Linshang Chemical
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1-Chloro-2,6-Dibromobenzene
Linshang Chemical
|
HS Code |
709761 |
| Chemical Formula | C6H3Br2Cl |
| Molecular Weight | 271.35 |
| Appearance | Solid (usually white to off - white) |
| Boiling Point | Around 258 - 260 °C |
| Melting Point | 38 - 40 °C |
| Density | 1.97 g/cm³ (approximate) |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Odor | Typical halogen - containing aromatic odor |
As an accredited 1-Chloro-2,6-Dibromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 2,6 - dibromobenzene in 500g sealed bottles for chemical packaging. |
| Storage | 1 - Chloro - 2,6 - dibromobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive substances. Avoid storing in areas prone to physical damage to prevent container breakage. |
| Shipping | 1 - Chloro - 2,6 - dibromobenzene should be shipped in tightly sealed, corrosion - resistant containers. It must be labeled as a hazardous chemical. Transport should follow strict regulations to prevent spills and ensure safety during transit. |
Competitive 1-Chloro-2,6-Dibromobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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What are the chemical properties of 1-chloro-2,6-dibromobenzene?
1-Chloro-2,6-dibromobenzene is also an organic compound. Its molecule contains a chlorine atom and a dibromine atom attached to the benzene ring. This substance has the general chemical properties of halogenated aromatics.
As far as its nucleophilic substitution reaction is concerned, the halogen atom can be replaced by a nucleophilic reagent. Both capped chlorine and bromine are electron-absorbing groups, which cause the electron cloud density of the benzene ring to decrease, but the activity of different halogen atoms is different. Usually, bromine atoms are more likely to leave than chlorine atoms. Under appropriate nucleophilic reagents and reaction conditions, bromine atoms can be replaced by nucleophilic reagents first. In case of hydroxyl negative ions (OH), they can be replaced by nucleophilic substitutes to
It can also participate in the electrophilic substitution reaction. Although the halogen atom is a blunt group, the halogen atom has a lone pair electron and can be conjugated with the benzene ring, so the electron cloud density of the benzene ring is relatively high, and the electrophilic reagent is easy to attack the ortho and para-position. However, due to the steric hindrance, in 1-chloro-2,6-dibromobenzene, the 2,6 position has been occupied by bromine, and the electrophilic substitution mainly occurs in the ortho and para-position of the chlorine atom, that is, the 4 position.
In addition, 1-chloro-2,6-dibromobenzene can participate in coupling reactions in the presence of metal catalysts, such as cross-coupling with metal-containing organic reagents to form carbon-carbon bonds, thereby deriving a variety of organic compounds, which have important uses in the field of organic synthesis.
As far as its nucleophilic substitution reaction is concerned, the halogen atom can be replaced by a nucleophilic reagent. Both capped chlorine and bromine are electron-absorbing groups, which cause the electron cloud density of the benzene ring to decrease, but the activity of different halogen atoms is different. Usually, bromine atoms are more likely to leave than chlorine atoms. Under appropriate nucleophilic reagents and reaction conditions, bromine atoms can be replaced by nucleophilic reagents first. In case of hydroxyl negative ions (OH), they can be replaced by nucleophilic substitutes to
It can also participate in the electrophilic substitution reaction. Although the halogen atom is a blunt group, the halogen atom has a lone pair electron and can be conjugated with the benzene ring, so the electron cloud density of the benzene ring is relatively high, and the electrophilic reagent is easy to attack the ortho and para-position. However, due to the steric hindrance, in 1-chloro-2,6-dibromobenzene, the 2,6 position has been occupied by bromine, and the electrophilic substitution mainly occurs in the ortho and para-position of the chlorine atom, that is, the 4 position.
In addition, 1-chloro-2,6-dibromobenzene can participate in coupling reactions in the presence of metal catalysts, such as cross-coupling with metal-containing organic reagents to form carbon-carbon bonds, thereby deriving a variety of organic compounds, which have important uses in the field of organic synthesis.
What are the physical properties of 1-chloro-2,6-dibromobenzene?
1 - chloro - 2,6 - dibromobenzene is an organic compound, and its physical properties are quite unique. Let me explain in detail.
This substance is mostly solid at room temperature, due to its strong intermolecular forces. Looking at its melting and boiling point, the melting point is relatively high. Due to the presence of chlorine and bromine atoms in the molecule, the intermolecular van der Waals force is increased, which requires more energy to overcome the intermolecular attractive force and turn the solid state into a liquid state. Therefore, the melting point is increased. Similarly, the boiling point is not low. To change it from a liquid state to a gas state, sufficient energy needs to be supplied to break the intermolecular forces.
Its density is greater than that of water. If it is placed in water, it will sink to the bottom of the water. This is because chlorine and bromine atoms are relatively heavy relative to atoms, which increases the molecular weight. Under the same volume, the larger the mass, the greater the density.
In terms of solubility, 1-chloro-2,6-dibromobenzene is insoluble in water. Because it is a non-polar or weakly polar molecule, while water is a polar molecule, according to the principle of "similar miscibility", the polarities are different, and the interaction between the two is weak, so it is difficult to dissolve. However, in organic solvents, such as benzene, carbon tetrachloride and other non-polar or weakly polar organic solvents, the solubility is quite good, and it is easy to mix with each other due to the similar intermolecular forces.
In addition, 1-chloro-2,6-dibromobenzene has some volatility, but because of its large intermolecular force, the volatility is weaker than some small molecule organic compounds. In the air, it can evaporate slowly and emit a special odor.
The above are the main physical properties of 1-chloro-2,6-dibromobenzene.
This substance is mostly solid at room temperature, due to its strong intermolecular forces. Looking at its melting and boiling point, the melting point is relatively high. Due to the presence of chlorine and bromine atoms in the molecule, the intermolecular van der Waals force is increased, which requires more energy to overcome the intermolecular attractive force and turn the solid state into a liquid state. Therefore, the melting point is increased. Similarly, the boiling point is not low. To change it from a liquid state to a gas state, sufficient energy needs to be supplied to break the intermolecular forces.
Its density is greater than that of water. If it is placed in water, it will sink to the bottom of the water. This is because chlorine and bromine atoms are relatively heavy relative to atoms, which increases the molecular weight. Under the same volume, the larger the mass, the greater the density.
In terms of solubility, 1-chloro-2,6-dibromobenzene is insoluble in water. Because it is a non-polar or weakly polar molecule, while water is a polar molecule, according to the principle of "similar miscibility", the polarities are different, and the interaction between the two is weak, so it is difficult to dissolve. However, in organic solvents, such as benzene, carbon tetrachloride and other non-polar or weakly polar organic solvents, the solubility is quite good, and it is easy to mix with each other due to the similar intermolecular forces.
In addition, 1-chloro-2,6-dibromobenzene has some volatility, but because of its large intermolecular force, the volatility is weaker than some small molecule organic compounds. In the air, it can evaporate slowly and emit a special odor.
The above are the main physical properties of 1-chloro-2,6-dibromobenzene.
What are the main uses of 1-chloro-2,6-dibromobenzene?
1-chloro-2,6-dibromobenzene, Chinese name 1-chloro-2,6-dibromobenzene, is an organic compound. Its main uses are quite extensive, and it is often used as a key intermediate in the field of organic synthesis.
The chlorine atom and bromine atom in the molecule of this compound are highly active, and it is easy to participate in many chemical reactions. For example, nucleophilic substitution reactions, which can react with various nucleophilic reagents by virtue of the characteristics of halogen atoms, thereby forming new carbon-heteroatomic bonds, thereby synthesizing organic compounds with more complex structures. In the field of medicinal chemistry, using this as a starting material, drug molecules with specific biological activities can be prepared through multi-step reactions.
Furthermore, in the field of materials science, it also has important uses. By functionalizing it, polymer materials with special properties can be synthesized. If it is introduced into the main chain or side chain of the polymer, the material is endowed with good thermal stability, chemical stability and optical properties.
At the same time, 1-chloro-2,6-dibromobenzene also plays an important role in the preparation of fine chemical products. Fine chemicals such as synthesizing special dyes and fragrances, with their unique structures, give products unique properties and qualities. In conclusion, the structure and reactivity of 1-chloro-2,6-dibromobenzene play an indispensable role in many fields.
The chlorine atom and bromine atom in the molecule of this compound are highly active, and it is easy to participate in many chemical reactions. For example, nucleophilic substitution reactions, which can react with various nucleophilic reagents by virtue of the characteristics of halogen atoms, thereby forming new carbon-heteroatomic bonds, thereby synthesizing organic compounds with more complex structures. In the field of medicinal chemistry, using this as a starting material, drug molecules with specific biological activities can be prepared through multi-step reactions.
Furthermore, in the field of materials science, it also has important uses. By functionalizing it, polymer materials with special properties can be synthesized. If it is introduced into the main chain or side chain of the polymer, the material is endowed with good thermal stability, chemical stability and optical properties.
At the same time, 1-chloro-2,6-dibromobenzene also plays an important role in the preparation of fine chemical products. Fine chemicals such as synthesizing special dyes and fragrances, with their unique structures, give products unique properties and qualities. In conclusion, the structure and reactivity of 1-chloro-2,6-dibromobenzene play an indispensable role in many fields.
What are the synthesis methods of 1-chloro-2,6-dibromobenzene?
For 1-chloro-2,6-dibromobenzene, there are various ways to synthesize it. One can start with benzene, first by bromination, so that benzene and bromine can be brominated in an appropriate catalyst, such as iron filings or iron tribromide, to obtain bromobenzene. Then bromine at a specific position of bromobenzene, so that bromine atoms are introduced into the 2,6 position. This step requires selecting specific reaction conditions and catalysts to achieve the purpose of precise positioning. After obtaining 2,6-dibromobenzene, chlorination is used to replace the hydrogen atom at a specific position on the benzene ring with a chlorine atom to obtain 1-chloro-2,6-dibromobenzene. When chlorinating, the reaction conditions, the proportion of reactants and other factors need to be considered to ensure the selectivity and yield of the reaction.
There are other methods, which can start from specific phenolic compounds. First, the phenolic hydroxyl group is protected by an appropriate protective group to prevent it from being affected in the subsequent reaction. Then, the bromination and chlorination reactions are carried out in sequence. The reaction conditions are similar to the above, but due to the particularity of the phenolic compound structure, the selectivity of the reaction may be different. After the reaction is completed, the protective group is removed, and 1-chloro-2,6-dibromobenzene can also be obtained.
Furthermore, the cross-coupling reaction of aryl halides can be used. Bromine-containing aromatic halides are prepared first, and then cross-coupled with chlorine-containing reagents under the action of appropriate metal catalysts, such as palladium catalysts, to synthesize the target product. This approach requires careful selection of reaction substrates, catalysts and ligands to optimize reaction conditions, improve reaction efficiency and selectivity.
There are various methods for synthesizing 1-chloro-2,6-dibromobenzene, and each method has its own advantages and disadvantages. Experimenters need to choose carefully according to actual needs and conditions.
There are other methods, which can start from specific phenolic compounds. First, the phenolic hydroxyl group is protected by an appropriate protective group to prevent it from being affected in the subsequent reaction. Then, the bromination and chlorination reactions are carried out in sequence. The reaction conditions are similar to the above, but due to the particularity of the phenolic compound structure, the selectivity of the reaction may be different. After the reaction is completed, the protective group is removed, and 1-chloro-2,6-dibromobenzene can also be obtained.
Furthermore, the cross-coupling reaction of aryl halides can be used. Bromine-containing aromatic halides are prepared first, and then cross-coupled with chlorine-containing reagents under the action of appropriate metal catalysts, such as palladium catalysts, to synthesize the target product. This approach requires careful selection of reaction substrates, catalysts and ligands to optimize reaction conditions, improve reaction efficiency and selectivity.
There are various methods for synthesizing 1-chloro-2,6-dibromobenzene, and each method has its own advantages and disadvantages. Experimenters need to choose carefully according to actual needs and conditions.
What are the precautions for 1-chloro-2,6-dibromobenzene during storage and transportation?
1-Chloro-2,6-dibromobenzene is an organic compound. When storing and transporting, many matters need to be taken into account.
First storage, this compound should be placed in a cool, dry and well-ventilated place. Cover it or be sensitive to heat, moisture, warm and humid environment, easy to cause deterioration and damage its chemical properties. The warehouse temperature should be controlled within an appropriate range, not too high to prevent dangerous chemical reactions. And it must be kept away from fire and heat sources. Open flames and hot topics can cause combustion or explosion, endangering safety.
Furthermore, it should be stored separately from oxidants and alkalis, and must not be mixed. Due to its active chemical properties, it encounters with oxidants or has a violent oxidation reaction; contact with alkalis may also cause chemical reactions, cause material deterioration, and even cause safety accidents.
As for transportation, it is necessary to ensure that the container is complete and sealed. If the container leaks, 1-chloro-2,6-dibromobenzene escapes, which not only pollutes the environment, but also poses a threat to the health of transportation personnel. During transportation, the speed should not be too fast, and do not brake abruptly to prevent damage to the container due to vibration and collision.
Transportation vehicles must also meet relevant safety standards and be equipped with corresponding fire equipment and leakage emergency treatment equipment. In the event of a leak, it can be disposed of in time to reduce the damage hazard. Transport personnel should also be professionally trained to be familiar with the properties and emergency treatment methods of 1-chloro-2,6-dibromobenzene, and be able to respond properly in case of emergencies.
All of these are things that should be paid attention to when storing and transporting 1-chloro-2,6-dibromobenzene, which are related to safety and material quality and should not be ignored.
First storage, this compound should be placed in a cool, dry and well-ventilated place. Cover it or be sensitive to heat, moisture, warm and humid environment, easy to cause deterioration and damage its chemical properties. The warehouse temperature should be controlled within an appropriate range, not too high to prevent dangerous chemical reactions. And it must be kept away from fire and heat sources. Open flames and hot topics can cause combustion or explosion, endangering safety.
Furthermore, it should be stored separately from oxidants and alkalis, and must not be mixed. Due to its active chemical properties, it encounters with oxidants or has a violent oxidation reaction; contact with alkalis may also cause chemical reactions, cause material deterioration, and even cause safety accidents.
As for transportation, it is necessary to ensure that the container is complete and sealed. If the container leaks, 1-chloro-2,6-dibromobenzene escapes, which not only pollutes the environment, but also poses a threat to the health of transportation personnel. During transportation, the speed should not be too fast, and do not brake abruptly to prevent damage to the container due to vibration and collision.
Transportation vehicles must also meet relevant safety standards and be equipped with corresponding fire equipment and leakage emergency treatment equipment. In the event of a leak, it can be disposed of in time to reduce the damage hazard. Transport personnel should also be professionally trained to be familiar with the properties and emergency treatment methods of 1-chloro-2,6-dibromobenzene, and be able to respond properly in case of emergencies.
All of these are things that should be paid attention to when storing and transporting 1-chloro-2,6-dibromobenzene, which are related to safety and material quality and should not be ignored.
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