Linshang Chemical
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1-Chloro-2,3,5,6-Tetrafluorobenzene
Linshang Chemical
|
HS Code |
182165 |
| Chemical Formula | C6HClF4 |
| Appearance | Colorless liquid |
| Boiling Point | 118 - 119 °C |
| Melting Point | -44 °C |
| Density | 1.456 g/mL at 25 °C |
| Vapor Pressure | 3.79 kPa at 20 °C |
| Solubility In Water | Insoluble |
| Flash Point | 26 °C |
| Refractive Index | 1.4295 |
As an accredited 1-Chloro-2,3,5,6-Tetrafluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 2,3,5,6 - tetrafluorobenzene in 500 - mL glass bottles, 20 bottles per carton. |
| Storage | 1 - Chloro - 2,3,5,6 - tetrafluorobenzene should be stored in a cool, well - ventilated area, away from heat sources and open flames. It should be stored in a tightly - sealed container made of materials compatible with the chemical, such as stainless steel or certain plastics. Keep it separate from oxidizing agents and reactive substances to prevent potential chemical reactions. |
| Shipping | 1 - Chloro - 2,3,5,6 - tetrafluorobenzene is shipped in sealed, corrosion - resistant containers. Shipment follows strict chemical transport regulations to ensure safety during transit, safeguarding against spills and environmental exposure. |
Competitive 1-Chloro-2,3,5,6-Tetrafluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Chloro-2,3,5,6-Tetrafluorobenzene in China?
As a trusted 1-Chloro-2,3,5,6-Tetrafluorobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Chloro-2,3,5,6-Tetrafluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 1-chloro-2,3,5, 6-tetrafluorobenzene
1-Chloro-2,3,5,6-tetrafluorobenzene is widely used in various fields of chemical industry.
First, it is often a key intermediate in the synthesis of medicine. Because of its unique structure, it can be chemically modified and introduced into the molecular structure of the drug to endow the drug with specific pharmacological activity. For example, the development of new drugs such as antibacterial and antiviral, based on this, through a series of reactions, complex and effective active ingredients can be constructed to help create drugs with better efficacy and fewer side effects.
Second, it is also important in the creation of pesticides. With this as the starting material, through exquisite synthesis design, high-efficiency, low-toxicity and environmentally friendly pesticide varieties can be prepared. Its special fluorochlorine atom combination can enhance the effect of pesticides on pest targets, improve insecticidal, bactericidal or herbicidal performance, and reduce the adverse effects on non-target organisms and the environment.
Third, in the field of materials science, it is also useful. Can participate in the synthesis of high-performance polymer materials. By reacting with other monomers, fluorochlorine groups are introduced into the main chain or side chain of the polymer, imparting properties such as excellent thermal stability, chemical stability and low surface energy to the material. It is used to make special engineering plastics, coatings or functional film materials, which are in high-end fields such as aerospace and electronics.
Or in the study of organic synthetic chemistry, as substrates to explore new reaction paths and methods. Its unique substitution mode can stimulate chemists to study new reaction mechanisms, expand the boundaries of organic synthesis chemistry, and provide new ideas and strategies for organic compound synthesis.
First, it is often a key intermediate in the synthesis of medicine. Because of its unique structure, it can be chemically modified and introduced into the molecular structure of the drug to endow the drug with specific pharmacological activity. For example, the development of new drugs such as antibacterial and antiviral, based on this, through a series of reactions, complex and effective active ingredients can be constructed to help create drugs with better efficacy and fewer side effects.
Second, it is also important in the creation of pesticides. With this as the starting material, through exquisite synthesis design, high-efficiency, low-toxicity and environmentally friendly pesticide varieties can be prepared. Its special fluorochlorine atom combination can enhance the effect of pesticides on pest targets, improve insecticidal, bactericidal or herbicidal performance, and reduce the adverse effects on non-target organisms and the environment.
Third, in the field of materials science, it is also useful. Can participate in the synthesis of high-performance polymer materials. By reacting with other monomers, fluorochlorine groups are introduced into the main chain or side chain of the polymer, imparting properties such as excellent thermal stability, chemical stability and low surface energy to the material. It is used to make special engineering plastics, coatings or functional film materials, which are in high-end fields such as aerospace and electronics.
Or in the study of organic synthetic chemistry, as substrates to explore new reaction paths and methods. Its unique substitution mode can stimulate chemists to study new reaction mechanisms, expand the boundaries of organic synthesis chemistry, and provide new ideas and strategies for organic compound synthesis.
What are the physical properties of 1-chloro-2,3,5, 6-tetrafluorobenzene
1 - chloro - 2,3,5,6 - tetrafluorobenzene is an organic compound with specific physical properties. It is a colorless to light yellow liquid with a special odor and has important uses in the chemical industry.
Its boiling point is between 128 and 130 ° C. This boiling point determines that at the corresponding temperature, the substance changes from a liquid state to a gaseous state. This property is of great significance in chemical operations such as distillation and separation. By precisely controlling the temperature, it can be effectively separated from the mixture.
And the melting point is about -27 ° C. At this temperature, the substance changes from a solid state to a liquid state. The melting point characteristics affect the storage and transportation conditions of the compound. If the outside temperature is lower than the melting point, it is in a solid state, and care should be taken to prevent the container from breaking due to low temperature.
In terms of density, it is about 1.57 g/cm ³. This value reflects its mass per unit volume. Density is a key parameter when it comes to mixing, metering, etc. For example, when preparing a solution of a specific concentration, the compound needs to be accurately measured according to the density.
In terms of solubility, 1-chloro-2,3,5,6-tetrafluorobenzene is insoluble in water, but soluble in most organic solvents, such as ethanol, ether, etc. This solubility characteristic determines its solvent choice in chemical reactions. If the reaction needs to be carried out in a non-aqueous system, an organic solvent that is soluble with it can be selected to promote the smooth development of the reaction.
In addition, the vapor pressure of the compound also has characteristics. The vapor pressure is closely related to the temperature, and when the temperature increases, the vapor pressure increases. The vapor pressure affects its volatilization degree in the air. During storage and use, this factor needs to be considered to avoid losses due to volatilization or safety problems.
The physical properties of 1-chloro-2,3,5,6-tetrafluorobenzene mentioned above play a key role in many fields such as chemical production and scientific research experiments. Operators need to be familiar with and use them well.
Its boiling point is between 128 and 130 ° C. This boiling point determines that at the corresponding temperature, the substance changes from a liquid state to a gaseous state. This property is of great significance in chemical operations such as distillation and separation. By precisely controlling the temperature, it can be effectively separated from the mixture.
And the melting point is about -27 ° C. At this temperature, the substance changes from a solid state to a liquid state. The melting point characteristics affect the storage and transportation conditions of the compound. If the outside temperature is lower than the melting point, it is in a solid state, and care should be taken to prevent the container from breaking due to low temperature.
In terms of density, it is about 1.57 g/cm ³. This value reflects its mass per unit volume. Density is a key parameter when it comes to mixing, metering, etc. For example, when preparing a solution of a specific concentration, the compound needs to be accurately measured according to the density.
In terms of solubility, 1-chloro-2,3,5,6-tetrafluorobenzene is insoluble in water, but soluble in most organic solvents, such as ethanol, ether, etc. This solubility characteristic determines its solvent choice in chemical reactions. If the reaction needs to be carried out in a non-aqueous system, an organic solvent that is soluble with it can be selected to promote the smooth development of the reaction.
In addition, the vapor pressure of the compound also has characteristics. The vapor pressure is closely related to the temperature, and when the temperature increases, the vapor pressure increases. The vapor pressure affects its volatilization degree in the air. During storage and use, this factor needs to be considered to avoid losses due to volatilization or safety problems.
The physical properties of 1-chloro-2,3,5,6-tetrafluorobenzene mentioned above play a key role in many fields such as chemical production and scientific research experiments. Operators need to be familiar with and use them well.
Is 1-chloro-2,3,5, 6-tetrafluorobenzene chemically stable?
The chemical properties of 1-chloro-2,3,5,6-tetrafluorobenzene are still stable in common sense. In this compound, the structure of the benzene ring gives it a certain stability. Although the substitution of chlorine atoms and fluorine atoms changes the electron cloud distribution, it does not cause its chemical properties to be overactive.
Fluorine atoms have strong electronegativity. On the benzene ring, they will attract electrons, which will reduce the density of the electron cloud of the benzene ring, thereby affecting the activity of the electrophilic substitution reaction. However, due to the relatively small volume of the fluorine atom, the steric resistance effect is not significant, so its stability can still be maintained. Chlorine atoms also affect the electron cloud of the benzene ring, intertwining with the interaction of fluorine atoms.
Under normal conditions, without special reagents or strong reaction conditions, this compound is not prone to spontaneous violent chemical reactions. If exposed to air at room temperature and pressure, it is difficult to react significantly with common substances such as water and oxygen. However, if it encounters strong oxidizing agents or reducing agents, and the reaction conditions are suitable, it may initiate specific chemical reactions and change its chemical structure. However, in general, in common environments and general experimental operations, the chemical properties of 1-chloro-2,3,5,6-tetrafluorobenzene are relatively stable, and it is not prone to unexpected changes. It can be stored and used relatively safely, but it is still necessary to follow the specifications of chemical experiments during operation.
Fluorine atoms have strong electronegativity. On the benzene ring, they will attract electrons, which will reduce the density of the electron cloud of the benzene ring, thereby affecting the activity of the electrophilic substitution reaction. However, due to the relatively small volume of the fluorine atom, the steric resistance effect is not significant, so its stability can still be maintained. Chlorine atoms also affect the electron cloud of the benzene ring, intertwining with the interaction of fluorine atoms.
Under normal conditions, without special reagents or strong reaction conditions, this compound is not prone to spontaneous violent chemical reactions. If exposed to air at room temperature and pressure, it is difficult to react significantly with common substances such as water and oxygen. However, if it encounters strong oxidizing agents or reducing agents, and the reaction conditions are suitable, it may initiate specific chemical reactions and change its chemical structure. However, in general, in common environments and general experimental operations, the chemical properties of 1-chloro-2,3,5,6-tetrafluorobenzene are relatively stable, and it is not prone to unexpected changes. It can be stored and used relatively safely, but it is still necessary to follow the specifications of chemical experiments during operation.
What are the synthesis methods of 1-chloro-2,3,5, 6-tetrafluorobenzene
The synthesis of 1-chloro-2,3,5,6-tetrafluorobenzene is an important research in the field of chemical synthesis. There are several common synthetic routes.
First, tetrafluorobenzene is used as the starting material. Tetrafluorobenzene and appropriate chlorination reagents, such as chlorine ($Cl_2 $), under suitable reaction conditions, such as light or the addition of catalysts (such as ferric chloride $FeCl_3 $), chlorination can occur, resulting in 1-chloro-2,3,5,6-tetrafluorobenzene. The principle of this reaction is that the chlorine atom in the chlorination reagent, under the action of light or catalyst, reacts with the benzene ring of tetrafluorobenzene to replace the hydrogen atom at a specific position on the benzene ring, and then obtains the target product.
Second, fluorohalobenzene can also be used as the starting material. For example, first select a suitable fluorohalobenzene, and through a specific fluorination reaction, introduce fluorine atoms into the benzene ring, adjust the substitution position and number of fluorine atoms, so that it becomes something close to the structure of the target product. Subsequently, the chlorination step is carried out to achieve the purpose of synthesizing 1-chloro-2,3,5,6-tetrafluorobenzene. The key to this method is to control the conditions of fluorination and chlorination reactions to ensure that the reaction can be precisely substituted at the desired position to obtain a high-purity target product.
Third, the reaction path involving organometallic reagents can also be used. For example, halogenated aromatics react with organometallic reagents (such as Grignard's reagent $RMgX $) to form organometallic intermediates with specific structures. After that, fluorine atoms are introduced by reacting with fluorinated reagents, and then chlorinated, and finally 1-chloro-2,3,5,6-tetrafluorobenzene is synthesized. This approach relies on the high activity and selectivity of organometallic reagents to cleverly construct molecular structures to achieve the synthesis of the target product. Each method has its own advantages and disadvantages. In practical application, the appropriate synthesis method needs to be carefully selected according to many factors such as the availability of raw materials, the difficulty of reaction conditions, and the purity requirements of the product.
First, tetrafluorobenzene is used as the starting material. Tetrafluorobenzene and appropriate chlorination reagents, such as chlorine ($Cl_2 $), under suitable reaction conditions, such as light or the addition of catalysts (such as ferric chloride $FeCl_3 $), chlorination can occur, resulting in 1-chloro-2,3,5,6-tetrafluorobenzene. The principle of this reaction is that the chlorine atom in the chlorination reagent, under the action of light or catalyst, reacts with the benzene ring of tetrafluorobenzene to replace the hydrogen atom at a specific position on the benzene ring, and then obtains the target product.
Second, fluorohalobenzene can also be used as the starting material. For example, first select a suitable fluorohalobenzene, and through a specific fluorination reaction, introduce fluorine atoms into the benzene ring, adjust the substitution position and number of fluorine atoms, so that it becomes something close to the structure of the target product. Subsequently, the chlorination step is carried out to achieve the purpose of synthesizing 1-chloro-2,3,5,6-tetrafluorobenzene. The key to this method is to control the conditions of fluorination and chlorination reactions to ensure that the reaction can be precisely substituted at the desired position to obtain a high-purity target product.
Third, the reaction path involving organometallic reagents can also be used. For example, halogenated aromatics react with organometallic reagents (such as Grignard's reagent $RMgX $) to form organometallic intermediates with specific structures. After that, fluorine atoms are introduced by reacting with fluorinated reagents, and then chlorinated, and finally 1-chloro-2,3,5,6-tetrafluorobenzene is synthesized. This approach relies on the high activity and selectivity of organometallic reagents to cleverly construct molecular structures to achieve the synthesis of the target product. Each method has its own advantages and disadvantages. In practical application, the appropriate synthesis method needs to be carefully selected according to many factors such as the availability of raw materials, the difficulty of reaction conditions, and the purity requirements of the product.
What are the precautions for storage and transportation of 1-chloro-2,3,5, 6-tetrafluorobenzene
1-Chloro-2,3,5,6-tetrafluorobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
First words storage. This substance should be placed in a cool and ventilated warehouse. Because of the cool and ventilated place, it can reduce the risk of excessive temperature or lack of air circulation. If it is in a high temperature environment, it may cause its volatilization to accelerate, or even cause chemical reactions, causing its properties to change. The temperature of the warehouse should be strictly controlled, not too high.
Furthermore, it should be kept away from fire and heat sources. Fire and heat sources can easily cause the compound to catch fire and burn, because it may be flammable, it is dangerous in case of open flames and hot topics. And it needs to be stored separately from oxidants, edible chemicals, etc., and must not be mixed. The edge oxidant or violent chemical reaction with 1-chloro-2,3,5,6-tetrafluorobenzene is dangerous; mixed with edible chemicals, in case of leakage, it may cause food contamination and endanger human health.
During storage, packaging is also crucial. The packaging must be sealed to prevent it from evaporating and dissipating, and to prevent it from reacting with ingredients in the air. At the same time, the storage environment and packaging should be checked regularly. If the packaging is damaged or there are signs of leakage, it needs to be dealt with immediately to prevent the situation from worsening.
As for transportation. Before transportation, make sure that the packaging is complete and the loading is secure. If the packaging is incomplete, it is easy to leak during transportation; if the loading is unstable, it is easy to cause collision and increase the risk of leakage. During transportation, strictly abide by the relevant transportation regulations, drive according to the specified route, and do not change it at will. Transportation vehicles are also required to be equipped with corresponding fire equipment and leakage emergency treatment equipment. In the event of a leak or fire, they can respond immediately. Escort personnel must be familiar with the nature of the chemical and emergency treatment methods, pay close attention during transportation, and take measures if there is any abnormality. In this way, the safety of 1-chloro-2,3,5,6-tetrafluorobenzene in storage and transportation can be guaranteed.
First words storage. This substance should be placed in a cool and ventilated warehouse. Because of the cool and ventilated place, it can reduce the risk of excessive temperature or lack of air circulation. If it is in a high temperature environment, it may cause its volatilization to accelerate, or even cause chemical reactions, causing its properties to change. The temperature of the warehouse should be strictly controlled, not too high.
Furthermore, it should be kept away from fire and heat sources. Fire and heat sources can easily cause the compound to catch fire and burn, because it may be flammable, it is dangerous in case of open flames and hot topics. And it needs to be stored separately from oxidants, edible chemicals, etc., and must not be mixed. The edge oxidant or violent chemical reaction with 1-chloro-2,3,5,6-tetrafluorobenzene is dangerous; mixed with edible chemicals, in case of leakage, it may cause food contamination and endanger human health.
During storage, packaging is also crucial. The packaging must be sealed to prevent it from evaporating and dissipating, and to prevent it from reacting with ingredients in the air. At the same time, the storage environment and packaging should be checked regularly. If the packaging is damaged or there are signs of leakage, it needs to be dealt with immediately to prevent the situation from worsening.
As for transportation. Before transportation, make sure that the packaging is complete and the loading is secure. If the packaging is incomplete, it is easy to leak during transportation; if the loading is unstable, it is easy to cause collision and increase the risk of leakage. During transportation, strictly abide by the relevant transportation regulations, drive according to the specified route, and do not change it at will. Transportation vehicles are also required to be equipped with corresponding fire equipment and leakage emergency treatment equipment. In the event of a leak or fire, they can respond immediately. Escort personnel must be familiar with the nature of the chemical and emergency treatment methods, pay close attention during transportation, and take measures if there is any abnormality. In this way, the safety of 1-chloro-2,3,5,6-tetrafluorobenzene in storage and transportation can be guaranteed.
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