Linshang Chemical
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1-(Bromomethyl)-4-Chloro-2-Fluorobenzene
Linshang Chemical
|
HS Code |
159926 |
| Chemical Formula | C7H5BrClF |
| Molecular Weight | 225.47 |
| Appearance | Typically a colorless to light - yellow liquid |
| Boiling Point | Data may vary, around 200 - 220 °C under normal pressure |
| Density | Estimated to be around 1.7 - 1.9 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, ethyl acetate |
| Flash Point | Caution, flammable, flash point data may be around 80 - 100 °C |
| Vapor Pressure | Low vapor pressure at room temperature |
| Reactivity | Highly reactive due to the presence of bromomethyl group, can undergo substitution reactions |
As an accredited 1-(Bromomethyl)-4-Chloro-2-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1-(bromomethyl)-4 - chloro - 2 - fluorobenzene in a sealed, labeled chemical bottle. |
| Storage | 1-(Bromomethyl)-4-chloro-2-fluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. It should be kept in a tightly closed container, preferably made of corrosion - resistant materials like glass or certain plastics. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to prevent unwanted reactions. |
| Shipping | 1-(Bromomethyl)-4-chloro-2-fluorobenzene is shipped in accordance with strict chemical transport regulations. Packed securely in appropriate containers, it's transported by methods ensuring safe handling and minimizing environmental risk. |
Competitive 1-(Bromomethyl)-4-Chloro-2-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 1-(Bromomethyl)-4-Chloro-2-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 1- (bromomethyl) -4-chloro-2-fluorobenzene?
1 - (bromomethyl) - 4 - chloro - 2 - fluorobenzene, this is an organic compound. It has a wide range of uses and plays a significant role in the field of organic synthesis.
First, it can be used as a key intermediate for the preparation of various drugs. In the long journey of creating new drugs, with its unique chemical structure, it can ingeniously react with many other compounds to construct complex molecular structures with specific pharmacological activities. For example, targeted drugs developed for some specific diseases may be synthesized with 1- (bromomethyl) -4-chloro-2-fluorobenzene as the starting material, and through multi-step reactions, the core structure of the drug molecule is gradually built, providing a strong material basis for combating diseases.
Second, it is also useful in the field of materials science. It can participate in the synthesis of functional materials. For example, when synthesizing polymer materials with special optical and electrical properties, 1- (bromomethyl) -4-chloro-2-fluorobenzene can be introduced as a structural unit, giving the material novel properties. By carefully designing the reaction path and polymerizing it with other monomers, it is expected to prepare materials with excellent application prospects in the fields of optoelectronic devices, sensors, etc., thereby promoting the progress and development of related technologies.
Furthermore, in the field of pesticides, it can also play an important role. It can be used as an important building block for the synthesis of new pesticides. By reacting with other compounds containing active groups, pesticide products with high efficiency to kill or inhibit specific pests or pathogens can be synthesized. And because of its unique structure, it may endow pesticides with better selectivity and environmental friendliness, ensuring agricultural production while reducing adverse effects on the environment.
In summary, 1- (bromomethyl) -4-chloro-2-fluorobenzene is an indispensable and important compound in many fields such as organic synthesis, materials science and pesticides, and has made outstanding contributions to promoting technological innovation and development in various fields.
First, it can be used as a key intermediate for the preparation of various drugs. In the long journey of creating new drugs, with its unique chemical structure, it can ingeniously react with many other compounds to construct complex molecular structures with specific pharmacological activities. For example, targeted drugs developed for some specific diseases may be synthesized with 1- (bromomethyl) -4-chloro-2-fluorobenzene as the starting material, and through multi-step reactions, the core structure of the drug molecule is gradually built, providing a strong material basis for combating diseases.
Second, it is also useful in the field of materials science. It can participate in the synthesis of functional materials. For example, when synthesizing polymer materials with special optical and electrical properties, 1- (bromomethyl) -4-chloro-2-fluorobenzene can be introduced as a structural unit, giving the material novel properties. By carefully designing the reaction path and polymerizing it with other monomers, it is expected to prepare materials with excellent application prospects in the fields of optoelectronic devices, sensors, etc., thereby promoting the progress and development of related technologies.
Furthermore, in the field of pesticides, it can also play an important role. It can be used as an important building block for the synthesis of new pesticides. By reacting with other compounds containing active groups, pesticide products with high efficiency to kill or inhibit specific pests or pathogens can be synthesized. And because of its unique structure, it may endow pesticides with better selectivity and environmental friendliness, ensuring agricultural production while reducing adverse effects on the environment.
In summary, 1- (bromomethyl) -4-chloro-2-fluorobenzene is an indispensable and important compound in many fields such as organic synthesis, materials science and pesticides, and has made outstanding contributions to promoting technological innovation and development in various fields.
What are the physical properties of 1- (bromomethyl) -4-chloro-2-fluorobenzene
1 - (bromomethyl) - 4 - chloro - 2 - fluorobenzene is one of the organic compounds. Its physical properties are particularly important, and it is related to the behavior of this compound in various scenarios.
First of all, its appearance, under room temperature and pressure, is mostly colorless to light yellow liquid, with a clear texture. If placed in light, its luster can be seen, like the flow of oil, smooth and not sticky.
Second on its melting point and boiling point. The melting point is about -20 ° C, which means that at relatively low temperatures, it starts to condense into a solid state. The boiling point is roughly between 220 and 230 degrees Celsius, and a higher temperature is required to boil it and convert it into a gaseous state. Such melting boiling point characteristics make it exist as a liquid in a room temperature environment.
Furthermore, its density is about 1.6-1.7g/cm ³, which is heavier than water. If mixed with water, it will sink to the bottom of the water, such as stones entering water, and naturally settle.
Solubility is also a key property. This compound is slightly soluble in water, just like oil floating in water, and is difficult to blend with water. However, in organic solvents, such as ethanol, ether, dichloromethane, etc., it has good solubility and can be miscible with it, just like water, regardless of each other.
In addition, 1- (bromomethyl) -4-chloro-2-fluorobenzene is volatile and can slowly emit an odor in the air. Its taste is specific and pungent, but it is not extremely strong, but it cannot be ignored.
The above physical properties are of great significance in the fields of organic synthesis, chemical analysis, etc. Practitioners need to know in detail in order to use them properly and avoid errors, so as to form the great cause of chemical experiments and industrial production.
First of all, its appearance, under room temperature and pressure, is mostly colorless to light yellow liquid, with a clear texture. If placed in light, its luster can be seen, like the flow of oil, smooth and not sticky.
Second on its melting point and boiling point. The melting point is about -20 ° C, which means that at relatively low temperatures, it starts to condense into a solid state. The boiling point is roughly between 220 and 230 degrees Celsius, and a higher temperature is required to boil it and convert it into a gaseous state. Such melting boiling point characteristics make it exist as a liquid in a room temperature environment.
Furthermore, its density is about 1.6-1.7g/cm ³, which is heavier than water. If mixed with water, it will sink to the bottom of the water, such as stones entering water, and naturally settle.
Solubility is also a key property. This compound is slightly soluble in water, just like oil floating in water, and is difficult to blend with water. However, in organic solvents, such as ethanol, ether, dichloromethane, etc., it has good solubility and can be miscible with it, just like water, regardless of each other.
In addition, 1- (bromomethyl) -4-chloro-2-fluorobenzene is volatile and can slowly emit an odor in the air. Its taste is specific and pungent, but it is not extremely strong, but it cannot be ignored.
The above physical properties are of great significance in the fields of organic synthesis, chemical analysis, etc. Practitioners need to know in detail in order to use them properly and avoid errors, so as to form the great cause of chemical experiments and industrial production.
What are the synthesis methods of 1- (bromomethyl) -4-chloro-2-fluorobenzene
The synthesis of 1 - (bromomethyl) -4 -chloro-2 -fluorobenzene is an important topic in organic synthetic chemistry. Its synthesis pathways are diverse and can be achieved through several classical organic reactions.
First, it can be started by the corresponding phenolic compound. First, the phenol is halogenated to introduce chlorine and fluorine atoms. During the halogenation process, careful selection of halogenating reagents and reaction conditions is required to ensure that the halogen atoms are precisely positioned to the desired position. Subsequently, the phenolic hydroxyl group is converted into methyl by a suitable method, and then bromine atoms are introduced into the methyl group with the help of brominating reagents to obtain the target product.
Second, it is also feasible to use halogenated benzene as the starting material. First, a metal-organic reagent, such as Grignard reagent or lithium reagent, is used to react with halogenated benzene to form an active intermediate. After that, bromomethyl is introduced by nucleophilic substitution reaction with suitable halogenated hydrocarbons. In this process, it is crucial to control the reaction solvent, temperature and reagent ratio to ensure the smooth progress of the reaction and obtain a high yield.
Third, this compound can also be synthesized by means of the Fu-G reaction. Select an appropriate halogenated benzene derivative, and carry out the Fu-G alkylation reaction with the halogenated methylation reagent catalyzed by Lewis acid. During the reaction, attention should be paid to the type and dosage of catalysts, as well as the ratio of reaction substrates, so that the reaction can efficiently and selectively generate 1- (bromomethyl) -4-chloro-2-fluorobenzene.
In short, there are many methods for synthesizing 1- (bromomethyl) -4-chloro-2-fluorobenzene. During the actual synthesis, the appropriate synthesis route must be carefully selected according to many factors such as the availability of starting materials, the simplicity of reaction conditions, and the purity and yield of the target product.
First, it can be started by the corresponding phenolic compound. First, the phenol is halogenated to introduce chlorine and fluorine atoms. During the halogenation process, careful selection of halogenating reagents and reaction conditions is required to ensure that the halogen atoms are precisely positioned to the desired position. Subsequently, the phenolic hydroxyl group is converted into methyl by a suitable method, and then bromine atoms are introduced into the methyl group with the help of brominating reagents to obtain the target product.
Second, it is also feasible to use halogenated benzene as the starting material. First, a metal-organic reagent, such as Grignard reagent or lithium reagent, is used to react with halogenated benzene to form an active intermediate. After that, bromomethyl is introduced by nucleophilic substitution reaction with suitable halogenated hydrocarbons. In this process, it is crucial to control the reaction solvent, temperature and reagent ratio to ensure the smooth progress of the reaction and obtain a high yield.
Third, this compound can also be synthesized by means of the Fu-G reaction. Select an appropriate halogenated benzene derivative, and carry out the Fu-G alkylation reaction with the halogenated methylation reagent catalyzed by Lewis acid. During the reaction, attention should be paid to the type and dosage of catalysts, as well as the ratio of reaction substrates, so that the reaction can efficiently and selectively generate 1- (bromomethyl) -4-chloro-2-fluorobenzene.
In short, there are many methods for synthesizing 1- (bromomethyl) -4-chloro-2-fluorobenzene. During the actual synthesis, the appropriate synthesis route must be carefully selected according to many factors such as the availability of starting materials, the simplicity of reaction conditions, and the purity and yield of the target product.
1- (bromomethyl) -4-chloro-2-fluorobenzene what are the precautions during storage and transportation
1 - (bromomethyl) - 4 - chloro - 2 - fluorobenzene is an organic compound, and many matters need careful attention during storage and transportation.
When storing, the first choice of environment. It should be placed in a cool and well-ventilated place, because the compound is prone to change in stability due to heat, or even cause danger. If the temperature is too high, it may cause its volatilization to accelerate, or react due to internal structural changes, so the cool environment can keep its properties stable. And good ventilation can disperse the gas that may be volatile in time, avoid the accumulation of excessive concentration, and reduce the latent risk.
Furthermore, keep away from fire and heat sources. This compound is flammable to a certain extent. In case of open flames and hot topics, it is easy to burn, and even cause explosions, endangering the safety of personnel and facilities.
This compound should be stored separately from oxidants, strong bases and other substances. Because of its active chemical properties, it can come into contact with oxidants or cause severe oxidation reactions; when it encounters strong bases, uncontrollable chemical reactions may also occur, causing product deterioration or dangerous substances.
As for transportation, the packaging must be solid and reliable. It is necessary to choose suitable packaging materials in accordance with relevant regulations to ensure that there is no leakage during transportation. Because of its toxicity and corrosiveness, once it leaks, it will not only pollute the environment, but also cause serious harm to the human body.
During transportation, follow the established route and avoid passing through densely populated areas. This is due to its potential danger. If an accident occurs in a densely populated place, a large number of people will be exposed to danger, resulting in serious consequences.
Transport vehicles also need to be equipped with corresponding fire equipment and leakage emergency treatment equipment. In the event of an emergency, they can respond quickly to reduce losses and hazards. The driving process should be ensured to be smooth and avoid severe bumps and collisions to prevent material leakage caused by damaged packaging.
When storing, the first choice of environment. It should be placed in a cool and well-ventilated place, because the compound is prone to change in stability due to heat, or even cause danger. If the temperature is too high, it may cause its volatilization to accelerate, or react due to internal structural changes, so the cool environment can keep its properties stable. And good ventilation can disperse the gas that may be volatile in time, avoid the accumulation of excessive concentration, and reduce the latent risk.
Furthermore, keep away from fire and heat sources. This compound is flammable to a certain extent. In case of open flames and hot topics, it is easy to burn, and even cause explosions, endangering the safety of personnel and facilities.
This compound should be stored separately from oxidants, strong bases and other substances. Because of its active chemical properties, it can come into contact with oxidants or cause severe oxidation reactions; when it encounters strong bases, uncontrollable chemical reactions may also occur, causing product deterioration or dangerous substances.
As for transportation, the packaging must be solid and reliable. It is necessary to choose suitable packaging materials in accordance with relevant regulations to ensure that there is no leakage during transportation. Because of its toxicity and corrosiveness, once it leaks, it will not only pollute the environment, but also cause serious harm to the human body.
During transportation, follow the established route and avoid passing through densely populated areas. This is due to its potential danger. If an accident occurs in a densely populated place, a large number of people will be exposed to danger, resulting in serious consequences.
Transport vehicles also need to be equipped with corresponding fire equipment and leakage emergency treatment equipment. In the event of an emergency, they can respond quickly to reduce losses and hazards. The driving process should be ensured to be smooth and avoid severe bumps and collisions to prevent material leakage caused by damaged packaging.
1- (bromomethyl) -4-chloro-2-fluorobenzene impact on the environment and human health
1 - (bromomethyl) -4-chloro-2-fluorobenzene is one of the organic compounds. This compound has considerable effects on the environment and human health.
In terms of the environment, it has certain stability, is not easy to degrade naturally, or causes accumulation in the environment. If released into the soil, or changes the physical and chemical properties of the soil, it will affect the structure and function of the soil microbial community, and then disturb the balance of the soil ecosystem. Inflow into water bodies can also cause harm to aquatic organisms. Because of its biological toxicity, it can cause abnormal physiological functions of aquatic organisms, such as affecting the respiratory, reproductive and other functions of fish, and even cause their death. And through the transmission and enrichment of the food chain, the concentration in high trophic level organisms may increase significantly, posing a threat to the structure and function of the entire aquatic ecosystem.
As for human health, 1- (bromomethyl) -4-chloro-2-fluorobenzene may enter the human body through respiratory tract, skin contact and dietary intake. After entering the body, it may interfere with the normal physiological and metabolic process of the human body. Because of its halogen atoms, or lipophilic, it is easy to accumulate in human adipose tissue. Studies have shown that such halogen-containing organic compounds may affect the human endocrine system, interfere with the synthesis, secretion and action of hormones, and cause reproductive and developmental abnormalities. Long-term exposure may increase the risk of cancer. Due to the genetic toxicity of the compound, it can cause genetic mutation, damage the genetic material of cells, and eventually cause cell cancer.
In summary, 1- (bromomethyl) -4-chloro-2-fluorobenzene has potential harm to the environment and human health. Its production, use and disposal should be treated with caution to prevent serious adverse consequences to the ecological environment and human health.
In terms of the environment, it has certain stability, is not easy to degrade naturally, or causes accumulation in the environment. If released into the soil, or changes the physical and chemical properties of the soil, it will affect the structure and function of the soil microbial community, and then disturb the balance of the soil ecosystem. Inflow into water bodies can also cause harm to aquatic organisms. Because of its biological toxicity, it can cause abnormal physiological functions of aquatic organisms, such as affecting the respiratory, reproductive and other functions of fish, and even cause their death. And through the transmission and enrichment of the food chain, the concentration in high trophic level organisms may increase significantly, posing a threat to the structure and function of the entire aquatic ecosystem.
As for human health, 1- (bromomethyl) -4-chloro-2-fluorobenzene may enter the human body through respiratory tract, skin contact and dietary intake. After entering the body, it may interfere with the normal physiological and metabolic process of the human body. Because of its halogen atoms, or lipophilic, it is easy to accumulate in human adipose tissue. Studies have shown that such halogen-containing organic compounds may affect the human endocrine system, interfere with the synthesis, secretion and action of hormones, and cause reproductive and developmental abnormalities. Long-term exposure may increase the risk of cancer. Due to the genetic toxicity of the compound, it can cause genetic mutation, damage the genetic material of cells, and eventually cause cell cancer.
In summary, 1- (bromomethyl) -4-chloro-2-fluorobenzene has potential harm to the environment and human health. Its production, use and disposal should be treated with caution to prevent serious adverse consequences to the ecological environment and human health.
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