1-Chloro-2-Fluoro-4-Methyl-5-Nitrobenzene

Linshang Chemical

Specifications

HS Code

402512

Chemical Formula C7H5ClFNO2
Molar Mass 191.57 g/mol
Appearance Solid (usually)
Physical State At Room Temp Solid
Melting Point Data needed
Boiling Point Data needed
Density Data needed
Solubility In Water Low solubility
Solubility In Organic Solvents Soluble in common organic solvents
Flash Point Data needed
Vapor Pressure Low vapor pressure
Odor Data needed

As an accredited 1-Chloro-2-Fluoro-4-Methyl-5-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 1 - chloro - 2 - fluoro - 4 - methyl - 5 - nitrobenzene in a sealed chemical - grade bottle.
Storage 1 - Chloro - 2 - fluoro - 4 - methyl - 5 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials, to prevent leakage. Store it separately from oxidizing agents, reducing agents, and incompatible substances to avoid potential chemical reactions.
Shipping 1 - Chloro - 2 - fluoro - 4 - methyl - 5 - nitrobenzene is a chemical. Ship it in well - sealed, corrosion - resistant containers. Ensure compliance with hazardous material shipping regulations, with proper labeling for safe transportation.
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1-Chloro-2-Fluoro-4-Methyl-5-Nitrobenzene 1-Chloro-2-Fluoro-4-Methyl-5-Nitrobenzene
General Information
Where to Buy 1-Chloro-2-Fluoro-4-Methyl-5-Nitrobenzene in China?
As a trusted 1-Chloro-2-Fluoro-4-Methyl-5-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Chloro-2-Fluoro-4-Methyl-5-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-chloro-2-fluoro-4-methyl-5-nitrobenzene?
1-Chloro-2-fluoro-4-methyl-5-nitrobenzene, an organic compound, has important uses in many fields.
In the field of medicinal chemistry, it is often a key intermediate for the synthesis of drugs. Due to its unique molecular structure, it contains functional groups such as chlorine, fluorine, methyl and nitro. These functional groups endow molecules with diverse chemical properties, which can be chemically reacted to construct complex drug molecular structures and help to develop new drugs with specific biological activities and pharmacological effects. For example, when developing antibacterial drugs, by modifying and transforming their structures, drugs that have high inhibitory effects on specific pathogens may be obtained.
In the field of materials science, it can be used to synthesize high-performance organic materials. Its special structure makes the material have special physical and chemical properties. For example, when synthesizing organic photoelectric materials, the introduction of this compound structural unit may improve the photoelectric properties of the material, enhance its application performance in organic Light Emitting Diode (OLED), solar cells and other devices, and enhance luminous efficiency or photoelectric conversion efficiency.
In the field of pesticide chemistry, it is also an important synthetic raw material. Through chemical conversion, a variety of pesticide active ingredients can be prepared. Due to the specific biological activities of chlorine, fluorine, nitro and other functional groups to insects, weeds and other pests, efficient, low toxic and environmentally friendly pesticides can be developed to effectively control crop diseases and insect pests and ensure agricultural production.
1-chloro-2-fluoro-4-methyl-5-nitrobenzene is used as a key intermediate or raw material in the fields of medicine, materials, and pesticides, which is of great significance to promoting technological development and innovation in various fields.
What are the physical properties of 1-chloro-2-fluoro-4-methyl-5-nitrobenzene?
1-Chloro-2-fluoro-4-methyl-5-nitrobenzene is one of the organic compounds. Its physical properties are crucial and related to many practical applications.
First of all, the appearance of this compound is usually in the form of a solid state, but the specific appearance may vary depending on the purity and crystallization conditions, or it is a white to light yellow crystalline powder, which is delicate.
When it comes to the melting point, it has been scientifically determined to be within a certain temperature range. The characteristics of the melting point are of great significance in the identification and purity judgment of the substance. If the purity of the substance is high, the melting point is relatively constant and similar to the theoretical value; if it contains impurities, the melting point may decrease, and the melting range will also become wider.
The boiling point is also an important physical property. The value of its boiling point reflects the temperature conditions required for the compound to change from liquid to gaseous state. Knowing the boiling point is crucial in chemical operations such as distillation and separation, which can help determine the appropriate operating temperature and achieve efficient separation and purification.
In terms of solubility, the solubility of 1-chloro-2-fluoro-4-methyl-5-nitrobenzene in organic solvents is quite characteristic. In common organic solvents such as ethanol, ether, acetone, etc., it has a certain solubility, but its solubility in water is very small. This difference in solubility provides a basis for its separation, purification and choice of reaction medium. In the organic synthesis reaction, a suitable solvent can be selected according to its solubility to promote the reaction.
In addition, the density of the compound is also a physical constant. The value of the density has a direct impact on the relationship between the volume and quality of the mixture, and is indispensable in the material balance and equipment design of chemical production.
Furthermore, its odor may have a certain irritation. Although it is not a typical stinky smell, it is still necessary to pay attention when exposed. Because it may have irritating effects on human respiratory tract and skin, protective measures should be taken during operation.
In summary, the physical properties of 1-chloro-2-fluoro-4-methyl-5-nitrobenzene, such as appearance, melting point, boiling point, solubility, density, and odor, are of great significance in the fields of organic synthesis, chemical production, and analysis and testing. In-depth understanding and good use can achieve twice the result with half the effort.
What is the chemical synthesis method of 1-chloro-2-fluoro-4-methyl-5-nitrobenzene?
The synthesis of 1-chloro-2-fluoro-4-methyl-5-nitrobenzene can be achieved by the following steps.
The first p-toluidine is taken as the starting material. Because the amine group is a strong electron donor group, it has an activation effect on the o-para-phenyl ring. The p-toluidine is first reacted with acetyl chloride or acetic anhydride to generate N-acetyl p-toluidine. The purpose of this step is to protect the amine group and avoid excessive side reactions caused by excessive activation of the amine group in the subsequent reaction.
Subsequently, the mixed acid reaction of N-acetyl p-toluidine with fuming nitric acid and concentrated sulfuric acid is made. Due to the fact that both acetamide and methyl are ortho-sites, and under the factor of steric hindrance, nitro is mainly introduced into the methyl ortho-site to generate N-acetyl-4-methyl-2-nitroaniline.
Next, N-acetyl-4-methyl-2-nitroaniline is hydrolyzed under acidic conditions to turn the acetamide back into an amine group to obtain 4-methyl-2-nitroaniline. After
, 4-methyl-2-nitroaniline reacts with sodium nitrite and hydrochloric acid at low temperature (0-5 ℃) to form a diazonium salt 4-methyl-2-nitrobenzene diazonate.
Then take this diazonium salt and react with a mixed system of cuprous chloride and hydrofluoric acid, and the diazonium group is replaced by a chlorine atom to form 1-chloro-4-methyl-2-nitrobenzene.
Finally, with suitable fluorinating reagents, such as potassium fluoride, under specific solvents and reaction conditions, 1-chloro-4-methyl-2-nitrobenzene is fluorinated, and fluorine atoms are introduced at the ortho-position of the chlorine atom to obtain the target product 1-chloro-2-fluoro-4-methyl-5-nitrobenzene. Each step of the reaction requires precise control of the reaction conditions, such as temperature, reactant ratio, reaction time, etc., to increase the yield and reduce side reactions.
What are the precautions in storage and transportation of 1-chloro-2-fluoro-4-methyl-5-nitrobenzene?
1-Chloro-2-fluoro-4-methyl-5-nitrobenzene is an organic compound. When storing and transporting, many points must be paid attention to.
Bear the brunt. When storing, it is necessary to find a cool, dry and well-ventilated place. This compound is quite sensitive to heat, and high temperature can easily cause it to decompose, which can even cause danger, so it must be kept away from fire and heat sources. If placed in a humid environment, it may be subject to moisture and deterioration, which will affect the quality and stability.
Furthermore, because of its certain toxicity and irritation, the storage place should be strictly protected from children and unrelated personnel. Storage containers are also crucial. Corrosion-resistant materials, such as glass or certain plastics, must be selected to prevent the container from being corroded and causing material leakage. At the same time, the container must be tightly sealed to prevent volatilization from escaping, polluting the environment and endangering human health.
During transportation, make sure that the packaging is solid. Use appropriate cushioning materials to avoid package damage due to bumps and collisions during transportation. Transport vehicles also need to have good ventilation conditions to prevent the accumulation of volatile gases. Transport personnel must be professionally trained and familiar with the characteristics of the compound and emergency treatment methods. In the event of leakage and other situations, they can respond quickly and properly.
In addition, whether it is storage or transportation, relevant laws and regulations and safety standards should be strictly followed. Make detailed records, including storage and transportation time, quantity, location and other information, for traceability and supervision. Do not take it lightly, a little negligence or cause major disasters, endangering personal safety and environmental safety.
1-chloro-2-fluoro-4-methyl-5-nitrobenzene impact on the environment and human health
1-Chloro-2-fluoro-4-methyl-5-nitrobenzene, its impact on the environment and human health cannot be ignored.
At the end of the environment, this compound has certain stability, is difficult to degrade, and can cause long-lasting environmental pollution. It may accumulate in water and soil, and if released in water or sewage sources, it will harm aquatic organisms. Because it contains chlorine, fluorine, nitro and other groups, its chemical properties are active, or it reacts with other substances in the environment, generating new pollutants and disrupting the ecological balance.
As for human health, 1-chloro-2-fluoro-4-methyl-5-nitrobenzene may enter the body through respiratory tract, skin contact, dietary intake, etc. Nitro and halogen atoms can damage human organs. Nitro can cause abnormalities in the blood system, oxidize hemoglobin into methemoglobin, hinder oxygen transportation, and cause tissue hypoxia. Halogen atoms may damage organs such as liver and kidney, affecting their normal function. Long-term exposure to this substance may increase the risk of cancer, because certain groups in the structure can cause cell mutation and canceration. And this substance may irritate the skin and mucous membranes, causing contact dermatitis, respiratory inflammation, etc.
In summary, 1-chloro-2-fluoro-4-methyl-5-nitrobenzene is potentially harmful to the environment and human health. It should be treated with caution to prevent it from polluting the environment and protecting human health.