Linshang Chemical
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1-Chloro-2,6-Difluorobenzene
Linshang Chemical
|
HS Code |
126595 |
| Chemical Formula | C6H3ClF2 |
| Molar Mass | 148.54 g/mol |
| Appearance | Colorless to light - yellow liquid |
| Boiling Point | 137 - 138 °C |
| Density | 1.32 g/cm³ |
| Vapor Pressure | At a given temperature, specific value depends on temp conditions |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 35 °C |
| Odor | Characteristic aromatic odor |
| Refractive Index | Typically around 1.483 - 1.485 |
As an accredited 1-Chloro-2,6-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 2,6 - difluorobenzene in 5 - liter sealed canisters for chemical storage. |
| Storage | 1 - Chloro - 2,6 - difluorobenzene should be stored in a cool, well - ventilated area, away from heat sources and open flames as it is likely flammable. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances. Ensure the storage area has appropriate spill - containment measures in case of accidental release. |
| Shipping | 1 - Chloro - 2,6 - difluorobenzene is shipped in tightly sealed, corrosion - resistant containers. These are carefully packed to prevent leakage during transit, following strict hazardous chemical shipping regulations. |
Competitive 1-Chloro-2,6-Difluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 1-Chloro-2,6-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-2,6-difluorobenzene?
1-chloro-2,6-difluorobenzene, Chinese name 1-chloro-2,6-difluorobenzene, is an important organic halide in the field of organic synthesis. It has a wide range of uses and is used in many fields such as medicine, pesticides and materials science.
In the field of pharmaceutical synthesis, this compound is often used as a key intermediate. Due to the unique activity and space effect of chlorine and fluorine atoms in the molecular structure, it can participate in various chemical reactions and help to build a molecular skeleton with specific biological activities. For example, when developing new antibacterial drugs, 1-chloro-2,6-difluorobenzene can be combined with other nitrogen, oxygen or sulfur-containing organic fragments through substitution reactions, coupling reactions, etc., and through a series of structural modifications and optimizations, drug molecules with ideal antibacterial properties can be obtained.
In the field of pesticide creation, 1-chloro-2,6-difluorobenzene also plays an important role. The introduction of fluorine atoms can significantly improve the biological activity, stability and environmental adaptability of pesticides. Using it as a starting material, new pesticides, fungicides or herbicides can be synthesized through multi-step reactions. For example, by reacting with active groups containing phosphorus and nitrogen, pesticide varieties with high efficiency, low toxicity, and environmental friendliness can be constructed, providing strong support for agricultural pest control.
In the field of materials science, 1-chloro-2,6-difluorobenzene can be used to prepare high-performance organic polymer materials. By polymerizing with other monomers, fluorine atoms can be introduced into the main chain or side chain of the polymer, giving the material excellent properties such as low dielectric constant, high chemical stability, and good thermal stability. Such materials have great application potential in high-end fields such as electronics and aerospace, such as the manufacture of high-performance circuit boards, aviation composites, etc.
In summary, 1-chloro-2,6-difluorobenzene has shown important application value in the fields of medicine, pesticides and materials science due to its unique chemical structure, providing key basic raw materials and technical support for the development of related industries.
In the field of pharmaceutical synthesis, this compound is often used as a key intermediate. Due to the unique activity and space effect of chlorine and fluorine atoms in the molecular structure, it can participate in various chemical reactions and help to build a molecular skeleton with specific biological activities. For example, when developing new antibacterial drugs, 1-chloro-2,6-difluorobenzene can be combined with other nitrogen, oxygen or sulfur-containing organic fragments through substitution reactions, coupling reactions, etc., and through a series of structural modifications and optimizations, drug molecules with ideal antibacterial properties can be obtained.
In the field of pesticide creation, 1-chloro-2,6-difluorobenzene also plays an important role. The introduction of fluorine atoms can significantly improve the biological activity, stability and environmental adaptability of pesticides. Using it as a starting material, new pesticides, fungicides or herbicides can be synthesized through multi-step reactions. For example, by reacting with active groups containing phosphorus and nitrogen, pesticide varieties with high efficiency, low toxicity, and environmental friendliness can be constructed, providing strong support for agricultural pest control.
In the field of materials science, 1-chloro-2,6-difluorobenzene can be used to prepare high-performance organic polymer materials. By polymerizing with other monomers, fluorine atoms can be introduced into the main chain or side chain of the polymer, giving the material excellent properties such as low dielectric constant, high chemical stability, and good thermal stability. Such materials have great application potential in high-end fields such as electronics and aerospace, such as the manufacture of high-performance circuit boards, aviation composites, etc.
In summary, 1-chloro-2,6-difluorobenzene has shown important application value in the fields of medicine, pesticides and materials science due to its unique chemical structure, providing key basic raw materials and technical support for the development of related industries.
What are the physical properties of 1-chloro-2,6-difluorobenzene?
1-Chloro-2,6-difluorobenzene is one of the organic compounds. It has unique physical properties and is widely used in the chemical industry and other fields.
First of all, under room temperature, 1-chloro-2,6-difluorobenzene is often a colorless to light yellow transparent liquid. It is clear in appearance, its liquid flow is supple, and its luster is also unique. This state is convenient for many operations, such as dumping, transfer, etc.
When it comes to odor, it emits an irritating smell. Although it is not pungent and intolerable, it cannot be ignored. If people smell this smell for a long time, or cause discomfort, such as dizziness, nausea, etc., they should pay attention to ventilation when operating.
Besides, its boiling point is between 127 ° C and 128 ° C. This boiling point determines its state change when heated. At this temperature, 1-chloro-2,6-difluorobenzene will change from liquid to gaseous state, which can be used in distillation, fractionation and other separation and purification processes.
Its melting point is about -37 ° C. At low temperatures, this substance will solidify into a solid state. This property is crucial when storing and setting specific reaction conditions.
In terms of density, it is about 1.388g/cm ³, which is heavier than water. If mixed with water, it will sink to the bottom of the water. This property can be used for reference when operations such as liquid-liquid separation are involved.
In terms of solubility, 1-chloro-2,6-difluorobenzene is slightly soluble in water, but easily soluble in organic solvents such as ethanol, ether, acetone, etc. This solubility characteristic makes it well miscible with many organic reagents in organic synthesis, which is conducive to the reaction.
In addition, the vapor pressure of 1-chloro-2,6-difluorobenzene is also an important property. Its vapor pressure affects its concentration in the gas phase and is related to the volatilization rate. At a certain temperature, the vapor pressure is relatively stable, but when the temperature increases, the vapor pressure increases and the volatilization accelerates, which has a corresponding impact on the storage and use environment requirements.
These physical properties are of key guiding significance in the synthesis, storage, transportation and application of 1-chloro-2,6-difluorobenzene. Only by understanding its properties can it be used well and play its role in chemical production, scientific research and other fields.
First of all, under room temperature, 1-chloro-2,6-difluorobenzene is often a colorless to light yellow transparent liquid. It is clear in appearance, its liquid flow is supple, and its luster is also unique. This state is convenient for many operations, such as dumping, transfer, etc.
When it comes to odor, it emits an irritating smell. Although it is not pungent and intolerable, it cannot be ignored. If people smell this smell for a long time, or cause discomfort, such as dizziness, nausea, etc., they should pay attention to ventilation when operating.
Besides, its boiling point is between 127 ° C and 128 ° C. This boiling point determines its state change when heated. At this temperature, 1-chloro-2,6-difluorobenzene will change from liquid to gaseous state, which can be used in distillation, fractionation and other separation and purification processes.
Its melting point is about -37 ° C. At low temperatures, this substance will solidify into a solid state. This property is crucial when storing and setting specific reaction conditions.
In terms of density, it is about 1.388g/cm ³, which is heavier than water. If mixed with water, it will sink to the bottom of the water. This property can be used for reference when operations such as liquid-liquid separation are involved.
In terms of solubility, 1-chloro-2,6-difluorobenzene is slightly soluble in water, but easily soluble in organic solvents such as ethanol, ether, acetone, etc. This solubility characteristic makes it well miscible with many organic reagents in organic synthesis, which is conducive to the reaction.
In addition, the vapor pressure of 1-chloro-2,6-difluorobenzene is also an important property. Its vapor pressure affects its concentration in the gas phase and is related to the volatilization rate. At a certain temperature, the vapor pressure is relatively stable, but when the temperature increases, the vapor pressure increases and the volatilization accelerates, which has a corresponding impact on the storage and use environment requirements.
These physical properties are of key guiding significance in the synthesis, storage, transportation and application of 1-chloro-2,6-difluorobenzene. Only by understanding its properties can it be used well and play its role in chemical production, scientific research and other fields.
Is 1-chloro-2,6-difluorobenzene chemically stable?
1 - chloro - 2,6 - difluorobenzene is also an organic compound. The stability of its chemical properties is related to multi-terminal, and today we will discuss it.
First of all, its structure. In this compound molecule, the benzene ring is a conjugated system with certain stability. The chlorine atom and the difluorine atom are connected to the benzene ring. The chlorine atom and the fluorine atom are both electronegative and have a significant electron-sucking induction effect. However, the conjugated large π bond of the benzene ring also has a certain influence on the electronic effect of these substituents. The interaction of the three together determines the stability of the compound.
Under normal conditions, 1 - chloro - 2,6 - difluorobenzene is quite stable. The conjugated structure of the benzene ring makes it less prone to ring-opening reactions. And the carbon-halogen bond between the chlorine and fluorine atoms and the benzene ring has a certain strength. The bond energy of the carbon-chlorine bond and the carbon-fluorine bond is sufficient to resist the attack of reagents under generally mild conditions.
When encountering strong nucleophilic reagents, the situation changes. Chlorine atoms are slightly smaller than fluorine atoms due to their electronegativity and larger atomic radius. Therefore, carbon-chlorine bonds are more susceptible to attack by nucleophilic reagents than carbon-fluorine bonds, and nucleophilic substitution reactions can occur. This is one example of stability being impacted.
In case of special conditions such as high temperature, light, or strong oxidizing agents or strong reducing agents, its stability may also be damaged. High temperature and light can cause molecules to obtain enough energy to excite electrons and cause changes in chemical bond activity. Strong oxidants or oxidizable benzene rings, or make substituents oxidize; strong reducing agents may hydrogenate benzene rings, or cause carbon-halogen bonds to be reduced and broken.
In general, 1-chloro-2,6-difluorobenzene is chemically stable under normal environmental and mild reaction conditions. However, under specific harsh conditions or the action of special reagents, its stability will be affected and corresponding chemical reactions will occur.
First of all, its structure. In this compound molecule, the benzene ring is a conjugated system with certain stability. The chlorine atom and the difluorine atom are connected to the benzene ring. The chlorine atom and the fluorine atom are both electronegative and have a significant electron-sucking induction effect. However, the conjugated large π bond of the benzene ring also has a certain influence on the electronic effect of these substituents. The interaction of the three together determines the stability of the compound.
Under normal conditions, 1 - chloro - 2,6 - difluorobenzene is quite stable. The conjugated structure of the benzene ring makes it less prone to ring-opening reactions. And the carbon-halogen bond between the chlorine and fluorine atoms and the benzene ring has a certain strength. The bond energy of the carbon-chlorine bond and the carbon-fluorine bond is sufficient to resist the attack of reagents under generally mild conditions.
When encountering strong nucleophilic reagents, the situation changes. Chlorine atoms are slightly smaller than fluorine atoms due to their electronegativity and larger atomic radius. Therefore, carbon-chlorine bonds are more susceptible to attack by nucleophilic reagents than carbon-fluorine bonds, and nucleophilic substitution reactions can occur. This is one example of stability being impacted.
In case of special conditions such as high temperature, light, or strong oxidizing agents or strong reducing agents, its stability may also be damaged. High temperature and light can cause molecules to obtain enough energy to excite electrons and cause changes in chemical bond activity. Strong oxidants or oxidizable benzene rings, or make substituents oxidize; strong reducing agents may hydrogenate benzene rings, or cause carbon-halogen bonds to be reduced and broken.
In general, 1-chloro-2,6-difluorobenzene is chemically stable under normal environmental and mild reaction conditions. However, under specific harsh conditions or the action of special reagents, its stability will be affected and corresponding chemical reactions will occur.
What are the production methods of 1-chloro-2,6-difluorobenzene?
1-Chloro-2,6-difluorobenzene is also an organic compound. The method of its preparation, as described in the past literature, is roughly numerous.
First, 2,6-difluoroaniline is used as the starting material, and it is obtained by diazotization and chlorination. In this process, shilling 2,6-difluoroaniline reacts with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. Then, the diazonium salt interacts with chlorinated reagents such as cuprous chloride, and the diazonium group is replaced by a chlorine atom through the Sandmeyer reaction, and then 1-chloro-2,6-difluorobenzene is obtained. The steps of this method are slightly complicated, but the raw material 2,6-difluoroaniline can be obtained, and the reaction conditions of each step are relatively clear, so it is quite commonly used in laboratory synthesis.
Second, starting from 2,6-difluorobenzoic acid. First, 2,6-difluorobenzoic acid is converted into the corresponding acid chloride, which can react with thionyl chloride and other reagents. Then, the acid chloride is reduced by Rosenmund to obtain 2,6-difluorobenzaldehyde. Then 2,6-difluorobenzaldehyde is reacted with chlorinated reagents such as sodium hypochlorite to introduce chlorine atoms, and then through suitable oxidation and decarboxylation steps, the target product 1-chloro-2,6-difluorobenzene can be obtained. This path involves a multi-step reaction, which requires fine control of the conditions of each step, so that the structure of the target molecule can be effectively constructed.
Third, fluorobenzene is prepared by selective halogenation reaction with fluorobenzene as raw material. Under specific catalyst and reaction conditions, such as selecting a suitable Lewis acid catalyst, controlling the reaction temperature, time and amount of halogenating reagent, etc., fluorobenzene is reacted with chlorine gas and fluorinated reagent successively, and chlorine atoms and fluorine atoms are selectively introduced at specific positions in the benzene ring to synthesize 1-chloro-2,6-difluorobenzene. The key to this method lies in the selection of catalysts and the precise regulation of reaction conditions to achieve ideal selectivity and yield.
All methods have advantages and disadvantages. In actual production or research, the choice should be based on factors such as the availability of raw materials, cost, and difficulty of reaction conditions.
First, 2,6-difluoroaniline is used as the starting material, and it is obtained by diazotization and chlorination. In this process, shilling 2,6-difluoroaniline reacts with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. Then, the diazonium salt interacts with chlorinated reagents such as cuprous chloride, and the diazonium group is replaced by a chlorine atom through the Sandmeyer reaction, and then 1-chloro-2,6-difluorobenzene is obtained. The steps of this method are slightly complicated, but the raw material 2,6-difluoroaniline can be obtained, and the reaction conditions of each step are relatively clear, so it is quite commonly used in laboratory synthesis.
Second, starting from 2,6-difluorobenzoic acid. First, 2,6-difluorobenzoic acid is converted into the corresponding acid chloride, which can react with thionyl chloride and other reagents. Then, the acid chloride is reduced by Rosenmund to obtain 2,6-difluorobenzaldehyde. Then 2,6-difluorobenzaldehyde is reacted with chlorinated reagents such as sodium hypochlorite to introduce chlorine atoms, and then through suitable oxidation and decarboxylation steps, the target product 1-chloro-2,6-difluorobenzene can be obtained. This path involves a multi-step reaction, which requires fine control of the conditions of each step, so that the structure of the target molecule can be effectively constructed.
Third, fluorobenzene is prepared by selective halogenation reaction with fluorobenzene as raw material. Under specific catalyst and reaction conditions, such as selecting a suitable Lewis acid catalyst, controlling the reaction temperature, time and amount of halogenating reagent, etc., fluorobenzene is reacted with chlorine gas and fluorinated reagent successively, and chlorine atoms and fluorine atoms are selectively introduced at specific positions in the benzene ring to synthesize 1-chloro-2,6-difluorobenzene. The key to this method lies in the selection of catalysts and the precise regulation of reaction conditions to achieve ideal selectivity and yield.
All methods have advantages and disadvantages. In actual production or research, the choice should be based on factors such as the availability of raw materials, cost, and difficulty of reaction conditions.
What should be paid attention to when storing and transporting 1-chloro-2,6-difluorobenzene?
1-Chloro-2,6-difluorobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
First word storage. This compound should be placed in a cool and well-ventilated warehouse. Because of its certain volatility and chemical activity, high temperature can easily cause its volatilization to intensify or cause chemical reactions, so it is necessary to avoid high temperature. The temperature of the warehouse should be controlled within a suitable range, usually not exceeding 30 ° C. And it should be kept away from fire and heat sources. Open flames and hot topics can cause danger, such as combustion or even explosion.
Furthermore, it should be stored separately from oxidants and alkalis, and should not be mixed. 1-Chloro-2,6-difluorobenzene meets the oxidizing agent, or causes a violent oxidation reaction; in contact with alkalis, chemical reactions may also occur, causing product deterioration or danger. The storage area should be equipped with suitable materials to contain leaks in case of leakage, which can be treated in time to avoid pollution expansion.
As for transportation, it is necessary to ensure that the packaging is complete and the loading is secure before transportation. The packaging should be able to resist the vibration, collision and friction of normal transportation, so as not to leak the product. The transportation process should be kept away from fire, heat sources, and sun exposure. Summer transportation should be selected when it is cool in the morning and evening to avoid high temperature periods. The means of transportation should be clean and dry, and there should be no residues that may react with the compound.
During transportation, drivers and escorts should pay close attention to the status of the goods and not leave the post without permission. Once any abnormalities are detected, such as damaged packaging or leakage, measures should be taken immediately, such as isolating the scene, evacuating the crowd, and reporting to the relevant departments. In this way, the storage and transportation of 1-chloro-2,6-difluorobenzene are guaranteed.
First word storage. This compound should be placed in a cool and well-ventilated warehouse. Because of its certain volatility and chemical activity, high temperature can easily cause its volatilization to intensify or cause chemical reactions, so it is necessary to avoid high temperature. The temperature of the warehouse should be controlled within a suitable range, usually not exceeding 30 ° C. And it should be kept away from fire and heat sources. Open flames and hot topics can cause danger, such as combustion or even explosion.
Furthermore, it should be stored separately from oxidants and alkalis, and should not be mixed. 1-Chloro-2,6-difluorobenzene meets the oxidizing agent, or causes a violent oxidation reaction; in contact with alkalis, chemical reactions may also occur, causing product deterioration or danger. The storage area should be equipped with suitable materials to contain leaks in case of leakage, which can be treated in time to avoid pollution expansion.
As for transportation, it is necessary to ensure that the packaging is complete and the loading is secure before transportation. The packaging should be able to resist the vibration, collision and friction of normal transportation, so as not to leak the product. The transportation process should be kept away from fire, heat sources, and sun exposure. Summer transportation should be selected when it is cool in the morning and evening to avoid high temperature periods. The means of transportation should be clean and dry, and there should be no residues that may react with the compound.
During transportation, drivers and escorts should pay close attention to the status of the goods and not leave the post without permission. Once any abnormalities are detected, such as damaged packaging or leakage, measures should be taken immediately, such as isolating the scene, evacuating the crowd, and reporting to the relevant departments. In this way, the storage and transportation of 1-chloro-2,6-difluorobenzene are guaranteed.
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