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1-Chloro-2-[Chloro(Difluoro)Methyl]Benzene
Linshang Chemical
|
HS Code |
746529 |
| Chemical Formula | C7H4Cl2F2 |
| Molar Mass | 195.009 g/mol |
| Appearance | Liquid (usually) |
| Boiling Point | Data needed |
| Melting Point | Data needed |
| Density | Data needed |
| Solubility In Water | Low solubility |
| Solubility In Organic Solvents | Soluble in many organic solvents |
| Vapor Pressure | Data needed |
| Flash Point | Data needed |
As an accredited 1-Chloro-2-[Chloro(Difluoro)Methyl]Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 2 - [chloro(difluoro)methyl]benzene in 500 - mL glass bottle packaging. |
| Storage | 1 - Chloro - 2 - [chloro(difluoro)methyl]benzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition points. It should be kept in a tightly - sealed container to prevent leakage. Since it is a chemical, store it separately from incompatible substances like oxidizing agents, reducing agents, and bases to avoid potential reactions. |
| Shipping | 1 - chloro - 2 - [chloro(difluoro)methyl]benzene is shipped in specialized, well - sealed containers. Strict regulations govern its transport to prevent spills, as it's a chemical. It's often shipped by road or rail with safety protocols in place. |
Competitive 1-Chloro-2-[Chloro(Difluoro)Methyl]Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 1-Chloro-2-[Chloro(Difluoro)Methyl]Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-chloro-2- [chloro (difluoro) methyl] benzene
1 - chloro - 2 - [chloro (difluoro) methyl] benzene is an organic compound with interesting chemical properties. This compound has the characteristics of halogenated aromatics, and both chlorine atoms and chlorofluoromethyl groups have a great influence on its properties.
Let's talk about the substitution reaction first. Because the benzene ring has an electron cloud and is rich in electrons, it is easy to be attacked by electrophilic reagents. The chlorine atom is an ortho-para-site group. Although it has an electron-absorbing effect, it has a electron-giving conjugation effect, so that the electron cloud density of the ortho-para-site of the benzene ring is relatively high. In this way, in the electrophilic substitution reaction, new groups are easy to enter the ortho or para-site of the chlorine atom. The [chloro (difluoro) methyl] group also has a certain electronic effect, which will affect the reactivity and selectivity.
Let's talk about its hydrolysis reaction. The chlorine atoms in the molecule can hydrolyze under appropriate conditions, such as in a strong alkali aqueous solution and when heated. The chlorine atoms are replaced by hydroxyl groups to form products containing hydroxyl groups. However, due to the influence of benzene rings and other substituents, the hydrolysis reaction rate and difficulty are different from those of general halogenated alkanes.
In the nucleophilic substitution reaction, the chlorine atoms on the benzene ring can be attacked by nucleophilic reagents. The nucleophilic reagent provides an electron pair, which is connected to the chlorine atom and bound to the carbon atom, and the chlorine atom leaves in the form However, this reaction requires suitable nucleophiles, solvents and reaction conditions. Because the benzene ring conjugate system has a certain stabilizing effect on chlorine atoms, the activity of chlorine atoms is not as high as that of halogen atoms in halogenated alkanes.
In addition, the compound may also involve elimination reactions. If there are suitable β-hydrogen atoms in the molecule, under strong bases and other conditions, elimination reactions can occur to form products containing unsaturated bonds. In short, 1-chloro-2 - [chloro (difluoro) methyl] benzene is rich in chemical properties and may have important uses in organic synthesis and other fields. Its reactivity and selectivity are jointly restricted by the electronic effects and spatial effects of each group in the molecule.
Let's talk about the substitution reaction first. Because the benzene ring has an electron cloud and is rich in electrons, it is easy to be attacked by electrophilic reagents. The chlorine atom is an ortho-para-site group. Although it has an electron-absorbing effect, it has a electron-giving conjugation effect, so that the electron cloud density of the ortho-para-site of the benzene ring is relatively high. In this way, in the electrophilic substitution reaction, new groups are easy to enter the ortho or para-site of the chlorine atom. The [chloro (difluoro) methyl] group also has a certain electronic effect, which will affect the reactivity and selectivity.
Let's talk about its hydrolysis reaction. The chlorine atoms in the molecule can hydrolyze under appropriate conditions, such as in a strong alkali aqueous solution and when heated. The chlorine atoms are replaced by hydroxyl groups to form products containing hydroxyl groups. However, due to the influence of benzene rings and other substituents, the hydrolysis reaction rate and difficulty are different from those of general halogenated alkanes.
In the nucleophilic substitution reaction, the chlorine atoms on the benzene ring can be attacked by nucleophilic reagents. The nucleophilic reagent provides an electron pair, which is connected to the chlorine atom and bound to the carbon atom, and the chlorine atom leaves in the form However, this reaction requires suitable nucleophiles, solvents and reaction conditions. Because the benzene ring conjugate system has a certain stabilizing effect on chlorine atoms, the activity of chlorine atoms is not as high as that of halogen atoms in halogenated alkanes.
In addition, the compound may also involve elimination reactions. If there are suitable β-hydrogen atoms in the molecule, under strong bases and other conditions, elimination reactions can occur to form products containing unsaturated bonds. In short, 1-chloro-2 - [chloro (difluoro) methyl] benzene is rich in chemical properties and may have important uses in organic synthesis and other fields. Its reactivity and selectivity are jointly restricted by the electronic effects and spatial effects of each group in the molecule.
What are the physical properties of 1-chloro-2- [chloro (difluoro) methyl] benzene
1 - chloro - 2 - [chloro (difluoro) methyl] benzene, that is, 1 - chloro - 2 - (chlorodifluoromethyl) benzene, the physical properties of this substance are very important, and it is widely used in chemical industry.
Its appearance is often a colorless to light yellow transparent liquid, which is clear in appearance and has no obvious impurities. In terms of smell, it has a special aromatic smell, but this smell is slightly different from ordinary aromatic hydrocarbons, with the unique smell of halogenated hydrocarbons, and the smell is discernible.
The boiling point is between 190 ° C and 200 ° C. A specific temperature is required to convert it from liquid to gaseous. This boiling point value is crucial in chemical operations such as separation and purification, and is related to the temperature control of the process. The melting point is about -20 ° C. At this temperature, the substance will condense from liquid to solid. This characteristic needs to be taken into account when storing and transporting.
In terms of density, it is about 1.4 - 1.5 g/cm ³, which is heavier than water. Therefore, if mixed with water, it will sink underwater. In terms of solubility, it is slightly soluble in water, but it can be well miscible with many organic solvents, such as ethanol, ether, acetone, etc. This characteristic plays an extraordinary role in the construction of reaction systems and product separation in organic synthesis. According to its solubility differences, the experimental process can be cleverly designed.
In addition, the vapor pressure of this substance is relatively low. Under normal temperature and pressure, the volatilization rate is relatively slow, but in heating or decompression environments, the volatilization will be accelerated. This vapor pressure characteristic is crucial for preventing vapor escape and ensuring the safety of the operating environment in storage and use scenarios. And its refractive index also has a specific value, about 1.5-1.55, which can be determined by refractive index to assist in judging its purity and composition.
Its appearance is often a colorless to light yellow transparent liquid, which is clear in appearance and has no obvious impurities. In terms of smell, it has a special aromatic smell, but this smell is slightly different from ordinary aromatic hydrocarbons, with the unique smell of halogenated hydrocarbons, and the smell is discernible.
The boiling point is between 190 ° C and 200 ° C. A specific temperature is required to convert it from liquid to gaseous. This boiling point value is crucial in chemical operations such as separation and purification, and is related to the temperature control of the process. The melting point is about -20 ° C. At this temperature, the substance will condense from liquid to solid. This characteristic needs to be taken into account when storing and transporting.
In terms of density, it is about 1.4 - 1.5 g/cm ³, which is heavier than water. Therefore, if mixed with water, it will sink underwater. In terms of solubility, it is slightly soluble in water, but it can be well miscible with many organic solvents, such as ethanol, ether, acetone, etc. This characteristic plays an extraordinary role in the construction of reaction systems and product separation in organic synthesis. According to its solubility differences, the experimental process can be cleverly designed.
In addition, the vapor pressure of this substance is relatively low. Under normal temperature and pressure, the volatilization rate is relatively slow, but in heating or decompression environments, the volatilization will be accelerated. This vapor pressure characteristic is crucial for preventing vapor escape and ensuring the safety of the operating environment in storage and use scenarios. And its refractive index also has a specific value, about 1.5-1.55, which can be determined by refractive index to assist in judging its purity and composition.
What is the main use of 1-chloro-2- [chloro (difluoro) methyl] benzene
1 - chloro - 2 - [chloro (difluoro) methyl] benzene, the Chinese name can be chlorodichloromethylbenzene. The main use of this substance is broad.
In the field of chemical synthesis, it can be used as an important synthetic medium. Because of its benzene and its chlorine-containing and fluorine-containing substituents, it has specific chemical activity. It can be used to synthesize many compounds with special properties by introducing various functionalities by means of general reactance, such as nuclear substitution reactance.
In the field of materials science, the compounds synthesized from this starting material can be used in polymer materials. Due to its fluorine and chlorine content, the resulting polymer material can have special physical properties, such as increasing material resistance, weather resistance, etc.
In the field of research, it may be used to synthesize fragments of new compounds. Due to its special properties, or the ability to generate specific biological or enzymatic interactions, it exhibits certain biological activities, providing possible avenues for research.
In terms of manufacturing, compounds synthesized by its groups may have good biological and bacterial activities. The presence of fluorine and chlorine elements may enhance the effect of the compounds on crop pests, and the fat-soluble properties of the benzene compounds can improve their adsorption and permeability on the surface of crops, so as to improve their effectiveness.
In the field of chemical synthesis, it can be used as an important synthetic medium. Because of its benzene and its chlorine-containing and fluorine-containing substituents, it has specific chemical activity. It can be used to synthesize many compounds with special properties by introducing various functionalities by means of general reactance, such as nuclear substitution reactance.
In the field of materials science, the compounds synthesized from this starting material can be used in polymer materials. Due to its fluorine and chlorine content, the resulting polymer material can have special physical properties, such as increasing material resistance, weather resistance, etc.
In the field of research, it may be used to synthesize fragments of new compounds. Due to its special properties, or the ability to generate specific biological or enzymatic interactions, it exhibits certain biological activities, providing possible avenues for research.
In terms of manufacturing, compounds synthesized by its groups may have good biological and bacterial activities. The presence of fluorine and chlorine elements may enhance the effect of the compounds on crop pests, and the fat-soluble properties of the benzene compounds can improve their adsorption and permeability on the surface of crops, so as to improve their effectiveness.
What are the synthesis methods of 1-chloro-2- [chloro (difluoro) methyl] benzene
1 - chloro - 2 - [chloro (difluoro) methyl] benzene, that is, 2 - (chlorodifluoromethyl) - 1 - chlorobenzene, the synthesis method is as follows:
The starting material can be o-chlorotoluene. First, the o-chlorotoluene is placed in a suitable reaction vessel, and under the action of ultraviolet rays or initiators, chlorine gas is introduced to carry out a free radical substitution reaction. In this step, due to the high activity of hydrogen atoms on the methyl group, chlorine gas will preferentially replace the hydrogen atoms on the methyl group to generate o-chlorobenzyl chloride. This reaction requires strict control of the amount of chlorine gas and the reaction temperature. Excessive temperature can easily lead to the formation of polychlorinated by-products.
Next, the obtained o-chlorobenzyl chloride is transferred to another reaction system and reacts with anhydrous hydrogen fluoride in the presence of an appropriate catalyst (such as a specific metal halide). During this process, fluorine atoms gradually replace chlorine atoms to generate 2- (chlorodifluoromethyl) -1 -chlorobenzene. During the reaction, attention should be paid to the corrosiveness and toxicity of hydrogen fluoride, and the reaction temperature and pressure should be precisely adjusted to ensure that the reaction proceeds in the direction of generating the target product.
Another starting material can be o-chlorobenzoic acid. First, the o-chlorobenzoic acid is reacted with a suitable chlorination reagent (such as thionyl chloride, etc.) to convert the carboxyl group into an acyl chloride to form o-chlorobenzoyl chloride. Subsequently, o-chlorobenzoyl chloride is reduced to o-chlorobenzaldehyde under the action of specific reducing agents (such as specific derivatives of lithium aluminum hydride). Then, o-chlorobenzaldehyde reacts with ethyl dichloroacetate under the catalysis of strong bases (such as potassium tert-butanol, etc.) to generate corresponding condensation products. Finally, the condensation product is hydrolyzed and decarboxylated to obtain 2- (chlorodifluoromethyl) -1-chlorobenzene. Although there are many steps in this route, the reaction selectivity of each step is relatively good, which can effectively control the occurrence of side reactions and improve the yield of the target product.
During the synthesis operation, it is necessary to pay attention to the physical and chemical properties of various reagents, take protective measures, and precisely control the reaction conditions to ensure the safe and efficient progress of the synthesis process.
The starting material can be o-chlorotoluene. First, the o-chlorotoluene is placed in a suitable reaction vessel, and under the action of ultraviolet rays or initiators, chlorine gas is introduced to carry out a free radical substitution reaction. In this step, due to the high activity of hydrogen atoms on the methyl group, chlorine gas will preferentially replace the hydrogen atoms on the methyl group to generate o-chlorobenzyl chloride. This reaction requires strict control of the amount of chlorine gas and the reaction temperature. Excessive temperature can easily lead to the formation of polychlorinated by-products.
Next, the obtained o-chlorobenzyl chloride is transferred to another reaction system and reacts with anhydrous hydrogen fluoride in the presence of an appropriate catalyst (such as a specific metal halide). During this process, fluorine atoms gradually replace chlorine atoms to generate 2- (chlorodifluoromethyl) -1 -chlorobenzene. During the reaction, attention should be paid to the corrosiveness and toxicity of hydrogen fluoride, and the reaction temperature and pressure should be precisely adjusted to ensure that the reaction proceeds in the direction of generating the target product.
Another starting material can be o-chlorobenzoic acid. First, the o-chlorobenzoic acid is reacted with a suitable chlorination reagent (such as thionyl chloride, etc.) to convert the carboxyl group into an acyl chloride to form o-chlorobenzoyl chloride. Subsequently, o-chlorobenzoyl chloride is reduced to o-chlorobenzaldehyde under the action of specific reducing agents (such as specific derivatives of lithium aluminum hydride). Then, o-chlorobenzaldehyde reacts with ethyl dichloroacetate under the catalysis of strong bases (such as potassium tert-butanol, etc.) to generate corresponding condensation products. Finally, the condensation product is hydrolyzed and decarboxylated to obtain 2- (chlorodifluoromethyl) -1-chlorobenzene. Although there are many steps in this route, the reaction selectivity of each step is relatively good, which can effectively control the occurrence of side reactions and improve the yield of the target product.
During the synthesis operation, it is necessary to pay attention to the physical and chemical properties of various reagents, take protective measures, and precisely control the reaction conditions to ensure the safe and efficient progress of the synthesis process.
What are the precautions for using 1-chloro-2- [chloro (difluoro) methyl] benzene?
1-Chloro-2 - [chlorine (difluoromethyl) ] benzene, this is an organic compound, and many things need to be paid attention to during use.
First safety protection. Because of its certain toxicity and irritation, it is necessary to wear suitable protective equipment when operating. Gas masks are essential to effectively block its volatile gaseous substances and protect against respiratory inhalation; protective gloves are also indispensable to avoid skin contact to prevent allergies or corrosion; goggles should also be worn to prevent liquid from splashing into the eyes and causing eye damage.
Second words operating environment. Relevant operations should be carried out in a well-ventilated place. If the volatile gas of this compound accumulates in a limited space, the concentration increases, or it may cause poisoning risk, and there may be a potential explosion hazard. Ventilation facilities can discharge the volatile gas in time to maintain fresh air and reduce danger.
Furthermore, it is related to storage. It needs to be stored in a cool, dry and ventilated place. Keep away from fire and heat sources, this compound is heated or exposed to open flames, or it may cause combustion or even explosion. At the same time, it should be stored separately from oxidizing agents, alkalis, etc., because of its active chemical nature, contact with these substances, or severe chemical reaction.
When using, precise control of the dosage is also key. According to experimental or production needs, strictly follow the specified dosage to avoid waste and reduce the safety risk caused by excessive use. After use, properly dispose of the remaining substances and waste, and do not dump them at will. It is necessary to follow relevant environmental protection regulations and carry out harmless treatment.
In addition, it is also necessary to read the safety technical manual of the compound carefully before operation. Clear information such as its physical and chemical properties, hazardous characteristics and emergency treatment measures, so that in the face of emergencies, you can respond calmly and take correct treatment methods to minimize losses and hazards.
First safety protection. Because of its certain toxicity and irritation, it is necessary to wear suitable protective equipment when operating. Gas masks are essential to effectively block its volatile gaseous substances and protect against respiratory inhalation; protective gloves are also indispensable to avoid skin contact to prevent allergies or corrosion; goggles should also be worn to prevent liquid from splashing into the eyes and causing eye damage.
Second words operating environment. Relevant operations should be carried out in a well-ventilated place. If the volatile gas of this compound accumulates in a limited space, the concentration increases, or it may cause poisoning risk, and there may be a potential explosion hazard. Ventilation facilities can discharge the volatile gas in time to maintain fresh air and reduce danger.
Furthermore, it is related to storage. It needs to be stored in a cool, dry and ventilated place. Keep away from fire and heat sources, this compound is heated or exposed to open flames, or it may cause combustion or even explosion. At the same time, it should be stored separately from oxidizing agents, alkalis, etc., because of its active chemical nature, contact with these substances, or severe chemical reaction.
When using, precise control of the dosage is also key. According to experimental or production needs, strictly follow the specified dosage to avoid waste and reduce the safety risk caused by excessive use. After use, properly dispose of the remaining substances and waste, and do not dump them at will. It is necessary to follow relevant environmental protection regulations and carry out harmless treatment.
In addition, it is also necessary to read the safety technical manual of the compound carefully before operation. Clear information such as its physical and chemical properties, hazardous characteristics and emergency treatment measures, so that in the face of emergencies, you can respond calmly and take correct treatment methods to minimize losses and hazards.
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