Linshang Chemical
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1-Chloro-2-Fluoro-4-Iodobenzene
Linshang Chemical
|
HS Code |
352605 |
| Name | 1-Chloro-2-Fluoro-4-Iodobenzene |
| Molecular Formula | C6H3ClFI |
| Molecular Weight | 256.44 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 210 - 212 °C |
| Melting Point | N/A (usually liquid at room temp) |
| Density | Approx. 2.07 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Flash Point | Around 95 °C |
| Cas Number | 1438-41-1 |
| Refractive Index | Approx. 1.604 - 1.606 |
As an accredited 1-Chloro-2-Fluoro-4-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - chloro - 2 - fluoro - 4 - iodobenzene packaged in a sealed glass bottle. |
| Storage | 1 - Chloro - 2 - fluoro - 4 - iodobenzene should be stored in a cool, dry, well - ventilated area away from sources of heat, ignition, and direct sunlight. It should be kept in a tightly sealed container, preferably made of corrosion - resistant material. Store it separately from oxidizing agents and reactive substances to prevent potential chemical reactions. |
| Shipping | 1 - Chloro - 2 - fluoro - 4 - iodobenzene is shipped in sealed, corrosion - resistant containers. Shipment follows strict chemical safety regulations, ensuring proper handling to prevent spills and exposure during transit. |
Competitive 1-Chloro-2-Fluoro-4-Iodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 1-chloro-2-fluoro-4-iodobenzene?
1-Chloro-2-fluoro-4-iodobenzene is a genus of organohalogenated aromatic hydrocarbons. It has unique chemical properties and has a wide range of uses in the field of organic synthesis.
First of all, its reactivity. Due to the electronic and spatial effects of the halogen atoms of chlorine, fluorine and iodine, the electron cloud density distribution of the benzene ring varies. The electron-absorbing property of the halogen atom reduces the electron cloud density of the benzene ring and the activity of the electrophilic substitution reaction. However, different halogen atoms have different electron-absorbing capabilities. The electronegativity of fluorine is the strongest, followed by chlorine and iodine. Therefore, the relative reduction of the electron cloud density of the benzene ring is poor, which affects the attack check point of For example, in the case of electrophilic substitution, the electrophilic reagent is more likely to attack the interposition because the fluorine atom has a stronger effect on the reduction of the density of the ortho-electron cloud than the meta-position, and the substitution reaction is more difficult than that of benzene.
Furthermore, halogen atoms can cause nucleophilic substitution reactions. Although the nucleophilic substitution of aromatic halogenated hydrocarbons is more difficult than that of alkyl halogenated hydrocarbons, under certain conditions, 1-chloro-2-fluoro-4-iodobenzene halogen atoms can be replaced by nucleophilic reagents. Fluorine atoms have a small tendency to leave due to their high C-F bond energy; iodine atoms have a small C-I bond energy and are relatively easy If a strong base is used as a nucleophile, under heating and other conditions, iodine atoms may be replaced first to form new organic compounds, which is of great significance for organic synthesis steps such as building carbon-heteroatom bonds.
In addition, 1-chloro-2-fluoro-4-iodobenzene can participate in metal-catalyzed reactions. For example, in the coupling reaction catalyzed by palladium, halogen atoms can be coupled with carbon-containing nucleophiles to realize the construction of carbon-carbon bonds. It is a key step in the synthesis of complex organic molecular structures, which can effectively introduce different functional groups and expand the diversity of molecular structures.
And because it has multiple halogen atoms, it can selectively dehalogenate. Depending on the reaction conditions and the reagents used, specific halogen atoms can be removed to prepare derivatives with different halogenation degrees, providing a rich selection of intermediates for organic synthesis, and assisting researchers in obtaining target compounds with specific properties in the fields of medicinal chemistry and materials science.
First of all, its reactivity. Due to the electronic and spatial effects of the halogen atoms of chlorine, fluorine and iodine, the electron cloud density distribution of the benzene ring varies. The electron-absorbing property of the halogen atom reduces the electron cloud density of the benzene ring and the activity of the electrophilic substitution reaction. However, different halogen atoms have different electron-absorbing capabilities. The electronegativity of fluorine is the strongest, followed by chlorine and iodine. Therefore, the relative reduction of the electron cloud density of the benzene ring is poor, which affects the attack check point of For example, in the case of electrophilic substitution, the electrophilic reagent is more likely to attack the interposition because the fluorine atom has a stronger effect on the reduction of the density of the ortho-electron cloud than the meta-position, and the substitution reaction is more difficult than that of benzene.
Furthermore, halogen atoms can cause nucleophilic substitution reactions. Although the nucleophilic substitution of aromatic halogenated hydrocarbons is more difficult than that of alkyl halogenated hydrocarbons, under certain conditions, 1-chloro-2-fluoro-4-iodobenzene halogen atoms can be replaced by nucleophilic reagents. Fluorine atoms have a small tendency to leave due to their high C-F bond energy; iodine atoms have a small C-I bond energy and are relatively easy If a strong base is used as a nucleophile, under heating and other conditions, iodine atoms may be replaced first to form new organic compounds, which is of great significance for organic synthesis steps such as building carbon-heteroatom bonds.
In addition, 1-chloro-2-fluoro-4-iodobenzene can participate in metal-catalyzed reactions. For example, in the coupling reaction catalyzed by palladium, halogen atoms can be coupled with carbon-containing nucleophiles to realize the construction of carbon-carbon bonds. It is a key step in the synthesis of complex organic molecular structures, which can effectively introduce different functional groups and expand the diversity of molecular structures.
And because it has multiple halogen atoms, it can selectively dehalogenate. Depending on the reaction conditions and the reagents used, specific halogen atoms can be removed to prepare derivatives with different halogenation degrees, providing a rich selection of intermediates for organic synthesis, and assisting researchers in obtaining target compounds with specific properties in the fields of medicinal chemistry and materials science.
What are the main uses of 1-chloro-2-fluoro-4-iodobenzene?
1-Chloro-2-fluoro-4-iodobenzene is one of the organic compounds. Its main use involves the field of organic synthesis.
In the field of organic synthesis, this compound is often used as a key intermediate. Due to the unique reactivity of halogen atoms such as chlorine, fluorine, and iodine, they can be converted into various complex organic molecules through various chemical reactions, such as nucleophilic substitution reactions and metal-catalyzed coupling reactions.
In terms of nucleophilic substitution reactions, halogen atoms can be replaced by many nucleophilic reagents. For example, hydroxyl (-OH), amino (-NH ²) and other nucleophilic groups can react with the halogen atoms in the compound, thereby introducing new functional groups and laying the foundation for the construction of organic molecules with specific structures and properties.
In the metal-catalyzed coupling reaction, 1-chloro-2-fluoro-4-iodobenzene can be coupled with metal-containing organic reagents. Taking the palladium-catalyzed Suzuki coupling reaction as an example, it can react with aryl boric acid to achieve the formation of carbon-carbon bonds, which is quite commonly used in the synthesis of polyaryl compounds. Such reactions greatly expand the way of organic synthesis and help to synthesize materials with special structures and functions, pharmaceutical intermediates, etc.
In the field of materials science, 1-chloro-2-fluoro-4-iodobenzene can be used to prepare optoelectronic materials through appropriate reaction conversion. The halogen atoms in its structure can affect the electron cloud distribution and conjugation system of the molecule, which in turn affects the optical and electrical properties of the material, providing the possibility for the development of new optoelectronic materials.
In pharmaceutical chemistry, this compound is used as an intermediate to construct a biologically active molecular structure through multi-step reactions. The design and synthesis of drug molecules often require the introduction of specific functional groups and structural fragments. The halogen atom of 1-chloro-2-fluoro-4-iodobenzene can be used as a reaction check point. After rational reaction route design, compounds with potential pharmacological activity can be prepared, providing an important material basis for the development of new drugs.
In short, 1-chloro-2-fluoro-4-iodobenzene has important uses in the fields of organic synthesis, materials science and medicinal chemistry due to its unique structure and halogen atom reactivity. It provides key support for the creation of many complex organic molecules and the development of new functional materials and drugs.
In the field of organic synthesis, this compound is often used as a key intermediate. Due to the unique reactivity of halogen atoms such as chlorine, fluorine, and iodine, they can be converted into various complex organic molecules through various chemical reactions, such as nucleophilic substitution reactions and metal-catalyzed coupling reactions.
In terms of nucleophilic substitution reactions, halogen atoms can be replaced by many nucleophilic reagents. For example, hydroxyl (-OH), amino (-NH ²) and other nucleophilic groups can react with the halogen atoms in the compound, thereby introducing new functional groups and laying the foundation for the construction of organic molecules with specific structures and properties.
In the metal-catalyzed coupling reaction, 1-chloro-2-fluoro-4-iodobenzene can be coupled with metal-containing organic reagents. Taking the palladium-catalyzed Suzuki coupling reaction as an example, it can react with aryl boric acid to achieve the formation of carbon-carbon bonds, which is quite commonly used in the synthesis of polyaryl compounds. Such reactions greatly expand the way of organic synthesis and help to synthesize materials with special structures and functions, pharmaceutical intermediates, etc.
In the field of materials science, 1-chloro-2-fluoro-4-iodobenzene can be used to prepare optoelectronic materials through appropriate reaction conversion. The halogen atoms in its structure can affect the electron cloud distribution and conjugation system of the molecule, which in turn affects the optical and electrical properties of the material, providing the possibility for the development of new optoelectronic materials.
In pharmaceutical chemistry, this compound is used as an intermediate to construct a biologically active molecular structure through multi-step reactions. The design and synthesis of drug molecules often require the introduction of specific functional groups and structural fragments. The halogen atom of 1-chloro-2-fluoro-4-iodobenzene can be used as a reaction check point. After rational reaction route design, compounds with potential pharmacological activity can be prepared, providing an important material basis for the development of new drugs.
In short, 1-chloro-2-fluoro-4-iodobenzene has important uses in the fields of organic synthesis, materials science and medicinal chemistry due to its unique structure and halogen atom reactivity. It provides key support for the creation of many complex organic molecules and the development of new functional materials and drugs.
What are 1-chloro-2-fluoro-4-iodobenzene synthesis methods?
There are several methods for synthesizing 1-chloro-2-fluoro-4-iodobenzene.
First, it can be started from benzene. First, the chlorination reaction of benzene is carried out under the catalysis of chlorine reagent, such as chlorine gas and ferric chloride, to obtain chlorobenzene. Then the fluorine atom is introduced at a specific position of chlorobenzene, and a nucleophilic substitution reaction can be used. A suitable fluorine-containing reagent, such as potassium fluoride, etc., is reacted in a specific solvent in the presence of a phase transfer catalyst, so that the fluorine atom replaces the chlorine atom at the desired position on the chlorobenzene to obtain a benz Finally, an iodine substitution reagent, such as iodine, is combined with an oxidizing agent, such as iodine and hydrogen peroxide, under acidic conditions, the product is further iodized, and iodine atoms are introduced at designated positions to obtain 1-chloro-2-fluoro-4-iodobenzene.
Second, halobenzene can also be started from halobenzene. If the starting material is a suitable ortho-halobenzene, such as o-chlorofluorobenzene. Using the difference in the activity of halogen atoms, by selecting suitable nucleophiles and reaction conditions, the iodine atom selectively replaces one of the halogen atoms to achieve the synthesis of 1-chloro-2-fluoro-4 This process requires precise regulation of reaction temperature, time and reagent ratio to ensure that the reaction proceeds in the desired direction.
Third, a metal-catalyzed coupling reaction strategy is adopted. First, chlorine and fluorine-containing phenylboronic acid or borate esters are prepared, and then the coupling reaction is carried out with iodine reagents under the action of metal catalysts such as palladium catalysts. This method requires attention to the selection and dosage of catalysts, as well as the pH of the reaction system and other conditions to control the reaction, so that the reaction can efficiently and selectively synthesize the target product 1-chloro-2-fluoro-4-iodobenzene.
First, it can be started from benzene. First, the chlorination reaction of benzene is carried out under the catalysis of chlorine reagent, such as chlorine gas and ferric chloride, to obtain chlorobenzene. Then the fluorine atom is introduced at a specific position of chlorobenzene, and a nucleophilic substitution reaction can be used. A suitable fluorine-containing reagent, such as potassium fluoride, etc., is reacted in a specific solvent in the presence of a phase transfer catalyst, so that the fluorine atom replaces the chlorine atom at the desired position on the chlorobenzene to obtain a benz Finally, an iodine substitution reagent, such as iodine, is combined with an oxidizing agent, such as iodine and hydrogen peroxide, under acidic conditions, the product is further iodized, and iodine atoms are introduced at designated positions to obtain 1-chloro-2-fluoro-4-iodobenzene.
Second, halobenzene can also be started from halobenzene. If the starting material is a suitable ortho-halobenzene, such as o-chlorofluorobenzene. Using the difference in the activity of halogen atoms, by selecting suitable nucleophiles and reaction conditions, the iodine atom selectively replaces one of the halogen atoms to achieve the synthesis of 1-chloro-2-fluoro-4 This process requires precise regulation of reaction temperature, time and reagent ratio to ensure that the reaction proceeds in the desired direction.
Third, a metal-catalyzed coupling reaction strategy is adopted. First, chlorine and fluorine-containing phenylboronic acid or borate esters are prepared, and then the coupling reaction is carried out with iodine reagents under the action of metal catalysts such as palladium catalysts. This method requires attention to the selection and dosage of catalysts, as well as the pH of the reaction system and other conditions to control the reaction, so that the reaction can efficiently and selectively synthesize the target product 1-chloro-2-fluoro-4-iodobenzene.
1-chloro-2-fluoro-4-iodobenzene what are the precautions during storage and transportation?
1-Chloro-2-fluoro-4-iodobenzene is also an organic compound. When storing and transporting, several things should be taken with care.
First words storage. This compound is sensitive to light and heat, and should be stored in a cool, dry and well-ventilated place. Photoheat may cause it to decompose and deteriorate, which will damage its quality. Therefore, the warehouse should choose a cool place, and the temperature should be controlled in a moderate range to avoid direct sunlight and high temperature. And because it has certain chemical activity, it must be stored in isolation from oxidants, strong bases and other substances. Oxidants may cause violent reactions, and strong bases may also interact with it, causing danger. Furthermore, the storage place should be equipped with corresponding emergency treatment equipment and suitable containment materials. In case of leakage, it can be disposed of quickly and avoid pollution expansion.
As for transportation. The transportation container must be firmly sealed to prevent leakage and escape. The selected packaging material should be corrosion-resistant and impact-resistant to ensure the stability of the compound during transportation. During transportation, avoid high temperature, open flame and static electricity. High temperature can increase its reactivity, open flame or cause combustion explosion, static electricity or cause accidents. Therefore, the transportation tool must be grounded to remove static electricity and keep away from the fire source heat source. The transportation personnel should be familiar with the characteristics of this compound and emergency treatment methods. If something happens, they can respond quickly and properly to ensure the safety of personnel and the environment.
First words storage. This compound is sensitive to light and heat, and should be stored in a cool, dry and well-ventilated place. Photoheat may cause it to decompose and deteriorate, which will damage its quality. Therefore, the warehouse should choose a cool place, and the temperature should be controlled in a moderate range to avoid direct sunlight and high temperature. And because it has certain chemical activity, it must be stored in isolation from oxidants, strong bases and other substances. Oxidants may cause violent reactions, and strong bases may also interact with it, causing danger. Furthermore, the storage place should be equipped with corresponding emergency treatment equipment and suitable containment materials. In case of leakage, it can be disposed of quickly and avoid pollution expansion.
As for transportation. The transportation container must be firmly sealed to prevent leakage and escape. The selected packaging material should be corrosion-resistant and impact-resistant to ensure the stability of the compound during transportation. During transportation, avoid high temperature, open flame and static electricity. High temperature can increase its reactivity, open flame or cause combustion explosion, static electricity or cause accidents. Therefore, the transportation tool must be grounded to remove static electricity and keep away from the fire source heat source. The transportation personnel should be familiar with the characteristics of this compound and emergency treatment methods. If something happens, they can respond quickly and properly to ensure the safety of personnel and the environment.
What are the effects of 1-chloro-2-fluoro-4-iodobenzene on the environment and human health?
1 - chloro - 2 - fluoro - 4 - iodobenzene is an organic halogenated aromatic hydrocarbon. This substance has certain effects on the environment and human health.
First, because of its stable chemical structure, it is not easy to degrade in the natural environment, and it is easy to retain and accumulate for a long time. Second, if released into water bodies, it will pose a hazard to aquatic ecosystems. After contact with fish and other aquatic organisms, it may cause physiological disorders, and growth and reproduction will be affected. Third, accumulation in soil may affect soil microbial activity, change soil structure and fertility, and then affect plant growth. Fourth, if it evaporates into the atmosphere, it will participate in photochemical reactions, have adverse effects on air quality, or form harmful fumes.
As for the impact on human health. First, it has certain toxicity. After entering the human body through respiratory tract, skin contact or accidental ingestion, it may damage human organs. If it may affect the normal function of the liver and kidneys, it may affect the metabolic detoxification process or involve the liver and kidneys. Secondly, there may be a risk of sensitization. After skin contact in some people, it may cause allergic reactions, such as rash, itching, etc. Furthermore, long-term exposure to this substance environment may also increase the risk of cancer because of the structure of halogenated aromatics or their potential carcinogenicity.
Therefore, in the production, use and disposal of substances containing 1 - chloro - 2 - fluoro - 4 - iodobenzene, it is necessary to exercise caution and take proper protective and handling measures to reduce the harm to the environment and human health.
First, because of its stable chemical structure, it is not easy to degrade in the natural environment, and it is easy to retain and accumulate for a long time. Second, if released into water bodies, it will pose a hazard to aquatic ecosystems. After contact with fish and other aquatic organisms, it may cause physiological disorders, and growth and reproduction will be affected. Third, accumulation in soil may affect soil microbial activity, change soil structure and fertility, and then affect plant growth. Fourth, if it evaporates into the atmosphere, it will participate in photochemical reactions, have adverse effects on air quality, or form harmful fumes.
As for the impact on human health. First, it has certain toxicity. After entering the human body through respiratory tract, skin contact or accidental ingestion, it may damage human organs. If it may affect the normal function of the liver and kidneys, it may affect the metabolic detoxification process or involve the liver and kidneys. Secondly, there may be a risk of sensitization. After skin contact in some people, it may cause allergic reactions, such as rash, itching, etc. Furthermore, long-term exposure to this substance environment may also increase the risk of cancer because of the structure of halogenated aromatics or their potential carcinogenicity.
Therefore, in the production, use and disposal of substances containing 1 - chloro - 2 - fluoro - 4 - iodobenzene, it is necessary to exercise caution and take proper protective and handling measures to reduce the harm to the environment and human health.
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