Linshang Chemical
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1-Chloro-2,4-Bis(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
981548 |
| Chemical Formula | C8H3ClF6 |
| Molecular Weight | 258.55 |
| Appearance | Liquid |
| Boiling Point | 153 - 155 °C |
| Melting Point | N/A |
| Density | 1.525 g/mL at 25 °C |
| Vapor Pressure | N/A |
| Water Solubility | Insoluble |
| Flash Point | 47 °C |
| Refractive Index | 1.386 |
As an accredited 1-Chloro-2,4-Bis(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 2,4 - bis(trifluoromethyl)benzene in 500 - mL glass bottles for chemical storage. |
| Storage | 1 - Chloro - 2,4 - bis(trifluoromethyl)benzene should be stored in a cool, well - ventilated area, away from heat sources and open flames as it is likely flammable. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive chemicals to avoid potential hazardous reactions. |
| Shipping | 1 - Chloro - 2,4 - bis(trifluoromethyl)benzene is shipped in specialized, leak - proof containers compliant with chemical transportation regulations. It's carefully packaged to prevent spills during transit due to its potentially hazardous nature. |
Competitive 1-Chloro-2,4-Bis(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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What are the chemical properties of 1-chloro-2,4-bis (trifluoromethyl) benzene?
1-Chloro-2,4-bis (trifluoromethyl) benzene, this substance has unique chemical properties, including the characteristics of halogenated aromatics and fluorinated compounds.
Its physical properties, at room temperature, are mostly colorless to light yellow liquid, with a special odor. Due to the large number of fluorine atoms in the molecule, its boiling point and density are different from common aromatics. Fluorine atoms have strong electronegativity, resulting in different intermolecular forces. The boiling point is higher than that of benzene series with similar structures and no fluorine substitution. However, compared with halogenated aromatics with high chlorine content, the boiling point is slightly lower. This is because the radius of fluorine atoms is small, and the effect on intermolecular forces is different from that of chlorine atoms.
When it comes to chemical activity, the chlorine atom above the benzene ring has lower nucleophilic substitution activity than the halogenated alkanes due to the conjugation effect of the benzene ring electron cloud. In case of strong nucleophilic reagents, and under suitable conditions, chlorine atoms can still be replaced. For example, with sodium alcohol as the nucleophilic reagent, in a heated polar solvent, chlorine atoms can be replaced by alkoxy groups to form corresponding ether compounds.
The trifluoromethyl group on the benzene ring is a strong electron-absorbing group, which greatly affects the density distribution of the benzene ring electron cloud, reducing the density of the benzene ring electron cloud and causing its electrophilic substitution activity to decrease. Compared with benzene, electrophilic substitution requires more severe reaction conditions, and the reaction check point is mostly at the position where the electron cloud density is relatively high, that is, the trifluoromethyl interposition. For example, during nitration, the nitro group mainly enters the trifluoromethyl interposition to form 3-nitro-1-chloro-2,4-bis (trifluoromethyl) benzene.
The chemical stability of this compound is also good. Due to the high C-F bond energy, the fluorine atom can protect the benzene ring from some reagents, making it resistant to oxidation and reduction reactions to a certain extent. However, under certain strong oxidation or strong reduction conditions, the reaction will still occur, such as under high temperature and strong oxidant action, the benzene ring may be oxidized to open the ring.
In addition, the fluorine-containing structure of 1-chloro-2,4-bis (trifluoromethyl) benzene makes it have certain biological activity and may have potential applications in the field of medicine and pesticides. Its special chemical properties make it an important intermediate in organic synthesis, and complex organic molecular structures can be constructed through various reactions.
Its physical properties, at room temperature, are mostly colorless to light yellow liquid, with a special odor. Due to the large number of fluorine atoms in the molecule, its boiling point and density are different from common aromatics. Fluorine atoms have strong electronegativity, resulting in different intermolecular forces. The boiling point is higher than that of benzene series with similar structures and no fluorine substitution. However, compared with halogenated aromatics with high chlorine content, the boiling point is slightly lower. This is because the radius of fluorine atoms is small, and the effect on intermolecular forces is different from that of chlorine atoms.
When it comes to chemical activity, the chlorine atom above the benzene ring has lower nucleophilic substitution activity than the halogenated alkanes due to the conjugation effect of the benzene ring electron cloud. In case of strong nucleophilic reagents, and under suitable conditions, chlorine atoms can still be replaced. For example, with sodium alcohol as the nucleophilic reagent, in a heated polar solvent, chlorine atoms can be replaced by alkoxy groups to form corresponding ether compounds.
The trifluoromethyl group on the benzene ring is a strong electron-absorbing group, which greatly affects the density distribution of the benzene ring electron cloud, reducing the density of the benzene ring electron cloud and causing its electrophilic substitution activity to decrease. Compared with benzene, electrophilic substitution requires more severe reaction conditions, and the reaction check point is mostly at the position where the electron cloud density is relatively high, that is, the trifluoromethyl interposition. For example, during nitration, the nitro group mainly enters the trifluoromethyl interposition to form 3-nitro-1-chloro-2,4-bis (trifluoromethyl) benzene.
The chemical stability of this compound is also good. Due to the high C-F bond energy, the fluorine atom can protect the benzene ring from some reagents, making it resistant to oxidation and reduction reactions to a certain extent. However, under certain strong oxidation or strong reduction conditions, the reaction will still occur, such as under high temperature and strong oxidant action, the benzene ring may be oxidized to open the ring.
In addition, the fluorine-containing structure of 1-chloro-2,4-bis (trifluoromethyl) benzene makes it have certain biological activity and may have potential applications in the field of medicine and pesticides. Its special chemical properties make it an important intermediate in organic synthesis, and complex organic molecular structures can be constructed through various reactions.
What are the common uses of 1-chloro-2,4-bis (trifluoromethyl) benzene?
1-Chloro-2,4-bis (trifluoromethyl) benzene has the following common uses.
In the field of organic synthesis, this compound is often used as a key intermediate. Due to the chlorine atom and trifluoromethyl contained in its molecular structure, it is endowed with unique reactivity. For example, chlorine atoms can interact with many nucleophilic reagents, such as alcohols and amines, through nucleophilic substitution reactions, thereby forming chemical bonds such as carbon-oxygen and carbon-nitrogen, which help to generate organic compounds with diverse structures. The strong electron-absorbing properties of trifluoromethyl can significantly affect the electron cloud distribution of molecules, changing the reactivity of ortho and para-sites, which is conducive to the functionalization of specific locations, and is often used in the creation of new drug molecules.
In the field of materials science, 1-chloro-2,4-bis (trifluoromethyl) benzene also has its uses. Due to the presence of trifluoromethyl in its structure, it can improve the chemical stability, thermal stability and weather resistance of materials. By introducing it into the structure of polymer materials, such as polymers, the surface properties of materials can be improved, such as reducing surface energy, making the material have better water and oil repellent properties, which can be applied to the preparation of high-performance coatings, films and other materials. It plays an important role in the aerospace, automotive industry and other fields that require strict material properties.
In the research and development of pesticides, the biological activity of this compound derived from its unique chemical structure has also attracted much attention. The introduction of trifluoromethyl can enhance the interaction between the compound and the target in the organism, and improve its ability to inhibit and kill specific pests or bacteria. Using it as a starting material, through a series of synthetic transformations, it is expected to create a new type of pesticide with high efficiency, low toxicity and environmental friendliness, providing a powerful means for the control of agricultural pests and diseases.
In addition, in the field of electronic chemicals, 1-chloro-2,4-bis (trifluoromethyl) benzene can be used to synthesize some special electronic materials. Its special chemical structure helps to regulate the electrical properties of materials, such as dielectric constant, etc., and can be used to manufacture high-performance electronic components to meet the needs of the electronics industry for new materials.
In the field of organic synthesis, this compound is often used as a key intermediate. Due to the chlorine atom and trifluoromethyl contained in its molecular structure, it is endowed with unique reactivity. For example, chlorine atoms can interact with many nucleophilic reagents, such as alcohols and amines, through nucleophilic substitution reactions, thereby forming chemical bonds such as carbon-oxygen and carbon-nitrogen, which help to generate organic compounds with diverse structures. The strong electron-absorbing properties of trifluoromethyl can significantly affect the electron cloud distribution of molecules, changing the reactivity of ortho and para-sites, which is conducive to the functionalization of specific locations, and is often used in the creation of new drug molecules.
In the field of materials science, 1-chloro-2,4-bis (trifluoromethyl) benzene also has its uses. Due to the presence of trifluoromethyl in its structure, it can improve the chemical stability, thermal stability and weather resistance of materials. By introducing it into the structure of polymer materials, such as polymers, the surface properties of materials can be improved, such as reducing surface energy, making the material have better water and oil repellent properties, which can be applied to the preparation of high-performance coatings, films and other materials. It plays an important role in the aerospace, automotive industry and other fields that require strict material properties.
In the research and development of pesticides, the biological activity of this compound derived from its unique chemical structure has also attracted much attention. The introduction of trifluoromethyl can enhance the interaction between the compound and the target in the organism, and improve its ability to inhibit and kill specific pests or bacteria. Using it as a starting material, through a series of synthetic transformations, it is expected to create a new type of pesticide with high efficiency, low toxicity and environmental friendliness, providing a powerful means for the control of agricultural pests and diseases.
In addition, in the field of electronic chemicals, 1-chloro-2,4-bis (trifluoromethyl) benzene can be used to synthesize some special electronic materials. Its special chemical structure helps to regulate the electrical properties of materials, such as dielectric constant, etc., and can be used to manufacture high-performance electronic components to meet the needs of the electronics industry for new materials.
What are the synthesis methods of 1-chloro-2,4-bis (trifluoromethyl) benzene?
The synthesis method of 1-chloro-2,4-bis (trifluoromethyl) benzene has been used by many parties throughout the ages. One of the common ones is to use aromatic hydrocarbons containing corresponding substituents as starting materials and introduce chlorine atoms through halogenation. In this process, it is necessary to carefully select halogenating reagents, such as chlorine gas, sulfoxide chloride, etc., and carefully adjust the reaction conditions, such as temperature, catalyst type and dosage. If the temperature is too high, side reactions may occur, resulting in impure products; if the temperature is too low, the reaction rate will be slow and time-consuming. The efficiency of the catalyst is also related to the success or failure of the reaction. If the activity is too high or excessive halogenation is caused, and if the activity is insufficient, the reaction will be difficult to start.
Second, the benzene ring structure can be constructed from fluorinated compounds through specific reactions. This path requires in-depth insight into the reactivity and selectivity of fluorinated reagents. There are many reaction steps involved, and each step needs to be precisely controlled, such as nucleophilic substitution, cyclization and other reactions. During nucleophilic substitution, the activity of nucleophilic reagents and the structural adaptation of the substrate are crucial. If there is no match, the reaction cannot occur or other by-products can be generated. Cyclization reactions require strict reaction conditions, and the polarity of the solvent and the reaction time can affect the efficiency of cyclization and the configuration of the product.
Furthermore, simple compounds containing chlorine and fluorine are used as raw materials, and the target product is gradually spliced into the target product through a multi-step organic synthesis strategy. This approach requires a good understanding of various reaction mechanisms in organic synthesis, and the separation and purification of the products after each step cannot be ignored. During the separation process, appropriate separation methods can be selected according to the physical and chemical properties of the products and impurities, such as distillation, extraction, column chromatography, etc. If the separation is not clean, impurities remain in the product, which will affect the subsequent reaction and product quality. In short, there are many methods for synthesizing 1-chloro-2,4-bis (trifluoromethyl) benzene, but all of them need to be carefully studied in the details of the reaction to obtain a pure and high-yield product.
Second, the benzene ring structure can be constructed from fluorinated compounds through specific reactions. This path requires in-depth insight into the reactivity and selectivity of fluorinated reagents. There are many reaction steps involved, and each step needs to be precisely controlled, such as nucleophilic substitution, cyclization and other reactions. During nucleophilic substitution, the activity of nucleophilic reagents and the structural adaptation of the substrate are crucial. If there is no match, the reaction cannot occur or other by-products can be generated. Cyclization reactions require strict reaction conditions, and the polarity of the solvent and the reaction time can affect the efficiency of cyclization and the configuration of the product.
Furthermore, simple compounds containing chlorine and fluorine are used as raw materials, and the target product is gradually spliced into the target product through a multi-step organic synthesis strategy. This approach requires a good understanding of various reaction mechanisms in organic synthesis, and the separation and purification of the products after each step cannot be ignored. During the separation process, appropriate separation methods can be selected according to the physical and chemical properties of the products and impurities, such as distillation, extraction, column chromatography, etc. If the separation is not clean, impurities remain in the product, which will affect the subsequent reaction and product quality. In short, there are many methods for synthesizing 1-chloro-2,4-bis (trifluoromethyl) benzene, but all of them need to be carefully studied in the details of the reaction to obtain a pure and high-yield product.
What are the precautions for storing and transporting 1-chloro-2,4-bis (trifluoromethyl) benzene?
1-Chloro-2,4-bis (trifluoromethyl) benzene is an organic compound. When storing and transporting, many matters must be paid attention to.
First of all, storage, because it has a certain chemical activity, it should be stored in a cool and well-ventilated place. High temperature can easily exacerbate its chemical reaction, or cause danger, so the storage temperature should not be too high. And it must be kept away from fire and heat sources. Open flames and hot topics may cause accidents. Because it is a chemical substance, it should be stored separately from oxidants and bases to avoid mixed storage to prevent interaction and dangerous reactions. The storage place should be equipped with suitable materials to contain leaks, in case of leakage, and can be properly handled in time to reduce harm.
As for transportation, there are also many precautions. Before transportation, it is necessary to ensure that the packaging is complete and well sealed to prevent leakage during transportation. During transportation, the relevant transportation regulations must be strictly adhered to, the installation position must be appropriate, and it cannot be mixed with contraindicated substances. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment to deal with emergencies. Drivers and escorts need to be familiar with the characteristics of the substance and emergency treatment methods, pay close attention to the status of the goods during transportation, and take effective measures immediately once any abnormalities are detected.
First of all, storage, because it has a certain chemical activity, it should be stored in a cool and well-ventilated place. High temperature can easily exacerbate its chemical reaction, or cause danger, so the storage temperature should not be too high. And it must be kept away from fire and heat sources. Open flames and hot topics may cause accidents. Because it is a chemical substance, it should be stored separately from oxidants and bases to avoid mixed storage to prevent interaction and dangerous reactions. The storage place should be equipped with suitable materials to contain leaks, in case of leakage, and can be properly handled in time to reduce harm.
As for transportation, there are also many precautions. Before transportation, it is necessary to ensure that the packaging is complete and well sealed to prevent leakage during transportation. During transportation, the relevant transportation regulations must be strictly adhered to, the installation position must be appropriate, and it cannot be mixed with contraindicated substances. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment to deal with emergencies. Drivers and escorts need to be familiar with the characteristics of the substance and emergency treatment methods, pay close attention to the status of the goods during transportation, and take effective measures immediately once any abnormalities are detected.
What are the environmental effects of 1-chloro-2,4-bis (trifluoromethyl) benzene?
1-Chloro-2,4-bis (trifluoromethyl) benzene is one of the organic compounds. The effects of this substance in the environment are quite complex.
Its chemical properties are relatively stable, and it is quite difficult to degrade in the natural environment. Because of its fluorine atom, fluorine is highly electronegative, resulting in an increase in the chemical bond energy of the compound, so it is difficult to be decomposed by microorganisms or chemical reactions, so it is easy to accumulate in the environment.
In water bodies, it is difficult to dissolve in water, or it will adhere to suspended particles, and then settle into the bottom sediment, and it will persist for a long time. If this substance enters the soil, it will change the chemical properties of the soil, or affect the soil microbial community, and then affect the normal function of the soil ecosystem.
In the atmospheric environment, this compound may undergo photochemical reactions under conditions such as light, generating other harmful products. And because of its vapor pressure characteristics, it may be able to travel long distances in the atmosphere, resulting in an expansion of the pollution range.
And because of its certain biological toxicity, it may have adverse effects on organisms. Aquatic organisms that come into contact with water bodies containing this compound may experience stunted growth and development, decreased reproductive capacity, etc. For terrestrial organisms, through the transmission and enrichment of the food chain, it may eventually enter the human body, posing a potential threat to human health.
In summary, 1-chloro-2,4-bis (trifluoromethyl) benzene has various effects on the physical, chemical and biological aspects of the environment, which need to be paid attention to and properly controlled.
Its chemical properties are relatively stable, and it is quite difficult to degrade in the natural environment. Because of its fluorine atom, fluorine is highly electronegative, resulting in an increase in the chemical bond energy of the compound, so it is difficult to be decomposed by microorganisms or chemical reactions, so it is easy to accumulate in the environment.
In water bodies, it is difficult to dissolve in water, or it will adhere to suspended particles, and then settle into the bottom sediment, and it will persist for a long time. If this substance enters the soil, it will change the chemical properties of the soil, or affect the soil microbial community, and then affect the normal function of the soil ecosystem.
In the atmospheric environment, this compound may undergo photochemical reactions under conditions such as light, generating other harmful products. And because of its vapor pressure characteristics, it may be able to travel long distances in the atmosphere, resulting in an expansion of the pollution range.
And because of its certain biological toxicity, it may have adverse effects on organisms. Aquatic organisms that come into contact with water bodies containing this compound may experience stunted growth and development, decreased reproductive capacity, etc. For terrestrial organisms, through the transmission and enrichment of the food chain, it may eventually enter the human body, posing a potential threat to human health.
In summary, 1-chloro-2,4-bis (trifluoromethyl) benzene has various effects on the physical, chemical and biological aspects of the environment, which need to be paid attention to and properly controlled.
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