Linshang Chemical
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1-Chloro-2,6-Difluoro-3-Nitrobenzene
Linshang Chemical
|
HS Code |
612486 |
| Chemical Formula | C6H2ClF2NO2 |
| Molar Mass | 193.535 g/mol |
| Appearance | Solid (presumed, common for aromatic nitro - halides) |
| Physical State At Room Temperature | Solid |
| Melting Point | Data needed |
| Boiling Point | Data needed |
| Density | Data needed |
| Solubility In Water | Low (due to non - polar aromatic and hydrophobic halogen and nitro groups) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Flash Point | Data needed |
| Vapor Pressure | Low (due to solid state and relatively high molecular weight) |
| Stability | Stable under normal conditions, but may react with strong reducing agents, bases, etc. |
As an accredited 1-Chloro-2,6-Difluoro-3-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1 - chloro - 2,6 - difluoro - 3 - nitrobenzene packaged in airtight glass bottles. |
| Storage | 1 - Chloro - 2,6 - difluoro - 3 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from sources of heat and ignition. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store separately from oxidizing agents, reducing agents, and other incompatible substances to prevent chemical reactions. Label the storage clearly for easy identification. |
| Shipping | 1 - Chloro - 2,6 - difluoro - 3 - nitrobenzene is a chemical. It should be shipped in accordance with hazardous material regulations. Use appropriate packaging to prevent leakage, label clearly, and ensure proper handling during transit. |
Competitive 1-Chloro-2,6-Difluoro-3-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
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1-Chloro-2, what are the physical properties of 6-difluoro-3-nitrobenzene?
1-Chloro-2,6-difluoro-3-nitrobenzene, this is an organic compound with unique physical properties, which is very important.
Looking at its appearance, under room temperature and pressure, it is often a light yellow to light brown liquid, with unique color and luster, which is easy to distinguish in many chemical reaction systems. It has a certain degree of volatility and can slowly emit an odor in the air, but the smell is not strong and pungent, but it is also clearly recognizable.
When talking about the melting point, it is between -10 ° C and -5 ° C. This temperature range makes it liquid at room temperature. This characteristic is convenient for the transfer and mixing of materials in chemical operations and related reactions. The boiling point is between 200 ° C and 210 ° C. A relatively high boiling point indicates that it will vaporize in a large amount in a higher temperature environment, providing key parameters for operations such as distillation separation.
Furthermore, the density is about 1.6 g/cm ³, which is relatively dense compared to common water. In liquid-liquid separation systems, stratified separation operations can be carried out according to this characteristic. Its solubility is also worthy of attention. It is slightly soluble in water, but it can be better dissolved in organic solvents such as dichloromethane, chloroform, and toluene. This solubility characteristic provides a guide for selecting the appropriate reaction medium in organic synthesis reactions.
The physical properties of 1-chloro-2,6-difluoro-3-nitrobenzene are of great significance in the fields of chemical production and organic synthesis, and lay the foundation for the smooth development of many operations and reactions.
Looking at its appearance, under room temperature and pressure, it is often a light yellow to light brown liquid, with unique color and luster, which is easy to distinguish in many chemical reaction systems. It has a certain degree of volatility and can slowly emit an odor in the air, but the smell is not strong and pungent, but it is also clearly recognizable.
When talking about the melting point, it is between -10 ° C and -5 ° C. This temperature range makes it liquid at room temperature. This characteristic is convenient for the transfer and mixing of materials in chemical operations and related reactions. The boiling point is between 200 ° C and 210 ° C. A relatively high boiling point indicates that it will vaporize in a large amount in a higher temperature environment, providing key parameters for operations such as distillation separation.
Furthermore, the density is about 1.6 g/cm ³, which is relatively dense compared to common water. In liquid-liquid separation systems, stratified separation operations can be carried out according to this characteristic. Its solubility is also worthy of attention. It is slightly soluble in water, but it can be better dissolved in organic solvents such as dichloromethane, chloroform, and toluene. This solubility characteristic provides a guide for selecting the appropriate reaction medium in organic synthesis reactions.
The physical properties of 1-chloro-2,6-difluoro-3-nitrobenzene are of great significance in the fields of chemical production and organic synthesis, and lay the foundation for the smooth development of many operations and reactions.
What are the chemical properties of 1-chloro-2, 6-difluoro-3-nitrobenzene?
1-Chloro-2,6-difluoro-3-nitrobenzene, this is an organic compound, its chemical properties are particularly important, and it is related to the process of many chemical synthesis reactions.
First describes its halogen atom properties. The chlorine atom in this compound has nucleophilic substitution reaction activity. Due to the high electronegativity of the chlorine atom, the carbon-chlorine bond connected to the benzene ring is polar, and the carbon is partially positively charged, which is easy to be attacked by nucleophilic reagents. When encountering nucleophilic reagents such as hydroxyl anion (OH) and amino anion (NH ²), chlorine atoms can be replaced to form derivatives such as 1-hydroxy-2,6-difluoro-3-nitrobenzene or 1-amino-2,6-difluoro-3-nitrobenzene. This reaction is a key step in organic synthesis to construct new compound structures.
Furthermore, fluorine atoms also have unique properties. Fluorine is extremely electronegative. Although fluorine atoms at positions 2,6 are not as easy to participate in nucleophilic substitution reactions as chlorine atoms, they have a significant impact on the electron cloud density distribution of benzene rings. Due to its strong electron-absorbing induction effect, the electron cloud density of the benzene ring decreases, especially at the adjacent and para-sites. This results in a decrease in the activity of the electrophilic substitution of the benzene ring, and the localization effect also changes. For example, subsequent electrophilic substitution reactions tend to occur more in the meta-site.
As for the nitro group, it is a strong electron-absorbing group. It not only greatly reduces the electron cloud density of the benzene ring, but also makes it more difficult for the electrophilic substitution of the benzene ring to occur, and under certain conditions, a reduction reaction can occur. In reduction systems such as metals and acids (such as iron and hydrochloric acid), nitro can be gradually reduced to amino groups to form 1-chloro-2,6-difluoro-3-aminobenzene. This product is an important intermediate in organic synthesis and is widely used in drug synthesis, dye preparation and other fields.
In addition, the chemical properties of the compound are also affected by the conjugation system of benzene rings. The conjugate structure of the benzene ring imparts a certain stability to the molecule, but the interaction of each substituent changes the stability. The superposition of the electronic effects between the substituents determines the overall reactivity and selectivity of the compound. In the reaction design and route planning of organic synthetic chemistry, these factors need to be carefully considered in order to achieve the efficient synthesis of the target compound.
First describes its halogen atom properties. The chlorine atom in this compound has nucleophilic substitution reaction activity. Due to the high electronegativity of the chlorine atom, the carbon-chlorine bond connected to the benzene ring is polar, and the carbon is partially positively charged, which is easy to be attacked by nucleophilic reagents. When encountering nucleophilic reagents such as hydroxyl anion (OH) and amino anion (NH ²), chlorine atoms can be replaced to form derivatives such as 1-hydroxy-2,6-difluoro-3-nitrobenzene or 1-amino-2,6-difluoro-3-nitrobenzene. This reaction is a key step in organic synthesis to construct new compound structures.
Furthermore, fluorine atoms also have unique properties. Fluorine is extremely electronegative. Although fluorine atoms at positions 2,6 are not as easy to participate in nucleophilic substitution reactions as chlorine atoms, they have a significant impact on the electron cloud density distribution of benzene rings. Due to its strong electron-absorbing induction effect, the electron cloud density of the benzene ring decreases, especially at the adjacent and para-sites. This results in a decrease in the activity of the electrophilic substitution of the benzene ring, and the localization effect also changes. For example, subsequent electrophilic substitution reactions tend to occur more in the meta-site.
As for the nitro group, it is a strong electron-absorbing group. It not only greatly reduces the electron cloud density of the benzene ring, but also makes it more difficult for the electrophilic substitution of the benzene ring to occur, and under certain conditions, a reduction reaction can occur. In reduction systems such as metals and acids (such as iron and hydrochloric acid), nitro can be gradually reduced to amino groups to form 1-chloro-2,6-difluoro-3-aminobenzene. This product is an important intermediate in organic synthesis and is widely used in drug synthesis, dye preparation and other fields.
In addition, the chemical properties of the compound are also affected by the conjugation system of benzene rings. The conjugate structure of the benzene ring imparts a certain stability to the molecule, but the interaction of each substituent changes the stability. The superposition of the electronic effects between the substituents determines the overall reactivity and selectivity of the compound. In the reaction design and route planning of organic synthetic chemistry, these factors need to be carefully considered in order to achieve the efficient synthesis of the target compound.
What are the main uses of 1-chloro-2, 6-difluoro-3-nitrobenzene?
1-Chloro-2,6-difluoro-3-nitrobenzene is an important intermediate in organic synthesis. Its main uses cover the following ends.
First introduced in the field of pharmaceutical synthesis, this compound is often a key starting material. Due to the unique combination of chlorine, fluorine and nitro groups in its structure, it is endowed with specific reactivity and chemical properties, which can be converted into biologically active structural fragments through many chemical reactions, such as nucleophilic substitution, reduction, etc. On this basis, chemists can construct complex drug molecular structures for the development of new drugs, the treatment of various diseases, such as the creation of anti-infection, anti-tumor drugs, etc., or rely on this as a starting material for synthesis.
Furthermore, it is also of great significance in the field of pesticides. In agricultural production, pest control is crucial, and 1-chloro-2,6-difluoro-3-nitrobenzene can be converted into highly effective pesticide active ingredients through a series of chemical modifications. Its fluorine-containing structure can often enhance the stability and biological activity of compounds, show good inhibition and killing effects on pests and pathogens, help improve crop yield and quality, and because of its specific chemical structure, it may reduce the negative impact on the environment, which is in line with the development trend of modern green pesticides.
In addition, in the field of materials science, this compound can participate in the synthesis of special functional materials. Through its reaction with other organic or inorganic reagents, polymer materials and optical materials with special properties can be prepared. For example, in the synthesis of some photochromic materials or electron transport materials, 1-chloro-2,6-difluoro-3-nitrobenzene or as an important structural unit is introduced to endow the material with unique optical and electrical properties, meeting the needs of special functional materials in fields such as display technology and electronic devices.
To sum up, the unique chemical structure of 1-chloro-2,6-difluoro-3-nitrophenyl has indispensable uses in many fields such as medicine, pesticides and materials science, and is indeed a key compound in the field of organic synthetic chemistry.
First introduced in the field of pharmaceutical synthesis, this compound is often a key starting material. Due to the unique combination of chlorine, fluorine and nitro groups in its structure, it is endowed with specific reactivity and chemical properties, which can be converted into biologically active structural fragments through many chemical reactions, such as nucleophilic substitution, reduction, etc. On this basis, chemists can construct complex drug molecular structures for the development of new drugs, the treatment of various diseases, such as the creation of anti-infection, anti-tumor drugs, etc., or rely on this as a starting material for synthesis.
Furthermore, it is also of great significance in the field of pesticides. In agricultural production, pest control is crucial, and 1-chloro-2,6-difluoro-3-nitrobenzene can be converted into highly effective pesticide active ingredients through a series of chemical modifications. Its fluorine-containing structure can often enhance the stability and biological activity of compounds, show good inhibition and killing effects on pests and pathogens, help improve crop yield and quality, and because of its specific chemical structure, it may reduce the negative impact on the environment, which is in line with the development trend of modern green pesticides.
In addition, in the field of materials science, this compound can participate in the synthesis of special functional materials. Through its reaction with other organic or inorganic reagents, polymer materials and optical materials with special properties can be prepared. For example, in the synthesis of some photochromic materials or electron transport materials, 1-chloro-2,6-difluoro-3-nitrobenzene or as an important structural unit is introduced to endow the material with unique optical and electrical properties, meeting the needs of special functional materials in fields such as display technology and electronic devices.
To sum up, the unique chemical structure of 1-chloro-2,6-difluoro-3-nitrophenyl has indispensable uses in many fields such as medicine, pesticides and materials science, and is indeed a key compound in the field of organic synthetic chemistry.
What are the synthesis methods of 1-chloro-2, 6-difluoro-3-nitrobenzene?
The synthesis method of 1-chloro-2,6-difluoro-3-nitrobenzene is often obtained in several ways.
First, it can be started from a suitable aromatic compound. With benzene as the group, the nitro group is first introduced, because the nitro group is the meta-localization group, by nitrification reaction, such as a mixed acid of concentrated nitric acid and concentrated sulfuric acid, at a suitable temperature, the benzene is nitrified to obtain nitrobenzene. After halogenation, suitable halogenating reagents, such as chlorine and fluorine, can be selected under specific reaction conditions, such as the presence of catalysts, controlled temperature and pressure, etc., to introduce chlorine atoms and fluorine atoms at corresponding positions on the benzene ring, so as to obtain the target product. In this way, the reaction conditions need to be finely regulated to achieve the ideal selectivity and yield.
Second, halogenated aromatics can also be used. Select an appropriate halogenated benzene, first introduce fluorine atoms, use nucleophilic substitution reaction, use fluorine-containing reagents, such as potassium fluoride, etc., in the presence of a phase transfer catalyst, heat the reaction in a suitable solvent to achieve fluorine atom substitution of specific halogen atoms. Subsequently, nitro groups and other halogen atoms are introduced. The introduction of nitro groups can be nitrified with mixed acids as before, and the introduction of another halogen atom can be completed by selecting the corresponding halogenated reagents and conditions according to the specific halogen atom and reaction conditions.
Third, use metal catalytic coupling reaction strategy. Using aromatic hydrocarbon halides containing specific substituents as raw materials, under the action of metal catalysts such as palladium catalysts, the coupling reaction occurs with reagents containing fluorine, chlorine, nitro and other groups. This process requires careful selection of catalysts, ligands, reaction solvents and bases to promote the efficient reaction and obtain the target 1-chloro-2,6-difluoro-3-nitrobenzene. Each method has its own advantages and disadvantages, and the implementation needs to be based on comprehensive trade-offs such as raw material availability, cost, yield and purity requirements.
First, it can be started from a suitable aromatic compound. With benzene as the group, the nitro group is first introduced, because the nitro group is the meta-localization group, by nitrification reaction, such as a mixed acid of concentrated nitric acid and concentrated sulfuric acid, at a suitable temperature, the benzene is nitrified to obtain nitrobenzene. After halogenation, suitable halogenating reagents, such as chlorine and fluorine, can be selected under specific reaction conditions, such as the presence of catalysts, controlled temperature and pressure, etc., to introduce chlorine atoms and fluorine atoms at corresponding positions on the benzene ring, so as to obtain the target product. In this way, the reaction conditions need to be finely regulated to achieve the ideal selectivity and yield.
Second, halogenated aromatics can also be used. Select an appropriate halogenated benzene, first introduce fluorine atoms, use nucleophilic substitution reaction, use fluorine-containing reagents, such as potassium fluoride, etc., in the presence of a phase transfer catalyst, heat the reaction in a suitable solvent to achieve fluorine atom substitution of specific halogen atoms. Subsequently, nitro groups and other halogen atoms are introduced. The introduction of nitro groups can be nitrified with mixed acids as before, and the introduction of another halogen atom can be completed by selecting the corresponding halogenated reagents and conditions according to the specific halogen atom and reaction conditions.
Third, use metal catalytic coupling reaction strategy. Using aromatic hydrocarbon halides containing specific substituents as raw materials, under the action of metal catalysts such as palladium catalysts, the coupling reaction occurs with reagents containing fluorine, chlorine, nitro and other groups. This process requires careful selection of catalysts, ligands, reaction solvents and bases to promote the efficient reaction and obtain the target 1-chloro-2,6-difluoro-3-nitrobenzene. Each method has its own advantages and disadvantages, and the implementation needs to be based on comprehensive trade-offs such as raw material availability, cost, yield and purity requirements.
1-chloro-2, 6-difluoro-3-nitrobenzene What are the precautions during storage and transportation?
1-Chloro-2,6-difluoro-3-nitrobenzene is one of the organic compounds. During storage and transportation, many matters need to be paid attention to to to ensure its safety.
First, when storing, choose a cool, dry and well-ventilated place. This is because it has a certain chemical activity, high temperature and humid environment can easily promote chemical reactions, cause deterioration or cause danger. The warehouse temperature should be controlled within a suitable range, not too high, to prevent the performance of the compound from changing.
Second, the compound must be stored separately with oxidizing agents, reducing agents, alkalis and other substances. Due to its active chemical properties, contact with the above substances may cause severe chemical reactions, such as serious accidents such as combustion and explosion.
Third, the storage container must be well sealed. 1-Chloro-2,6-difluoro-3-nitrobenzene may be volatile and poorly sealed, which not only causes material loss, but also escapes steam or endangers the environment and human health. The container used should be resistant to the corrosion of the compound, and the material is suitable to prevent leakage due to damage to the container.
Fourth, during transportation, it is necessary to operate in strict accordance with relevant regulations. The means of transportation should be clean, dry and free of residual other chemicals to avoid impurities from mixing and triggering reactions. The goods are firmly fixed to avoid vibration and collision during transportation, resulting in package damage.
Fifth, whether it is storage or transportation, it needs to be supervised by professionals. They should be familiar with the characteristics of the compound and emergency treatment methods. In case of emergencies such as leakage, it can be handled quickly and correctly to minimize the harm.
In short, the storage and transportation of 1-chloro-2,6-difluoro-3-nitrobenzene should be treated with caution and operated in strict accordance with regulations to ensure safety.
First, when storing, choose a cool, dry and well-ventilated place. This is because it has a certain chemical activity, high temperature and humid environment can easily promote chemical reactions, cause deterioration or cause danger. The warehouse temperature should be controlled within a suitable range, not too high, to prevent the performance of the compound from changing.
Second, the compound must be stored separately with oxidizing agents, reducing agents, alkalis and other substances. Due to its active chemical properties, contact with the above substances may cause severe chemical reactions, such as serious accidents such as combustion and explosion.
Third, the storage container must be well sealed. 1-Chloro-2,6-difluoro-3-nitrobenzene may be volatile and poorly sealed, which not only causes material loss, but also escapes steam or endangers the environment and human health. The container used should be resistant to the corrosion of the compound, and the material is suitable to prevent leakage due to damage to the container.
Fourth, during transportation, it is necessary to operate in strict accordance with relevant regulations. The means of transportation should be clean, dry and free of residual other chemicals to avoid impurities from mixing and triggering reactions. The goods are firmly fixed to avoid vibration and collision during transportation, resulting in package damage.
Fifth, whether it is storage or transportation, it needs to be supervised by professionals. They should be familiar with the characteristics of the compound and emergency treatment methods. In case of emergencies such as leakage, it can be handled quickly and correctly to minimize the harm.
In short, the storage and transportation of 1-chloro-2,6-difluoro-3-nitrobenzene should be treated with caution and operated in strict accordance with regulations to ensure safety.
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