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1-Chloro-2-Fluoro-3-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
392885 |
| Chemical Formula | C7H3ClF4 |
| Molecular Weight | 198.54 |
| Appearance | Liquid (usually) |
| Boiling Point | Approximately 130 - 135 °C |
| Density | Data may vary, but around 1.4 - 1.5 g/cm³ |
| Vapor Pressure | Low, volatile organic compound properties suggest relatively low vapor pressure |
| Solubility In Water | Poorly soluble, as it's an organic halogenated compound |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Flash Point | No specific common data, but likely flammable due to organic nature |
As an accredited 1-Chloro-2-Fluoro-3-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 2 - fluoro - 3 - (trifluoromethyl)benzene packaged in 500 - mL bottles. |
| Storage | 1 - Chloro - 2 - fluoro - 3 - (trifluoromethyl)benzene should be stored in a cool, well - ventilated area away from heat sources and open flames. Keep it in a tightly - sealed container to prevent leakage. As it is a chemical, store it separately from incompatible substances, like oxidizing agents and bases, in a designated chemical storage area to ensure safety. |
| Shipping | 1 - chloro - 2 - fluoro - 3 - (trifluoromethyl)benzene is shipped in well - sealed, corrosion - resistant containers. Shipment follows strict hazardous chemical regulations, ensuring proper handling, storage, and transportation to prevent leaks and risks. |
Competitive 1-Chloro-2-Fluoro-3-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
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What are the main uses of 1-chloro-2-fluoro-3- (trifluoromethyl) benzene?
1-Chloro-2-fluoro-3- (trifluoromethyl) benzene, this is an organic compound with important uses in many fields.
In the field of medicinal chemistry, it is often used as a key intermediate. Due to the special structure of this compound, it can endow the synthesized drug with unique properties. With the combination of benzene ring, chlorine, fluorine and trifluoromethyl, it can participate in a variety of chemical reactions and help to construct molecular structures with specific pharmacological activities. For example, when developing new antibacterial drugs, it can be used to participate in the reaction and introduce suitable functional groups to enhance the affinity and inhibition of the drug on bacteria and improve the antibacterial effect.
In the field of materials science, 1-chloro-2-fluoro-3- (trifluoromethyl) benzene also has outstanding performance. Due to its fluorine-containing atoms, it can be used to prepare high-performance materials. The introduction of fluorine atoms can significantly improve the chemical stability, thermal stability and corrosion resistance of materials. For example, when preparing special coating materials, this compound can be used as raw material, and the coating can have excellent weather resistance and chemical resistance through specific reactions, which is suitable for harsh environments, such as marine, chemical and other fields.
In the field of pesticide chemistry, its role should not be underestimated. Fluorinated organic compounds often have high biological activity against pests and weeds. 1-Chloro-2-fluoro-3- (trifluoromethyl) benzene can be used as an important starting material for the synthesis of new pesticides. After chemical modification and reaction, a pesticide with a unique mechanism of action can be obtained, which enhances the killing or inhibitory effect on target organisms. And because of its special structure, it may have environmentally friendly properties and reduce the adverse effects on non-target organisms and the environment.
In short, 1-chloro-2-fluoro-3- (trifluoromethyl) benzene has become an indispensable and important compound in many fields such as medicine, materials, and pesticides, providing key support for technological development and product innovation in various fields.
In the field of medicinal chemistry, it is often used as a key intermediate. Due to the special structure of this compound, it can endow the synthesized drug with unique properties. With the combination of benzene ring, chlorine, fluorine and trifluoromethyl, it can participate in a variety of chemical reactions and help to construct molecular structures with specific pharmacological activities. For example, when developing new antibacterial drugs, it can be used to participate in the reaction and introduce suitable functional groups to enhance the affinity and inhibition of the drug on bacteria and improve the antibacterial effect.
In the field of materials science, 1-chloro-2-fluoro-3- (trifluoromethyl) benzene also has outstanding performance. Due to its fluorine-containing atoms, it can be used to prepare high-performance materials. The introduction of fluorine atoms can significantly improve the chemical stability, thermal stability and corrosion resistance of materials. For example, when preparing special coating materials, this compound can be used as raw material, and the coating can have excellent weather resistance and chemical resistance through specific reactions, which is suitable for harsh environments, such as marine, chemical and other fields.
In the field of pesticide chemistry, its role should not be underestimated. Fluorinated organic compounds often have high biological activity against pests and weeds. 1-Chloro-2-fluoro-3- (trifluoromethyl) benzene can be used as an important starting material for the synthesis of new pesticides. After chemical modification and reaction, a pesticide with a unique mechanism of action can be obtained, which enhances the killing or inhibitory effect on target organisms. And because of its special structure, it may have environmentally friendly properties and reduce the adverse effects on non-target organisms and the environment.
In short, 1-chloro-2-fluoro-3- (trifluoromethyl) benzene has become an indispensable and important compound in many fields such as medicine, materials, and pesticides, providing key support for technological development and product innovation in various fields.
What are the physical properties of 1-chloro-2-fluoro-3- (trifluoromethyl) benzene
1-Chloro-2-fluoro-3- (trifluoromethyl) benzene, this is an organic compound. Its physical properties are quite critical and are of great significance in various fields such as chemicals and materials.
Looking at its properties, under room temperature and pressure, it is mostly colorless to light yellow liquid. Smell, or have a special smell, but the description of this smell is not exactly unified, because different people have different olfactory sensations.
When it comes to boiling point, it is about a certain temperature range, but the exact value will vary slightly depending on the measurement conditions. It is probably in a certain temperature range, which is determined by the intermolecular forces. In its molecular structure, the presence of atoms such as chlorine and fluorine makes the intermolecular forces unique, which affects the boiling point.
In terms of melting point, it is also a specific temperature. This temperature reflects the critical condition for the substance to change from a solid state to a liquid state. The melting point of the compound is determined by its crystal structure and intermolecular interactions.
In terms of density, it is a certain value, usually expressed in grams per cubic centimeter. The density is related to the mass of the molecule and the degree of close arrangement between molecules. The relative atomic mass and spatial arrangement of each atom in this compound jointly determine its density characteristics.
In terms of solubility, in organic solvents such as ethanol, ether, etc., there may be a certain solubility. However, in water, because the compound is an organohalogenated compound with a large polar difference from water, its solubility is poor. This solubility characteristic has important applications in chemical synthesis, separation and purification.
The physical properties of 1-chloro-2-fluoro-3- (trifluoromethyl) benzene, whether its appearance, boiling point, melting point, density, or solubility, are determined by its unique molecular structure, and play a pivotal role in many chemical-related applications.
Looking at its properties, under room temperature and pressure, it is mostly colorless to light yellow liquid. Smell, or have a special smell, but the description of this smell is not exactly unified, because different people have different olfactory sensations.
When it comes to boiling point, it is about a certain temperature range, but the exact value will vary slightly depending on the measurement conditions. It is probably in a certain temperature range, which is determined by the intermolecular forces. In its molecular structure, the presence of atoms such as chlorine and fluorine makes the intermolecular forces unique, which affects the boiling point.
In terms of melting point, it is also a specific temperature. This temperature reflects the critical condition for the substance to change from a solid state to a liquid state. The melting point of the compound is determined by its crystal structure and intermolecular interactions.
In terms of density, it is a certain value, usually expressed in grams per cubic centimeter. The density is related to the mass of the molecule and the degree of close arrangement between molecules. The relative atomic mass and spatial arrangement of each atom in this compound jointly determine its density characteristics.
In terms of solubility, in organic solvents such as ethanol, ether, etc., there may be a certain solubility. However, in water, because the compound is an organohalogenated compound with a large polar difference from water, its solubility is poor. This solubility characteristic has important applications in chemical synthesis, separation and purification.
The physical properties of 1-chloro-2-fluoro-3- (trifluoromethyl) benzene, whether its appearance, boiling point, melting point, density, or solubility, are determined by its unique molecular structure, and play a pivotal role in many chemical-related applications.
1-chloro-2-fluoro-3- (trifluoromethyl) benzene
1 - chloro - 2 - fluoro - 3 - (trifluoromethyl) benzene is an organic compound, and its chemical properties are particularly important. The investigation of its properties is of great significance in organic synthesis and related fields.
This compound is aromatic, because of its benzene ring structure, and the benzene ring conjugation system gives it special stability. The delocalization of the benzene ring electron cloud makes it difficult to undergo addition reactions, while the electrophilic substitution reaction is a typical reaction path.
As far as the substituent is concerned, both chlorine and fluorine atoms have electron-withdrawing induction effects, which can reduce the electron cloud density of the benzene ring. However, the two also have electron-withdrawing conjugation effects, but this effect is weaker than the electron-withdrawing induction effect. As for trifluoromethyl, its strong electron absorption can greatly reduce the electron cloud density of the benzene ring, which in turn affects the activity of the electrophilic substitution reaction of the benzene ring. The presence of this substituent decreases the electron cloud density of the benzene ring ortho and para-position especially, and the meta-position is relatively high, so the electrophilic substitution reaction is prone to occur in the meta-position.
In the electrophilic substitution reaction, during the halogenation reaction, the electron cloud density of the benzene ring is reduced, and the reaction conditions are more severe than that of benzene. For example, during bromination, a catalyst may be required and the temperature is increased. The nitrification reaction is also similar, and more intense conditions are required, and due to the influence of trifluoromethyl, nitro groups are mainly introduced into the meta-position.
Chlorine atoms are relatively active and can be replaced under appropriate nucleophilic reagents and conditions. For example, when reacting with sodium alcohol, chlorine atoms can be replaced by alkoxy groups to form corresponding ether compounds.
Its chemical properties are determined by the interaction of phenyl rings and various substituents. In the field of organic synthesis, it can be used as an important intermediate to construct various complex organic molecules by means of electrophilic substitution, nucleophilic substitution and other reactions.
This compound is aromatic, because of its benzene ring structure, and the benzene ring conjugation system gives it special stability. The delocalization of the benzene ring electron cloud makes it difficult to undergo addition reactions, while the electrophilic substitution reaction is a typical reaction path.
As far as the substituent is concerned, both chlorine and fluorine atoms have electron-withdrawing induction effects, which can reduce the electron cloud density of the benzene ring. However, the two also have electron-withdrawing conjugation effects, but this effect is weaker than the electron-withdrawing induction effect. As for trifluoromethyl, its strong electron absorption can greatly reduce the electron cloud density of the benzene ring, which in turn affects the activity of the electrophilic substitution reaction of the benzene ring. The presence of this substituent decreases the electron cloud density of the benzene ring ortho and para-position especially, and the meta-position is relatively high, so the electrophilic substitution reaction is prone to occur in the meta-position.
In the electrophilic substitution reaction, during the halogenation reaction, the electron cloud density of the benzene ring is reduced, and the reaction conditions are more severe than that of benzene. For example, during bromination, a catalyst may be required and the temperature is increased. The nitrification reaction is also similar, and more intense conditions are required, and due to the influence of trifluoromethyl, nitro groups are mainly introduced into the meta-position.
Chlorine atoms are relatively active and can be replaced under appropriate nucleophilic reagents and conditions. For example, when reacting with sodium alcohol, chlorine atoms can be replaced by alkoxy groups to form corresponding ether compounds.
Its chemical properties are determined by the interaction of phenyl rings and various substituents. In the field of organic synthesis, it can be used as an important intermediate to construct various complex organic molecules by means of electrophilic substitution, nucleophilic substitution and other reactions.
What are the synthesis methods of 1-chloro-2-fluoro-3- (trifluoromethyl) benzene
There are many ways to synthesize 1-chloro-2-fluoro-3- (trifluoromethyl) benzene. The common one is to use aromatic hydrocarbons containing corresponding substituents as the starting material and prepare them by halogenation reaction. If 2-fluoro-3- (trifluoromethyl) benzoic acid is used as the raw material, it is first converted into the corresponding acid chloride, and then through the Sandmeier reaction, with cuprous chloride as the catalyst, interacting with hydrogen chloride and sodium nitrite, chlorine atoms can be introduced to obtain the target product.
Furthermore, starting from 1-chloro-2-fluorobenzene, through the Fu-gram alkylation reaction, with trifluoromethylation reagents, such as trifluoromethyl magnesium halide, etc., in the presence of a suitable catalyst such as anhydrous aluminum trichloride, trifluoromethyl can also be introduced to obtain 1-chloro-2-fluoro-3- (trifluoromethyl) benzene. This process requires attention to the control of reaction conditions. Because the Fu-gram reaction is prone to side reactions such as multiple substitution, temperature, reagent ratio and other factors have a great influence on the reaction.
Another method is to couple halogenated aromatics with organometallic reagents containing trifluoromethyl groups. For example, 1-chloro-2-fluorobenzene and zinc or magnesium reagents containing trifluoromethyl groups are coupled under the catalysis of transition metal catalysts such as palladium or nickel, and the target product can be obtained. Such coupling reaction conditions are relatively mild, but the choice and dosage of catalysts have a significant impact on the reaction efficiency and selectivity, and the preparation of organic metal reagents also requires certain skills and conditions.
When synthesizing this compound, the appropriate synthesis method should be weighed according to various factors such as the availability of raw materials, the difficulty of reaction conditions, cost and yield.
Furthermore, starting from 1-chloro-2-fluorobenzene, through the Fu-gram alkylation reaction, with trifluoromethylation reagents, such as trifluoromethyl magnesium halide, etc., in the presence of a suitable catalyst such as anhydrous aluminum trichloride, trifluoromethyl can also be introduced to obtain 1-chloro-2-fluoro-3- (trifluoromethyl) benzene. This process requires attention to the control of reaction conditions. Because the Fu-gram reaction is prone to side reactions such as multiple substitution, temperature, reagent ratio and other factors have a great influence on the reaction.
Another method is to couple halogenated aromatics with organometallic reagents containing trifluoromethyl groups. For example, 1-chloro-2-fluorobenzene and zinc or magnesium reagents containing trifluoromethyl groups are coupled under the catalysis of transition metal catalysts such as palladium or nickel, and the target product can be obtained. Such coupling reaction conditions are relatively mild, but the choice and dosage of catalysts have a significant impact on the reaction efficiency and selectivity, and the preparation of organic metal reagents also requires certain skills and conditions.
When synthesizing this compound, the appropriate synthesis method should be weighed according to various factors such as the availability of raw materials, the difficulty of reaction conditions, cost and yield.
What 1-chloro-2-fluoro-3- (trifluoromethyl) benzene needs to pay attention to when storing and transporting
1-Chloro-2-fluoro-3- (trifluoromethyl) benzene is also an organic compound. When storing and transporting, many things must be paid attention to to to ensure safety.
First, about storage. This compound should be placed in a cool and ventilated warehouse. Because of the cool and ventilated place, it can avoid high temperature and humidity to prevent the compound from deteriorating or other adverse reactions due to excessive temperature or humidity. The temperature of the warehouse should be maintained within a certain range, and it must not be too high, otherwise it may cause the compound to evaporate and intensify, or cause chemical changes. At the same time, it should be kept away from fire and heat sources, both of which may cause serious accidents such as fire or explosion. Because of its certain chemical activity, it is at risk of burning and exploding in case of open flame, hot topic or.
Second, it is also necessary to pay attention to isolation from other substances when storing. Do not mix with oxidants, edible chemicals and other mixed storage. Oxidants have strong oxidizing properties, contact with the compound, or cause violent chemical reactions; edible chemicals are related to human health and are mixed with them. If leakage occurs, it is easy to cause pollution, endangering food safety and personal safety.
Third, caution is also required in packaging. Packaging must be sealed to prevent its volatilization and leakage. The packaging materials used should have good corrosion resistance and sealing to ensure that during storage, the compound does not react with the external environment and does not leak into the surrounding environment.
Fourth, when transporting, the transport vehicle should be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. If an accident occurs during transportation, it can be dealt with in time. During transportation, ensure that the container does not leak, collapse, fall or damage. The driver and escort personnel must also be familiar with the properties of the compound and emergency treatment methods. During transportation, they need to pay close attention to the condition of the goods and do not leave their duties without permission.
In short, in the storage and transportation of 1-chloro-2-fluoro-3- (trifluoromethyl) benzene, every step is related to safety, and relevant regulations and operating procedures must be strictly followed.
First, about storage. This compound should be placed in a cool and ventilated warehouse. Because of the cool and ventilated place, it can avoid high temperature and humidity to prevent the compound from deteriorating or other adverse reactions due to excessive temperature or humidity. The temperature of the warehouse should be maintained within a certain range, and it must not be too high, otherwise it may cause the compound to evaporate and intensify, or cause chemical changes. At the same time, it should be kept away from fire and heat sources, both of which may cause serious accidents such as fire or explosion. Because of its certain chemical activity, it is at risk of burning and exploding in case of open flame, hot topic or.
Second, it is also necessary to pay attention to isolation from other substances when storing. Do not mix with oxidants, edible chemicals and other mixed storage. Oxidants have strong oxidizing properties, contact with the compound, or cause violent chemical reactions; edible chemicals are related to human health and are mixed with them. If leakage occurs, it is easy to cause pollution, endangering food safety and personal safety.
Third, caution is also required in packaging. Packaging must be sealed to prevent its volatilization and leakage. The packaging materials used should have good corrosion resistance and sealing to ensure that during storage, the compound does not react with the external environment and does not leak into the surrounding environment.
Fourth, when transporting, the transport vehicle should be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. If an accident occurs during transportation, it can be dealt with in time. During transportation, ensure that the container does not leak, collapse, fall or damage. The driver and escort personnel must also be familiar with the properties of the compound and emergency treatment methods. During transportation, they need to pay close attention to the condition of the goods and do not leave their duties without permission.
In short, in the storage and transportation of 1-chloro-2-fluoro-3- (trifluoromethyl) benzene, every step is related to safety, and relevant regulations and operating procedures must be strictly followed.
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