Linshang Chemical
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1-Chloro-2-Fluoro-4-Methoxybenzene
Linshang Chemical
|
HS Code |
914353 |
| Chemical Formula | C7H6ClFO |
| Molecular Weight | 160.57 |
As an accredited 1-Chloro-2-Fluoro-4-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - chloro - 2 - fluoro - 4 - methoxybenzene packaged in a sealed glass bottle. |
| Storage | 1 - Chloro - 2 - fluoro - 4 - methoxybenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent evaporation and contamination. Label the storage container clearly with the chemical name and relevant safety information. |
| Shipping | 1 - chloro - 2 - fluoro - 4 - methoxybenzene should be shipped in tightly sealed containers, compliant with chemical transport regulations. Use appropriate packaging to prevent leakage, and label clearly indicating its chemical nature for safe transit. |
Competitive 1-Chloro-2-Fluoro-4-Methoxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 1-Chloro-2-Fluoro-4-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-2-fluoro-4-methoxybenzene?
1-chloro-2-fluoro-4-methoxybenzene, that is, 1-chloro-2-fluoro-4-methoxybenzene, is widely used. In the field of organic synthesis, its position is pivotal.
One of them is often the key raw material for pharmaceutical synthesis. The preparation of many drugs depends on its participation in the reaction. Due to its unique chemical structure, it can introduce specific functional groups to build the skeleton of drug-active molecules. Through a series of chemical reactions, such as nucleophilic substitution, coupling reactions, etc., it can be cleverly combined with other compounds to generate substances with specific pharmacological activities. For example, in the synthesis of some antimicrobial drugs, 1-chloro-2-fluoro-4-methoxybenzene is used as a starting material. After multi-step reaction, the characteristics of chlorine, fluorine and methoxy are fully utilized, and finally the finished drug with antibacterial effect is obtained.
Second, in the field of materials science, it also shows extraordinary effects. It can be used to prepare functional materials, such as polymer materials with special properties. By polymerizing with suitable monomers, its structural units can be embedded in the polymer chain, giving the material unique physical and chemical properties, such as improving the solubility, thermal stability or optical properties of the material. In the field of electronic materials, such materials composed of 1-chloro-2-fluoro-4-methoxybenzene can be used in organic Light Emitting Diode (OLED), solar cells and other devices to help improve the performance of the device.
Furthermore, in the fine chemical industry, it is an important intermediate for the preparation of various fine chemicals. During the synthesis of fine chemicals such as dyes and fragrances, 1-chloro-2-fluoro-4-methoxybenzene can be converted into the desired structural fragments through specific reactions, giving the product a unique color or aroma characteristics. For example, in the development and preparation of some new fragrances, the derivatization reaction is carried out by using their structures to create fragrances with novel aroma characteristics.
One of them is often the key raw material for pharmaceutical synthesis. The preparation of many drugs depends on its participation in the reaction. Due to its unique chemical structure, it can introduce specific functional groups to build the skeleton of drug-active molecules. Through a series of chemical reactions, such as nucleophilic substitution, coupling reactions, etc., it can be cleverly combined with other compounds to generate substances with specific pharmacological activities. For example, in the synthesis of some antimicrobial drugs, 1-chloro-2-fluoro-4-methoxybenzene is used as a starting material. After multi-step reaction, the characteristics of chlorine, fluorine and methoxy are fully utilized, and finally the finished drug with antibacterial effect is obtained.
Second, in the field of materials science, it also shows extraordinary effects. It can be used to prepare functional materials, such as polymer materials with special properties. By polymerizing with suitable monomers, its structural units can be embedded in the polymer chain, giving the material unique physical and chemical properties, such as improving the solubility, thermal stability or optical properties of the material. In the field of electronic materials, such materials composed of 1-chloro-2-fluoro-4-methoxybenzene can be used in organic Light Emitting Diode (OLED), solar cells and other devices to help improve the performance of the device.
Furthermore, in the fine chemical industry, it is an important intermediate for the preparation of various fine chemicals. During the synthesis of fine chemicals such as dyes and fragrances, 1-chloro-2-fluoro-4-methoxybenzene can be converted into the desired structural fragments through specific reactions, giving the product a unique color or aroma characteristics. For example, in the development and preparation of some new fragrances, the derivatization reaction is carried out by using their structures to create fragrances with novel aroma characteristics.
What are the physical properties of 1-chloro-2-fluoro-4-methoxybenzene?
1-Chloro-2-fluoro-4-methoxybenzene is one of the organic compounds. Its physical properties are worth exploring.
First of all, its properties are mostly colorless to light yellow liquids at room temperature, with a clear appearance and a specific luster. Looking at its color, this yellowish color, or the absorption of light of a specific wavelength due to electronic transitions in the molecular structure, shows this color.
times and its boiling point, about within a certain temperature range. The boiling point is the temperature at which a substance changes from liquid to gas. The boiling point of 1-chloro-2-fluoro-4-methoxybenzene is determined by the intermolecular force. There is a van der Waals force between the molecules, which originates from the polarity and instantaneous dipole moment of the molecule. Due to the difference in electronegativity of chlorine, fluorine and other atoms in the molecule, the molecule has a certain polarity, which increases the intermolecular force and the boiling point.
In addition, the melting point of this substance also has a specific value. The level of melting point is related to the regularity of lattice energy and molecular arrangement. The atomic arrangement in the molecular structure of this compound forms a specific lattice in the solid state, and the size of the lattice energy determines the level of melting point. In organic solvents, such as ethanol, ether, etc., 1-chloro-2-fluoro-4-methoxybenzene exhibits good solubility. This is due to the principle of "similarity and miscibility". Its molecular structure is similar to that of organic solvents. Both are organic molecules, and the types of intermolecular forces are similar, so they can be miscible with each other. However, in water, its solubility is very small, because water is a very polar solvent, and the intermolecular forces of the compound are quite different, making it difficult to form a uniform and stable mixed system.
In terms of its density, compared to water, the density of 1-chloro-2-fluoro-4-methoxybenzene may be different. This is due to the type and number of atoms in the molecule, the relative atomic mass and spatial arrangement of the atoms, which work together to make its density different from that of water.
And its smell often has a special aromatic smell. This smell comes from the synergistic effect of benzene ring structure and halogen atoms, methoxy groups, etc., which stimulates olfactory receptors and makes people perceive this unique smell.
In summary, the physical properties of 1-chloro-2-fluoro-4-methoxybenzene are determined by its molecular structure, and each property is interrelated, which is of great significance in the research and application of organic chemistry.
First of all, its properties are mostly colorless to light yellow liquids at room temperature, with a clear appearance and a specific luster. Looking at its color, this yellowish color, or the absorption of light of a specific wavelength due to electronic transitions in the molecular structure, shows this color.
times and its boiling point, about within a certain temperature range. The boiling point is the temperature at which a substance changes from liquid to gas. The boiling point of 1-chloro-2-fluoro-4-methoxybenzene is determined by the intermolecular force. There is a van der Waals force between the molecules, which originates from the polarity and instantaneous dipole moment of the molecule. Due to the difference in electronegativity of chlorine, fluorine and other atoms in the molecule, the molecule has a certain polarity, which increases the intermolecular force and the boiling point.
In addition, the melting point of this substance also has a specific value. The level of melting point is related to the regularity of lattice energy and molecular arrangement. The atomic arrangement in the molecular structure of this compound forms a specific lattice in the solid state, and the size of the lattice energy determines the level of melting point. In organic solvents, such as ethanol, ether, etc., 1-chloro-2-fluoro-4-methoxybenzene exhibits good solubility. This is due to the principle of "similarity and miscibility". Its molecular structure is similar to that of organic solvents. Both are organic molecules, and the types of intermolecular forces are similar, so they can be miscible with each other. However, in water, its solubility is very small, because water is a very polar solvent, and the intermolecular forces of the compound are quite different, making it difficult to form a uniform and stable mixed system.
In terms of its density, compared to water, the density of 1-chloro-2-fluoro-4-methoxybenzene may be different. This is due to the type and number of atoms in the molecule, the relative atomic mass and spatial arrangement of the atoms, which work together to make its density different from that of water.
And its smell often has a special aromatic smell. This smell comes from the synergistic effect of benzene ring structure and halogen atoms, methoxy groups, etc., which stimulates olfactory receptors and makes people perceive this unique smell.
In summary, the physical properties of 1-chloro-2-fluoro-4-methoxybenzene are determined by its molecular structure, and each property is interrelated, which is of great significance in the research and application of organic chemistry.
What is the chemistry of 1-chloro-2-fluoro-4-methoxybenzene?
The chemical properties of 1-chloro-2-fluoro-4-methoxybenzene are particularly important, which are related to many chemical reactions and practical applications. This compound has a unique structure, in which the existence of chlorine, fluorine and methoxy groups has a great impact on its properties.
Let's talk about the substitution reaction first. Because the benzene ring has a certain electron cloud density, although the chlorine atom is an electron-withdrawing group, under suitable conditions, nucleophilic substitution can occur. In case of nucleophilic reagents, chlorine atoms may be replaced by nucleophilic reagents to form new compounds. The methoxy group is the power supply group, which can increase the density of electron clouds in the ortho and para-sites of the benzene ring. In the electrophilic substitution reaction, it can guide the electrophilic reagents to attack the ortho and para-sites.
Let's talk about its physical properties. This compound may be liquid or solid at room temperature, depending on the specific conditions. Its solubility also has characteristics. Because it contains halogen atoms and methoxy groups such as fluorine and chlorine, it may have a certain solubility in organic solvents such as alcohols and ethers, but its solubility in water may be limited, and the lid is not very strong due to its molecular polarity.
In terms of its stability, although the benzene ring itself has conjugate stability, the existence of halogen atoms and methoxy groups may affect its stability. Under extreme conditions such as high temperature, strong acid or strong base, the molecular structure may change, such as methoxy or hydrolysis.
In the field of organic synthesis, 1-chloro-2-fluoro-4-methoxylbenzene is often used as an important intermediate. With its substitutability of chlorine atoms, special electronic effects of fluorine atoms and positioning effects of methoxy groups, a variety of organic compounds with specific functions can be synthesized, which have potential uses in pharmaceutical chemistry, materials science and other fields.
Let's talk about the substitution reaction first. Because the benzene ring has a certain electron cloud density, although the chlorine atom is an electron-withdrawing group, under suitable conditions, nucleophilic substitution can occur. In case of nucleophilic reagents, chlorine atoms may be replaced by nucleophilic reagents to form new compounds. The methoxy group is the power supply group, which can increase the density of electron clouds in the ortho and para-sites of the benzene ring. In the electrophilic substitution reaction, it can guide the electrophilic reagents to attack the ortho and para-sites.
Let's talk about its physical properties. This compound may be liquid or solid at room temperature, depending on the specific conditions. Its solubility also has characteristics. Because it contains halogen atoms and methoxy groups such as fluorine and chlorine, it may have a certain solubility in organic solvents such as alcohols and ethers, but its solubility in water may be limited, and the lid is not very strong due to its molecular polarity.
In terms of its stability, although the benzene ring itself has conjugate stability, the existence of halogen atoms and methoxy groups may affect its stability. Under extreme conditions such as high temperature, strong acid or strong base, the molecular structure may change, such as methoxy or hydrolysis.
In the field of organic synthesis, 1-chloro-2-fluoro-4-methoxylbenzene is often used as an important intermediate. With its substitutability of chlorine atoms, special electronic effects of fluorine atoms and positioning effects of methoxy groups, a variety of organic compounds with specific functions can be synthesized, which have potential uses in pharmaceutical chemistry, materials science and other fields.
What are 1-chloro-2-fluoro-4-methoxybenzene synthesis methods?
The synthesis methods of 1-chloro-2-fluoro-4-methoxybenzene often have different paths. The following are common methods:
First, p-methoxyphenol is used as the starting material. First, p-methoxyphenol is reacted with fluorination reagents, such as potassium fluoride, etc., in a suitable solvent such as dimethyl sulfoxide (DMSO), under heating conditions, the hydroxyl group is replaced by fluorine atoms to generate 2-fluoro-4-methoxyphenol. This step requires attention to the reaction temperature and time. If the temperature is too high or the time is too long, side reactions are prone to occur. Then, the obtained product is reacted with chlorinated reagents, such as thionyl chloride (SOCl ³), in the presence of catalysts such as pyridine, phenolic hydroxyl groups are converted into chlorine atoms, and finally 1-chloro-2-fluoro-4-methoxylbenzene is obtained. This route step is relatively clear, but the fluorination reaction conditions are relatively harsh and need to be precisely controlled.
Second, start from 1-chloro-4-methoxylbenzene. Electrophilic substitution reaction can be used, because methoxy is an ortho-and para-site group, which can increase the density of the ortho-and para-site electron clouds of the benzene ring, which is conducive to the attack of electrophilic reagents. The fluorination reaction is carried out with suitable fluorination reagents, such as Selectfluor, under the action of appropriate solvents and catalysts. The reaction conditions are relatively mild, but the price of reagents such as Selectfluor is higher and the cost increases. And the amount of fluorination reagents and reaction selectivity should be paid attention to during the reaction process to avoid the formation of polyfluorinated by-products.
Third, 1-fluoro-4-methoxybenzene is used as the raw material. The target product is synthesized through chlorination reaction. Commonly used chlorinated reagents such as N-chlorosuccinimide (NCS), under the action of light or initiators such as azobisisobutyronitrile (AIBN), free radical substitution reaction is carried out. This reaction condition is relatively easy to achieve, but the reaction selectivity of free radicals is slightly worse, and by-products of chlorination at other positions may be generated, which needs to be purified by subsequent separation methods such as column chromatography.
First, p-methoxyphenol is used as the starting material. First, p-methoxyphenol is reacted with fluorination reagents, such as potassium fluoride, etc., in a suitable solvent such as dimethyl sulfoxide (DMSO), under heating conditions, the hydroxyl group is replaced by fluorine atoms to generate 2-fluoro-4-methoxyphenol. This step requires attention to the reaction temperature and time. If the temperature is too high or the time is too long, side reactions are prone to occur. Then, the obtained product is reacted with chlorinated reagents, such as thionyl chloride (SOCl ³), in the presence of catalysts such as pyridine, phenolic hydroxyl groups are converted into chlorine atoms, and finally 1-chloro-2-fluoro-4-methoxylbenzene is obtained. This route step is relatively clear, but the fluorination reaction conditions are relatively harsh and need to be precisely controlled.
Second, start from 1-chloro-4-methoxylbenzene. Electrophilic substitution reaction can be used, because methoxy is an ortho-and para-site group, which can increase the density of the ortho-and para-site electron clouds of the benzene ring, which is conducive to the attack of electrophilic reagents. The fluorination reaction is carried out with suitable fluorination reagents, such as Selectfluor, under the action of appropriate solvents and catalysts. The reaction conditions are relatively mild, but the price of reagents such as Selectfluor is higher and the cost increases. And the amount of fluorination reagents and reaction selectivity should be paid attention to during the reaction process to avoid the formation of polyfluorinated by-products.
Third, 1-fluoro-4-methoxybenzene is used as the raw material. The target product is synthesized through chlorination reaction. Commonly used chlorinated reagents such as N-chlorosuccinimide (NCS), under the action of light or initiators such as azobisisobutyronitrile (AIBN), free radical substitution reaction is carried out. This reaction condition is relatively easy to achieve, but the reaction selectivity of free radicals is slightly worse, and by-products of chlorination at other positions may be generated, which needs to be purified by subsequent separation methods such as column chromatography.
1-chloro-2-fluoro-4-methoxybenzene What are the precautions in storage and transportation?
1-Chloro-2-fluoro-4-methoxybenzene is an organic compound. When storing and transporting, many matters need to be paid attention to.
First of all, storage, this compound should be placed in a cool, dry and well-ventilated place. Because of its certain chemical activity, it is easy to react when heated, so it must be kept away from fire and heat sources to prevent accidents. At the same time, it should be stored separately from oxidants, acids, bases, etc., because it is easy to react chemically with these substances, and it may be dangerous to mix with them. Furthermore, the storage container must be tightly sealed to prevent leakage. It is advisable to use containers made of corrosion-resistant materials, and the lid may leak because the compound may interact with certain materials, causing damage to the container. And the storage area should be equipped with suitable materials to contain leaks, so as to deal with possible leaks in a timely manner.
As for transportation, it should not be taken lightly. Make sure that the packaging is complete and sealed before transportation. Select transportation tools that meet safety standards, and they should be shock-proof and collision-proof during transportation to avoid package damage due to bumps and collisions. Transportation personnel should also be familiar with the characteristics of the compound and emergency treatment methods, and can dispose of it quickly and properly in the event of an accident. In addition, the transportation route should be planned to avoid densely populated areas and environmentally sensitive areas to prevent serious harm to people and the environment in the event of leakage. In conclusion, the storage and transportation of 1-chloro-2-fluoro-4-methoxybenzene should be handled with caution, and relevant safety regulations should be strictly followed to ensure safety.
First of all, storage, this compound should be placed in a cool, dry and well-ventilated place. Because of its certain chemical activity, it is easy to react when heated, so it must be kept away from fire and heat sources to prevent accidents. At the same time, it should be stored separately from oxidants, acids, bases, etc., because it is easy to react chemically with these substances, and it may be dangerous to mix with them. Furthermore, the storage container must be tightly sealed to prevent leakage. It is advisable to use containers made of corrosion-resistant materials, and the lid may leak because the compound may interact with certain materials, causing damage to the container. And the storage area should be equipped with suitable materials to contain leaks, so as to deal with possible leaks in a timely manner.
As for transportation, it should not be taken lightly. Make sure that the packaging is complete and sealed before transportation. Select transportation tools that meet safety standards, and they should be shock-proof and collision-proof during transportation to avoid package damage due to bumps and collisions. Transportation personnel should also be familiar with the characteristics of the compound and emergency treatment methods, and can dispose of it quickly and properly in the event of an accident. In addition, the transportation route should be planned to avoid densely populated areas and environmentally sensitive areas to prevent serious harm to people and the environment in the event of leakage. In conclusion, the storage and transportation of 1-chloro-2-fluoro-4-methoxybenzene should be handled with caution, and relevant safety regulations should be strictly followed to ensure safety.
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