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1-(Bromomethyl)-4-Chlorobenzene
Linshang Chemical
|
HS Code |
166380 |
| Chemical Formula | C7H6BrCl |
| Molecular Weight | 205.48 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 234 - 236 °C |
| Melting Point | N/A |
| Density | 1.664 g/mL at 25 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 101.7 °C |
| Vapor Pressure | Low at room temperature |
| Stability | Stable under normal conditions, but reactive towards strong bases and nucleophiles |
As an accredited 1-(Bromomethyl)-4-Chlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1-(bromomethyl)-4-chlorobenzene packaged in a sealed glass bottle. |
| Storage | 1-(Bromomethyl)-4-chlorobenzene should be stored in a cool, dry, well - ventilated area, away from sources of heat, ignition, and oxidizing agents. Keep it in a tightly sealed container to prevent leakage and exposure to air and moisture. Store it in a dedicated chemical storage cabinet, segregated from incompatible substances to avoid potential reactions. |
| Shipping | 1-(Bromomethyl)-4-chlorobenzene is shipped in well - sealed, corrosion - resistant containers. Compliance with regulations for hazardous chemicals is ensured, with proper labeling indicating its nature and precautions during transport. |
Competitive 1-(Bromomethyl)-4-Chlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-(Bromomethyl)-4-Chlorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1- (bromomethyl) -4-chlorobenzene?
1 - (bromomethyl) - 4 -chlorobenzene has a wide range of main uses. In the field of organic synthesis, it can be called a crucial intermediate.
Because of the unique activity of bromomethyl and chlorine atoms in the structure, a variety of organic compounds can be derived through many chemical reactions. For example, in nucleophilic substitution reactions, bromomethyl is highly susceptible to attack by nucleophiles, which in turn introduces various functional groups. For example, when reacting with alcohols, ether substances can be formed; when interacting with amine compounds, amine-substituted products can be formed.
Furthermore, in the field of medicinal chemistry, it also plays an indispensable role. With its special chemical structure, it can provide key structural fragments for the design of drug molecules. Many biologically active drug molecules are often synthesized with 1- (bromomethyl) -4-chlorobenzene as the starting material. Through a series of delicate reaction steps, complex molecular structures with specific pharmacological activities are constructed to meet the needs of treating various diseases.
In addition, in the field of materials science, it also shows certain application potential. Through its participation in polymerization reactions or modification reactions, polymer materials with special properties can be prepared. For example, functional modification of certain polymers imparts materials with better solubility, thermal stability or optical properties, thereby expanding the application range of materials in different fields.
To sum up, 1- (bromomethyl) -4-chlorobenzene has important uses in many fields such as organic synthesis, medicinal chemistry, and materials science, and plays a significant role in promoting the development of related fields.
Because of the unique activity of bromomethyl and chlorine atoms in the structure, a variety of organic compounds can be derived through many chemical reactions. For example, in nucleophilic substitution reactions, bromomethyl is highly susceptible to attack by nucleophiles, which in turn introduces various functional groups. For example, when reacting with alcohols, ether substances can be formed; when interacting with amine compounds, amine-substituted products can be formed.
Furthermore, in the field of medicinal chemistry, it also plays an indispensable role. With its special chemical structure, it can provide key structural fragments for the design of drug molecules. Many biologically active drug molecules are often synthesized with 1- (bromomethyl) -4-chlorobenzene as the starting material. Through a series of delicate reaction steps, complex molecular structures with specific pharmacological activities are constructed to meet the needs of treating various diseases.
In addition, in the field of materials science, it also shows certain application potential. Through its participation in polymerization reactions or modification reactions, polymer materials with special properties can be prepared. For example, functional modification of certain polymers imparts materials with better solubility, thermal stability or optical properties, thereby expanding the application range of materials in different fields.
To sum up, 1- (bromomethyl) -4-chlorobenzene has important uses in many fields such as organic synthesis, medicinal chemistry, and materials science, and plays a significant role in promoting the development of related fields.
What are the physical properties of 1- (bromomethyl) -4-chlorobenzene?
1 - (bromomethyl) - 4 - chlorobenzene is an organic compound. It has unique physical properties, which are described below.
Looking at its properties, under room temperature and pressure, 1- (bromomethyl) - 4 - chlorobenzene is a colorless to light yellow liquid, but the color may be slightly changed due to some impurities. Its appearance is oily, the texture is relatively uniform, and it has a certain fluidity. It is like Yingying autumn water, with slight ripples.
As for the smell, this compound emits a special smell, which has a pungent smell. Although it is not as strong as the stench, it is enough to make people perceive its unique smell. This odor can be tolerated in a well-ventilated place; if it is in a confined space, the odor will gradually accumulate and cause discomfort.
When it comes to the melting point, its melting point is about -21 ° C. At this temperature, the substance gradually melts from a solid state to a liquid state, such as ice disappearing under the warm sun. The boiling point is about 239-241 ° C. When the temperature rises to this temperature, the liquid boils and becomes gaseous. The characteristics of this melting point are of great significance in its separation, purification and storage.
In terms of solubility, 1- (bromomethyl) -4-chlorobenzene is insoluble in water. The two seem to be incompatible with water and fire. After standing, they are clearly layered, with water taking the place, and the compound takes the lead. However, in organic solvents, such as carbon tetrachloride, ether, etc., it shows good solubility and can be miscible with it, just like water emulsion.
Above the density, its density is greater than that of water, about 1.66 g/cm ³. Drop it into water, such as a stone sinking to the bottom of the water, and slowly settle. This density characteristic also provides a convenient way to separate its mixture with water.
In addition, 1- (bromomethyl) -4-chlorobenzene is volatile to a certain extent. At room temperature, although the volatilization rate is not very fast, if exposed to air, its quality will be reduced over time. This is something that must be observed during actual operation and storage.
Looking at its properties, under room temperature and pressure, 1- (bromomethyl) - 4 - chlorobenzene is a colorless to light yellow liquid, but the color may be slightly changed due to some impurities. Its appearance is oily, the texture is relatively uniform, and it has a certain fluidity. It is like Yingying autumn water, with slight ripples.
As for the smell, this compound emits a special smell, which has a pungent smell. Although it is not as strong as the stench, it is enough to make people perceive its unique smell. This odor can be tolerated in a well-ventilated place; if it is in a confined space, the odor will gradually accumulate and cause discomfort.
When it comes to the melting point, its melting point is about -21 ° C. At this temperature, the substance gradually melts from a solid state to a liquid state, such as ice disappearing under the warm sun. The boiling point is about 239-241 ° C. When the temperature rises to this temperature, the liquid boils and becomes gaseous. The characteristics of this melting point are of great significance in its separation, purification and storage.
In terms of solubility, 1- (bromomethyl) -4-chlorobenzene is insoluble in water. The two seem to be incompatible with water and fire. After standing, they are clearly layered, with water taking the place, and the compound takes the lead. However, in organic solvents, such as carbon tetrachloride, ether, etc., it shows good solubility and can be miscible with it, just like water emulsion.
Above the density, its density is greater than that of water, about 1.66 g/cm ³. Drop it into water, such as a stone sinking to the bottom of the water, and slowly settle. This density characteristic also provides a convenient way to separate its mixture with water.
In addition, 1- (bromomethyl) -4-chlorobenzene is volatile to a certain extent. At room temperature, although the volatilization rate is not very fast, if exposed to air, its quality will be reduced over time. This is something that must be observed during actual operation and storage.
What are the chemical properties of 1- (bromomethyl) -4-chlorobenzene
1 - (bromomethyl) - 4 - chlorobenzene has important chemical properties and is widely used in the field of organic synthesis.
This compound has the characteristics of halogenated hydrocarbons. The benzene ring connected to the bromomethyl and chlorine atoms is unique due to the conjugation system of the benzene ring.
As far as bromomethyl is concerned, the bromine atom has high activity and is prone to nucleophilic substitution reactions. The capping bromide atom has a large electronegativity, and the carbon-bromide bond connected to the methyl group has a certain polarity. The carbon has a partial positive charge and is vulnerable to attack by nucleophilic reagents. Common nucleophilic reagents such as alcohols, amines, carboxylates, etc., can react with it For example, under alkali catalysis with alcohols, ether compounds can be formed; when reacted with amines, amine-substituted products can be obtained.
Furthermore, the 4-chlorobenzene ring part, although the chlorine atom can also participate in the nucleophilic substitution reaction, due to the conjugation effect of the benzene ring, its activity is slightly lower than that of the bromine atom in the bromo methyl group. However, under certain conditions, such as high temperature, strong base or the presence of catalytically active metal complexes, the chlorine atom can also be replaced by a nucleophilic reagent. In addition, the benzene ring can also undergo electrophilic substitution reaction. Because the chlorine atom is an ortho-para-position group, when the electrophilic reagent attacks the benzene ring, it tends to react in the ortho
1- (bromomethyl) -4 -chlorobenzene contains two halogen atoms of bromine and chlorine, and is rich in chemical properties. It is an important intermediate in organic synthesis chemistry. It can construct organic compounds with diverse structures through various reaction paths.
This compound has the characteristics of halogenated hydrocarbons. The benzene ring connected to the bromomethyl and chlorine atoms is unique due to the conjugation system of the benzene ring.
As far as bromomethyl is concerned, the bromine atom has high activity and is prone to nucleophilic substitution reactions. The capping bromide atom has a large electronegativity, and the carbon-bromide bond connected to the methyl group has a certain polarity. The carbon has a partial positive charge and is vulnerable to attack by nucleophilic reagents. Common nucleophilic reagents such as alcohols, amines, carboxylates, etc., can react with it For example, under alkali catalysis with alcohols, ether compounds can be formed; when reacted with amines, amine-substituted products can be obtained.
Furthermore, the 4-chlorobenzene ring part, although the chlorine atom can also participate in the nucleophilic substitution reaction, due to the conjugation effect of the benzene ring, its activity is slightly lower than that of the bromine atom in the bromo methyl group. However, under certain conditions, such as high temperature, strong base or the presence of catalytically active metal complexes, the chlorine atom can also be replaced by a nucleophilic reagent. In addition, the benzene ring can also undergo electrophilic substitution reaction. Because the chlorine atom is an ortho-para-position group, when the electrophilic reagent attacks the benzene ring, it tends to react in the ortho
1- (bromomethyl) -4 -chlorobenzene contains two halogen atoms of bromine and chlorine, and is rich in chemical properties. It is an important intermediate in organic synthesis chemistry. It can construct organic compounds with diverse structures through various reaction paths.
What are the preparation methods of 1- (bromomethyl) -4-chlorobenzene
1 - (bromomethyl) - 4 -chlorobenzene, there are several ways to prepare it. First, p-chlorotoluene can be co-heated with N-bromosuccinimide (NBS), with benzoyl peroxide as the initiator. In this reaction, NBS is the source of bromine, and benzoyl peroxide can initiate a free radical reaction. The methyl of p-chlorotoluene is substituted by bromine atoms under the action of free radicals, resulting in 1 - (bromomethyl) - 4 -chlorobenzene. During the reaction, attention should be paid to temperature control, and the solvent should be selected as inert ones such as carbon tetrachloride to avoid side reactions.
Furthermore, it can be prepared by the reaction of p-chlorobenzyl alcohol and hydrobromic acid. The hydroxyl group of p-chlorobenzyl alcohol can be replaced by the bromine ion of hydrobromic acid. This reaction often requires a catalyst such as sulfuric acid to promote the speed of the reaction. In the reaction system, the temperature also needs to be adjusted. If it is too high, it is easy to cause side reactions, and if it is too low, the reaction will be delayed. And after the reaction is completed, it needs to be separated and purified to obtain a pure product.
There are also those who use p-chlorobenzaldehyde as raw material. First, p-chlorobenzaldehyde is reduced to p-chlorobenzyl alcohol, which is commonly used as a reducing agent such as sodium borohydride. Then, p-chlorobenzyl alcohol is reacted with hydrobromic acid according to the previous method, and finally 1- (bromomethyl) -4 -chlorobenz Although the steps of this path are slightly more complicated, the raw materials may be easier to obtain, and the reaction conditions of each step may be easier to control, so it is also one of the methods for preparing this compound. All preparation methods have their own advantages and disadvantages. In practice, it should be selected according to the availability of raw materials, the cost, and the purity of the product.
Furthermore, it can be prepared by the reaction of p-chlorobenzyl alcohol and hydrobromic acid. The hydroxyl group of p-chlorobenzyl alcohol can be replaced by the bromine ion of hydrobromic acid. This reaction often requires a catalyst such as sulfuric acid to promote the speed of the reaction. In the reaction system, the temperature also needs to be adjusted. If it is too high, it is easy to cause side reactions, and if it is too low, the reaction will be delayed. And after the reaction is completed, it needs to be separated and purified to obtain a pure product.
There are also those who use p-chlorobenzaldehyde as raw material. First, p-chlorobenzaldehyde is reduced to p-chlorobenzyl alcohol, which is commonly used as a reducing agent such as sodium borohydride. Then, p-chlorobenzyl alcohol is reacted with hydrobromic acid according to the previous method, and finally 1- (bromomethyl) -4 -chlorobenz Although the steps of this path are slightly more complicated, the raw materials may be easier to obtain, and the reaction conditions of each step may be easier to control, so it is also one of the methods for preparing this compound. All preparation methods have their own advantages and disadvantages. In practice, it should be selected according to the availability of raw materials, the cost, and the purity of the product.
What are the precautions for 1- (bromomethyl) -4-chlorobenzene during storage and transportation?
1 - (bromomethyl) -4 -chlorobenzene is also an organic compound. During storage and transportation, there are a number of urgent precautions that should not be ignored.
First words storage, this compound should be placed in a cool, dry and well-ventilated place. Because it is more sensitive to heat, if heated, it may cause chemical changes or even cause danger. Therefore, it is necessary to avoid the side of heat sources and fire sources, and must not be exposed to direct sunlight. The temperature of the warehouse should be maintained within a moderate range to prevent it from decomposing or deteriorating due to excessive temperature.
Furthermore, this compound may be toxic and corrosive to a certain extent. When storing, it must be placed separately from oxidizing agents, strong alkalis, strong acids and other substances to prevent violent reactions from interacting and causing disasters. At the same time, storage containers should also be carefully selected, and corrosion-resistant and well-sealed materials should be used to prevent leakage.
As for transportation, the carrier must have professional qualifications and rich experience, and be familiar with the characteristics and transportation specifications of such chemicals. Transportation vehicles should be equipped with complete fire protection facilities and leakage emergency treatment equipment for emergencies.
During transportation, vehicles must run smoothly to avoid violent vibrations and collisions to prevent material leakage caused by damage to the container. And the temperature and humidity of the transportation environment should also be strictly controlled and maintained within an appropriate range. If the transportation process passes through densely populated areas, it is even more prudent to follow a specific route and time to reduce the possibility of accidents.
In addition, whether it is storage or transportation, relevant personnel should be familiar with the emergency treatment methods for the leakage of this compound. If something happens, they can respond quickly and properly to ensure the safety of personnel and the environment.
First words storage, this compound should be placed in a cool, dry and well-ventilated place. Because it is more sensitive to heat, if heated, it may cause chemical changes or even cause danger. Therefore, it is necessary to avoid the side of heat sources and fire sources, and must not be exposed to direct sunlight. The temperature of the warehouse should be maintained within a moderate range to prevent it from decomposing or deteriorating due to excessive temperature.
Furthermore, this compound may be toxic and corrosive to a certain extent. When storing, it must be placed separately from oxidizing agents, strong alkalis, strong acids and other substances to prevent violent reactions from interacting and causing disasters. At the same time, storage containers should also be carefully selected, and corrosion-resistant and well-sealed materials should be used to prevent leakage.
As for transportation, the carrier must have professional qualifications and rich experience, and be familiar with the characteristics and transportation specifications of such chemicals. Transportation vehicles should be equipped with complete fire protection facilities and leakage emergency treatment equipment for emergencies.
During transportation, vehicles must run smoothly to avoid violent vibrations and collisions to prevent material leakage caused by damage to the container. And the temperature and humidity of the transportation environment should also be strictly controlled and maintained within an appropriate range. If the transportation process passes through densely populated areas, it is even more prudent to follow a specific route and time to reduce the possibility of accidents.
In addition, whether it is storage or transportation, relevant personnel should be familiar with the emergency treatment methods for the leakage of this compound. If something happens, they can respond quickly and properly to ensure the safety of personnel and the environment.
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