Linshang Chemical
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1-Chloro-2,4-Difluoro-5-Nitrobenzene
Linshang Chemical
|
HS Code |
894893 |
| Chemical Formula | C6H2ClF2NO2 |
| Molar Mass | 195.54 g/mol |
| Appearance | Solid |
| Color | Yellow |
| Melting Point | 67 - 71 °C |
| Boiling Point | 231.4 °C at 760 mmHg |
| Density | 1.629 g/cm³ |
| Solubility In Water | Insoluble |
| Flash Point | 93.8 °C |
| Purity | Typically high - purity for chemical synthesis |
As an accredited 1-Chloro-2,4-Difluoro-5-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 2,4 - difluoro - 5 - nitrobenzene: Packed in 500g bottles for chemical storage. |
| Storage | 1 - Chloro - 2,4 - difluoro - 5 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from sources of heat, ignition, and incompatible substances such as strong oxidizing agents and reducing agents. Store in a tightly - sealed container to prevent leakage and exposure to air and moisture, which could potentially lead to chemical reactions or degradation. |
| Shipping | 1 - chloro - 2,4 - difluoro - 5 - nitrobenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported under regulated conditions, following safety protocols due to its chemical nature to prevent spills and ensure safe transit. |
Competitive 1-Chloro-2,4-Difluoro-5-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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What are the chemical properties of 1-chloro-2, 4-difluoro-5-nitrobenzene?
1-Chloro-2,4-difluoro-5-nitrobenzene is one of the organic compounds. It has unique chemical properties and is widely used in the field of organic synthesis.
Its chemical properties are first of all the characteristics of halogenated aromatics. It contains chlorine and fluorohalogen atoms, and the activities of halogen atoms are different. Chlorine atoms are relatively active, and under appropriate conditions, nucleophilic substitution reactions can occur. In case of nucleophilic reagents, such as sodium alcohol, amines, etc., chlorine atoms can be replaced by corresponding groups, and many new compounds can be derived. This reaction mechanism is mostly for nucleophilic reagents to attack the carbon atoms connected to chlorine on the benzene ring, and the chloride ions leave to form new carbon-heteroatomic bonds.
Fluorine atoms, due to high electronegativity, reduce the electron cloud density of the benzene ring, resulting in a decrease in the activity of the electrophilic substitution reaction of the benzene ring. However, the introduction of fluorine atoms also increases the molecular stability and fat solubility, which is of great significance in the creation of medicines and pesticides.
Furthermore, the existence of its nitro group also affects the molecular chemical behavior. Nitro is a strong electron-absorbing group, which makes the benzene ring electron cloud more biased towards nitro, which not only further reduces the electrophilic substitution activity of the benzene ring, but also makes the electron cloud density of adjacent and para-carbon atoms lower, making it more vulnerable to attack by nucleophiles. At the same time, nitro groups can be reduced, and the common reduction products are With suitable reducing agents, such as iron and hydrochloric acid, hydrogen and catalysts, nitro can be gradually converted into amino groups to obtain 1-chloro-2,4-difluoro-5-aminobenzene, which is an important raw material for the synthesis of dyes and pharmaceutical intermediates.
And because of the coexistence of a variety of functional groups in its structure, the functional groups interact with each other, so that the compound can participate in a variety of chemical reactions, providing rich possibilities for organic synthesis chemistry, and playing a key role in the construction of complex organic molecular systems.
Its chemical properties are first of all the characteristics of halogenated aromatics. It contains chlorine and fluorohalogen atoms, and the activities of halogen atoms are different. Chlorine atoms are relatively active, and under appropriate conditions, nucleophilic substitution reactions can occur. In case of nucleophilic reagents, such as sodium alcohol, amines, etc., chlorine atoms can be replaced by corresponding groups, and many new compounds can be derived. This reaction mechanism is mostly for nucleophilic reagents to attack the carbon atoms connected to chlorine on the benzene ring, and the chloride ions leave to form new carbon-heteroatomic bonds.
Fluorine atoms, due to high electronegativity, reduce the electron cloud density of the benzene ring, resulting in a decrease in the activity of the electrophilic substitution reaction of the benzene ring. However, the introduction of fluorine atoms also increases the molecular stability and fat solubility, which is of great significance in the creation of medicines and pesticides.
Furthermore, the existence of its nitro group also affects the molecular chemical behavior. Nitro is a strong electron-absorbing group, which makes the benzene ring electron cloud more biased towards nitro, which not only further reduces the electrophilic substitution activity of the benzene ring, but also makes the electron cloud density of adjacent and para-carbon atoms lower, making it more vulnerable to attack by nucleophiles. At the same time, nitro groups can be reduced, and the common reduction products are With suitable reducing agents, such as iron and hydrochloric acid, hydrogen and catalysts, nitro can be gradually converted into amino groups to obtain 1-chloro-2,4-difluoro-5-aminobenzene, which is an important raw material for the synthesis of dyes and pharmaceutical intermediates.
And because of the coexistence of a variety of functional groups in its structure, the functional groups interact with each other, so that the compound can participate in a variety of chemical reactions, providing rich possibilities for organic synthesis chemistry, and playing a key role in the construction of complex organic molecular systems.
What are the common synthesis methods of 1-chloro-2, 4-difluoro-5-nitrobenzene?
1-Chloro-2,4-difluoro-5-nitrobenzene is a common intermediate in organic synthesis. The synthesis method often follows various paths.
First, 2,4-difluoro-5-nitroaniline is obtained by diazotization and Sandmeier reaction. First, 2,4-difluoro-5-nitroaniline is reacted with sodium nitrite and hydrochloric acid at low temperature to obtain diazonium salt. Then, cuprous chloride is used as a catalyst to react with hydrogen halide, and the diazo group is replaced by a chlorine atom to obtain 1-chloro-2,4-difluoro-5-nitrobenzene. In this path, the diazotization reaction needs to be controlled at a low temperature to prevent the decomposition of diazonium salts, and the catalytic activity of cuprous chloride has a great influence on the reaction.
Second, 2,4-difluorobenzene is used as the raw material. First, nitro is introduced through nitrification reaction. Using mixed acid (a mixture of nitric acid and sulfuric acid) as the nitrifying agent, nitro is introduced at a specific position on the benzene ring of 2,4-difluorobenzene at an appropriate temperature to obtain 2,4-difluoro-5-nitrobenzene. After the chlorination reaction, under suitable conditions, chlorine atoms are introduced into the benzene ring to obtain the target product. In the nitration reaction, the ratio of mixed acid, reaction temperature and time need to be carefully adjusted to prevent excessive nitrification; the chlorination reaction also needs to select suitable chlorination reagents and reaction conditions to achieve good selectivity and yield.
Third, other benzene derivatives containing fluorine, chlorine and nitro groups are used as starting materials and are prepared by a series of reactions such as substitution and condensation. These pathways are often designed according to the availability of raw materials and the feasibility of the reaction. Each step requires careful planning of reaction steps to consider the effects of reaction conditions, yields, and side reactions, so as to achieve the purpose of efficient synthesis of 1-chloro-2,4-difluoro-5-nitrobenzene.
First, 2,4-difluoro-5-nitroaniline is obtained by diazotization and Sandmeier reaction. First, 2,4-difluoro-5-nitroaniline is reacted with sodium nitrite and hydrochloric acid at low temperature to obtain diazonium salt. Then, cuprous chloride is used as a catalyst to react with hydrogen halide, and the diazo group is replaced by a chlorine atom to obtain 1-chloro-2,4-difluoro-5-nitrobenzene. In this path, the diazotization reaction needs to be controlled at a low temperature to prevent the decomposition of diazonium salts, and the catalytic activity of cuprous chloride has a great influence on the reaction.
Second, 2,4-difluorobenzene is used as the raw material. First, nitro is introduced through nitrification reaction. Using mixed acid (a mixture of nitric acid and sulfuric acid) as the nitrifying agent, nitro is introduced at a specific position on the benzene ring of 2,4-difluorobenzene at an appropriate temperature to obtain 2,4-difluoro-5-nitrobenzene. After the chlorination reaction, under suitable conditions, chlorine atoms are introduced into the benzene ring to obtain the target product. In the nitration reaction, the ratio of mixed acid, reaction temperature and time need to be carefully adjusted to prevent excessive nitrification; the chlorination reaction also needs to select suitable chlorination reagents and reaction conditions to achieve good selectivity and yield.
Third, other benzene derivatives containing fluorine, chlorine and nitro groups are used as starting materials and are prepared by a series of reactions such as substitution and condensation. These pathways are often designed according to the availability of raw materials and the feasibility of the reaction. Each step requires careful planning of reaction steps to consider the effects of reaction conditions, yields, and side reactions, so as to achieve the purpose of efficient synthesis of 1-chloro-2,4-difluoro-5-nitrobenzene.
1-Chloro-2, 4-difluoro-5-nitrobenzene in what areas?
1-Chloro-2,4-difluoro-5-nitrobenzene is widely used in the field of chemical synthesis. It can be used as a key intermediate and participates in the preparation of many fine chemicals.
In the field of pharmaceutical synthesis, with its unique chemical structure, it can be converted into compounds with specific pharmacological activities through a series of reactions. For example, in the synthesis of some antibacterial and anti-inflammatory drugs, 1-chloro-2,4-difluoro-5-nitrobenzene may be used as the starting material. After ingeniously designed reaction steps, other functional groups are introduced to shape the molecular structure that meets pharmacological requirements.
In the field of pesticides, it also plays an important role. It can be used as a key component in the synthesis of new pesticides. For specific pests or diseases, it can be rationally derived to create high-efficiency, low-toxicity and environmentally friendly pesticide products. Due to the introduction of fluorine atoms, the biological activity, stability and fat solubility of pesticides can often be improved, making it easier to penetrate biofilms and enhance efficacy.
In the dye industry, 1-chloro-2,4-difluoro-5-nitrobenzene can be used to construct the core structure of dye molecules. Through subsequent connection with various chromophore groups and chromophore groups, dyes with rich color and excellent fastness can be prepared. Due to the presence of nitro and halogen atoms, it can affect the electron cloud distribution of dye molecules, thereby changing their absorption spectra and showing different colors.
There are also potential applications in materials science. For example, when synthesizing some functional polymer materials, it can be introduced into the polymer chain as a monomer or modifier to give the material special properties, such as improving the heat resistance and chemical corrosion resistance of the material. Because of the electron-absorbing properties of halogen atoms and nitro groups in the structure, it may be able to adjust the electronic conductivity and optical properties of polymer materials.
In the field of pharmaceutical synthesis, with its unique chemical structure, it can be converted into compounds with specific pharmacological activities through a series of reactions. For example, in the synthesis of some antibacterial and anti-inflammatory drugs, 1-chloro-2,4-difluoro-5-nitrobenzene may be used as the starting material. After ingeniously designed reaction steps, other functional groups are introduced to shape the molecular structure that meets pharmacological requirements.
In the field of pesticides, it also plays an important role. It can be used as a key component in the synthesis of new pesticides. For specific pests or diseases, it can be rationally derived to create high-efficiency, low-toxicity and environmentally friendly pesticide products. Due to the introduction of fluorine atoms, the biological activity, stability and fat solubility of pesticides can often be improved, making it easier to penetrate biofilms and enhance efficacy.
In the dye industry, 1-chloro-2,4-difluoro-5-nitrobenzene can be used to construct the core structure of dye molecules. Through subsequent connection with various chromophore groups and chromophore groups, dyes with rich color and excellent fastness can be prepared. Due to the presence of nitro and halogen atoms, it can affect the electron cloud distribution of dye molecules, thereby changing their absorption spectra and showing different colors.
There are also potential applications in materials science. For example, when synthesizing some functional polymer materials, it can be introduced into the polymer chain as a monomer or modifier to give the material special properties, such as improving the heat resistance and chemical corrosion resistance of the material. Because of the electron-absorbing properties of halogen atoms and nitro groups in the structure, it may be able to adjust the electronic conductivity and optical properties of polymer materials.
1-Chloro-2, what are the physical properties of 4-difluoro-5-nitrobenzene?
1-Chloro-2,4-difluoro-5-nitrobenzene is a kind of organic compound. Its physical properties are quite important, and it is related to its behavior in various chemical processes and practical applications.
First of all, its appearance is often light yellow to light brown crystalline solid form at room temperature and pressure. This color and morphology can be used as an important basis for the preliminary identification and determination of the substance.
As for the melting point, it is about 57-61 ° C. The melting point is the inherent characteristic of the substance. This value is relatively clear, and it is quite valuable for reference in laboratory purification and identification of the compound. When heated to this temperature range, the substance gradually changes from a solid state to a liquid state, and the temperature of this phase transition process is clearly defined.
The boiling point is also a key physical property. Its boiling point is about 240 - 242 ° C. The boiling point reflects the temperature conditions required for a substance to change from a liquid state to a gaseous state. At this temperature, the vapor pressure of the substance is equal to the external atmospheric pressure and begins to vaporize violently.
In terms of density, it is about 1.64 g/cm ³. This value indicates the mass of the substance per unit volume, and the density information is extremely critical when it comes to mixing, separation, and considering its distribution in different media.
In terms of solubility, 1-chloro-2,4-difluoro-5-nitrobenzene is insoluble in water. Water is a common solvent, and this substance has poor miscibility with it, but it is soluble in organic solvents such as ethanol, ether, and acetone. The polarity and molecular structure of organic solvents enable them to form intermolecular forces with the compound to promote dissolution. This solubility characteristic is of great significance for selecting suitable solvents, designing reaction systems and separation processes in chemical synthesis, extraction and separation.
In summary, the physical properties of 1-chloro-2,4-difluoro-5-nitrobenzene, from appearance, melting point, boiling point, density to solubility, are all indispensable in chemical research, industrial production and other fields. Researchers and practitioners need to understand and apply them in detail.
First of all, its appearance is often light yellow to light brown crystalline solid form at room temperature and pressure. This color and morphology can be used as an important basis for the preliminary identification and determination of the substance.
As for the melting point, it is about 57-61 ° C. The melting point is the inherent characteristic of the substance. This value is relatively clear, and it is quite valuable for reference in laboratory purification and identification of the compound. When heated to this temperature range, the substance gradually changes from a solid state to a liquid state, and the temperature of this phase transition process is clearly defined.
The boiling point is also a key physical property. Its boiling point is about 240 - 242 ° C. The boiling point reflects the temperature conditions required for a substance to change from a liquid state to a gaseous state. At this temperature, the vapor pressure of the substance is equal to the external atmospheric pressure and begins to vaporize violently.
In terms of density, it is about 1.64 g/cm ³. This value indicates the mass of the substance per unit volume, and the density information is extremely critical when it comes to mixing, separation, and considering its distribution in different media.
In terms of solubility, 1-chloro-2,4-difluoro-5-nitrobenzene is insoluble in water. Water is a common solvent, and this substance has poor miscibility with it, but it is soluble in organic solvents such as ethanol, ether, and acetone. The polarity and molecular structure of organic solvents enable them to form intermolecular forces with the compound to promote dissolution. This solubility characteristic is of great significance for selecting suitable solvents, designing reaction systems and separation processes in chemical synthesis, extraction and separation.
In summary, the physical properties of 1-chloro-2,4-difluoro-5-nitrobenzene, from appearance, melting point, boiling point, density to solubility, are all indispensable in chemical research, industrial production and other fields. Researchers and practitioners need to understand and apply them in detail.
What are the precautions in the preparation of 1-chloro-2, 4-difluoro-5-nitrobenzene?
There are many precautions for the preparation of 1-chloro-2,4-difluoro-5-nitrobenzene.
First of all, the selection of raw materials is crucial. The raw materials used must be pure, and impurities will seriously interfere with the reaction process and product purity. For example, halogenated aromatic hydrocarbons, whose purity does not meet the requirements, or other aromatic hydrocarbon impurities are mixed in, may cause side reactions during the reaction, making the product mixed, and the subsequent separation and purification difficulty is greatly increased.
The reaction conditions cannot be ignored. Temperature needs to be strictly controlled, and this reaction is extremely sensitive to temperature. If the temperature is too high, it is easy to cause the reaction to go out of control and generate many by-products; if the temperature is too low, the reaction rate will be delayed or even stagnant. For example, in a particular reaction stage, the appropriate temperature is 80-90 ° C. If the deviation is too large, the yield and quality of the product will be affected. Pressure conditions are also critical, and specific reactions may need to be carried out under a certain pressure. If the pressure is unstable, the equilibrium of the reaction will be shifted, which will affect the formation of the product.
Furthermore, the choice of reaction solvent needs to be cautious. The solvent must not only be able to dissolve the reactants well, but also cannot chemically react with the reactants and products. At the same time, the boiling point and polarity of the solvent will also affect the reaction. For example, polar solvents may promote certain ionic reactions, while non-polar solvents are suitable for specific free radical reactions. If the wrong solvent is selected, the reaction may not proceed smoothly. The use of
catalysts is also The type and dosage of the catalyst will have a significant impact on the reaction rate and selectivity. If the dosage is too small, the catalytic effect will be poor; if the dosage is too large, it will not only be wasted, but may also lead to unnecessary side reactions. Moreover, different catalysts have different selectivity for the reaction, which needs to be carefully selected according to the reaction mechanism and the expected product.
Stirring during the reaction is also indispensable. Good stirring can ensure that the reactants are in full contact and the reaction proceeds uniformly. If the stirring is uneven, the concentration of the local reactants is too high or too low, which will cause inconsistent reaction progress and difficult to guarantee the quality of the product.
Finally, the separation and purification of the product is crucial. After the reaction, the product is often mixed with impurities such as unreacted raw materials Appropriate separation methods, such as distillation, extraction, recrystallization, etc. should be selected for purification. The operation process must be standardized to avoid product loss or the introduction of new impurities.
First of all, the selection of raw materials is crucial. The raw materials used must be pure, and impurities will seriously interfere with the reaction process and product purity. For example, halogenated aromatic hydrocarbons, whose purity does not meet the requirements, or other aromatic hydrocarbon impurities are mixed in, may cause side reactions during the reaction, making the product mixed, and the subsequent separation and purification difficulty is greatly increased.
The reaction conditions cannot be ignored. Temperature needs to be strictly controlled, and this reaction is extremely sensitive to temperature. If the temperature is too high, it is easy to cause the reaction to go out of control and generate many by-products; if the temperature is too low, the reaction rate will be delayed or even stagnant. For example, in a particular reaction stage, the appropriate temperature is 80-90 ° C. If the deviation is too large, the yield and quality of the product will be affected. Pressure conditions are also critical, and specific reactions may need to be carried out under a certain pressure. If the pressure is unstable, the equilibrium of the reaction will be shifted, which will affect the formation of the product.
Furthermore, the choice of reaction solvent needs to be cautious. The solvent must not only be able to dissolve the reactants well, but also cannot chemically react with the reactants and products. At the same time, the boiling point and polarity of the solvent will also affect the reaction. For example, polar solvents may promote certain ionic reactions, while non-polar solvents are suitable for specific free radical reactions. If the wrong solvent is selected, the reaction may not proceed smoothly. The use of
catalysts is also The type and dosage of the catalyst will have a significant impact on the reaction rate and selectivity. If the dosage is too small, the catalytic effect will be poor; if the dosage is too large, it will not only be wasted, but may also lead to unnecessary side reactions. Moreover, different catalysts have different selectivity for the reaction, which needs to be carefully selected according to the reaction mechanism and the expected product.
Stirring during the reaction is also indispensable. Good stirring can ensure that the reactants are in full contact and the reaction proceeds uniformly. If the stirring is uneven, the concentration of the local reactants is too high or too low, which will cause inconsistent reaction progress and difficult to guarantee the quality of the product.
Finally, the separation and purification of the product is crucial. After the reaction, the product is often mixed with impurities such as unreacted raw materials Appropriate separation methods, such as distillation, extraction, recrystallization, etc. should be selected for purification. The operation process must be standardized to avoid product loss or the introduction of new impurities.
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