Linshang Chemical
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1-Chloro-2,5-Difluorobenzene
Linshang Chemical
|
HS Code |
668200 |
| Chemical Formula | C6H3ClF2 |
| Molar Mass | 148.537 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 133 - 135 °C |
| Density | 1.33 g/cm³ (approximate) |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 38 °C (approximate) |
As an accredited 1-Chloro-2,5-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1 - chloro - 2,5 - difluorobenzene packaged in a sealed, chemical - resistant bottle. |
| Storage | 1 - Chloro - 2,5 - difluorobenzene should be stored in a cool, well - ventilated area, away from heat sources and ignition points due to its flammability risks. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials, to prevent leakage and contact with air or moisture. Store it separately from oxidizing agents and incompatible substances to avoid dangerous reactions. |
| Shipping | 1 - Chloro - 2,5 - difluorobenzene is shipped in well - sealed, corrosion - resistant containers. Compliance with regulations for hazardous chemicals is ensured. Shipment is carefully monitored for temperature and handling to prevent spills and ensure safety. |
Competitive 1-Chloro-2,5-Difluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Chloro-2,5-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-2,5-difluorobenzene?
1-Chloro-2,5-difluorobenzene is also an organic compound. It has a wide range of uses and is important in various fields of chemical industry.
First, in the synthesis of medicine, this compound is often a key intermediate. Cover because of its unique structure, containing chlorine, fluorine and other atoms, can be added to the drug molecular structure by chemical reaction to improve the physical and chemical properties of drugs, such as solubility, stability and biological activity. Based on this, a variety of drugs can be prepared, or have antibacterial, antiviral, anti-tumor and other effects. It is the cornerstone of medical research and development, and helps to create new drugs to solve the suffering of patients.
Second, in the field of pesticides, it also plays an important role. Due to its halogen-containing atoms, it imparts certain biological activity to the molecules and can be used as raw materials for the synthesis of highly efficient and low-toxic pesticides. Such pesticides can effectively remove pests, prevent diseases, protect crop growth, and maintain agricultural harvests. They are indispensable in agricultural production.
Third, in the field of materials science, 1-chloro-2,5-difluorobenzene can participate in the synthesis of special materials. After a specific chemical reaction, it can be introduced into the main chain or side chain of polymer materials to improve material properties, such as improving heat resistance, corrosion resistance and mechanical properties. This is especially needed in high-end fields such as aerospace and electronics, and can be used to make materials suitable for special environments.
Fourth, in the study of organic synthetic chemistry, 1-chloro-2,5-difluorobenzene is a commonly used reagent. Chemists use its unique structure and reactivity to explore various organic synthesis reactions to expand the variety of organic compounds, deepen the theoretical understanding of organic chemistry, and inject impetus into the development of organic synthetic chemistry.
In summary, 1-chloro-2,5-difluorobenzene has important uses in the fields of medicine, pesticides, materials and scientific research, promoting technological progress and development in various fields.
First, in the synthesis of medicine, this compound is often a key intermediate. Cover because of its unique structure, containing chlorine, fluorine and other atoms, can be added to the drug molecular structure by chemical reaction to improve the physical and chemical properties of drugs, such as solubility, stability and biological activity. Based on this, a variety of drugs can be prepared, or have antibacterial, antiviral, anti-tumor and other effects. It is the cornerstone of medical research and development, and helps to create new drugs to solve the suffering of patients.
Second, in the field of pesticides, it also plays an important role. Due to its halogen-containing atoms, it imparts certain biological activity to the molecules and can be used as raw materials for the synthesis of highly efficient and low-toxic pesticides. Such pesticides can effectively remove pests, prevent diseases, protect crop growth, and maintain agricultural harvests. They are indispensable in agricultural production.
Third, in the field of materials science, 1-chloro-2,5-difluorobenzene can participate in the synthesis of special materials. After a specific chemical reaction, it can be introduced into the main chain or side chain of polymer materials to improve material properties, such as improving heat resistance, corrosion resistance and mechanical properties. This is especially needed in high-end fields such as aerospace and electronics, and can be used to make materials suitable for special environments.
Fourth, in the study of organic synthetic chemistry, 1-chloro-2,5-difluorobenzene is a commonly used reagent. Chemists use its unique structure and reactivity to explore various organic synthesis reactions to expand the variety of organic compounds, deepen the theoretical understanding of organic chemistry, and inject impetus into the development of organic synthetic chemistry.
In summary, 1-chloro-2,5-difluorobenzene has important uses in the fields of medicine, pesticides, materials and scientific research, promoting technological progress and development in various fields.
What are the physical properties of 1-chloro-2,5-difluorobenzene?
1-Chloro-2,5-difluorobenzene is one of the organic compounds. It has unique physical properties and is very important in the field of industry and scientific research.
First of all, its appearance, under room temperature and pressure, 1-chloro-2,5-difluorobenzene is a colorless to light yellow transparent liquid, which is clear in appearance and has no visible impurities. Its smell is special, slightly irritating, but not extremely strong. People can feel its odor, but it is uncomfortable if they smell it too much.
When it comes to the boiling point, the boiling point of this compound is about 137-139 ° C. The boiling point is the temperature at which a substance changes from liquid to gaseous state. This boiling point value means that at this temperature and corresponding pressure conditions, 1-chloro-2,5-difluorobenzene will boil into steam. This property is very critical in chemical operations such as distillation and separation. According to its boiling point, the substance can be effectively separated from the mixture.
Besides the melting point, the melting point of 1-chloro-2,5-difluorobenzene is about -45 ° C. The melting point is the temperature limit for solid to liquid state. Below this temperature, the substance is solid, and above it is liquid. Knowing the melting point is of great significance in setting storage and transportation conditions to ensure that it is stored and transferred in a suitable state.
Its density is about 1.36 g/cm ³, which is heavier than water. Density, the mass per unit volume of a substance, this value indicates that under the same volume, the mass of 1-chloro-2,5-difluorobenzene is greater than that of water. When it comes to operations such as liquid-liquid separation or mixing, the density difference is an important consideration, which can be used to separate from water or other liquids of different densities.
In terms of solubility, 1-chloro-2,5-difluorobenzene is insoluble in water, because water is a polar solvent, and the polarity of this compound is weak. According to the principle of "similar miscibility", the two are insoluble. However, it is soluble in most organic solvents, such as ethanol, ether, acetone, etc. Organic solvents have good solubility, which facilitates their use as solvents or reactants in organic synthesis reactions, allowing the reaction to proceed smoothly in homogeneous systems, improving reaction efficiency and selectivity.
In addition, the vapor pressure of 1-chloro-2,5-difluorobenzene is also an important physical property. Vapor pressure reflects the tendency of substances to evaporate. Although the specific value varies depending on temperature, in general, it has a certain vapor pressure at room temperature and will evaporate into the air. Pay attention to ventilation during operation to avoid danger caused by vapor accumulation.
In summary, the physical properties of 1-chloro-2,5-difluorobenzene, such as appearance, boiling point, melting point, density, solubility, and vapor pressure, are interrelated and have their own uses. They have a profound impact on their applications in chemical production, scientific research experiments, etc. Knowing and making good use of these properties can better control this compound and contribute to the development of related fields.
First of all, its appearance, under room temperature and pressure, 1-chloro-2,5-difluorobenzene is a colorless to light yellow transparent liquid, which is clear in appearance and has no visible impurities. Its smell is special, slightly irritating, but not extremely strong. People can feel its odor, but it is uncomfortable if they smell it too much.
When it comes to the boiling point, the boiling point of this compound is about 137-139 ° C. The boiling point is the temperature at which a substance changes from liquid to gaseous state. This boiling point value means that at this temperature and corresponding pressure conditions, 1-chloro-2,5-difluorobenzene will boil into steam. This property is very critical in chemical operations such as distillation and separation. According to its boiling point, the substance can be effectively separated from the mixture.
Besides the melting point, the melting point of 1-chloro-2,5-difluorobenzene is about -45 ° C. The melting point is the temperature limit for solid to liquid state. Below this temperature, the substance is solid, and above it is liquid. Knowing the melting point is of great significance in setting storage and transportation conditions to ensure that it is stored and transferred in a suitable state.
Its density is about 1.36 g/cm ³, which is heavier than water. Density, the mass per unit volume of a substance, this value indicates that under the same volume, the mass of 1-chloro-2,5-difluorobenzene is greater than that of water. When it comes to operations such as liquid-liquid separation or mixing, the density difference is an important consideration, which can be used to separate from water or other liquids of different densities.
In terms of solubility, 1-chloro-2,5-difluorobenzene is insoluble in water, because water is a polar solvent, and the polarity of this compound is weak. According to the principle of "similar miscibility", the two are insoluble. However, it is soluble in most organic solvents, such as ethanol, ether, acetone, etc. Organic solvents have good solubility, which facilitates their use as solvents or reactants in organic synthesis reactions, allowing the reaction to proceed smoothly in homogeneous systems, improving reaction efficiency and selectivity.
In addition, the vapor pressure of 1-chloro-2,5-difluorobenzene is also an important physical property. Vapor pressure reflects the tendency of substances to evaporate. Although the specific value varies depending on temperature, in general, it has a certain vapor pressure at room temperature and will evaporate into the air. Pay attention to ventilation during operation to avoid danger caused by vapor accumulation.
In summary, the physical properties of 1-chloro-2,5-difluorobenzene, such as appearance, boiling point, melting point, density, solubility, and vapor pressure, are interrelated and have their own uses. They have a profound impact on their applications in chemical production, scientific research experiments, etc. Knowing and making good use of these properties can better control this compound and contribute to the development of related fields.
What are the chemical properties of 1-chloro-2,5-difluorobenzene?
1-Chloro-2,5-difluorobenzene is also an organic compound. It has an aromatic ring structure, and chlorine and difluorine atoms are based on the benzene ring. The chemical properties of this substance have much to be investigated.
In terms of its reactivity, the electron cloud density of the benzene ring varies due to the presence of fluorine and chlorine atoms. Fluorine atoms have strong electronegativity and have electron-sucking induction effects. The electron cloud density of the benzene ring is reduced, resulting in lower electrophilic substitution reaction activity than benzene. However, under appropriate conditions, electrophilic substitution can still occur. For example, when encountering electrophilic reagents, a substitution reaction can take place at a specific position in the benzene ring, and the substitution check point is controlled by the positioning effect of fluorine and chlorine atoms. Fluorine and chlorine are both ortho and para-sites, so electrophilic reagents tend to attack the ortho and para-sites of the benzene ring.
And they can participate in nucleophilic substitution reactions. Because the carbon atoms connected to the halogen atoms are partially positively charged, when encountering nucleophilic reagents, the halogen atoms can be replaced by nucleophilic reagents. This reaction is easier to carry out in a basic environment or with appropriate catalysts.
The stability of 1-chloro-2,5-difluorobenzene is increased due to the formation of a conjugated system between fluorine and chlorine atoms and the benzene ring. However, under extreme conditions such as high temperature and strong acid and base, its structure may change. In the field of organic synthesis, this substance can be used as a key intermediate to form complex organic molecules through various reactions, providing an important foundation for the research and development of drugs, materials, and many other fields.
In terms of its reactivity, the electron cloud density of the benzene ring varies due to the presence of fluorine and chlorine atoms. Fluorine atoms have strong electronegativity and have electron-sucking induction effects. The electron cloud density of the benzene ring is reduced, resulting in lower electrophilic substitution reaction activity than benzene. However, under appropriate conditions, electrophilic substitution can still occur. For example, when encountering electrophilic reagents, a substitution reaction can take place at a specific position in the benzene ring, and the substitution check point is controlled by the positioning effect of fluorine and chlorine atoms. Fluorine and chlorine are both ortho and para-sites, so electrophilic reagents tend to attack the ortho and para-sites of the benzene ring.
And they can participate in nucleophilic substitution reactions. Because the carbon atoms connected to the halogen atoms are partially positively charged, when encountering nucleophilic reagents, the halogen atoms can be replaced by nucleophilic reagents. This reaction is easier to carry out in a basic environment or with appropriate catalysts.
The stability of 1-chloro-2,5-difluorobenzene is increased due to the formation of a conjugated system between fluorine and chlorine atoms and the benzene ring. However, under extreme conditions such as high temperature and strong acid and base, its structure may change. In the field of organic synthesis, this substance can be used as a key intermediate to form complex organic molecules through various reactions, providing an important foundation for the research and development of drugs, materials, and many other fields.
What is the production method of 1-chloro-2,5-difluorobenzene?
The preparation method of 1-chloro-2,5-difluorobenzene is studied in the field of chemical synthesis. The method has various paths, which are described in detail below.
First, it can be started by fluorobenzene-containing compounds. Using 2,5-difluorobenzene as a raw material, chlorination is often used to introduce chlorine atoms. Among them, suitable chlorination reagents can be selected, such as chlorine (Cl ²). Under specific reaction conditions, such as in the presence of a catalyst, the reaction can proceed smoothly. Common catalysts include Lewis acids, such as iron trichloride (FeCl ²). At the time of the reaction, chlorine gas undergoes an electrophilic substitution reaction with 2,5-difluorobenzene under the catalysis of ferric chloride, and the chlorine atom selects the position to replace the hydrogen atom on the benzene ring to obtain 1-chloro-2,5-difluorobenzene. This process requires fine regulation of reaction temperature, pressure, reactant ratio and catalyst dosage. If the temperature is too high, it may cause the formation of polychlorinated by-products; if the temperature is too low, the reaction rate will be slow.
Second, halogenated aromatics can also be used as starting materials. If a suitable halogenated aromatic hydrocarbon containing fluorine is selected, if the benzene ring already has fluorine atoms and there is a suitable substitution check point, chlorine atoms can be introduced. It can be achieved by nucleoph If the halogen atom of fluorohalobenzene is used as the leaving group, a suitable nucleophilic reagent, such as a chlorine-containing nucleophilic reagent, is selected. Under suitable reaction media and conditions, the nucleophilic reagent attacks the benzene ring, replaces the original halogen atom, and generates the target product 1-chloro-2,5-difluorobenzene. Among them, the polarity of the reaction medium, the activity of the nucleophilic reagent, and the reaction temperature all have a great influence on the process and yield of the reaction.
Third, a multi-step reaction strategy can also be used. Compounds with partial target structures are first constructed, and then fluorine atoms and chlorine atoms are gradually introduced. For example, chlorobenzene-containing derivatives are first synthesized, and then fluorine atoms are introduced The fluorination reaction uses a variety of fluorinating reagents, such as Selectfluor. Under suitable reaction conditions, fluorine atoms can be substituted for specific positions, and finally 1-chloro-2,5-difluorobenzene is obtained. This multi-step reaction strategy, although the steps are complicated, can be carefully controlled for each step of the reaction to improve the purity and yield of the product.
In short, there are many methods for preparing 1-chloro-2,5-difluorobenzene. Each method has its own advantages and disadvantages. According to actual needs, factors such as raw material availability, cost, difficulty of reaction conditions and product purity requirements should be considered in order to choose the optimal preparation path.
First, it can be started by fluorobenzene-containing compounds. Using 2,5-difluorobenzene as a raw material, chlorination is often used to introduce chlorine atoms. Among them, suitable chlorination reagents can be selected, such as chlorine (Cl ²). Under specific reaction conditions, such as in the presence of a catalyst, the reaction can proceed smoothly. Common catalysts include Lewis acids, such as iron trichloride (FeCl ²). At the time of the reaction, chlorine gas undergoes an electrophilic substitution reaction with 2,5-difluorobenzene under the catalysis of ferric chloride, and the chlorine atom selects the position to replace the hydrogen atom on the benzene ring to obtain 1-chloro-2,5-difluorobenzene. This process requires fine regulation of reaction temperature, pressure, reactant ratio and catalyst dosage. If the temperature is too high, it may cause the formation of polychlorinated by-products; if the temperature is too low, the reaction rate will be slow.
Second, halogenated aromatics can also be used as starting materials. If a suitable halogenated aromatic hydrocarbon containing fluorine is selected, if the benzene ring already has fluorine atoms and there is a suitable substitution check point, chlorine atoms can be introduced. It can be achieved by nucleoph If the halogen atom of fluorohalobenzene is used as the leaving group, a suitable nucleophilic reagent, such as a chlorine-containing nucleophilic reagent, is selected. Under suitable reaction media and conditions, the nucleophilic reagent attacks the benzene ring, replaces the original halogen atom, and generates the target product 1-chloro-2,5-difluorobenzene. Among them, the polarity of the reaction medium, the activity of the nucleophilic reagent, and the reaction temperature all have a great influence on the process and yield of the reaction.
Third, a multi-step reaction strategy can also be used. Compounds with partial target structures are first constructed, and then fluorine atoms and chlorine atoms are gradually introduced. For example, chlorobenzene-containing derivatives are first synthesized, and then fluorine atoms are introduced The fluorination reaction uses a variety of fluorinating reagents, such as Selectfluor. Under suitable reaction conditions, fluorine atoms can be substituted for specific positions, and finally 1-chloro-2,5-difluorobenzene is obtained. This multi-step reaction strategy, although the steps are complicated, can be carefully controlled for each step of the reaction to improve the purity and yield of the product.
In short, there are many methods for preparing 1-chloro-2,5-difluorobenzene. Each method has its own advantages and disadvantages. According to actual needs, factors such as raw material availability, cost, difficulty of reaction conditions and product purity requirements should be considered in order to choose the optimal preparation path.
What are the precautions for using 1-chloro-2,5-difluorobenzene?
1-Chloro-2,5-difluorobenzene is a commonly used raw material in organic synthesis. During use, several matters should be paid attention to.
First, safety protection is the key. This material is toxic and irritating to a certain extent, and contact with the human body can cause damage. When operating, be sure to wear appropriate protective equipment, such as protective gloves, goggles and gas masks, to avoid skin contact, eye contamination and inhalation of its vapor. In case of inadvertent contact, rinse with plenty of water immediately and seek medical treatment according to the specific situation.
Second, when storing, it should be placed in a cool, well-ventilated place, away from fire and heat sources. Because it is flammable, it can cause combustion and explosion in case of open flame, hot topic or. And should be stored separately from oxidants and alkalis, etc., and should not be mixed with storage to prevent dangerous chemical reactions.
Third, in the process of use, it is very important to precisely control the reaction conditions. The reaction of 1-chloro-2,5-difluorobenzene is sensitive to conditions such as temperature, pressure, reactant ratio and reaction time. The conditions are slightly deviated, or the reaction yield is reduced, or by-products are formed. Therefore, the reaction conditions need to be carefully adjusted in strict accordance with the experimental procedures or production process requirements to ensure the smooth progress of the reaction.
Fourth, properly dispose of waste. After use, the remaining 1-chloro-2,5-difluorobenzene and related reaction products, by-products and other wastes should not be discarded at will. Relevant environmental regulations should be followed, and appropriate methods should be used for disposal to avoid pollution to the environment.
All of these are what should be paid attention to when using 1-chloro-2,5-difluorobenzene. Be sure not to be negligent and operate with caution to ensure personal safety, smooth production and the environment.
First, safety protection is the key. This material is toxic and irritating to a certain extent, and contact with the human body can cause damage. When operating, be sure to wear appropriate protective equipment, such as protective gloves, goggles and gas masks, to avoid skin contact, eye contamination and inhalation of its vapor. In case of inadvertent contact, rinse with plenty of water immediately and seek medical treatment according to the specific situation.
Second, when storing, it should be placed in a cool, well-ventilated place, away from fire and heat sources. Because it is flammable, it can cause combustion and explosion in case of open flame, hot topic or. And should be stored separately from oxidants and alkalis, etc., and should not be mixed with storage to prevent dangerous chemical reactions.
Third, in the process of use, it is very important to precisely control the reaction conditions. The reaction of 1-chloro-2,5-difluorobenzene is sensitive to conditions such as temperature, pressure, reactant ratio and reaction time. The conditions are slightly deviated, or the reaction yield is reduced, or by-products are formed. Therefore, the reaction conditions need to be carefully adjusted in strict accordance with the experimental procedures or production process requirements to ensure the smooth progress of the reaction.
Fourth, properly dispose of waste. After use, the remaining 1-chloro-2,5-difluorobenzene and related reaction products, by-products and other wastes should not be discarded at will. Relevant environmental regulations should be followed, and appropriate methods should be used for disposal to avoid pollution to the environment.
All of these are what should be paid attention to when using 1-chloro-2,5-difluorobenzene. Be sure not to be negligent and operate with caution to ensure personal safety, smooth production and the environment.
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