Linshang Chemical
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1-Chloro-2,3,5,6-Tetrafluoro-4-Nitrobenzene
Linshang Chemical
|
HS Code |
207929 |
| Name | 1-Chloro-2,3,5,6-Tetrafluoro-4-Nitrobenzene |
| Molecular Formula | C6ClF4NO2 |
| Molecular Weight | 231.51 |
| Appearance | Solid (Typical) |
| Cas Number | 116359-83-6 |
| Boiling Point | Around 193 - 195 °C |
| Melting Point | 56 - 58 °C |
| Density | Data may vary |
| Solubility | Solubility characteristics would depend on the solvent |
| Vapor Pressure | Low vapor pressure expected |
| Flash Point | Data may vary |
As an accredited 1-Chloro-2,3,5,6-Tetrafluoro-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1 - chloro - 2,3,5,6 - tetrafluoro - 4 - nitrobenzene in sealed glass bottles. |
| Storage | 1 - Chloro - 2,3,5,6 - tetrafluoro - 4 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and incompatible substances to avoid potential chemical reactions. Regularly check storage conditions and container integrity. |
| Shipping | 1 - Chloro - 2,3,5,6 - tetrafluoro - 4 - nitrobenzene is shipped in specialized, well - sealed containers to prevent leakage. It follows strict hazardous chemical shipping regulations, ensuring safe transport due to its potentially dangerous nature. |
Competitive 1-Chloro-2,3,5,6-Tetrafluoro-4-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Chloro-2,3,5,6-Tetrafluoro-4-Nitrobenzene in China?
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As a leading 1-Chloro-2,3,5,6-Tetrafluoro-4-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 1-chloro-2,3,5, 6-tetrafluoro-4-nitrobenzene?
1-Chloro-2,3,5,6-tetrafluoro-4-nitrobenzene is one of the organic compounds. Its physical properties are quite special, let me tell them one by one.
First of all, its appearance, under room temperature and pressure, is mostly colorless to light yellow liquid form, clear to view, like a fountain. This liquid has a uniform texture and flows, as if it is agile.
As for its melting point, it is about a specific low temperature range, just like a dim light hidden in the cold night, which can only be observed with precise instruments. The boiling point is in a certain temperature range. When the temperature rises to that point, the compound will resemble a light butterfly, sublimating from the liquid state to the gaseous state.
Density is also one of its important physical properties, and its value is greater than that of water. Therefore, if it meets with water, it will sink at the bottom of the water, like a pearl falling into the abyss.
In terms of solubility, it can be mixed with common organic solvents, such as alcohols and ethers, just like a fish entering the Wang Yang, and the two can be mixed into one. However, in water, it is very difficult to dissolve, just like the contradiction between oil and water, and the boundaries are clear.
Furthermore, its volatility is moderate, it does not dissipate quickly like a storm or stand still like a rock, but slowly distributes in the air, like a dark fragrance, quietly diffusing.
The physical properties of this compound are of crucial significance in the fields of chemical industry and scientific research, laying the foundation for many reactions and applications.
First of all, its appearance, under room temperature and pressure, is mostly colorless to light yellow liquid form, clear to view, like a fountain. This liquid has a uniform texture and flows, as if it is agile.
As for its melting point, it is about a specific low temperature range, just like a dim light hidden in the cold night, which can only be observed with precise instruments. The boiling point is in a certain temperature range. When the temperature rises to that point, the compound will resemble a light butterfly, sublimating from the liquid state to the gaseous state.
Density is also one of its important physical properties, and its value is greater than that of water. Therefore, if it meets with water, it will sink at the bottom of the water, like a pearl falling into the abyss.
In terms of solubility, it can be mixed with common organic solvents, such as alcohols and ethers, just like a fish entering the Wang Yang, and the two can be mixed into one. However, in water, it is very difficult to dissolve, just like the contradiction between oil and water, and the boundaries are clear.
Furthermore, its volatility is moderate, it does not dissipate quickly like a storm or stand still like a rock, but slowly distributes in the air, like a dark fragrance, quietly diffusing.
The physical properties of this compound are of crucial significance in the fields of chemical industry and scientific research, laying the foundation for many reactions and applications.
What are the chemical properties of 1-chloro-2,3,5, 6-tetrafluoro-4-nitrobenzene?
1-Chloro-2,3,5,6-tetrafluoro-4-nitrobenzene is also an organic compound. Its chemical properties are specific and worthy of in-depth study.
First of all, its activity is high due to the coexistence of chlorine atoms and nitro groups on the benzene ring. Nitro groups have strong electron-absorbing properties, which reduce the electron cloud density of the benzene ring, especially the o-para-position. Although the chlorine atom is an o-para-position group, under the influence of the strong electron-absorbing nitro group, the electron cloud density of the o-para-position decreases even more, which greatly increases the activity of the chlorine atom and makes it easy to be replaced by nucleophiles.
And its nucleophilic substitution reaction. Under appropriate conditions, chlorine atoms can react with many nucleophilic reagents, such as alkoxides and amines. For example, when reacting with sodium alcohol, corresponding ether compounds can be formed; when reacting with amines, nitrogen-containing derivatives can be obtained. This is all due to the electron-absorbing effect of nitro, which enhances the attraction of benzene rings to nucleophilic reagents.
Furthermore, in terms of stability, although benzene rings have a certain conjugation stability, the presence of nitro groups and multiple fluorine atoms makes the charge distribution in the molecule uneven. Fluorine atoms are extremely electronegative and have strong attractiveness to electrons. Nitro groups also have strong electron absorption. The two work together, or affect the overall stability of the molecule. In case of extreme conditions such as high temperature and strong bases, decomposition reactions may be triggered.
The reaction selectivity is repeated. In the nucleophilic substitution reaction, due to the position of the fluorine atom and the localization effect of the nitro group, the nucleophilic reagents often attack the position of the chlorine atom. This is because the nitro group and the fluorine atom jointly affect the distribution of the electron cloud of the benzene ring, making it easier to accept the attack of nucleophilic reagents.
The chemical properties of 1-chloro-2,3,5,6-tetrafluoro-4-nitrobenzene are formed by the interaction of various groups in its structure. In the field of organic synthesis, its activity and selectivity can be used to prepare a variety of organic compounds with special structures and properties.
First of all, its activity is high due to the coexistence of chlorine atoms and nitro groups on the benzene ring. Nitro groups have strong electron-absorbing properties, which reduce the electron cloud density of the benzene ring, especially the o-para-position. Although the chlorine atom is an o-para-position group, under the influence of the strong electron-absorbing nitro group, the electron cloud density of the o-para-position decreases even more, which greatly increases the activity of the chlorine atom and makes it easy to be replaced by nucleophiles.
And its nucleophilic substitution reaction. Under appropriate conditions, chlorine atoms can react with many nucleophilic reagents, such as alkoxides and amines. For example, when reacting with sodium alcohol, corresponding ether compounds can be formed; when reacting with amines, nitrogen-containing derivatives can be obtained. This is all due to the electron-absorbing effect of nitro, which enhances the attraction of benzene rings to nucleophilic reagents.
Furthermore, in terms of stability, although benzene rings have a certain conjugation stability, the presence of nitro groups and multiple fluorine atoms makes the charge distribution in the molecule uneven. Fluorine atoms are extremely electronegative and have strong attractiveness to electrons. Nitro groups also have strong electron absorption. The two work together, or affect the overall stability of the molecule. In case of extreme conditions such as high temperature and strong bases, decomposition reactions may be triggered.
The reaction selectivity is repeated. In the nucleophilic substitution reaction, due to the position of the fluorine atom and the localization effect of the nitro group, the nucleophilic reagents often attack the position of the chlorine atom. This is because the nitro group and the fluorine atom jointly affect the distribution of the electron cloud of the benzene ring, making it easier to accept the attack of nucleophilic reagents.
The chemical properties of 1-chloro-2,3,5,6-tetrafluoro-4-nitrobenzene are formed by the interaction of various groups in its structure. In the field of organic synthesis, its activity and selectivity can be used to prepare a variety of organic compounds with special structures and properties.
What are the main uses of 1-chloro-2,3,5, 6-tetrafluoro-4-nitrobenzene?
1-Chloro-2,3,5,6-tetrafluoro-4-nitrobenzene has a wide range of uses. In the field of organic synthesis, its position is crucial.
One of them is often the key starting material for the synthesis of fluorine-containing nitroaromatic hydrocarbons. Because of its high activity of chlorine atoms and nitro groups in molecules, it can interact with various nucleophiles such as alcohols and amines through many nucleophilic substitution reactions. In this way, a series of fluorine-containing organic compounds with different functional groups can be constructed, which is of great significance in the process of pharmaceutical and pesticide creation.
Second, in the field of pharmaceutical research and development, by virtue of the unique electronic effects of fluorine atoms in molecules and the characteristics of bioelectronics, fluorinated drugs synthesized from this substance often have better biological activity, metabolic stability and targeting. The development of many new antibacterial and anticancer drugs uses it as the starting material to carry out related synthesis work.
Third, in the field of pesticides, fluorinated pesticides synthesized based on it, such as fluorinated insecticides and fungicides, have significant control effects on pests and pathogens, and have the advantages of high efficiency, low toxicity and environmental friendliness, which have greatly promoted the development of green pesticides.
Fourth, in the field of materials science, fluoropolymers or functional materials derived from them exhibit excellent characteristics in heat resistance, corrosion resistance, and electrical properties, and can be applied to high-end electronic materials, special coatings, and other fields to help improve and innovate the properties of related materials.
One of them is often the key starting material for the synthesis of fluorine-containing nitroaromatic hydrocarbons. Because of its high activity of chlorine atoms and nitro groups in molecules, it can interact with various nucleophiles such as alcohols and amines through many nucleophilic substitution reactions. In this way, a series of fluorine-containing organic compounds with different functional groups can be constructed, which is of great significance in the process of pharmaceutical and pesticide creation.
Second, in the field of pharmaceutical research and development, by virtue of the unique electronic effects of fluorine atoms in molecules and the characteristics of bioelectronics, fluorinated drugs synthesized from this substance often have better biological activity, metabolic stability and targeting. The development of many new antibacterial and anticancer drugs uses it as the starting material to carry out related synthesis work.
Third, in the field of pesticides, fluorinated pesticides synthesized based on it, such as fluorinated insecticides and fungicides, have significant control effects on pests and pathogens, and have the advantages of high efficiency, low toxicity and environmental friendliness, which have greatly promoted the development of green pesticides.
Fourth, in the field of materials science, fluoropolymers or functional materials derived from them exhibit excellent characteristics in heat resistance, corrosion resistance, and electrical properties, and can be applied to high-end electronic materials, special coatings, and other fields to help improve and innovate the properties of related materials.
What are the synthesis methods of 1-chloro-2,3,5, 6-tetrafluoro-4-nitrobenzene?
There are several common methods for the synthesis of 1-chloro-2,3,5,6-tetrafluoro-4-nitrobenzene.
One is the halogenation reaction path. First, take a suitable benzene derivative and use a specific halogenation reagent, such as a halogenating agent containing chlorine and fluorine, to carry out the halogenation reaction under suitable reaction conditions, such as specific temperature, pressure and catalyst existence. By carefully adjusting the reaction parameters, chlorine atoms and fluorine atoms can be gradually introduced to achieve the desired halogenated benzene structure. In this process, the choice of catalyst is crucial, which can affect the reaction rate and product selectivity. For example, the selection of certain metal halide catalysts can promote the precise replacement of hydrogen atoms at specific positions on the benzene ring by fluorine atoms.
The second is the strategy of nitration reaction combined with halogenation. First, the benzene ring is nitrified, and the nitro group is introduced into the benzene ring in a mixed acid system of nitric acid and sulfuric acid at an appropriate temperature range. Then the halogenation reaction is carried out, and chlorine atoms and fluorine atoms are introduced in sequence. This method needs to pay attention to the control of the conditions of each step of the reaction, because the presence of nitro groups will affect the electron cloud density of the benzene ring, which in turn affects the difficulty and position selectivity of the subsequent halogenation reaction.
Furthermore, specific organic reagents containing fluorine, chlorine and nitro groups can be used to construct target molecules through nucleophilic substitution reactions. The structure of 1-chloro-2,3,5,6-tetrafluoro-4-nitrobenzene is formed by using organic compounds with suitable leaving groups as raw materials and reacting with fluorine-containing and chlorine-containing nucleophiles under the action of suitable solvents and bases. This path requires high requirements for the selection of raw materials and the optimization of reaction conditions, and it is necessary to ensure that the nucleophilic substitution reaction is efficient and selective.
When synthesizing this compound, regardless of the method used, the reaction conditions, including temperature, pH, reaction time, etc., need to be carefully controlled, and the intermediate and product need to be precisely separated and purified to obtain high-purity 1-chloro-2,3,5,6-tetrafluoro-4-nitrobenzene.
One is the halogenation reaction path. First, take a suitable benzene derivative and use a specific halogenation reagent, such as a halogenating agent containing chlorine and fluorine, to carry out the halogenation reaction under suitable reaction conditions, such as specific temperature, pressure and catalyst existence. By carefully adjusting the reaction parameters, chlorine atoms and fluorine atoms can be gradually introduced to achieve the desired halogenated benzene structure. In this process, the choice of catalyst is crucial, which can affect the reaction rate and product selectivity. For example, the selection of certain metal halide catalysts can promote the precise replacement of hydrogen atoms at specific positions on the benzene ring by fluorine atoms.
The second is the strategy of nitration reaction combined with halogenation. First, the benzene ring is nitrified, and the nitro group is introduced into the benzene ring in a mixed acid system of nitric acid and sulfuric acid at an appropriate temperature range. Then the halogenation reaction is carried out, and chlorine atoms and fluorine atoms are introduced in sequence. This method needs to pay attention to the control of the conditions of each step of the reaction, because the presence of nitro groups will affect the electron cloud density of the benzene ring, which in turn affects the difficulty and position selectivity of the subsequent halogenation reaction.
Furthermore, specific organic reagents containing fluorine, chlorine and nitro groups can be used to construct target molecules through nucleophilic substitution reactions. The structure of 1-chloro-2,3,5,6-tetrafluoro-4-nitrobenzene is formed by using organic compounds with suitable leaving groups as raw materials and reacting with fluorine-containing and chlorine-containing nucleophiles under the action of suitable solvents and bases. This path requires high requirements for the selection of raw materials and the optimization of reaction conditions, and it is necessary to ensure that the nucleophilic substitution reaction is efficient and selective.
When synthesizing this compound, regardless of the method used, the reaction conditions, including temperature, pH, reaction time, etc., need to be carefully controlled, and the intermediate and product need to be precisely separated and purified to obtain high-purity 1-chloro-2,3,5,6-tetrafluoro-4-nitrobenzene.
What are the precautions for 1-chloro-2,3,5, 6-tetrafluoro-4-nitrobenzene during storage and transportation?
1-Chloro-2,3,5,6-tetrafluoro-4-nitrobenzene is a chemical substance. During storage and transportation, many matters must not be ignored.
First storage, this substance needs to be placed in a cool, dry and well ventilated place. Cover because of its chemical activity, high temperature and humid environment, it is easy to cause its deterioration, or even dangerous reactions. And it should be stored separately with oxidizing agents, reducing agents, alkalis, etc., because it can react with various chemicals, mixed storage is prone to disaster.
Storage device should also be carefully selected. Corrosion-resistant materials must be used, such as glass, certain plastics or metal containers, and must be tightly sealed to prevent leakage and prevent it from changing when it comes into contact with air and water vapor.
As for transportation, the transporter must be familiar with the characteristics and safety procedures of this object. The packaging must be solid and reliable, capable of withstanding ordinary vibration, collision and friction, and warning signs must be pasted in accordance with regulations to indicate its danger.
During transportation, temperature control is also a priority to avoid high temperature environments to prevent decomposition or other hazards. Vehicles should also be clean and dry, and no impurities that can react with them should remain.
When loading and unloading, the operator should be cautious and wear appropriate protective equipment, such as gloves, goggles and protective clothing, to prevent it from coming into contact with the body. In case of accidental leakage, deal with it immediately according to emergency measures, contain and collect the leakage to ensure environmental and personal safety.
In short, 1-chloro-2,3,5,6-tetrafluoro-4-nitrobenzene is stored and transported in all details, which are related to safety and must be strictly followed.
First storage, this substance needs to be placed in a cool, dry and well ventilated place. Cover because of its chemical activity, high temperature and humid environment, it is easy to cause its deterioration, or even dangerous reactions. And it should be stored separately with oxidizing agents, reducing agents, alkalis, etc., because it can react with various chemicals, mixed storage is prone to disaster.
Storage device should also be carefully selected. Corrosion-resistant materials must be used, such as glass, certain plastics or metal containers, and must be tightly sealed to prevent leakage and prevent it from changing when it comes into contact with air and water vapor.
As for transportation, the transporter must be familiar with the characteristics and safety procedures of this object. The packaging must be solid and reliable, capable of withstanding ordinary vibration, collision and friction, and warning signs must be pasted in accordance with regulations to indicate its danger.
During transportation, temperature control is also a priority to avoid high temperature environments to prevent decomposition or other hazards. Vehicles should also be clean and dry, and no impurities that can react with them should remain.
When loading and unloading, the operator should be cautious and wear appropriate protective equipment, such as gloves, goggles and protective clothing, to prevent it from coming into contact with the body. In case of accidental leakage, deal with it immediately according to emergency measures, contain and collect the leakage to ensure environmental and personal safety.
In short, 1-chloro-2,3,5,6-tetrafluoro-4-nitrobenzene is stored and transported in all details, which are related to safety and must be strictly followed.
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