Linshang Chemical
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1-Chloro-2-Fluoro-3-Nitrobenzene
Linshang Chemical
|
HS Code |
886186 |
| Chemical Formula | C6H3ClFNO2 |
| Molar Mass | 177.545 g/mol |
| Appearance | Yellow - liquid |
| Boiling Point | 213 - 214 °C |
| Density | 1.499 g/cm³ |
| Flash Point | 86.1 °C |
| Solubility In Water | Insoluble |
| Vapor Pressure | Low |
| Stability | Stable under normal conditions |
| Hazard Class | Irritant |
As an accredited 1-Chloro-2-Fluoro-3-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1 - chloro - 2 - fluoro - 3 - nitrobenzene packaged in a sealed, corrosion - resistant bottle. |
| Storage | 1 - Chloro - 2 - fluoro - 3 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from sources of heat, ignition, and direct sunlight. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals to prevent potential reactions. |
| Shipping | 1 - chloro - 2 - fluoro - 3 - nitrobenzene is a hazardous chemical. Shipping requires proper packaging in accordance with regulations. It must be labeled clearly and transported by carriers approved for hazardous substances. |
Competitive 1-Chloro-2-Fluoro-3-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Chloro-2-Fluoro-3-Nitrobenzene in China?
As a trusted 1-Chloro-2-Fluoro-3-Nitrobenzene manufacturer, we deliver:
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Chloro-2-Fluoro-3-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-2-fluoro-3-nitrobenzene?
1 - chloro - 2 - fluoro - 3 - nitrobenzene is an organic compound with a wide range of main uses.
In the field of organic synthesis, this compound is often used as a key intermediate. Because the chlorine, fluorine and nitro groups attached to the benzene ring have certain reactivity, they can be modified by various chemical reactions. For example, chlorine atoms can be replaced by other nucleophiles through nucleophilic substitution reactions, and then various organic molecules with different structures can be constructed; nitro groups can be reduced to amino groups, expanding the reaction path of compounds, and assisting in the synthesis of many nitrogen-containing organic compounds, which is of great significance in drug synthesis and material preparation.
In medicinal chemistry, 1-chloro-2-fluoro-3-nitrobenzene can be converted through a series of reactions, or can become a drug molecule or lead compound with specific biological activities. Due to its unique molecular structure, or can interact with specific targets in vivo, it can be used as a starting material in the development of new drugs, laying the foundation for the creation of novel drug structures.
In the field of materials science, organic materials synthesized from this raw material may have special electrical and optical properties. The synergistic effect of benzene ring structure with chlorine, fluorine, and nitro groups may enable materials to exhibit unique properties. For example, in the field of organic optoelectronic materials, it can be used to prepare materials required for devices such as Light Emitting Diode and solar cells to improve the functionality and performance of materials.
In addition, in the preparation of fine chemical products, 1-chloro-2-fluoro-3-nitrobenzene also plays an important role. Or it can be used to synthesize fine chemicals such as special dyes, fragrances, and additives. Through structural modification and derivatization, fine chemical products are endowed with unique properties and functions to meet the specific needs of different industries.
In the field of organic synthesis, this compound is often used as a key intermediate. Because the chlorine, fluorine and nitro groups attached to the benzene ring have certain reactivity, they can be modified by various chemical reactions. For example, chlorine atoms can be replaced by other nucleophiles through nucleophilic substitution reactions, and then various organic molecules with different structures can be constructed; nitro groups can be reduced to amino groups, expanding the reaction path of compounds, and assisting in the synthesis of many nitrogen-containing organic compounds, which is of great significance in drug synthesis and material preparation.
In medicinal chemistry, 1-chloro-2-fluoro-3-nitrobenzene can be converted through a series of reactions, or can become a drug molecule or lead compound with specific biological activities. Due to its unique molecular structure, or can interact with specific targets in vivo, it can be used as a starting material in the development of new drugs, laying the foundation for the creation of novel drug structures.
In the field of materials science, organic materials synthesized from this raw material may have special electrical and optical properties. The synergistic effect of benzene ring structure with chlorine, fluorine, and nitro groups may enable materials to exhibit unique properties. For example, in the field of organic optoelectronic materials, it can be used to prepare materials required for devices such as Light Emitting Diode and solar cells to improve the functionality and performance of materials.
In addition, in the preparation of fine chemical products, 1-chloro-2-fluoro-3-nitrobenzene also plays an important role. Or it can be used to synthesize fine chemicals such as special dyes, fragrances, and additives. Through structural modification and derivatization, fine chemical products are endowed with unique properties and functions to meet the specific needs of different industries.
What are the physical properties of 1-chloro-2-fluoro-3-nitrobenzene?
1-Chloro-2-fluoro-3-nitrobenzene is also an organic compound. Its physical properties are as follows:
Under normal conditions, it is a colorless to light yellow liquid. This is due to the action of chlorine, fluorine, nitro and other groups in its molecular structure, which makes it appear like this. Its pungent taste is due to the presence of nitro and halogen atoms. Such groups have strong chemical activity and can stimulate the olfactory nerve.
When it comes to melting point, it is between -20 ° C and -15 ° C, which is determined by intermolecular forces. The chlorine and fluorine atoms in the molecule are relatively small, and the steric hindrance is not large. Although the nitro group is slightly larger, the overall molecular arrangement does not reach a tight and orderly state, and the melting point is not high. The boiling point of
is about 200 ° C to 210 ° C. Due to the fact that in addition to van der Waals force, there is still a certain dipole-dipole interaction between molecules. The electronegativity difference between chlorine, fluorine and nitro groups makes the molecule polar and enhances the attraction between molecules, so the boiling point is higher.
In terms of solubility, it is extremely insoluble in water, because water is a very polar solvent, and 1-chloro-2-fluoro-3-nitrobenzene has polarity, but the proportion of organic groups is relatively large, and the interaction with water is weak. On the contrary, in most organic solvents such as ethanol, ether, benzene, etc., it is very soluble. Due to the principle of "similar compatibility", organic solvents and compounds have organic structural characteristics, and the intermolecular forces are similar, so they can be miscible.
Its density is greater than that of water, about 1.5 g/cm ³. Due to the fact that the chlorine and fluorine atoms in its molecules are relatively large in atomic weight, and the nitro group also increases the molecular weight, making the unit volume mass greater than that of water.
In addition, the compound is volatile. Although it is not as volatile as small molecule organic compounds, it will also evaporate slowly under normal temperature exposure, which is related to the intermolecular force and boiling point. After the molecule is energized, part of the liquid phase escapes into the gas phase.
Under normal conditions, it is a colorless to light yellow liquid. This is due to the action of chlorine, fluorine, nitro and other groups in its molecular structure, which makes it appear like this. Its pungent taste is due to the presence of nitro and halogen atoms. Such groups have strong chemical activity and can stimulate the olfactory nerve.
When it comes to melting point, it is between -20 ° C and -15 ° C, which is determined by intermolecular forces. The chlorine and fluorine atoms in the molecule are relatively small, and the steric hindrance is not large. Although the nitro group is slightly larger, the overall molecular arrangement does not reach a tight and orderly state, and the melting point is not high. The boiling point of
is about 200 ° C to 210 ° C. Due to the fact that in addition to van der Waals force, there is still a certain dipole-dipole interaction between molecules. The electronegativity difference between chlorine, fluorine and nitro groups makes the molecule polar and enhances the attraction between molecules, so the boiling point is higher.
In terms of solubility, it is extremely insoluble in water, because water is a very polar solvent, and 1-chloro-2-fluoro-3-nitrobenzene has polarity, but the proportion of organic groups is relatively large, and the interaction with water is weak. On the contrary, in most organic solvents such as ethanol, ether, benzene, etc., it is very soluble. Due to the principle of "similar compatibility", organic solvents and compounds have organic structural characteristics, and the intermolecular forces are similar, so they can be miscible.
Its density is greater than that of water, about 1.5 g/cm ³. Due to the fact that the chlorine and fluorine atoms in its molecules are relatively large in atomic weight, and the nitro group also increases the molecular weight, making the unit volume mass greater than that of water.
In addition, the compound is volatile. Although it is not as volatile as small molecule organic compounds, it will also evaporate slowly under normal temperature exposure, which is related to the intermolecular force and boiling point. After the molecule is energized, part of the liquid phase escapes into the gas phase.
What is the chemical synthesis method of 1-chloro-2-fluoro-3-nitrobenzene?
The chemical synthesis of 1-chloro-2-fluoro-3-nitrobenzene is a key issue in the field of organic synthesis. To prepare this compound, the following steps can be followed.
The starting material is often selected as a suitable benzene derivative. The benzene can be nitrified first to introduce nitro groups. In the mixed acid system of sulfuric acid and nitric acid, benzene can be smoothly converted into nitrobenzene. This reaction condition needs to be precisely controlled, such as temperature, mixed acid ratio, etc., to prevent the occurrence of polynitroylation side reactions.
After nitrobenzene is obtained, it can be halogenated. Because the introduction sequence and position of fluorine and chlorine atoms are very important. In the fluorination reaction, specific fluorination reagents, such as Selectfluor, can be selected. In the presence of suitable solvents and catalysts, nitrobenzene can be fluorinated at specific positions to generate fluorine-containing nitrobenzene derivatives. In this step, the polarity of the solvent, the type and dosage of the catalyst will all affect the selectivity and yield of the reaction.
Then, the chlorination reaction is carried out. Select suitable chlorination reagents, such as sulfoxide chloride, phosphorus oxychloride, etc., and introduce chlorine atoms into the target position under appropriate reaction conditions to achieve the synthesis of 1-chloro-2-fluoro-3-nitrobenzene. After the reaction is completed, it still needs to be separated and purified. The commonly used methods include distillation, column chromatography, etc., to obtain high-purity products.
The entire synthesis process has strict requirements on reaction conditions, raw material proportions, and reagent selection. Each step is related to each other and needs to be carefully regulated to synthesize 1-chloro-2-fluoro-3-nitrobenzene with high efficiency and high purity.
The starting material is often selected as a suitable benzene derivative. The benzene can be nitrified first to introduce nitro groups. In the mixed acid system of sulfuric acid and nitric acid, benzene can be smoothly converted into nitrobenzene. This reaction condition needs to be precisely controlled, such as temperature, mixed acid ratio, etc., to prevent the occurrence of polynitroylation side reactions.
After nitrobenzene is obtained, it can be halogenated. Because the introduction sequence and position of fluorine and chlorine atoms are very important. In the fluorination reaction, specific fluorination reagents, such as Selectfluor, can be selected. In the presence of suitable solvents and catalysts, nitrobenzene can be fluorinated at specific positions to generate fluorine-containing nitrobenzene derivatives. In this step, the polarity of the solvent, the type and dosage of the catalyst will all affect the selectivity and yield of the reaction.
Then, the chlorination reaction is carried out. Select suitable chlorination reagents, such as sulfoxide chloride, phosphorus oxychloride, etc., and introduce chlorine atoms into the target position under appropriate reaction conditions to achieve the synthesis of 1-chloro-2-fluoro-3-nitrobenzene. After the reaction is completed, it still needs to be separated and purified. The commonly used methods include distillation, column chromatography, etc., to obtain high-purity products.
The entire synthesis process has strict requirements on reaction conditions, raw material proportions, and reagent selection. Each step is related to each other and needs to be carefully regulated to synthesize 1-chloro-2-fluoro-3-nitrobenzene with high efficiency and high purity.
1-chloro-2-fluoro-3-nitrobenzene What are the precautions during storage and transportation?
1-Chloro-2-fluoro-3-nitrobenzene is also an organic compound. When storing and transporting, you must pay attention to many matters to ensure security.
First, when storing, you must choose a cool and well-ventilated place. Because of its flammability, if it is heated or exposed to open flames, it may cause fire risk. Under high temperature, its chemical properties or become active, causing dangerous reactions. Therefore, the warehouse temperature should be controlled within a reasonable range and must not be too high.
Second, this compound should be stored separately from oxidants, edible chemicals, etc., and must not be mixed. Because its structure contains nitro groups, it is oxidizing. If it coexists with other oxidants, it may cause violent chemical reactions and cause serious consequences such as explosion. Mixed with edible chemicals, it is easy to contaminate food and endanger human health.
Third, the storage area should be equipped with suitable materials to contain leaks. If a leak occurs accidentally, it can be collected in time to prevent its spread and cause greater harm to the environment.
Fourth, during transportation, it is necessary to ensure that the container does not leak, collapse, fall, or damage. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. Driving routes should also be reasonably selected to avoid densely populated areas and important facilities to prevent major casualties and losses in the event of an accident.
Fifth, when the operator handles this object, it must be handled lightly to avoid collision and friction. Due to its relatively active nature, improper operation or package damage will cause leakage.
In short, 1-chloro-2-fluoro-3-nitrobenzene should be stored and transported in strict accordance with safety regulations and carefully operated to prevent various dangerous accidents.
First, when storing, you must choose a cool and well-ventilated place. Because of its flammability, if it is heated or exposed to open flames, it may cause fire risk. Under high temperature, its chemical properties or become active, causing dangerous reactions. Therefore, the warehouse temperature should be controlled within a reasonable range and must not be too high.
Second, this compound should be stored separately from oxidants, edible chemicals, etc., and must not be mixed. Because its structure contains nitro groups, it is oxidizing. If it coexists with other oxidants, it may cause violent chemical reactions and cause serious consequences such as explosion. Mixed with edible chemicals, it is easy to contaminate food and endanger human health.
Third, the storage area should be equipped with suitable materials to contain leaks. If a leak occurs accidentally, it can be collected in time to prevent its spread and cause greater harm to the environment.
Fourth, during transportation, it is necessary to ensure that the container does not leak, collapse, fall, or damage. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. Driving routes should also be reasonably selected to avoid densely populated areas and important facilities to prevent major casualties and losses in the event of an accident.
Fifth, when the operator handles this object, it must be handled lightly to avoid collision and friction. Due to its relatively active nature, improper operation or package damage will cause leakage.
In short, 1-chloro-2-fluoro-3-nitrobenzene should be stored and transported in strict accordance with safety regulations and carefully operated to prevent various dangerous accidents.
1-chloro-2-fluoro-3-nitrobenzene impact on the environment and human health
1-Chloro-2-fluoro-3-nitrobenzene is also an organic compound. Its impact on the environment and human health cannot be ignored.
At the environmental end, this compound has a certain stability and is not easy to decompose naturally. If it flows into natural water bodies and soils, it may persist for a long time. It may be toxic to aquatic organisms and damage the balance of aquatic ecosystems. If fish, plankton, etc. come into contact with it, it may cause physiological disturbances, growth, reproduction, and even death. In soil, it may affect the activity and community structure of soil microorganisms, and hinder the normal material cycle and nutrient transformation of soil.
As for personal health, 1-chloro-2-fluoro-3-nitrobenzene may be very harmful after being ingested into the human body through breathing, skin contact or diet. Respiratory inhalation, or irritation of respiratory mucosa, causing cough, asthma, breathing difficulties and other diseases. Skin contact, or cause contact dermatitis, redness, swelling, itching, pain. If ingested by mistake, or damage the digestive system, cause nausea, vomiting, abdominal pain, diarrhea. What's more, this compound may be potentially carcinogenic, teratogenic, mutagenic, long-term exposure, or increase the risk of cancer, affect reproductive cells, endanger the health of future generations. Therefore, 1-chloro-2-fluoro-3-nitrobenzene poses a potential threat to both the environment and human health. When it is produced, used, and disposed of, it should be done with caution to reduce its negative effects.
At the environmental end, this compound has a certain stability and is not easy to decompose naturally. If it flows into natural water bodies and soils, it may persist for a long time. It may be toxic to aquatic organisms and damage the balance of aquatic ecosystems. If fish, plankton, etc. come into contact with it, it may cause physiological disturbances, growth, reproduction, and even death. In soil, it may affect the activity and community structure of soil microorganisms, and hinder the normal material cycle and nutrient transformation of soil.
As for personal health, 1-chloro-2-fluoro-3-nitrobenzene may be very harmful after being ingested into the human body through breathing, skin contact or diet. Respiratory inhalation, or irritation of respiratory mucosa, causing cough, asthma, breathing difficulties and other diseases. Skin contact, or cause contact dermatitis, redness, swelling, itching, pain. If ingested by mistake, or damage the digestive system, cause nausea, vomiting, abdominal pain, diarrhea. What's more, this compound may be potentially carcinogenic, teratogenic, mutagenic, long-term exposure, or increase the risk of cancer, affect reproductive cells, endanger the health of future generations. Therefore, 1-chloro-2-fluoro-3-nitrobenzene poses a potential threat to both the environment and human health. When it is produced, used, and disposed of, it should be done with caution to reduce its negative effects.
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