Linshang Chemical
PRODUCTS
1-Chloro-2-(Chloromethyl)-3-Fluorobenzene
Linshang Chemical
|
HS Code |
504749 |
| Chemical Formula | C7H5Cl2F |
| Molar Mass | 181.02 g/mol |
| Appearance | Typically a colorless to light - colored liquid |
| Boiling Point | Data needed for accurate value |
| Melting Point | Data needed for accurate value |
| Density | Data needed for accurate value |
| Solubility In Water | Low solubility, likely immiscible |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Vapor Pressure | Data needed for accurate value |
| Flash Point | Data needed for accurate value |
| Odor | May have a characteristic chloro - aromatic odor |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 1-Chloro-2-(Chloromethyl)-3-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 2 - (chloromethyl)-3 - fluorobenzene in 1 - kg bottles for packaging. |
| Storage | 1 - Chloro - 2 - (chloromethyl)-3 - fluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials like high - density polyethylene, to prevent leakage and exposure to air and moisture. |
| Shipping | 1 - chloro - 2 - (chloromethyl)-3 - fluorobenzene is shipped in specialized, leak - proof containers compliant with chemical transport regulations. It's carefully handled to prevent exposure due to its potentially hazardous nature during transit. |
Competitive 1-Chloro-2-(Chloromethyl)-3-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Chloro-2-(Chloromethyl)-3-Fluorobenzene in China?
As a trusted 1-Chloro-2-(Chloromethyl)-3-Fluorobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Chloro-2-(Chloromethyl)-3-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-2- (chloromethyl) -3-fluorobenzene?
1-Chloro-2- (chloromethyl) -3-fluorobenzene is one of the organic compounds. Its main uses are quite extensive, and it is often used as a key intermediate in the field of organic synthesis.
First, in the process of pharmaceutical synthesis, a series of chemical reactions can be used to introduce specific functional groups to construct biologically active molecular structures, laying the foundation for the creation of new drugs. For example, it can be reacted with reagents containing heteroatoms such as nitrogen and oxygen to generate heterocyclic compounds with specific pharmacological activities. These compounds often play a pivotal role in the development of antibacterial, antiviral, antitumor and many other drugs.
Second, it also plays an important role in the field of pesticide synthesis. It can combine with various active groups to prepare high-efficiency, low-toxicity and environmentally friendly pesticide varieties. For example, it can react with reagents containing phosphorus, sulfur and other elements to synthesize organophosphorus or organosulfur pesticides, in order to achieve the purpose of controlling crop diseases and insect pests and ensuring agricultural harvests.
Third, it is also applied in the field of materials science. After appropriate polymerization or modification means, it can be introduced into the structure of polymer materials, thereby endowing the materials with unique properties, such as improving the heat resistance and chemical corrosion resistance of the materials, providing the possibility for the development of new functional materials.
In conclusion, 1-chloro-2- (chloromethyl) -3-fluorobenzene has shown important application value in many fields related to organic synthesis, such as medicine, pesticides and materials, due to its unique molecular structure, and has made great contributions to the development of various fields.
First, in the process of pharmaceutical synthesis, a series of chemical reactions can be used to introduce specific functional groups to construct biologically active molecular structures, laying the foundation for the creation of new drugs. For example, it can be reacted with reagents containing heteroatoms such as nitrogen and oxygen to generate heterocyclic compounds with specific pharmacological activities. These compounds often play a pivotal role in the development of antibacterial, antiviral, antitumor and many other drugs.
Second, it also plays an important role in the field of pesticide synthesis. It can combine with various active groups to prepare high-efficiency, low-toxicity and environmentally friendly pesticide varieties. For example, it can react with reagents containing phosphorus, sulfur and other elements to synthesize organophosphorus or organosulfur pesticides, in order to achieve the purpose of controlling crop diseases and insect pests and ensuring agricultural harvests.
Third, it is also applied in the field of materials science. After appropriate polymerization or modification means, it can be introduced into the structure of polymer materials, thereby endowing the materials with unique properties, such as improving the heat resistance and chemical corrosion resistance of the materials, providing the possibility for the development of new functional materials.
In conclusion, 1-chloro-2- (chloromethyl) -3-fluorobenzene has shown important application value in many fields related to organic synthesis, such as medicine, pesticides and materials, due to its unique molecular structure, and has made great contributions to the development of various fields.
What are the physical properties of 1-chloro-2- (chloromethyl) -3-fluorobenzene
1-Chloro-2- (chloromethyl) -3-fluorobenzene is one of the organic compounds. Its physical properties are quite important, let me tell you in detail.
Looking at its appearance, under room temperature and pressure, it is mostly a colorless to light yellow liquid with a clear texture. The characteristics of this color state can be used for preliminary identification. Its smell often has a special aromatic smell, but this smell may vary slightly due to differences in environment and concentration. It should be sniffed cautiously because it may be irritating.
As for the melting point and boiling point, it is also a key physical property. Its melting point is low, causing it to be liquid at room temperature; the boiling point varies according to specific conditions, usually boiling within a specific temperature range. This property is crucial in the separation and purification process. According to the boiling point, it can be separated from the mixture by distillation and other methods.
In terms of density, compared with water, 1-chloro-2- (chloromethyl) -3-fluorobenzene has a slightly higher density, so if mixed with water, it will sink underwater. This property is quite instructive in operations involving liquid-liquid separation.
Solubility cannot be ignored. In organic solvents, such as ethanol, ether, etc., it shows good solubility and can be mutually soluble with it; however, the solubility in water is very small, which is due to the characteristics of its molecular structure. The polarity of the molecule is quite different from that of water, so it is difficult to dissolve in water.
In addition, the volatility of 1-chloro-2- (chloromethyl) -3-fluorobenzene also belongs to the category of physical properties. It has a certain volatility and can gradually evaporate into the air in an open environment. This process requires attention to its potential impact on the environment and human body.
The above physical properties are indispensable information in many fields such as chemical production and scientific research experiments, which can help researchers and producers better control the properties and applications of this substance.
Looking at its appearance, under room temperature and pressure, it is mostly a colorless to light yellow liquid with a clear texture. The characteristics of this color state can be used for preliminary identification. Its smell often has a special aromatic smell, but this smell may vary slightly due to differences in environment and concentration. It should be sniffed cautiously because it may be irritating.
As for the melting point and boiling point, it is also a key physical property. Its melting point is low, causing it to be liquid at room temperature; the boiling point varies according to specific conditions, usually boiling within a specific temperature range. This property is crucial in the separation and purification process. According to the boiling point, it can be separated from the mixture by distillation and other methods.
In terms of density, compared with water, 1-chloro-2- (chloromethyl) -3-fluorobenzene has a slightly higher density, so if mixed with water, it will sink underwater. This property is quite instructive in operations involving liquid-liquid separation.
Solubility cannot be ignored. In organic solvents, such as ethanol, ether, etc., it shows good solubility and can be mutually soluble with it; however, the solubility in water is very small, which is due to the characteristics of its molecular structure. The polarity of the molecule is quite different from that of water, so it is difficult to dissolve in water.
In addition, the volatility of 1-chloro-2- (chloromethyl) -3-fluorobenzene also belongs to the category of physical properties. It has a certain volatility and can gradually evaporate into the air in an open environment. This process requires attention to its potential impact on the environment and human body.
The above physical properties are indispensable information in many fields such as chemical production and scientific research experiments, which can help researchers and producers better control the properties and applications of this substance.
What are the synthesis methods of 1-chloro-2- (chloromethyl) -3-fluorobenzene
There are several methods for synthesizing 1-chloro-2- (chloromethyl) -3-fluorobenzene.
First, a specific halogenated aromatic hydrocarbon is used as the starting material. First, the halogenated aromatic hydrocarbon is chloromethylated with an appropriate chloromethylating reagent, such as chloromethyl ether, and in the presence of a suitable catalyst, such as anhydrous zinc chloride, etc., chloromethyl can be introduced. Subsequently, under the specific reaction conditions, the halogen atom at a specific position is replaced with a fluorine atom by a suitable fluorine-containing reagent, such as potassium fluoride, to obtain the target product 1-chloro-2- (chloromethyl) -3-fluorobenzene. This process requires fine regulation of reaction temperature, reaction time, and reagent dosage to ensure that the reaction proceeds in the desired direction.
Second, it can start from fluorinated benzene derivatives. First, the fluorobenzene derivatives are selectively halogenated to introduce chlorine atoms at specific positions. After that, through a specific reaction path, such as the use of a suitable halogenating agent, in a suitable reaction system, chloromethylation is carried out, and chloromethylation is successfully introduced, and finally 1-chloro-2- (chloromethyl) -3-fluorobenzene is obtained. The key to this approach is the selective control of halogenation and chloromethylation reactions to avoid unnecessary side reactions and affect the purity and yield of the product.
Third, the strategy of step-by-step construction of benzene ring can also be adopted. First, a fluorine-containing benzene ring structure framework with appropriate substituents is constructed through a multi-step reaction of simple organic compounds. Then, through subsequent modification steps such as halogenation and chloromethylation, 1-chloro-2 - (chloromethyl) -3-fluorobenzene is finally synthesized. Although this method is complicated, it has unique advantages for precise control of the position and type of substituents on the benzene ring, but it requires high separation and purification of reaction conditions and intermediates.
All synthetic methods have their own advantages and disadvantages, and the appropriate method should be selected based on actual needs, such as the availability of raw materials, cost considerations, and product purity requirements.
First, a specific halogenated aromatic hydrocarbon is used as the starting material. First, the halogenated aromatic hydrocarbon is chloromethylated with an appropriate chloromethylating reagent, such as chloromethyl ether, and in the presence of a suitable catalyst, such as anhydrous zinc chloride, etc., chloromethyl can be introduced. Subsequently, under the specific reaction conditions, the halogen atom at a specific position is replaced with a fluorine atom by a suitable fluorine-containing reagent, such as potassium fluoride, to obtain the target product 1-chloro-2- (chloromethyl) -3-fluorobenzene. This process requires fine regulation of reaction temperature, reaction time, and reagent dosage to ensure that the reaction proceeds in the desired direction.
Second, it can start from fluorinated benzene derivatives. First, the fluorobenzene derivatives are selectively halogenated to introduce chlorine atoms at specific positions. After that, through a specific reaction path, such as the use of a suitable halogenating agent, in a suitable reaction system, chloromethylation is carried out, and chloromethylation is successfully introduced, and finally 1-chloro-2- (chloromethyl) -3-fluorobenzene is obtained. The key to this approach is the selective control of halogenation and chloromethylation reactions to avoid unnecessary side reactions and affect the purity and yield of the product.
Third, the strategy of step-by-step construction of benzene ring can also be adopted. First, a fluorine-containing benzene ring structure framework with appropriate substituents is constructed through a multi-step reaction of simple organic compounds. Then, through subsequent modification steps such as halogenation and chloromethylation, 1-chloro-2 - (chloromethyl) -3-fluorobenzene is finally synthesized. Although this method is complicated, it has unique advantages for precise control of the position and type of substituents on the benzene ring, but it requires high separation and purification of reaction conditions and intermediates.
All synthetic methods have their own advantages and disadvantages, and the appropriate method should be selected based on actual needs, such as the availability of raw materials, cost considerations, and product purity requirements.
What are the precautions for 1-chloro-2- (chloromethyl) -3-fluorobenzene during storage and transportation?
1-Chloro-2- (chloromethyl) -3-fluorobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
First words storage, this compound should be placed in a cool, dry and well-ventilated place. Because the cover is more sensitive to heat, if it is in a high temperature environment, it may cause chemical reactions, cause changes in its properties, and even risk safety. Therefore, choose a cool place to ensure its stability. And a dry environment is indispensable, moisture can easily make the compound damp, which in turn affects its quality. Good ventilation can disperse harmful gases that may evaporate in time to protect people's safety.
Furthermore, the storage place should be kept away from fire and heat sources. This compound is flammable, and it is dangerous to encounter open flames, hot topics, or cause combustion and explosion. Therefore, fireworks must be strictly prohibited around, and electrical equipment must also meet explosion-proof requirements to avoid static electricity or sparks and cause accidents.
In addition, it should be stored separately from oxidants, strong alkalis and other substances. Because of its active chemical properties, it encounters with oxidants or undergoes severe oxidation reactions; contact with strong alkalis may also cause chemical reactions, which will endanger safety. Therefore, it can be stored in categories to avoid the harm of interaction.
As for transportation, transportation vehicles need to ensure that they are in good condition and have corresponding protective facilities. Fire extinguishing equipment should be provided in the car to prevent fires during transportation. And the loading and unloading process must be handled with care. If the package of this compound is violently collided, dropped, or damaged, the material leaks, causing environmental pollution and safety accidents.
Transportation personnel also need to undergo professional training, familiar with the characteristics of the compound and emergency treatment methods. Once there is an accident such as leakage on the way, they can respond quickly and correctly to reduce the damage. At the same time, the transportation route planning also needs to be careful to avoid crowded areas and environmentally sensitive areas, so as to ensure smooth and safe storage and transportation.
First words storage, this compound should be placed in a cool, dry and well-ventilated place. Because the cover is more sensitive to heat, if it is in a high temperature environment, it may cause chemical reactions, cause changes in its properties, and even risk safety. Therefore, choose a cool place to ensure its stability. And a dry environment is indispensable, moisture can easily make the compound damp, which in turn affects its quality. Good ventilation can disperse harmful gases that may evaporate in time to protect people's safety.
Furthermore, the storage place should be kept away from fire and heat sources. This compound is flammable, and it is dangerous to encounter open flames, hot topics, or cause combustion and explosion. Therefore, fireworks must be strictly prohibited around, and electrical equipment must also meet explosion-proof requirements to avoid static electricity or sparks and cause accidents.
In addition, it should be stored separately from oxidants, strong alkalis and other substances. Because of its active chemical properties, it encounters with oxidants or undergoes severe oxidation reactions; contact with strong alkalis may also cause chemical reactions, which will endanger safety. Therefore, it can be stored in categories to avoid the harm of interaction.
As for transportation, transportation vehicles need to ensure that they are in good condition and have corresponding protective facilities. Fire extinguishing equipment should be provided in the car to prevent fires during transportation. And the loading and unloading process must be handled with care. If the package of this compound is violently collided, dropped, or damaged, the material leaks, causing environmental pollution and safety accidents.
Transportation personnel also need to undergo professional training, familiar with the characteristics of the compound and emergency treatment methods. Once there is an accident such as leakage on the way, they can respond quickly and correctly to reduce the damage. At the same time, the transportation route planning also needs to be careful to avoid crowded areas and environmentally sensitive areas, so as to ensure smooth and safe storage and transportation.
What are the effects of 1-chloro-2- (chloromethyl) -3-fluorobenzene on the environment and human health?
1-Chloro-2- (chloromethyl) -3-fluorobenzene is one of the organic compounds. Its impact on the environment and human health is of great concern to the world.
In the environment, 1-chloro-2- (chloromethyl) -3-fluorobenzene has certain stability and is difficult to degrade naturally. If it is released into the atmosphere or migrates with air flow, it will affect the regional air quality. It falls into the soil, or seeps into the ground, polluting soil and groundwater. The chlorine and fluorine atoms of this compound, under specific conditions, or participate in chemical reactions, generate other harmful substances, resulting in increased environmental burden. And because it is toxic to microorganisms, or interferes with the normal function of soil ecosystems, inhibits the growth and metabolism of microorganisms, and then affects soil material circulation and energy conversion.
As for human health, 1-chloro-2- (chloromethyl) -3-fluorobenzene is ingested into the human body through respiratory tract, skin contact and diet. After entering the body, or accumulated in fat tissue. It has a stimulating effect. If it comes into contact with the skin and eyes, it can cause redness, swelling, pain and other discomfort. Inhalation of high concentrations may cause respiratory irritation symptoms, such as cough, asthma, and even damage lung function. Long-term exposure to this compound may involve organs such as the liver and kidneys, affecting its normal metabolism and detoxification function. Animal experiments have also shown that it may have potential carcinogenicity and teratogenicity. Although the definitive evidence related to the human body is not complete, its potential threat to human health should not be underestimated.
In summary, 1-chloro-2- (chloromethyl) -3-fluorobenzene has many latent risks to the environment and human health. It should be treated with caution, and control and monitoring should be strengthened to reduce its harm.
In the environment, 1-chloro-2- (chloromethyl) -3-fluorobenzene has certain stability and is difficult to degrade naturally. If it is released into the atmosphere or migrates with air flow, it will affect the regional air quality. It falls into the soil, or seeps into the ground, polluting soil and groundwater. The chlorine and fluorine atoms of this compound, under specific conditions, or participate in chemical reactions, generate other harmful substances, resulting in increased environmental burden. And because it is toxic to microorganisms, or interferes with the normal function of soil ecosystems, inhibits the growth and metabolism of microorganisms, and then affects soil material circulation and energy conversion.
As for human health, 1-chloro-2- (chloromethyl) -3-fluorobenzene is ingested into the human body through respiratory tract, skin contact and diet. After entering the body, or accumulated in fat tissue. It has a stimulating effect. If it comes into contact with the skin and eyes, it can cause redness, swelling, pain and other discomfort. Inhalation of high concentrations may cause respiratory irritation symptoms, such as cough, asthma, and even damage lung function. Long-term exposure to this compound may involve organs such as the liver and kidneys, affecting its normal metabolism and detoxification function. Animal experiments have also shown that it may have potential carcinogenicity and teratogenicity. Although the definitive evidence related to the human body is not complete, its potential threat to human health should not be underestimated.
In summary, 1-chloro-2- (chloromethyl) -3-fluorobenzene has many latent risks to the environment and human health. It should be treated with caution, and control and monitoring should be strengthened to reduce its harm.
Scan to WhatsApp
