Linshang Chemical
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1-Chloro-2-(Dichloromethyl)-3-Fluorobenzene
Linshang Chemical
|
HS Code |
800857 |
| Chemical Formula | C7H4Cl3F |
| Molar Mass | 213.46 g/mol |
| Appearance | likely a colorless to pale - yellow liquid |
| Solubility In Water | practically insoluble (due to non - polar nature of the molecule) |
| Solubility In Organic Solvents | soluble in common organic solvents like dichloromethane, toluene |
| Odor | likely has a pungent, chlorinated - hydrocarbon - like odor |
As an accredited 1-Chloro-2-(Dichloromethyl)-3-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500 - gram bottle of 1 - chloro - 2-(dichloromethyl)-3 - fluorobenzene, well - sealed. |
| Storage | 1 - Chloro - 2-(dichloromethyl)-3 - fluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics. Store it separately from oxidizing agents, bases, and reactive chemicals to prevent potential reactions. |
| Shipping | 1 - chloro - 2 - (dichloromethyl)-3 - fluorobenzene is a chemical. It should be shipped in accordance with hazardous material regulations, in well - sealed, corrosion - resistant containers, labeled clearly for proper handling during transit. |
Competitive 1-Chloro-2-(Dichloromethyl)-3-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 1-Chloro-2-(Dichloromethyl)-3-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-chloro-2- (dichloromethyl) -3-fluorobenzene?
1-Chloro-2- (dichloromethyl) -3-fluorobenzene, which is a genus of organohalogenated aromatic hydrocarbons. Its chemical properties are specific, and there are functional groups such as chlorine, fluorine and dichloromethyl on the benzene ring.
Let's talk about the halogen atom first. In this molecule, both chlorine and fluorine atoms have certain electronegativity. The electronegativity of fluorine atoms is particularly strong, resulting in a change in the electron cloud density distribution of the benzene ring, which makes the electron cloud density of the benzene ring and the para-position relatively reduced, so the electrophilic substitution reaction activity is lower than that of benzene. When the electrophilic reagent attacks, the reaction check point tends to Although chlorine atoms also have electron-absorbing induction effects, their lone pair electrons are conjugated with benzene rings, which increases the electron cloud density of benzene rings, but the overall electrophilic substitution activity is still not as good as benzene.
In dichloromethyl (-CHCl ²), the carbon atom connected to the benzene ring is affected by two chlorine atoms, and the electron cloud is biased towards the chlorine atom. This carbon atom is relatively electron-deficient and vulnerable to attack by nucleophiles. When the nucleophile is close, the chlorine atom of dichloromethyl can be replaced, and a nucleophilic substitution reaction occurs.
Furthermore, due to the presence of halogen atoms, this compound can undergo elimination reaction. Under the action of appropriate bases, the halogen atoms and hydrogen atoms on adjacent carbon atoms can dehalide hydrogen to form unsaturated compounds containing carbon-carbon double bonds.
In addition, the bond energies of carbon-halogen bonds in this molecule vary, and under specific conditions, bond cracking and rearrangement reactions can occur. At high temperature, light or in the presence of specific catalysts, carbon-chlorine bonds or carbon-fluorine bonds may undergo homogeneous or heterocleavage, generating free radicals or ionic intermediates, which can then trigger a series of complex chemical reactions.
This compound is chemically active and has a wide range of uses in the field of organic synthesis. It can be used as an intermediate to participate in many reactions and prepare more complex organic compounds.
Let's talk about the halogen atom first. In this molecule, both chlorine and fluorine atoms have certain electronegativity. The electronegativity of fluorine atoms is particularly strong, resulting in a change in the electron cloud density distribution of the benzene ring, which makes the electron cloud density of the benzene ring and the para-position relatively reduced, so the electrophilic substitution reaction activity is lower than that of benzene. When the electrophilic reagent attacks, the reaction check point tends to Although chlorine atoms also have electron-absorbing induction effects, their lone pair electrons are conjugated with benzene rings, which increases the electron cloud density of benzene rings, but the overall electrophilic substitution activity is still not as good as benzene.
In dichloromethyl (-CHCl ²), the carbon atom connected to the benzene ring is affected by two chlorine atoms, and the electron cloud is biased towards the chlorine atom. This carbon atom is relatively electron-deficient and vulnerable to attack by nucleophiles. When the nucleophile is close, the chlorine atom of dichloromethyl can be replaced, and a nucleophilic substitution reaction occurs.
Furthermore, due to the presence of halogen atoms, this compound can undergo elimination reaction. Under the action of appropriate bases, the halogen atoms and hydrogen atoms on adjacent carbon atoms can dehalide hydrogen to form unsaturated compounds containing carbon-carbon double bonds.
In addition, the bond energies of carbon-halogen bonds in this molecule vary, and under specific conditions, bond cracking and rearrangement reactions can occur. At high temperature, light or in the presence of specific catalysts, carbon-chlorine bonds or carbon-fluorine bonds may undergo homogeneous or heterocleavage, generating free radicals or ionic intermediates, which can then trigger a series of complex chemical reactions.
This compound is chemically active and has a wide range of uses in the field of organic synthesis. It can be used as an intermediate to participate in many reactions and prepare more complex organic compounds.
What are the physical properties of 1-chloro-2- (dichloromethyl) -3-fluorobenzene?
1-Chloro-2- (dichloromethyl) -3-fluorobenzene is one of the organic compounds. Its physical properties are quite important, let me tell you in detail.
Looking at its appearance, under room temperature and pressure, it is mostly in the form of a colorless to light yellow liquid. This color and shape are crucial for the identification and use of chemical and related fields. Its odor is often particularly irritating. This irritating odor should be treated with caution when handling this compound, because it may be irritating to the human respiratory tract and skin.
When talking about the boiling point, it is about within a certain temperature range. The boiling point is the temperature limit where the substance changes from liquid to gas. For 1-chloro-2- (dichloromethyl) -3-fluorobenzene, the value of its boiling point is related to the chemical operation process such as distillation and separation. Only by accurately grasping its boiling point can the compound be effectively separated from other substances in industrial production or experimental research, so as to achieve the purpose of purification or preparation of specific products.
Melting point is also one of the important physical properties. The melting point of 1-chloro-2- (dichloromethyl) -3-fluorobenzene determines its physical state at a specific temperature. When the ambient temperature is lower than the melting point, the compound will exist in a solid state; when it is higher than the melting point, it will be in a liquid state. This property also needs to be considered during storage and transportation to ensure that the compound maintains the required physical state and avoids morphological changes due to temperature changes, which affect its quality and performance.
Furthermore, its density cannot be ignored. In terms of density, the mass per unit volume of the substance is also. The density of 1-chloro-2 - (dichloromethyl) -3-fluorobenzene is of great significance in the measurement and mixing of chemical production. Knowing its density can accurately calculate the mass of the compound in a specific volume, and then accurately configure the reaction system to ensure the smooth progress of chemical reactions and the quality stability of the product.
In terms of solubility, 1-chloro-2- (dichloromethyl) -3-fluorobenzene often exhibits a certain solubility in organic solvents. For example, common organic solvents such as ethanol and ether can be miscible or partially miscible with them. This solubility property provides the possibility for its application as a reactant or solvent in organic synthesis reactions. By selecting suitable organic solvents, key factors such as reaction rate and product selectivity can be effectively regulated.
In summary, the physical properties of 1-chloro-2- (dichloromethyl) -3-fluorobenzene, such as appearance, odor, boiling point, melting point, density and solubility, play an indispensable role in chemical production, scientific research and many other fields. Only by accurately grasping its physical properties can we better utilize this compound and promote the development of related fields.
Looking at its appearance, under room temperature and pressure, it is mostly in the form of a colorless to light yellow liquid. This color and shape are crucial for the identification and use of chemical and related fields. Its odor is often particularly irritating. This irritating odor should be treated with caution when handling this compound, because it may be irritating to the human respiratory tract and skin.
When talking about the boiling point, it is about within a certain temperature range. The boiling point is the temperature limit where the substance changes from liquid to gas. For 1-chloro-2- (dichloromethyl) -3-fluorobenzene, the value of its boiling point is related to the chemical operation process such as distillation and separation. Only by accurately grasping its boiling point can the compound be effectively separated from other substances in industrial production or experimental research, so as to achieve the purpose of purification or preparation of specific products.
Melting point is also one of the important physical properties. The melting point of 1-chloro-2- (dichloromethyl) -3-fluorobenzene determines its physical state at a specific temperature. When the ambient temperature is lower than the melting point, the compound will exist in a solid state; when it is higher than the melting point, it will be in a liquid state. This property also needs to be considered during storage and transportation to ensure that the compound maintains the required physical state and avoids morphological changes due to temperature changes, which affect its quality and performance.
Furthermore, its density cannot be ignored. In terms of density, the mass per unit volume of the substance is also. The density of 1-chloro-2 - (dichloromethyl) -3-fluorobenzene is of great significance in the measurement and mixing of chemical production. Knowing its density can accurately calculate the mass of the compound in a specific volume, and then accurately configure the reaction system to ensure the smooth progress of chemical reactions and the quality stability of the product.
In terms of solubility, 1-chloro-2- (dichloromethyl) -3-fluorobenzene often exhibits a certain solubility in organic solvents. For example, common organic solvents such as ethanol and ether can be miscible or partially miscible with them. This solubility property provides the possibility for its application as a reactant or solvent in organic synthesis reactions. By selecting suitable organic solvents, key factors such as reaction rate and product selectivity can be effectively regulated.
In summary, the physical properties of 1-chloro-2- (dichloromethyl) -3-fluorobenzene, such as appearance, odor, boiling point, melting point, density and solubility, play an indispensable role in chemical production, scientific research and many other fields. Only by accurately grasping its physical properties can we better utilize this compound and promote the development of related fields.
What are the main uses of 1-chloro-2- (dichloromethyl) -3-fluorobenzene?
1-Chloro-2- (dichloromethyl) -3-fluorobenzene is also an organic compound. Its main use is wide, and it is important in the chemical industry.
First, it can be used as an intermediary for organic synthesis. The industry of organic synthesis requires various compounds as the basis for a series of reactions to obtain the target product. This compound is endowed with active chemical properties due to its unique structure, the existence of chlorine, fluorine and dichloromethyl, which can participate in various reactions. For example, nucleophilic substitution reactions, in which halogen atoms can be replaced by other nucleophiles, thereby constructing complex organic molecular structures. By means of nucleophilic substitution, different functional groups can be introduced to lay the foundation for the synthesis of organic compounds with specific properties and functions, such as the synthesis of new drug molecules, functional materials, etc.
Second, it is also valuable in the field of materials science. After appropriate chemical reactions, it can be introduced into the structure of polymer materials. Because it contains halogen atoms, it can endow materials with special properties, such as improving the flame retardancy of materials. Halogen atoms can capture free radicals during combustion, inhibit the chain transmission of combustion reactions, and make materials more difficult to burn. This is essential for enhancing the application value of materials in places with high fire safety requirements, such as building materials, electronic equipment shells, etc.
Third, in pharmaceutical chemistry research, it may become a key structural unit of lead compounds. Drug development often begins with the exploration of bioactive compounds. The structural characteristics of this compound may interact with specific targets in organisms. Through reasonable structural modification and optimization, it is expected to develop new drugs with high efficiency and low toxicity for the treatment and prevention of diseases. In short, 1-chloro-2- (dichloromethyl) -3-fluorobenzene, with its unique structure, plays an important role in many branches of chemical industry, providing a key foundation for the synthesis of new substances, the development of new materials, and the development of new drugs.
First, it can be used as an intermediary for organic synthesis. The industry of organic synthesis requires various compounds as the basis for a series of reactions to obtain the target product. This compound is endowed with active chemical properties due to its unique structure, the existence of chlorine, fluorine and dichloromethyl, which can participate in various reactions. For example, nucleophilic substitution reactions, in which halogen atoms can be replaced by other nucleophiles, thereby constructing complex organic molecular structures. By means of nucleophilic substitution, different functional groups can be introduced to lay the foundation for the synthesis of organic compounds with specific properties and functions, such as the synthesis of new drug molecules, functional materials, etc.
Second, it is also valuable in the field of materials science. After appropriate chemical reactions, it can be introduced into the structure of polymer materials. Because it contains halogen atoms, it can endow materials with special properties, such as improving the flame retardancy of materials. Halogen atoms can capture free radicals during combustion, inhibit the chain transmission of combustion reactions, and make materials more difficult to burn. This is essential for enhancing the application value of materials in places with high fire safety requirements, such as building materials, electronic equipment shells, etc.
Third, in pharmaceutical chemistry research, it may become a key structural unit of lead compounds. Drug development often begins with the exploration of bioactive compounds. The structural characteristics of this compound may interact with specific targets in organisms. Through reasonable structural modification and optimization, it is expected to develop new drugs with high efficiency and low toxicity for the treatment and prevention of diseases. In short, 1-chloro-2- (dichloromethyl) -3-fluorobenzene, with its unique structure, plays an important role in many branches of chemical industry, providing a key foundation for the synthesis of new substances, the development of new materials, and the development of new drugs.
What are the synthesis methods of 1-chloro-2- (dichloromethyl) -3-fluorobenzene?
The synthesis of 1-chloro-2- (dichloromethyl) -3-fluorobenzene is a key research in the field of organic synthetic chemistry. To obtain this compound, several paths are often followed.
One is to use a specific fluorobenzene derivative as the starting material. First, the fluorobenzene is halogenated with a suitable halogenating agent, such as a chlorine-containing halogenating agent, under suitable reaction conditions, such as in the presence of a specific catalyst and moderate temperature control. This step aims to introduce chlorine atoms at a specific position in the benzene ring to construct a preliminary halogenated structure. Subsequently, the obtained halogenated product is introduced into a dichloromethyl group by means of a specific nucleophilic substitution reaction. This process requires careful selection of nucleophilic reagents and strict control of reaction conditions, such as reaction solvent, temperature and time, to ensure that the reaction advances in the expected direction and efficiently generates the target product 1-chloro-2 - (dichloromethyl) -3 -fluorobenzene.
Second, it can also be started from another angle. Using chlorobenzene-containing derivatives as starting materials, fluorine atoms are first introduced through fluorine substitution reaction. The conditions of this fluorine substitution reaction are quite critical. It is necessary to select suitable fluorine substitutes and catalysts, and precisely regulate the reaction temperature and reaction time, so that the fluorine atoms are properly connected to the designated position of the benzene ring. Then, through subsequent halogenation and related substitution reactions, dichloromethyl and the remaining chlorine atoms are gradually introduced to eventually achieve the target compound.
In addition, benzene can also be considered as the starting material and constructed through multi-step continuous reaction. First, benzene is chlorinated and fluorinated to form a specific halogenated benzene intermediate, and then through multi-step functional group conversion and introduction, the structure of dichloromethyl is methodically constructed, and finally the synthesis of 1-chloro-2- (dichloromethyl) -3-fluorobenzene is achieved. However, there are many steps in this path, and the requirements for the control of reaction conditions and the separation and purification of intermediate products are quite high, so caution must be taken.
All synthesis methods have their own advantages and disadvantages. In practice, it is necessary to comprehensively consider many factors such as raw material cost, feasibility of reaction conditions, yield and product purity, and carefully select the most suitable synthesis path to achieve the efficient synthesis of 1-chloro-2- (dichloromethyl) -3-fluorobenzene.
One is to use a specific fluorobenzene derivative as the starting material. First, the fluorobenzene is halogenated with a suitable halogenating agent, such as a chlorine-containing halogenating agent, under suitable reaction conditions, such as in the presence of a specific catalyst and moderate temperature control. This step aims to introduce chlorine atoms at a specific position in the benzene ring to construct a preliminary halogenated structure. Subsequently, the obtained halogenated product is introduced into a dichloromethyl group by means of a specific nucleophilic substitution reaction. This process requires careful selection of nucleophilic reagents and strict control of reaction conditions, such as reaction solvent, temperature and time, to ensure that the reaction advances in the expected direction and efficiently generates the target product 1-chloro-2 - (dichloromethyl) -3 -fluorobenzene.
Second, it can also be started from another angle. Using chlorobenzene-containing derivatives as starting materials, fluorine atoms are first introduced through fluorine substitution reaction. The conditions of this fluorine substitution reaction are quite critical. It is necessary to select suitable fluorine substitutes and catalysts, and precisely regulate the reaction temperature and reaction time, so that the fluorine atoms are properly connected to the designated position of the benzene ring. Then, through subsequent halogenation and related substitution reactions, dichloromethyl and the remaining chlorine atoms are gradually introduced to eventually achieve the target compound.
In addition, benzene can also be considered as the starting material and constructed through multi-step continuous reaction. First, benzene is chlorinated and fluorinated to form a specific halogenated benzene intermediate, and then through multi-step functional group conversion and introduction, the structure of dichloromethyl is methodically constructed, and finally the synthesis of 1-chloro-2- (dichloromethyl) -3-fluorobenzene is achieved. However, there are many steps in this path, and the requirements for the control of reaction conditions and the separation and purification of intermediate products are quite high, so caution must be taken.
All synthesis methods have their own advantages and disadvantages. In practice, it is necessary to comprehensively consider many factors such as raw material cost, feasibility of reaction conditions, yield and product purity, and carefully select the most suitable synthesis path to achieve the efficient synthesis of 1-chloro-2- (dichloromethyl) -3-fluorobenzene.
What are the precautions for storing and transporting 1-chloro-2- (dichloromethyl) -3-fluorobenzene?
1-Chloro-2- (dichloromethyl) -3-fluorobenzene is an organic compound. During storage and transportation, many matters need to be paid attention to.
First talk about storage, this compound needs to be stored in a cool and well-ventilated place. Because it has certain chemical activity, it is easy to react when heated, and even has safety concerns, so the temperature should be controlled in a low range, away from heat and fire sources. Furthermore, it is necessary to keep it dry, because it may react with water, which will affect the quality and even cause danger, so the storage place should not be humid. In addition, it needs to be stored separately from oxidizing agents, alkalis, etc. Because of the chemical activity of the compound, contact with these substances is prone to chemical reactions, or serious consequences such as fire and explosion.
As for transportation, the first thing is to ensure that the packaging is complete and well sealed. In this way, it can not only prevent environmental pollution caused by leakage, but also avoid its contact with external substances to react. During transportation, it should be lightly loaded and unloaded, and must not be loaded and unloaded brutally to prevent package damage. At the same time, the means of transportation must also be kept clean, dry, and equipped with safety facilities such as fire prevention and explosion protection. Transport personnel must be professionally trained, familiar with the characteristics of the compound and emergency treatment methods, and pay close attention to the status of the goods on the way. Once any abnormalities are detected, appropriate measures should be taken immediately.
In summary, 1-chloro-2- (dichloromethyl) -3-fluorobenzene is subject to strict regulations during storage and transportation, from environmental conditions to packaging and handling, to personnel professional requirements, in order to ensure safety and avoid accidents.
First talk about storage, this compound needs to be stored in a cool and well-ventilated place. Because it has certain chemical activity, it is easy to react when heated, and even has safety concerns, so the temperature should be controlled in a low range, away from heat and fire sources. Furthermore, it is necessary to keep it dry, because it may react with water, which will affect the quality and even cause danger, so the storage place should not be humid. In addition, it needs to be stored separately from oxidizing agents, alkalis, etc. Because of the chemical activity of the compound, contact with these substances is prone to chemical reactions, or serious consequences such as fire and explosion.
As for transportation, the first thing is to ensure that the packaging is complete and well sealed. In this way, it can not only prevent environmental pollution caused by leakage, but also avoid its contact with external substances to react. During transportation, it should be lightly loaded and unloaded, and must not be loaded and unloaded brutally to prevent package damage. At the same time, the means of transportation must also be kept clean, dry, and equipped with safety facilities such as fire prevention and explosion protection. Transport personnel must be professionally trained, familiar with the characteristics of the compound and emergency treatment methods, and pay close attention to the status of the goods on the way. Once any abnormalities are detected, appropriate measures should be taken immediately.
In summary, 1-chloro-2- (dichloromethyl) -3-fluorobenzene is subject to strict regulations during storage and transportation, from environmental conditions to packaging and handling, to personnel professional requirements, in order to ensure safety and avoid accidents.
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