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1-Chloro-2-(Chloromethyl)-4-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
314232 |
| Chemical Formula | C8H5Cl2F3 |
| Molar Mass | 225.026 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Approximately 198 - 200 °C |
| Solubility In Water | Poorly soluble, as it's an organic halogen - containing compound |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Vapor Pressure | Relatively low due to its high molar mass and liquid state |
As an accredited 1-Chloro-2-(Chloromethyl)-4-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 2 - (chloromethyl) - 4 - (trifluoromethyl) benzene: Packed in 5 - liter drums. |
| Storage | 1 - chloro - 2 - (chloromethyl)-4-(trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area away from sources of ignition and heat. Keep it in a tightly sealed container to prevent leakage. Store it separately from oxidizing agents, bases, and reactive chemicals to avoid potential chemical reactions. Use appropriate storage cabinets for hazardous chemicals. |
| Shipping | 1 - chloro - 2 - (chloromethyl)-4-(trifluoromethyl)benzene is shipped in sealed, corrosion - resistant containers. Compliance with strict chemical shipping regulations is ensured to prevent leaks and safeguard transport safety. |
Competitive 1-Chloro-2-(Chloromethyl)-4-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 1-chloro-2- (chloromethyl) -4- (trifluoromethyl) benzene
1 - chloro - 2 - (chloromethyl) -4 - (trifluoromethyl) benzene, this is an organic compound, the Chinese name is 1 - chloro - 2 - chloromethyl - 4 - (trifluoromethyl) benzene. Its chemical properties are unique and it is widely used in the field of organic synthesis.
First, its molecular structure contains chlorine atoms and chloromethyl groups, which give the compound a certain reactivity. Chlorine atoms are good leaving groups and are easily replaced by nucleophiles in nucleophilic substitution reactions. For example, if reacted with alcohols under basic conditions, chlorine atoms can be replaced by alkoxy groups to form corresponding ether compounds. The reaction mechanism is that the nucleophilic reagent attacks the chlorine-containing carbon atom, and the chlorine atom leaves with a pair of electrons, thus forming a new carbon-oxygen bond.
Furthermore, the presence of chloromethyl also increases the reaction check point of the molecule. The chlorine atom on the chlorine methyl group also has certain activity, and similar nucleophilic substitution reactions can occur. At the same time, chloromethyl groups can also participate in some special reactions, such as reacting with aldehyde compounds under specific conditions to construct more complex organic structures.
The trifluoromethyl group in the molecule has a strong electron-absorbing effect due to the strong electronegativity of the fluorine atom. This effect significantly affects the electron cloud distribution of the molecule, which in turn affects its chemical properties. On the one hand, it can reduce the electron cloud density on the benzene ring and reduce the activity of the electrophilic substitution reaction of the benzene ring. On the other hand, in some reactions involving the formation of carbon-carbon bonds, the electron-absorbing effect of trifluoromethyl can affect the regioselectivity and stereoselectivity of the reaction. For example, in some metal-catalyzed coupling reactions, the presence of trifluoromethyl can guide the reaction in a specific direction, resulting in a product with a specific structure.
In addition, 1-chloro-2-chloromethyl-4- (trifluoromethyl) benzene can also be used as a synthetic intermediate, through a series of chemical reactions, to construct organic compounds with biological activity or special functions. Due to the synergy of various active groups in the structure, it provides a rich strategy and path for organic synthetic chemists to create novel organic molecules to meet the needs of many fields such as medicinal chemistry and materials science.
First, its molecular structure contains chlorine atoms and chloromethyl groups, which give the compound a certain reactivity. Chlorine atoms are good leaving groups and are easily replaced by nucleophiles in nucleophilic substitution reactions. For example, if reacted with alcohols under basic conditions, chlorine atoms can be replaced by alkoxy groups to form corresponding ether compounds. The reaction mechanism is that the nucleophilic reagent attacks the chlorine-containing carbon atom, and the chlorine atom leaves with a pair of electrons, thus forming a new carbon-oxygen bond.
Furthermore, the presence of chloromethyl also increases the reaction check point of the molecule. The chlorine atom on the chlorine methyl group also has certain activity, and similar nucleophilic substitution reactions can occur. At the same time, chloromethyl groups can also participate in some special reactions, such as reacting with aldehyde compounds under specific conditions to construct more complex organic structures.
The trifluoromethyl group in the molecule has a strong electron-absorbing effect due to the strong electronegativity of the fluorine atom. This effect significantly affects the electron cloud distribution of the molecule, which in turn affects its chemical properties. On the one hand, it can reduce the electron cloud density on the benzene ring and reduce the activity of the electrophilic substitution reaction of the benzene ring. On the other hand, in some reactions involving the formation of carbon-carbon bonds, the electron-absorbing effect of trifluoromethyl can affect the regioselectivity and stereoselectivity of the reaction. For example, in some metal-catalyzed coupling reactions, the presence of trifluoromethyl can guide the reaction in a specific direction, resulting in a product with a specific structure.
In addition, 1-chloro-2-chloromethyl-4- (trifluoromethyl) benzene can also be used as a synthetic intermediate, through a series of chemical reactions, to construct organic compounds with biological activity or special functions. Due to the synergy of various active groups in the structure, it provides a rich strategy and path for organic synthetic chemists to create novel organic molecules to meet the needs of many fields such as medicinal chemistry and materials science.
What are the main uses of 1-chloro-2- (chloromethyl) -4- (trifluoromethyl) benzene
1 - chloro - 2 - (chloromethyl) - 4 - (trifluoromethyl) benzene, Chinese name 1 - chloro - 2 - (chloromethyl) - 4 - (trifluoromethyl) benzene, this substance has a wide range of uses and is an important part in the field of organic synthesis.
First, it can be used as a key intermediate for the preparation of various fluorine-containing fine chemicals. On the road of pharmaceutical research and development, it can participate in the synthesis of many specific drugs. For example, to create new antibacterial drugs, with its unique chemical structure, active groups can be added to enhance the targeting and lethality of drugs to bacteria, and for human health and well-being.
Second, it is also important in the process of pesticide creation. With this as the starting material, high-efficiency, low-toxicity and environmentally friendly pesticide varieties can be derived. Due to its fluorine-containing structure, pesticides are endowed with excellent stability and biological activity, or can accurately combat pests, and degrade rapidly in the environment, reducing ecological damage.
Third, it also plays a role in the field of materials science. In the process of preparing functional materials, the compound can be introduced to give the material special properties. For example, the preparation of fluorine-containing polymer materials may have excellent corrosion resistance and weather resistance, which are very useful in high-end fields such as aerospace and electronics industries. It can be used to make outer protective materials for spacecraft to resist the erosion of harsh space environments; or for insulating coatings for electronic equipment to enhance equipment stability and service life.
First, it can be used as a key intermediate for the preparation of various fluorine-containing fine chemicals. On the road of pharmaceutical research and development, it can participate in the synthesis of many specific drugs. For example, to create new antibacterial drugs, with its unique chemical structure, active groups can be added to enhance the targeting and lethality of drugs to bacteria, and for human health and well-being.
Second, it is also important in the process of pesticide creation. With this as the starting material, high-efficiency, low-toxicity and environmentally friendly pesticide varieties can be derived. Due to its fluorine-containing structure, pesticides are endowed with excellent stability and biological activity, or can accurately combat pests, and degrade rapidly in the environment, reducing ecological damage.
Third, it also plays a role in the field of materials science. In the process of preparing functional materials, the compound can be introduced to give the material special properties. For example, the preparation of fluorine-containing polymer materials may have excellent corrosion resistance and weather resistance, which are very useful in high-end fields such as aerospace and electronics industries. It can be used to make outer protective materials for spacecraft to resist the erosion of harsh space environments; or for insulating coatings for electronic equipment to enhance equipment stability and service life.
What is the synthesis method of 1-chloro-2- (chloromethyl) -4- (trifluoromethyl) benzene
The synthesis method of 1-chloro-2- (chloromethyl) -4- (trifluoromethyl) benzene can follow the following steps.
Take p-trifluoromethyl chlorobenzene as the starting material, and carry out the Fu-gram alkylation reaction with chloromethyl methyl ether in a suitable reaction vessel with anhydrous aluminum trichloride as the catalyst. This reaction needs to be carried out at a low temperature and in an anhydrous environment to inhibit the occurrence of side reactions. The reaction temperature should be maintained between about -10 ° C and 10 ° C, and stirred continuously for several hours to allow the reaction to proceed fully.
When the reaction is completed, quench the reaction with water, and then extract with an organic solvent such as dichloromethane. After the organic phase is dried by anhydrous sodium sulfate, the desiccant is filtered off, and the solvent is removed by vacuum distillation to obtain the crude product.
The crude product needs to be further purified, and column chromatography can be used. Silica gel is used as the stationary phase, and the solution of petroleum ether and ethyl acetate mixed in a certain proportion is used as the mobile phase for column chromatography separation. Collect the fractions containing the target product, and then perform vacuum distillation to remove the residual solvent. Finally, pure 1-chloro-2 - (chloromethyl) -4 - (trifluoromethyl) benzene can be obtained.
In addition, there are other synthesis paths. For example, p-trifluoromethylbenzoic acid is used as a starting material to obtain p-trifluoromethylbenzyl alcohol through reduction reaction, and then chlorination is carried out with chlorination reagents such as dichlorosulfoxide to obtain p-trifluoromethylbenzyl chloride. Then, p-trifluoromethylbenzyl chloride and chlorine gas undergo free radical substitution reaction in the presence of light or initiator, and chloromethyl chloride is introduced at the ortho position to obtain the target product 1-chloro-2 - (chloromethyl) -4 - (trifluoromethyl) benzene. The reaction conditions in each step of this path also need to be strictly controlled to ensure the selectivity and yield of the reaction.
Take p-trifluoromethyl chlorobenzene as the starting material, and carry out the Fu-gram alkylation reaction with chloromethyl methyl ether in a suitable reaction vessel with anhydrous aluminum trichloride as the catalyst. This reaction needs to be carried out at a low temperature and in an anhydrous environment to inhibit the occurrence of side reactions. The reaction temperature should be maintained between about -10 ° C and 10 ° C, and stirred continuously for several hours to allow the reaction to proceed fully.
When the reaction is completed, quench the reaction with water, and then extract with an organic solvent such as dichloromethane. After the organic phase is dried by anhydrous sodium sulfate, the desiccant is filtered off, and the solvent is removed by vacuum distillation to obtain the crude product.
The crude product needs to be further purified, and column chromatography can be used. Silica gel is used as the stationary phase, and the solution of petroleum ether and ethyl acetate mixed in a certain proportion is used as the mobile phase for column chromatography separation. Collect the fractions containing the target product, and then perform vacuum distillation to remove the residual solvent. Finally, pure 1-chloro-2 - (chloromethyl) -4 - (trifluoromethyl) benzene can be obtained.
In addition, there are other synthesis paths. For example, p-trifluoromethylbenzoic acid is used as a starting material to obtain p-trifluoromethylbenzyl alcohol through reduction reaction, and then chlorination is carried out with chlorination reagents such as dichlorosulfoxide to obtain p-trifluoromethylbenzyl chloride. Then, p-trifluoromethylbenzyl chloride and chlorine gas undergo free radical substitution reaction in the presence of light or initiator, and chloromethyl chloride is introduced at the ortho position to obtain the target product 1-chloro-2 - (chloromethyl) -4 - (trifluoromethyl) benzene. The reaction conditions in each step of this path also need to be strictly controlled to ensure the selectivity and yield of the reaction.
What to pay attention to when storing and transporting 1-chloro-2- (chloromethyl) -4- (trifluoromethyl) benzene
1-Chloro-2- (chloromethyl) -4- (trifluoromethyl) benzene is also an organic compound. When storing and transporting, many matters must be paid attention to.
First words storage. This compound is active in nature and is prone to reaction, deterioration or danger when exposed to light, heat or oxidizing agents. Therefore, it should be stored in a cool, dry and well ventilated place. Avoid direct sunlight, choose a shading container to reduce the influence of light. The temperature should be controlled in a lower range, usually below 20 ° C. Temperature control equipment is provided to prevent temperature fluctuations. Air humidity is also the key. If the humidity is too high, it may cause reactions such as hydrolysis, so the ambient humidity should be maintained at 40% - 60%. The place of storage must be kept away from fire, heat sources and oxidants, and clear warning signs should be set up to wake up everyone.
Then transport. Before transportation, make sure that the packaging is intact. Use suitable packaging materials, such as steel drums, plastic drums, etc., and stick a dangerous chemical label on the outside of the barrel to indicate its hazardous nature. Transport vehicles should be qualified and equipped with fire fighting equipment and emergency treatment equipment. During transportation, drive slowly to avoid severe bumps and vibrations, and avoid package damage. If passing through densely populated areas or water sources, choose a suitable route to reduce the stay time. The escort personnel are professionally trained and familiar with emergency response methods. If something happens, they can respond quickly.
In short, the storage and transportation of 1-chloro-2- (chloromethyl) -4- (trifluoromethyl) benzene must be handled with caution and in accordance with regulations to ensure the safety of personnel and the environment.
First words storage. This compound is active in nature and is prone to reaction, deterioration or danger when exposed to light, heat or oxidizing agents. Therefore, it should be stored in a cool, dry and well ventilated place. Avoid direct sunlight, choose a shading container to reduce the influence of light. The temperature should be controlled in a lower range, usually below 20 ° C. Temperature control equipment is provided to prevent temperature fluctuations. Air humidity is also the key. If the humidity is too high, it may cause reactions such as hydrolysis, so the ambient humidity should be maintained at 40% - 60%. The place of storage must be kept away from fire, heat sources and oxidants, and clear warning signs should be set up to wake up everyone.
Then transport. Before transportation, make sure that the packaging is intact. Use suitable packaging materials, such as steel drums, plastic drums, etc., and stick a dangerous chemical label on the outside of the barrel to indicate its hazardous nature. Transport vehicles should be qualified and equipped with fire fighting equipment and emergency treatment equipment. During transportation, drive slowly to avoid severe bumps and vibrations, and avoid package damage. If passing through densely populated areas or water sources, choose a suitable route to reduce the stay time. The escort personnel are professionally trained and familiar with emergency response methods. If something happens, they can respond quickly.
In short, the storage and transportation of 1-chloro-2- (chloromethyl) -4- (trifluoromethyl) benzene must be handled with caution and in accordance with regulations to ensure the safety of personnel and the environment.
What are the effects of 1-chloro-2- (chloromethyl) -4- (trifluoromethyl) benzene on the environment and the human body?
1-Chloro-2- (chloromethyl) -4- (trifluoromethyl) benzene is one of the organic compounds. The impact of this substance on the environment and human body is of great concern to the world.
In the environment, it may be quite harmful. Due to its relatively stable chemical properties, it is not easy to degrade rapidly in the natural environment. If released into the soil, it may cause soil pollution, affecting the ecological balance of soil microorganisms, which in turn affects the growth and development of plants. When it enters the water body, it poses a threat to aquatic organisms due to its hydrophobicity or adsorption on suspended particles and settles to the bottom. If aquatic organisms ingest this substance, it may cause physiological disorders, such as affecting their reproduction, growth and behavior. And this substance or biomagnification through the food chain, enrichment in high-trophic organisms, has a profound impact on the structure and function of the entire ecosystem.
As for the human body, 1-chloro-2- (chloromethyl) -4- (trifluoromethyl) benzene is also a potential risk. If people inhale through the respiratory tract, skin contact or accidentally eat items containing this substance, they may be harmed. Inhalation through the respiratory tract, or irritate the mucosa of the respiratory tract, causing symptoms such as cough and asthma. Long-term exposure, or damage to lung function. Skin contact, or cause skin allergies, redness, swelling, itching, etc. If eaten by mistake, or harm the digestive system, causing nausea, vomiting, abdominal pain and other phenomena. What's more, this substance may have potential carcinogenicity, teratogenicity and mutagenicity, long-term exposure, or increase the risk of human cancer, affect the normal development of the fetus, and cause adverse consequences such as gene mutation.
Therefore, for 1-chloro-2- (chloromethyl) -4- (trifluoromethyl) benzene, its production, use and emission should be strictly controlled to reduce its harm to the environment and human body.
In the environment, it may be quite harmful. Due to its relatively stable chemical properties, it is not easy to degrade rapidly in the natural environment. If released into the soil, it may cause soil pollution, affecting the ecological balance of soil microorganisms, which in turn affects the growth and development of plants. When it enters the water body, it poses a threat to aquatic organisms due to its hydrophobicity or adsorption on suspended particles and settles to the bottom. If aquatic organisms ingest this substance, it may cause physiological disorders, such as affecting their reproduction, growth and behavior. And this substance or biomagnification through the food chain, enrichment in high-trophic organisms, has a profound impact on the structure and function of the entire ecosystem.
As for the human body, 1-chloro-2- (chloromethyl) -4- (trifluoromethyl) benzene is also a potential risk. If people inhale through the respiratory tract, skin contact or accidentally eat items containing this substance, they may be harmed. Inhalation through the respiratory tract, or irritate the mucosa of the respiratory tract, causing symptoms such as cough and asthma. Long-term exposure, or damage to lung function. Skin contact, or cause skin allergies, redness, swelling, itching, etc. If eaten by mistake, or harm the digestive system, causing nausea, vomiting, abdominal pain and other phenomena. What's more, this substance may have potential carcinogenicity, teratogenicity and mutagenicity, long-term exposure, or increase the risk of human cancer, affect the normal development of the fetus, and cause adverse consequences such as gene mutation.
Therefore, for 1-chloro-2- (chloromethyl) -4- (trifluoromethyl) benzene, its production, use and emission should be strictly controlled to reduce its harm to the environment and human body.
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