific pH conditions, otherwise the reaction will be blocked.
Third, the operation process needs to be rigorous and meticulous. The wrong order of adding reagents or insufficient stirring can affect the reaction effect. The addition of reagents should be added slowly in sequence according to the reaction mechanism and characteristics, and at the same time, sufficient stirring should be done to make the reactants mix evenly and promote the reaction to proceed fully. The construction of the reaction device should not be ignored to ensure good air tightness to prevent the escape of reactants or the intrusion of external impurities.
Fourth, the separation and purification of the product should not be underestimated. After the reaction, the product is often mixed with impurities such as unreacted raw materials It is necessary to choose a suitable separation method according to the properties of the product and the impurities, such as extraction, distillation, recrystallization, etc. The purification process should be careful to avoid product loss and strive to obtain high-purity products.
Preparation of 1- (bromomethyl) -3 -chlorobenzene, from the raw material to the product, all links are closely linked, and all need to be treated carefully before it can be achieved.
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