1-Chloro-2,3-Difluoro-5-Nitrobenzene
Linshang Chemical
HS Code |
698994 |
Chemical Formula | C6H2ClF2NO2 |
Molar Mass | 193.535 g/mol |
Appearance | Solid (usually) |
Color | May be colorless to pale yellow |
Odor | Characteristic organic odor |
Melting Point | Data - specific value needed |
Boiling Point | Data - specific value needed |
Density | Data - specific value needed |
Solubility In Water | Low solubility |
Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
Purity | Typically expressed as a percentage (e.g., 98%+ in commercial products) |
Flash Point | Data - specific value needed |
Hazard Class | May be classified as a hazardous chemical due to nitro and halogen groups |
As an accredited 1-Chloro-2,3-Difluoro-5-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
Packing | 1 - chloro - 2,3 - difluoro - 5 - nitrobenzene: Packed in 500g bottles for chemical storage. |
Storage | 1 - Chloro - 2,3 - difluoro - 5 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent leakage and exposure to air or moisture. Store it separately from oxidizing agents, reducing agents, and other incompatible substances to avoid potential chemical reactions. |
Shipping | 1 - Chloro - 2,3 - difluoro - 5 - nitrobenzene is shipped in tightly sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations to ensure safe transportation due to its potentially harmful nature. |
Competitive 1-Chloro-2,3-Difluoro-5-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com


As a leading 1-Chloro-2,3-Difluoro-5-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
- ** Appearance and properties **: Under normal circumstances, this substance is mostly a light yellow to yellow crystalline powder. Its color is bright and visible. In experimental and industrial scenarios, this feature is helpful for preliminary identification.
- ** Melting point **: The melting point of this compound is in a specific range, about [X] ° C. The characteristics of the melting point are particularly critical when identifying and separating and purifying substances. The purity of the substance can be determined by the melting point. If the purity is high, the melting point range is narrow and approaches the standard value; if it contains impurities, the melting point is reduced and the melting range is widened.
- ** Boiling Point **: The boiling point is about [X] ° C. The boiling point is related to the temperature at which a substance changes from liquid to gaseous state under a specific pressure. This property is crucial in separation operations such as distillation. By controlling the temperature, 1-chloro-2,3-difluoro-5-nitrobenzene can be separated from the mixture.
- ** Solubility **: Solubility in organic solvents is also an important physical property. It exhibits good solubility in common organic solvents such as dichloromethane, chloroform, toluene, etc. This property makes it possible to choose a suitable solvent in the organic synthesis reaction to facilitate the reaction. However, in water, its solubility is poor, which is related to the polarity of the molecule. The polarity of the molecule is relatively weak, and the force between it and the water molecules is small, so it is difficult to dissolve.
- ** Density **: The density is about [X] g/cm ³. Density is also significant in chemical production and experimental operations. For example, in mixed liquid systems, operations such as stratification and separation of substances can be realized according to density differences.
The above physical properties are of great value in the research, production and application of 1-chloro-2,3-difluoro-5-nitrobenzene, providing a key basis for related work.
First, the properties of halogenated hydrocarbons. Due to the presence of chlorine atoms, nucleophilic substitution reactions can occur. Hydroxyl, alkoxy and other nucleophilic reagents can attack carbon atoms connected to chlorine, and chloride ions leave to form new compounds. If co-heated with sodium hydroxide aqueous solution, chlorine atoms can be replaced by hydroxyl groups to obtain corresponding phenolic compounds; when reacted with sodium alcohol, ether substances are formed. This reaction mechanism is that the nucleophilic reagent provides electron pairs to attack the carbon atoms that lack electrons and initiate substitution.
Second, the activity of the aromatic electrophilic substitution reaction. There are nitro and halogen atoms on the benzene ring. Nitro is a strong electron-absorbing group, which reduces the electron cloud density of the benzene ring, weakens the activity of the electrophilic substitution reaction of the benzene ring, and the new substituents mainly enter the nitro meta-position. If nitrification is carried out, the new nitro mainly enters the meta-position due to the localization effect of the original nitro group. However, due to the presence of halogen atoms and nitro groups on the benzene ring, such reaction conditions are usually harsh, and suitable catalysts and reaction temperatures are required.
Third, the properties of fluorine-containing compounds. The electronegativity of fluorine atoms is large, which can enhance the polarity of molecules and affect the physical properties of compounds, such as boiling point and solubility. At the same time, the carbon-fluorine bond energy is large, which enhances the stability of molecules. In some reactions, the fluorine-containing part is relatively difficult to be destroyed or reacted.
Fourth, nitro-related properties. Nitro is oxidizing and can be reduced under specific conditions. If iron, hydrochloric acid, etc. are used as reducing agents, nitro can be gradually reduced to amino groups to obtain 1-chloro-2,3-difluoro-5-aminobenzene. This reaction is often an important step in organic synthesis, used to introduce amino functional groups to prepare organic compounds containing amino groups. In conclusion, the functional groups of 1-chloro-2,3-difluoro-5-nitrobenzene exhibit diverse chemical properties and are of great application value and research significance in the fields of organic synthesis and medicinal chemistry.
In the field of pesticides, it is often the key intermediate for creating new pesticides. Due to the chlorine, fluorine, nitro and other groups attached to the benzene ring, this compound has unique chemical and biological activities. It can be introduced into specific structural fragments through a series of chemical reactions to prepare pesticide products with high insecticidal, bactericidal or herbicidal properties. If reacted with specific amine compounds, pesticide derivatives with significant biological activity can be generated to resist a variety of crop pests and pathogens, protect crop growth, and improve agricultural output.
In the field of medicine, 1-chloro-2,3-difluoro-5-nitrobenzene is also an important starting material for the synthesis of many drugs. Its special functional group layout can guide the construction of drug molecules and help form structures with specific pharmacological activities. For example, it can be converted into drug intermediates with therapeutic effects on specific diseases through reaction steps such as reduction and substitution. It is expected to be used in the development of anti-tumor, anti-infection and other drugs, contributing to human health.
In the field of materials, it can be used as a basic raw material for the synthesis of functional materials. By polymerizing with other organic compounds, its structural units can be introduced into polymer materials, which can endow materials with special properties such as good thermal stability, chemical stability and electrical properties. In this way, new materials for electronic devices, high-performance coatings, etc. can be prepared, promoting the development and progress of materials science.
Second, other aromatic hydrocarbon derivatives can also be used. For example, with a specific halogenated aromatic hydrocarbon as the initial material, nitro groups are first introduced, and then the position and type of halogen atoms are adjusted through the substitution reaction of halogen atoms, so as to achieve the purpose of synthesizing 1-chloro-2,3-difluoro-5-nitrobenzene. In this process, the introduction of nitro groups can be achieved by the reaction of nitrifying reagents and aromatic derivatives; the substitution of halogen atoms needs to be based on the characteristics of the reaction substrate, and the appropriate halogenating reagents and reaction conditions are selected to ensure the selectivity and yield of the reaction.
Furthermore, the synthesis can also be considered through the reaction of organometallic reagents. Using organometallic reagents for the nucleophilic substitution of halogenated aromatics, chlorine atoms, fluorine atoms and nitro groups are skillfully introduced to gradually construct the structure of the target molecule. This method requires fine regulation of reaction conditions to avoid side reactions and improve the purity and yield of the product. In short, there are various ways to synthesize 1-chloro-2,3-difluoro-5-nitrobenzene, and each method has its advantages and disadvantages. It is necessary to weigh the selection according to the actual situation.
First words storage. This compound is dangerous and should be placed in a cool, dry and well-ventilated place. The cover is sensitive to heat, high temperature is easy to decompose, or dangerous, so the warehouse temperature should be controlled within a specific range, not too high. In addition, it must be stored separately from oxidizing agents, reducing agents, alkalis and other substances. When these numbers meet, they are prone to chemical reactions and accidents. The storage place should also be equipped with suitable materials to contain possible leaks.
Second on transportation. Before transportation, it is necessary to ensure that the packaging is complete and sealed to prevent leakage. During transportation, the relevant regulations on the transportation of hazardous chemicals must be strictly followed, and the transportation enterprises and vehicles with corresponding qualifications must be selected. The escort personnel must also be familiar with their nature and emergency response methods. The transportation vehicle should be equipped with fire extinguishing equipment and leakage emergency treatment equipment to deal with it in case. When driving, avoid high temperature and open flames, and the route should be far away from densely populated areas. If there is an accident such as leakage on the way, the escort personnel should deal with it quickly according to the plan, evacuate the surrounding people, and prevent the harm from expanding.
All of these are important matters that should be paid attention to in the storage and transportation of 1-chloro-2,3-difluoro-5-nitrobenzene, and must not be negligent, causing harm.

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