Linshang Chemical
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1-Chloro-2,4-Dinitrobenzene
Linshang Chemical
|
HS Code |
878257 |
| Chemical Formula | C6H3ClN2O4 |
| Molar Mass | 202.55 g/mol |
| Appearance | yellow crystalline solid |
| Odor | pungent |
| Density | 1.697 g/cm³ |
| Melting Point | 53 - 58 °C |
| Boiling Point | 315.7 °C |
| Solubility In Water | insoluble |
| Solubility In Organic Solvents | soluble in benzene, toluene, etc. |
| Flash Point | 166 °C |
| Hazard Class | 6.1 (Poisonous substances) |
| Vapor Pressure | 1.33 Pa (20 °C) |
As an accredited 1-Chloro-2,4-Dinitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 2,4 - dinitrobenzene in 500g glass bottle, well - sealed for packaging. |
| Storage | 1 - Chloro - 2,4 - dinitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources. It must be stored separately from oxidizing agents, reducing agents, and bases. Keep it in a tightly - sealed container to prevent leakage and exposure to air and moisture, ensuring safety during storage. |
| Shipping | 1 - Chloro - 2,4 - dinitrobenzene is a hazardous chemical. Shipping must comply with strict regulations. It should be properly packaged in approved containers, labeled clearly, and transported by carriers licensed for such hazardous substances. |
Competitive 1-Chloro-2,4-Dinitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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Where to Buy 1-Chloro-2,4-Dinitrobenzene in China?
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As a leading 1-Chloro-2,4-Dinitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 1-chloro-2,4-dinitrobenzene?
1 + -Deuterium-2,4-diaminotrexate, its main uses are as follows:
This drug is a crucial anti-metabolic drug in the field of medicine. It can strongly inhibit dihydrofolate reductase, making it difficult to convert dihydrofolate to tetrahydrofolate. Tetrahydrofolate plays an indispensable role in many key biosynthetic processes, such as the synthesis of purine and pyrimidine nucleotides.
When dihydrofolate reductase is inhibited, the nucleic acid synthesis of cells will be hindered, which in turn makes cell proliferation and division impossible. This property makes 1 + -deuterium-2,4-diaminotrexate useful in the field of tumor treatment. Tumor cells proliferate rapidly and have a huge demand for nucleic acid synthesis. By interfering with nucleic acid synthesis, this drug can effectively curb the growth of tumor cells and then achieve the purpose of treating tumors.
In addition, in the treatment of some autoimmune diseases, 1 + -deuterium-2,4-diaminotrexate can also play a role. Autoimmune diseases usually involve excessive activation of the immune system, in which abnormal proliferation of immune cells is an important part. By inhibiting the nucleic acid synthesis of immune cells, this drug can regulate the immune system and relieve the symptoms of autoimmune diseases.
However, it should be noted that when the drug has therapeutic effect, it also has a certain impact on the nucleic acid synthesis of normal cells, so it will cause a series of adverse reactions such as bone marrow suppression and gastrointestinal discomfort. During the application process, it is necessary to strictly control the dose and closely monitor the patient's physical condition to ensure the safety and efficacy of the medication.
This drug is a crucial anti-metabolic drug in the field of medicine. It can strongly inhibit dihydrofolate reductase, making it difficult to convert dihydrofolate to tetrahydrofolate. Tetrahydrofolate plays an indispensable role in many key biosynthetic processes, such as the synthesis of purine and pyrimidine nucleotides.
When dihydrofolate reductase is inhibited, the nucleic acid synthesis of cells will be hindered, which in turn makes cell proliferation and division impossible. This property makes 1 + -deuterium-2,4-diaminotrexate useful in the field of tumor treatment. Tumor cells proliferate rapidly and have a huge demand for nucleic acid synthesis. By interfering with nucleic acid synthesis, this drug can effectively curb the growth of tumor cells and then achieve the purpose of treating tumors.
In addition, in the treatment of some autoimmune diseases, 1 + -deuterium-2,4-diaminotrexate can also play a role. Autoimmune diseases usually involve excessive activation of the immune system, in which abnormal proliferation of immune cells is an important part. By inhibiting the nucleic acid synthesis of immune cells, this drug can regulate the immune system and relieve the symptoms of autoimmune diseases.
However, it should be noted that when the drug has therapeutic effect, it also has a certain impact on the nucleic acid synthesis of normal cells, so it will cause a series of adverse reactions such as bone marrow suppression and gastrointestinal discomfort. During the application process, it is necessary to strictly control the dose and closely monitor the patient's physical condition to ensure the safety and efficacy of the medication.
What are the hazards of 1-chloro-2,4-dinitrobenzene to the human body?
Eh! Fu 2,4-diaminonaphthalene, this substance is very harmful to the human body.
It can cause damage to the organs. Liver, the metabolic hub of human beings, 2,4-diaminonaphthalene enters the body, or interferes with the metabolism and detoxification of the liver, causing abnormal liver function, biochemical index disorders, and long-term liver diseases, such as hepatomegaly and hepatic fibrosis. The excretion of the renal division is also harmed by it, affecting the filtration and reabsorption of the kidney, or causing renal insufficiency, abnormal protein and blood cells in the urine.
And it is also damaged in the blood system. It can cause suppression of hematopoietic function, damage to the activity of hematopoietic stem cells in the bone marrow, and hinder the production of red blood cells, white blood cells, and platelets. Decreased red blood cells cause deficiency of qi and blood, and people feel weak, dizzy, and pale; less white blood cells, the ability of immunity to control evil is weakened, and they are prone to various diseases; platelet deficiency, loss of coagulation function, and bleeding is difficult to stop when touched.
And 2,4-diaminonaphthalene has the risk of mutation. Can damage human genetic material DNA and cause genetic mutation. If germ cells are harmed by it, they can cause congenital defects and hereditary diseases in offspring. Somatic cell mutation, or the source of tumors, long-term exposure, increases the risk of cancer, such as leukemia, liver cancer, kidney cancer, etc., are all possible.
Furthermore, it also affects the nervous system. Disturbing nerve conduction, causing headaches, dizziness, insomnia, memory loss, severe mental disorders, blurred consciousness, and great fatigue in daily work and life.
Therefore, when we are in 2,4-diaminonaphthalene, we should be careful and avoid it to protect our health.
It can cause damage to the organs. Liver, the metabolic hub of human beings, 2,4-diaminonaphthalene enters the body, or interferes with the metabolism and detoxification of the liver, causing abnormal liver function, biochemical index disorders, and long-term liver diseases, such as hepatomegaly and hepatic fibrosis. The excretion of the renal division is also harmed by it, affecting the filtration and reabsorption of the kidney, or causing renal insufficiency, abnormal protein and blood cells in the urine.
And it is also damaged in the blood system. It can cause suppression of hematopoietic function, damage to the activity of hematopoietic stem cells in the bone marrow, and hinder the production of red blood cells, white blood cells, and platelets. Decreased red blood cells cause deficiency of qi and blood, and people feel weak, dizzy, and pale; less white blood cells, the ability of immunity to control evil is weakened, and they are prone to various diseases; platelet deficiency, loss of coagulation function, and bleeding is difficult to stop when touched.
And 2,4-diaminonaphthalene has the risk of mutation. Can damage human genetic material DNA and cause genetic mutation. If germ cells are harmed by it, they can cause congenital defects and hereditary diseases in offspring. Somatic cell mutation, or the source of tumors, long-term exposure, increases the risk of cancer, such as leukemia, liver cancer, kidney cancer, etc., are all possible.
Furthermore, it also affects the nervous system. Disturbing nerve conduction, causing headaches, dizziness, insomnia, memory loss, severe mental disorders, blurred consciousness, and great fatigue in daily work and life.
Therefore, when we are in 2,4-diaminonaphthalene, we should be careful and avoid it to protect our health.
What are the physical properties of 1-chloro-2,4-dinitrobenzene
2,4-Diaminonaphthalene is an organic compound. Its physical properties are quite characteristic, let me tell you one by one.
Looking at its appearance, under room temperature and pressure, 2,4-diaminonaphthalene is mostly white to light yellow crystalline powder. This shape is easy to identify and is also related to its internal structure. Intermolecular forces make it appear in such an aggregated state.
Talking about the melting point, the melting point of 2,4-diaminonaphthalene is about 190 ° C - 194 ° C. The characteristics of the melting point are derived from the interaction energy between molecules. When the outside world provides enough energy to overcome the attractive forces between molecules, the substance changes from solid to liquid state.
As for solubility, 2,4-diaminonaphthalene is slightly soluble in water. This is because water is a polar solvent, while the polarity of 2,4-diaminonaphthalene molecules is relatively weak. According to the principle of "similar miscibility", its solubility in water is limited. However, it is soluble in organic solvents, such as ethanol, ether, etc. The polarity of organic solvents is better matched with 2,4-diaminonaphthalene, and the molecules can form a good interaction to dissolve it.
2,4-diaminonaphthalene is relatively stable chemically at room temperature, but it should be noted that it may be flammable in case of open flame and hot topic. Due to the presence of active groups such as amino groups, it can participate in a variety of chemical reactions under specific conditions, showing a lively side.
The physical properties of this compound are significant in many fields. In chemical synthesis, melting point and solubility affect the choice of reaction conditions; during storage and transportation, stability and flammability are key considerations.
Looking at its appearance, under room temperature and pressure, 2,4-diaminonaphthalene is mostly white to light yellow crystalline powder. This shape is easy to identify and is also related to its internal structure. Intermolecular forces make it appear in such an aggregated state.
Talking about the melting point, the melting point of 2,4-diaminonaphthalene is about 190 ° C - 194 ° C. The characteristics of the melting point are derived from the interaction energy between molecules. When the outside world provides enough energy to overcome the attractive forces between molecules, the substance changes from solid to liquid state.
As for solubility, 2,4-diaminonaphthalene is slightly soluble in water. This is because water is a polar solvent, while the polarity of 2,4-diaminonaphthalene molecules is relatively weak. According to the principle of "similar miscibility", its solubility in water is limited. However, it is soluble in organic solvents, such as ethanol, ether, etc. The polarity of organic solvents is better matched with 2,4-diaminonaphthalene, and the molecules can form a good interaction to dissolve it.
2,4-diaminonaphthalene is relatively stable chemically at room temperature, but it should be noted that it may be flammable in case of open flame and hot topic. Due to the presence of active groups such as amino groups, it can participate in a variety of chemical reactions under specific conditions, showing a lively side.
The physical properties of this compound are significant in many fields. In chemical synthesis, melting point and solubility affect the choice of reaction conditions; during storage and transportation, stability and flammability are key considerations.
What are the chemical properties of 1-chloro-2,4-dinitrobenzene
2,4-Diaminonaphthalene, its chemical properties are as follows:
This substance is alkaline, because the nitrogen atom in the amino group has an unshared electron pair, which can bind protons, and can form ammonium salts in acidic solutions. In case of strong acid, protonation reaction will occur to form corresponding ammonium ions, which makes it able to participate in many acid-base related chemical reactions.
2,4-diaminonaphthalene is reductive, and the amino group is easily oxidized. In case of strong oxidants, such as potassium permanganate, potassium dichromate, etc., the amino group will be oxidized and an oxidation reaction will occur. The oxidation products vary according to the reaction conditions and the type of oxidant, and nitro, nitroso or other nitrogen-containing oxidation products may be formed.
This substance can undergo a substitution reaction, and the hydrogen atom on the naphthalene ring can be replaced by other atoms or groups under specific conditions, such as suitable catalysts, temperatures and reagents. For example, in halogenation reactions, the hydrogen atom on the naphthalene ring can be replaced by halogen atoms; in nitration reactions, nitro groups can be introduced.
2,4-diaminonaphthalene can perform condensation reactions, and the amino group can be condensed with active groups such as carbonyl groups. Like with aldehyde compounds, under certain conditions, the amino group and aldehyde group will condensate to form a carbon-nitrogen double bond structure product. This reaction is often used in organic synthesis to construct new carbon-nitrogen bonds and synthesize complex organic compounds.
It can also participate in coordination reactions, where the lone pair electrons of amino nitrogen atoms can coordinate with metal ions to form complexes. It can coordinate with transition metal ions, such as copper ions, zinc ions, etc. The structure and properties of the formed complexes depend on the type of metal ions, ligand structure and reaction conditions, and are widely used in the fields of materials science and catalysis.
This substance is alkaline, because the nitrogen atom in the amino group has an unshared electron pair, which can bind protons, and can form ammonium salts in acidic solutions. In case of strong acid, protonation reaction will occur to form corresponding ammonium ions, which makes it able to participate in many acid-base related chemical reactions.
2,4-diaminonaphthalene is reductive, and the amino group is easily oxidized. In case of strong oxidants, such as potassium permanganate, potassium dichromate, etc., the amino group will be oxidized and an oxidation reaction will occur. The oxidation products vary according to the reaction conditions and the type of oxidant, and nitro, nitroso or other nitrogen-containing oxidation products may be formed.
This substance can undergo a substitution reaction, and the hydrogen atom on the naphthalene ring can be replaced by other atoms or groups under specific conditions, such as suitable catalysts, temperatures and reagents. For example, in halogenation reactions, the hydrogen atom on the naphthalene ring can be replaced by halogen atoms; in nitration reactions, nitro groups can be introduced.
2,4-diaminonaphthalene can perform condensation reactions, and the amino group can be condensed with active groups such as carbonyl groups. Like with aldehyde compounds, under certain conditions, the amino group and aldehyde group will condensate to form a carbon-nitrogen double bond structure product. This reaction is often used in organic synthesis to construct new carbon-nitrogen bonds and synthesize complex organic compounds.
It can also participate in coordination reactions, where the lone pair electrons of amino nitrogen atoms can coordinate with metal ions to form complexes. It can coordinate with transition metal ions, such as copper ions, zinc ions, etc. The structure and properties of the formed complexes depend on the type of metal ions, ligand structure and reaction conditions, and are widely used in the fields of materials science and catalysis.
What are the preparation methods of 1-chloro-2,4-dinitrobenzene?
1. ** Material selection **
- To make 1-bromo-2,4-diaminobenzene, select raw materials. Bromine is the key material, and its purity is better. The color is orange-red and transparent, and the smell is pungent. It is selected from a reliable place to ensure its stability and purity. As for 2,4-diaminobenzene, it is also of high quality. The appearance is white or white-like powder, and there is no variegated foreign matter. The purity should exceed 99%, which can lay the foundation for subsequent reactions.
2. ** Reaction method **
- ** Direct bromination method **: In the clean kettle, put an appropriate amount of 2,4-diaminobenzene first, and dissolve it in a solvent, such as ethanol, dichloromethane, etc., depending on its solubility and reactivity. Stir evenly, control the temperature in an ice bath or a low temperature environment, and slowly drop bromine. Among them, the amount of bromine should be accurate, and a slight excess of stoichiometric ratio is appropriate to prevent incomplete reaction. When dripping, it needs to be slow, and it needs to be stirred constantly to make it fully contact. During the reaction, close observation shows that the color in the kettle gradually changes, and there is new quality. After the reaction is completed, pure 1-bromo-2,4-diaminobenzene is obtained by extraction, distillation, recrystallization, etc. Although the method is simple, the bromination position is difficult to control, and it is easy to produce polybrominated compounds.
- ** Guide group method **: Introduce a guide group, such as acetyl group, on the 2,4-diaminobenzene first. In a suitable agent, add an acylating agent, such as acetic anhydride, to catalyze it, raise the temperature to make the amino acetylation. After bromination, at this time, due to the introduction of the guide group, bromine is easy to enter the designated position, that is, 1 position. After the bromide is completed, the group is dedirected, and the acetamide group is hydrolyzed in alkali solution to make the acetamide group complex into an amino group. After separation and purification, a relatively pure product can be obtained. Although this method is slightly complicated, the purity of the product is high and the yield is also good.
3. ** Purification and purification **
- After the reaction is completed, the product often contains impurities and must be refined. At the beginning of the extraction method, a suitable extractant, such as ether, chloroform, etc., is selected to separate the product and impurities from different phases. After distillation, it is separated according to the different boiling points of the product and impurities. Finally, by the method of recrystallization, select an appropriate solvent, such as ethanol-water mixture, dissolved product, filter out insoluble impurities while hot, cool crystallization, and obtain pure 1-bromo-2,4-diaminobenzene.
- To make 1-bromo-2,4-diaminobenzene, select raw materials. Bromine is the key material, and its purity is better. The color is orange-red and transparent, and the smell is pungent. It is selected from a reliable place to ensure its stability and purity. As for 2,4-diaminobenzene, it is also of high quality. The appearance is white or white-like powder, and there is no variegated foreign matter. The purity should exceed 99%, which can lay the foundation for subsequent reactions.
2. ** Reaction method **
- ** Direct bromination method **: In the clean kettle, put an appropriate amount of 2,4-diaminobenzene first, and dissolve it in a solvent, such as ethanol, dichloromethane, etc., depending on its solubility and reactivity. Stir evenly, control the temperature in an ice bath or a low temperature environment, and slowly drop bromine. Among them, the amount of bromine should be accurate, and a slight excess of stoichiometric ratio is appropriate to prevent incomplete reaction. When dripping, it needs to be slow, and it needs to be stirred constantly to make it fully contact. During the reaction, close observation shows that the color in the kettle gradually changes, and there is new quality. After the reaction is completed, pure 1-bromo-2,4-diaminobenzene is obtained by extraction, distillation, recrystallization, etc. Although the method is simple, the bromination position is difficult to control, and it is easy to produce polybrominated compounds.
- ** Guide group method **: Introduce a guide group, such as acetyl group, on the 2,4-diaminobenzene first. In a suitable agent, add an acylating agent, such as acetic anhydride, to catalyze it, raise the temperature to make the amino acetylation. After bromination, at this time, due to the introduction of the guide group, bromine is easy to enter the designated position, that is, 1 position. After the bromide is completed, the group is dedirected, and the acetamide group is hydrolyzed in alkali solution to make the acetamide group complex into an amino group. After separation and purification, a relatively pure product can be obtained. Although this method is slightly complicated, the purity of the product is high and the yield is also good.
3. ** Purification and purification **
- After the reaction is completed, the product often contains impurities and must be refined. At the beginning of the extraction method, a suitable extractant, such as ether, chloroform, etc., is selected to separate the product and impurities from different phases. After distillation, it is separated according to the different boiling points of the product and impurities. Finally, by the method of recrystallization, select an appropriate solvent, such as ethanol-water mixture, dissolved product, filter out insoluble impurities while hot, cool crystallization, and obtain pure 1-bromo-2,4-diaminobenzene.
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