Linshang Chemical
PRODUCTS
1-Chloro-2-(4-Ethoxybenzyl)-4-Iodobenzene
Linshang Chemical
|
HS Code |
667586 |
| Chemical Formula | C15H14ClIO |
| Molecular Weight | 376.63 |
| Appearance | Solid (predicted) |
| Boiling Point | Predicted to be high due to molecular weight and structure |
| Density | Estimated based on similar aromatic halides, around 1.6 - 1.8 g/cm³ (predicted) |
| Solubility In Water | Low, as it is an organic halide with non - polar groups |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Flash Point | Predicted to be relatively high due to the nature of the molecule |
| Stability | Stable under normal conditions, but may react with strong oxidizing or reducing agents |
As an accredited 1-Chloro-2-(4-Ethoxybenzyl)-4-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - chloro - 2-(4 - ethoxybenzyl)-4 - iodobenzene packaged in a sealed glass bottle. |
| Storage | 1 - chloro - 2 - (4 - ethoxybenzyl) - 4 - iodobenzene should be stored in a cool, dry place away from heat sources and direct sunlight. Keep it in a tightly - sealed container to prevent exposure to air and moisture, which could potentially cause degradation. Store it separately from oxidizing agents and incompatible substances to avoid chemical reactions. |
| Shipping | 1 - chloro - 2 - (4 - ethoxybenzyl) - 4 - iodobenzene will be carefully packaged in suitable containers to prevent breakage and leakage. Shipment will follow strict chemical transport regulations, ensuring safe and timely delivery. |
Competitive 1-Chloro-2-(4-Ethoxybenzyl)-4-Iodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Chloro-2-(4-Ethoxybenzyl)-4-Iodobenzene in China?
As a trusted 1-Chloro-2-(4-Ethoxybenzyl)-4-Iodobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Chloro-2-(4-Ethoxybenzyl)-4-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-2- (4-ethoxybenzyl) -4-iodobenzene?
1 - chloro - 2 - (4 - ethoxybenzyl) - 4 - iodobenzene is one of the organic compounds. Such compounds have a wide range of uses in the field of organic synthesis.
One of them is often the key intermediate for the synthesis of complex organic molecules. The art of organic synthesis aims to construct organic compounds with delicate structures and specific functions. Due to the active groups such as chlorine, iodine and ethoxybenzyl, this compound can be connected with other organic fragments by various chemical reactions, such as nucleophilic substitution and coupling reactions, to build a more complex molecular structure. For example, chlorine atoms and iodine atoms can be used as check points for nucleophilic substitution reactions, and can be replaced by various nucleophilic reagents to introduce different functional groups, which lays the foundation for the synthesis of target products with specific structures.
Second, in the field of materials science, it also has potential applications. With the advance of science and technology, the demand for new materials is increasing. This compound may be chemically modified appropriately and introduced into a polymer system to endow the material with unique properties. For example, because of its benzene-containing ring structure, it can enhance the rigidity and stability of the material; while the existence of groups such as ethoxy groups may adjust the solubility and thermal stability of the material, which is expected to be used in the preparation of high-performance polymer materials, optoelectronic materials, etc.
Third, in the field of medicinal chemistry, or play an important role. In the process of drug development, it is necessary to create compounds with specific biological activities. The structural characteristics of the compound may interact with specific targets in organisms. Through rational design and modification, it can be used as a starting material to synthesize derivatives, or have potential pharmacological activities, such as antibacterial, anti-inflammatory, anti-tumor, etc., providing opportunities for the development of new drugs.
One of them is often the key intermediate for the synthesis of complex organic molecules. The art of organic synthesis aims to construct organic compounds with delicate structures and specific functions. Due to the active groups such as chlorine, iodine and ethoxybenzyl, this compound can be connected with other organic fragments by various chemical reactions, such as nucleophilic substitution and coupling reactions, to build a more complex molecular structure. For example, chlorine atoms and iodine atoms can be used as check points for nucleophilic substitution reactions, and can be replaced by various nucleophilic reagents to introduce different functional groups, which lays the foundation for the synthesis of target products with specific structures.
Second, in the field of materials science, it also has potential applications. With the advance of science and technology, the demand for new materials is increasing. This compound may be chemically modified appropriately and introduced into a polymer system to endow the material with unique properties. For example, because of its benzene-containing ring structure, it can enhance the rigidity and stability of the material; while the existence of groups such as ethoxy groups may adjust the solubility and thermal stability of the material, which is expected to be used in the preparation of high-performance polymer materials, optoelectronic materials, etc.
Third, in the field of medicinal chemistry, or play an important role. In the process of drug development, it is necessary to create compounds with specific biological activities. The structural characteristics of the compound may interact with specific targets in organisms. Through rational design and modification, it can be used as a starting material to synthesize derivatives, or have potential pharmacological activities, such as antibacterial, anti-inflammatory, anti-tumor, etc., providing opportunities for the development of new drugs.
What are the physical properties of 1-chloro-2- (4-ethoxybenzyl) -4-iodobenzene?
1 - chloro - 2 - (4 - ethoxybenzyl) - 4 - iodobenzene, this is an organic compound. Its physical properties are particularly important for its application in various scenarios.
Looking at its physical state, under normal temperature and pressure, it is mostly in a solid state. Due to the strong intermolecular force, the large number of carbon atoms and the relatively complex structure, the molecules are closely arranged, so it is a solid state. The value of its melting point depends on the accurate experimental determination, but it can be slightly inferred from the structure. The presence of benzene rings and substituents increases the intermolecular force, which increases the melting point. Or between tens and hundreds of degrees Celsius, depending on the accurate experiment.
When it comes to boiling point, it is also quite high due to complex structure and strong intermolecular forces. To make molecules break free from the shackles of the liquid phase and turn into the gas phase, more energy is required. Therefore, the boiling point or above hundreds of degrees Celsius, the specific data needs to be experimentally determined.
In terms of solubility, the compound has a certain hydrophobicity due to its benzene ring, halogen atom and ethoxy group, and its solubility in water is very small. However, in organic solvents, such as common ether, chloroform, and dichloromethane, the solubility is relatively large. Due to the principle of similar miscibility, its organic structure is similar to that of organic solvents, and the interaction is strong, which is easy to dissolve.
Its density is greater than that of water. Due to the fact that the molecules contain elements with relatively large atomic mass such as chlorine and iodine, the mass per unit volume increases, so the density is higher than that of water.
The color state of this compound may be white to light yellow solid when pure, but the color may change due to impurities or light, storage conditions, etc. And it has certain stability, but under specific conditions, such as high temperature, strong acid and alkali or specific catalysts, chemical reactions may occur, resulting in changes in structure and properties.
Looking at its physical state, under normal temperature and pressure, it is mostly in a solid state. Due to the strong intermolecular force, the large number of carbon atoms and the relatively complex structure, the molecules are closely arranged, so it is a solid state. The value of its melting point depends on the accurate experimental determination, but it can be slightly inferred from the structure. The presence of benzene rings and substituents increases the intermolecular force, which increases the melting point. Or between tens and hundreds of degrees Celsius, depending on the accurate experiment.
When it comes to boiling point, it is also quite high due to complex structure and strong intermolecular forces. To make molecules break free from the shackles of the liquid phase and turn into the gas phase, more energy is required. Therefore, the boiling point or above hundreds of degrees Celsius, the specific data needs to be experimentally determined.
In terms of solubility, the compound has a certain hydrophobicity due to its benzene ring, halogen atom and ethoxy group, and its solubility in water is very small. However, in organic solvents, such as common ether, chloroform, and dichloromethane, the solubility is relatively large. Due to the principle of similar miscibility, its organic structure is similar to that of organic solvents, and the interaction is strong, which is easy to dissolve.
Its density is greater than that of water. Due to the fact that the molecules contain elements with relatively large atomic mass such as chlorine and iodine, the mass per unit volume increases, so the density is higher than that of water.
The color state of this compound may be white to light yellow solid when pure, but the color may change due to impurities or light, storage conditions, etc. And it has certain stability, but under specific conditions, such as high temperature, strong acid and alkali or specific catalysts, chemical reactions may occur, resulting in changes in structure and properties.
What is the synthesis method of 1-chloro-2- (4-ethoxybenzyl) -4-iodobenzene?
To prepare 1 - chloro - 2 - (4 - ethoxybenzyl) - 4 - iodobenzene, the following ancient method can be used.
Take 4 - ethoxybenzyl chloride and 1 - chloro - 4 - iodobenzene as starting materials. In a clean reactor, add an appropriate amount of alkali, such as potassium carbonate, to provide an alkaline environment and promote the smooth progress of the reaction. Then add a suitable organic solvent, such as N, N - dimethylformamide (DMF), this solvent can effectively dissolve the reactants and make the reaction proceed uniformly.
Warm up to an appropriate temperature, about 60-80 ° C. This temperature range can not only speed up the reaction rate, but also avoid the excessive occurrence of side reactions. Under stirring, the reaction between the two is slow, and the chlorine atom of benzyl in 4-ethoxybenzyl chloride is active. Under the action of alkali, the nucleophilic substitution reaction occurs with the hydrogen atom at the 2-position on the 1-chloro-4-iodobenzene benzene ring. When the reaction duration is several, the reaction progress is monitored by thin-layer chromatography (TLC) at regular intervals. When the raw material point disappears and the product point is significant, the main reaction can be regarded as basically completed.
After the reaction is completed, pour the reaction solution into an appropriate amount of ice water to quench the reaction, reduce the solubility of the product in the organic solvent, and promote its precipitation. Extraction is performed, and organic solvents such as dichloromethane are extracted several times to combine the organic phases. Then the organic phase is washed with saturated salt water to remove residual moisture and water-soluble impurities. The organic phase is dried with anhydrous sodium sulfate, and the desiccant is filtered off. After the organic solvent is removed by vacuum distillation, the crude product can be obtained.
Finally, the crude product was purified by column chromatography, silica gel was used as the stationary phase, petroleum ether and ethyl acetate were prepared into a mobile phase in an appropriate proportion, leached and separated, and the fractions containing the pure product were collected. The solvent was evaporated to obtain pure 1-chloro-2 - (4-ethoxybenzyl) -4-iodobenzene.
Take 4 - ethoxybenzyl chloride and 1 - chloro - 4 - iodobenzene as starting materials. In a clean reactor, add an appropriate amount of alkali, such as potassium carbonate, to provide an alkaline environment and promote the smooth progress of the reaction. Then add a suitable organic solvent, such as N, N - dimethylformamide (DMF), this solvent can effectively dissolve the reactants and make the reaction proceed uniformly.
Warm up to an appropriate temperature, about 60-80 ° C. This temperature range can not only speed up the reaction rate, but also avoid the excessive occurrence of side reactions. Under stirring, the reaction between the two is slow, and the chlorine atom of benzyl in 4-ethoxybenzyl chloride is active. Under the action of alkali, the nucleophilic substitution reaction occurs with the hydrogen atom at the 2-position on the 1-chloro-4-iodobenzene benzene ring. When the reaction duration is several, the reaction progress is monitored by thin-layer chromatography (TLC) at regular intervals. When the raw material point disappears and the product point is significant, the main reaction can be regarded as basically completed.
After the reaction is completed, pour the reaction solution into an appropriate amount of ice water to quench the reaction, reduce the solubility of the product in the organic solvent, and promote its precipitation. Extraction is performed, and organic solvents such as dichloromethane are extracted several times to combine the organic phases. Then the organic phase is washed with saturated salt water to remove residual moisture and water-soluble impurities. The organic phase is dried with anhydrous sodium sulfate, and the desiccant is filtered off. After the organic solvent is removed by vacuum distillation, the crude product can be obtained.
Finally, the crude product was purified by column chromatography, silica gel was used as the stationary phase, petroleum ether and ethyl acetate were prepared into a mobile phase in an appropriate proportion, leached and separated, and the fractions containing the pure product were collected. The solvent was evaporated to obtain pure 1-chloro-2 - (4-ethoxybenzyl) -4-iodobenzene.
What are the chemical properties of 1-chloro-2- (4-ethoxybenzyl) -4-iodobenzene
1 - chloro - 2 - (4 - ethoxybenzyl) - 4 - iodobenzene is an organic compound with unique chemical properties. Its molecules contain chlorine atoms, iodine atoms and ethoxybenzyl groups, and these structures cause it to exhibit a variety of chemical activities.
Chlorine atoms are highly active and can be replaced by nucleophilic substitution by many nucleophilic reagents. In case of hydroxyl negative ions, chlorine atoms may be replaced by hydroxyl groups to form compounds containing hydroxyl groups; in case of amino negative ions, nucleophilic substitution can also occur to obtain products containing amino groups. In this process, chlorine atoms become a check point for reaction activity due to differences in electronegativity.
Although the iodine atom is relatively large, the stability is not good, and it is easy to leave under certain conditions. For example, in metal-catalyzed coupling reactions, iodine atoms can participate in the reaction and couple with other organic fragments to form new carbon-carbon bonds or carbon-heteroatom bonds, which are extremely important in organic synthesis to build complex molecular structures.
4 -ethoxylbenzyl moiety, ethoxy group has a electron conductor effect, which can increase the electron cloud density of the benzene ring and enhance the activity of the electrophilic substitution reaction of the benzene ring. Benzyl is connected to the benzene ring, which makes the molecular space structure more complex and affects the physical and chemical properties of the molecule, such as solubility, melting point and boiling point.
1 - chloro - 2 - (4 - ethoxybenzyl) - 4 - iodobenzene is rich in chemical properties and has a wide range of uses in the field of organic synthesis. It provides an important way for the preparation of various organic compounds. It can be used to design reactions rationally, regulate their chemical activities, and synthesize desired target products.
Chlorine atoms are highly active and can be replaced by nucleophilic substitution by many nucleophilic reagents. In case of hydroxyl negative ions, chlorine atoms may be replaced by hydroxyl groups to form compounds containing hydroxyl groups; in case of amino negative ions, nucleophilic substitution can also occur to obtain products containing amino groups. In this process, chlorine atoms become a check point for reaction activity due to differences in electronegativity.
Although the iodine atom is relatively large, the stability is not good, and it is easy to leave under certain conditions. For example, in metal-catalyzed coupling reactions, iodine atoms can participate in the reaction and couple with other organic fragments to form new carbon-carbon bonds or carbon-heteroatom bonds, which are extremely important in organic synthesis to build complex molecular structures.
4 -ethoxylbenzyl moiety, ethoxy group has a electron conductor effect, which can increase the electron cloud density of the benzene ring and enhance the activity of the electrophilic substitution reaction of the benzene ring. Benzyl is connected to the benzene ring, which makes the molecular space structure more complex and affects the physical and chemical properties of the molecule, such as solubility, melting point and boiling point.
1 - chloro - 2 - (4 - ethoxybenzyl) - 4 - iodobenzene is rich in chemical properties and has a wide range of uses in the field of organic synthesis. It provides an important way for the preparation of various organic compounds. It can be used to design reactions rationally, regulate their chemical activities, and synthesize desired target products.
What are the precautions for storing and transporting 1-chloro-2- (4-ethoxybenzyl) -4-iodobenzene?
1 - chloro - 2 - (4 - ethoxybenzyl) - 4 - iodobenzene is an organic compound. When storing and transporting, the following things should be paid attention to:
First, because of its chemical activity, it is easy to react with other substances, so it must be stored in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent danger such as thermal decomposition or combustion. If it is placed in a humid environment or deteriorated due to moisture, its chemical properties will change, so the control of environmental humidity is essential.
Second, this compound is sensitive to light. Light or cause it to undergo photochemical reactions, which will damage the quality and structure. When storing, it is advisable to use an opaque container, or store it in a place protected from light to prevent direct light.
Third, 1-chloro-2 - (4-ethoxybenzyl) -4-iodobenzene may be toxic and corrosive. During transportation and storage, strict protective measures should be taken. Operators should wear protective clothing, gloves and goggles, etc., to avoid direct contact. If inadvertent contact, rinse with plenty of water immediately and seek medical attention according to specific circumstances.
Fourth, when storing, it should be stored separately from oxidants, reducing agents, acids, bases, etc., and must not be mixed with storage and transportation. Because it encounters with these substances, or causes violent chemical reactions, it endangers safety.
Fifth, during transportation, ensure that the container is well sealed to prevent leakage. Select suitable transportation tools and follow relevant transportation regulations. In the event of a leak, emergency measures should be taken promptly, such as evacuating personnel, isolating the leak area, and containing and handling the leak with appropriate materials.
First, because of its chemical activity, it is easy to react with other substances, so it must be stored in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent danger such as thermal decomposition or combustion. If it is placed in a humid environment or deteriorated due to moisture, its chemical properties will change, so the control of environmental humidity is essential.
Second, this compound is sensitive to light. Light or cause it to undergo photochemical reactions, which will damage the quality and structure. When storing, it is advisable to use an opaque container, or store it in a place protected from light to prevent direct light.
Third, 1-chloro-2 - (4-ethoxybenzyl) -4-iodobenzene may be toxic and corrosive. During transportation and storage, strict protective measures should be taken. Operators should wear protective clothing, gloves and goggles, etc., to avoid direct contact. If inadvertent contact, rinse with plenty of water immediately and seek medical attention according to specific circumstances.
Fourth, when storing, it should be stored separately from oxidants, reducing agents, acids, bases, etc., and must not be mixed with storage and transportation. Because it encounters with these substances, or causes violent chemical reactions, it endangers safety.
Fifth, during transportation, ensure that the container is well sealed to prevent leakage. Select suitable transportation tools and follow relevant transportation regulations. In the event of a leak, emergency measures should be taken promptly, such as evacuating personnel, isolating the leak area, and containing and handling the leak with appropriate materials.
Scan to WhatsApp
