Linshang Chemical
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1-Chloro-2-Fluoro-4-Methylbenzene
Linshang Chemical
|
HS Code |
468575 |
| Chemical Formula | C7H6ClF |
| Molar Mass | 144.573 g/mol |
| Appearance | Colorless liquid |
| Boiling Point | 154 - 156 °C |
| Density | 1.165 g/mL at 25 °C |
| Solubility | Insoluble in water, soluble in organic solvents like ethanol, ether |
| Flash Point | 44 °C |
| Refractive Index | 1.493 at 20 °C |
As an accredited 1-Chloro-2-Fluoro-4-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 2 - fluoro - 4 - methylbenzene in 500 mL glass bottle, tightly sealed. |
| Storage | 1 - Chloro - 2 - fluoro - 4 - methylbenzene should be stored in a cool, well - ventilated area away from heat, sparks, and open flames as it is likely flammable. Keep it in a tightly sealed container to prevent vapor release. Store it separately from oxidizing agents and incompatible substances to avoid potential reactions. Ensure proper labeling for easy identification and safety. |
| Shipping | 1 - Chloro - 2 - fluoro - 4 - methylbenzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict hazardous chemical shipping regulations, with proper labeling for safe and compliant transportation. |
Competitive 1-Chloro-2-Fluoro-4-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 1-Chloro-2-Fluoro-4-Methylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-chloro-2-fluoro-4-methylbenzene?
1-Chloro-2-fluoro-4-methylbenzene is also an organic compound. Its chemical properties are unique and valuable for investigation.
In this compound, chlorine, fluorine atoms and methyl groups are attached to the benzene ring. The benzene ring has a stable conjugate system, but the introduction of chlorine, fluorine atoms and methyl groups changes the distribution of electron clouds, which in turn affects its chemical properties.
As far as electrophilic substitution is concerned, chlorine and fluorine are electron-withdrawing groups and have the effect of passivating the benzene ring. However, because they are located in the orthopanal position, electrophilic reagents still tend to attack their orthopanal and para-positions. Methyl group is the power supply group, which has the ability to activate the benzene ring, and mainly causes the electrophilic substitution reaction to occur in its adjacent and para-positions. The superposition of these two effects makes the electrophilic substitution reaction activity and localization effect of 1-chloro-2-fluoro-4-methylbenzene complex.
Its halogen atom properties are also worthy of attention. Chlorine and fluorine atoms can participate in nucleophilic substitution reactions, and can be replaced to form corresponding derivatives under suitable nucleophilic reagents and reaction conditions. For example, in the case of strong nucleophilic reagents, one of the chlorine atoms or fluorine atoms can be replaced by a nucleophilic group, which involves the breaking and formation of covalent bonds.
In addition, 1-chloro-2-fluoro-4-methylbenzene may participate in redox reactions. Under certain conditions, the benzene ring can be oxidized, or its side chain methyl can undergo oxidation reactions to generate products such as carboxylic acids. Or under the action of some catalysts, it can participate in reduction reactions such as hydrogenation, so that the benzene ring is partially or completely hydrosaturated.
Furthermore, because of its fluorine atom, the molecule has certain special physical and chemical properties, such as its boiling point, solubility, etc., and the existence of fluorine atoms or endows the compound with unique biological activities, which may have potential applications in pharmaceutical chemistry, pesticide chemistry and other fields.
In this compound, chlorine, fluorine atoms and methyl groups are attached to the benzene ring. The benzene ring has a stable conjugate system, but the introduction of chlorine, fluorine atoms and methyl groups changes the distribution of electron clouds, which in turn affects its chemical properties.
As far as electrophilic substitution is concerned, chlorine and fluorine are electron-withdrawing groups and have the effect of passivating the benzene ring. However, because they are located in the orthopanal position, electrophilic reagents still tend to attack their orthopanal and para-positions. Methyl group is the power supply group, which has the ability to activate the benzene ring, and mainly causes the electrophilic substitution reaction to occur in its adjacent and para-positions. The superposition of these two effects makes the electrophilic substitution reaction activity and localization effect of 1-chloro-2-fluoro-4-methylbenzene complex.
Its halogen atom properties are also worthy of attention. Chlorine and fluorine atoms can participate in nucleophilic substitution reactions, and can be replaced to form corresponding derivatives under suitable nucleophilic reagents and reaction conditions. For example, in the case of strong nucleophilic reagents, one of the chlorine atoms or fluorine atoms can be replaced by a nucleophilic group, which involves the breaking and formation of covalent bonds.
In addition, 1-chloro-2-fluoro-4-methylbenzene may participate in redox reactions. Under certain conditions, the benzene ring can be oxidized, or its side chain methyl can undergo oxidation reactions to generate products such as carboxylic acids. Or under the action of some catalysts, it can participate in reduction reactions such as hydrogenation, so that the benzene ring is partially or completely hydrosaturated.
Furthermore, because of its fluorine atom, the molecule has certain special physical and chemical properties, such as its boiling point, solubility, etc., and the existence of fluorine atoms or endows the compound with unique biological activities, which may have potential applications in pharmaceutical chemistry, pesticide chemistry and other fields.
What are the main uses of 1-chloro-2-fluoro-4-methylbenzene?
1-Chloro-2-fluoro-4-methylbenzene has a wide range of uses and is used in all fields of chemical industry.
First, it can be a key intermediate in the synthesis of materials. In the process of organic synthesis, it is often necessary to build more complex structures based on this. If you want to make special polymer materials or functional materials containing fluorine or chlorine, 1-chloro-2-fluoro-4-methylbenzene is often the starting material. Through delicate reactions, such as nucleophilic substitution, coupling reactions, etc., it can be combined with other reagents to produce new materials with specific properties. This material may have good heat resistance, chemical corrosion resistance and other characteristics, and is very useful in fields such as aerospace, electronics and electrical appliances that require strict material properties.
Second, it also plays an important role in the field of pharmaceutical chemistry. The creation of many drugs requires the help of its unique chemical structure. Because it contains chlorine, fluorine and other atoms, it can have a significant impact on the physical and chemical properties and biological activities of drug molecules. As a building block for drug synthesis, it can be modified by multi-step reactions, or new drugs with high efficiency and low toxicity can be produced for the treatment of specific diseases, such as antibacterial, anti-tumor and so on.
Furthermore, in the manufacture of fine chemicals, 1-chloro-2-fluoro-4-methylbenzene is also indispensable. For example, when preparing special fragrances and dyes, it can be used as an important raw material to give products unique color, aroma and other characteristics to meet the diverse needs of the market for fine chemicals.
To sum up, 1-chloro-2-fluoro-4-methylbenzene is as important as a cornerstone in many fields of chemical industry, and has played a great role in promoting the development of materials, medicine, fine chemicals and other industries.
First, it can be a key intermediate in the synthesis of materials. In the process of organic synthesis, it is often necessary to build more complex structures based on this. If you want to make special polymer materials or functional materials containing fluorine or chlorine, 1-chloro-2-fluoro-4-methylbenzene is often the starting material. Through delicate reactions, such as nucleophilic substitution, coupling reactions, etc., it can be combined with other reagents to produce new materials with specific properties. This material may have good heat resistance, chemical corrosion resistance and other characteristics, and is very useful in fields such as aerospace, electronics and electrical appliances that require strict material properties.
Second, it also plays an important role in the field of pharmaceutical chemistry. The creation of many drugs requires the help of its unique chemical structure. Because it contains chlorine, fluorine and other atoms, it can have a significant impact on the physical and chemical properties and biological activities of drug molecules. As a building block for drug synthesis, it can be modified by multi-step reactions, or new drugs with high efficiency and low toxicity can be produced for the treatment of specific diseases, such as antibacterial, anti-tumor and so on.
Furthermore, in the manufacture of fine chemicals, 1-chloro-2-fluoro-4-methylbenzene is also indispensable. For example, when preparing special fragrances and dyes, it can be used as an important raw material to give products unique color, aroma and other characteristics to meet the diverse needs of the market for fine chemicals.
To sum up, 1-chloro-2-fluoro-4-methylbenzene is as important as a cornerstone in many fields of chemical industry, and has played a great role in promoting the development of materials, medicine, fine chemicals and other industries.
What is 1-chloro-2-fluoro-4-methylbenzene synthesis method?
The synthesis of 1-chloro-2-fluoro-4-methylbenzene is an important topic in the field of organic synthesis. To make this compound, several common chemical pathways can be followed.
One of them can be started from toluene. Toluene is halogenated and chlorine atoms are introduced first. In this step, a suitable chlorination reagent, such as chlorine, can be used. Under the action of light or catalyst, the chlorine atom replaces the hydrogen atom on the toluene-benzene ring to form chlorotoluene. However, this reaction requires attention to control the reaction conditions so that the chlorine atom is mainly replaced in a specific position to achieve the expected regioselectivity.
Then, the obtained chlorotoluene is fluorinated. Commonly used fluorination reagents such as potassium fluoride, under specific solvents and reaction conditions, cause fluorine atoms to replace another hydrogen atom on chlorotoluene, thereby introducing fluorine atoms to obtain the target product 1-chloro-2-fluoro-4-methylbenzene. This fluorination step needs to be carefully regulated, because the activity and selectivity of fluorination reactions have special requirements. Many factors such as solvent properties, reaction temperatures, catalysts, etc., have a significant impact on the reaction process and product yield.
Another approach can be started from other suitable aromatic compounds, and this goal can also be achieved through gradual functional group conversion and modification. For example, selecting benzene derivatives containing suitable substituents, through a series of electrophilic substitution, nucleophilic substitution and other reactions, chlorine, fluorine and methyl functional groups are introduced one by one to obtain 1-chloro-2-fluoro-4-methylbenzene. However, in this process, the sequence and condition control of each step of the reaction need to be carefully designed to ensure the smooth progress of the reaction and obtain a product with higher yield and purity.
In short, the method of synthesizing 1-chloro-2-fluoro-4-methylbenzene requires comprehensive consideration of various factors such as the availability of raw materials, the ease of control of reaction conditions, the yield and purity of the product, and can be successfully achieved through rational design and fine operation.
One of them can be started from toluene. Toluene is halogenated and chlorine atoms are introduced first. In this step, a suitable chlorination reagent, such as chlorine, can be used. Under the action of light or catalyst, the chlorine atom replaces the hydrogen atom on the toluene-benzene ring to form chlorotoluene. However, this reaction requires attention to control the reaction conditions so that the chlorine atom is mainly replaced in a specific position to achieve the expected regioselectivity.
Then, the obtained chlorotoluene is fluorinated. Commonly used fluorination reagents such as potassium fluoride, under specific solvents and reaction conditions, cause fluorine atoms to replace another hydrogen atom on chlorotoluene, thereby introducing fluorine atoms to obtain the target product 1-chloro-2-fluoro-4-methylbenzene. This fluorination step needs to be carefully regulated, because the activity and selectivity of fluorination reactions have special requirements. Many factors such as solvent properties, reaction temperatures, catalysts, etc., have a significant impact on the reaction process and product yield.
Another approach can be started from other suitable aromatic compounds, and this goal can also be achieved through gradual functional group conversion and modification. For example, selecting benzene derivatives containing suitable substituents, through a series of electrophilic substitution, nucleophilic substitution and other reactions, chlorine, fluorine and methyl functional groups are introduced one by one to obtain 1-chloro-2-fluoro-4-methylbenzene. However, in this process, the sequence and condition control of each step of the reaction need to be carefully designed to ensure the smooth progress of the reaction and obtain a product with higher yield and purity.
In short, the method of synthesizing 1-chloro-2-fluoro-4-methylbenzene requires comprehensive consideration of various factors such as the availability of raw materials, the ease of control of reaction conditions, the yield and purity of the product, and can be successfully achieved through rational design and fine operation.
1-chloro-2-fluoro-4-methylbenzene what are the precautions during storage and transportation?
1-Chloro-2-fluoro-4-methylbenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
First words storage, this compound should be placed in a cool and ventilated warehouse. Because of its flammability, high temperature or open flame is prone to danger, so it is important to stay away from fire and heat sources. The temperature of the warehouse should be controlled within a suitable range to prevent excessive temperature from causing its volatilization to intensify or triggering other chemical reactions. And should be stored separately from oxidants, acids, bases, etc., and must not be mixed. This is due to the chemical properties of the compound, contact with the above substances, or react violently, causing serious consequences such as fire and explosion. At the same time, the storage area should be equipped with suitable materials to contain the leakage, so as to prevent the accidental leakage from being dealt with in time, so as not to cause greater harm due to its spread.
As for transportation, it is necessary to ensure that the packaging is complete and sealed before transportation. Packaging materials must be able to withstand a certain amount of external force to prevent package damage and material leakage due to bumps and collisions during transportation. During transportation, fire and heat sources should also be kept away, and transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. Drivers and escorts need to be professionally trained and familiar with the nature of the chemical and emergency treatment methods. During driving, it is necessary to protect against sun exposure, rain exposure and high temperature. If transported by rail, the assembly should be strictly in accordance with the dangerous goods assembly table in the "Dangerous Goods Transport Rules" of the Ministry of Railways.
In this way, the above points should be carefully followed during the storage and transportation of 1-chloro-2-fluoro-4-methylbenzene to ensure safety.
First words storage, this compound should be placed in a cool and ventilated warehouse. Because of its flammability, high temperature or open flame is prone to danger, so it is important to stay away from fire and heat sources. The temperature of the warehouse should be controlled within a suitable range to prevent excessive temperature from causing its volatilization to intensify or triggering other chemical reactions. And should be stored separately from oxidants, acids, bases, etc., and must not be mixed. This is due to the chemical properties of the compound, contact with the above substances, or react violently, causing serious consequences such as fire and explosion. At the same time, the storage area should be equipped with suitable materials to contain the leakage, so as to prevent the accidental leakage from being dealt with in time, so as not to cause greater harm due to its spread.
As for transportation, it is necessary to ensure that the packaging is complete and sealed before transportation. Packaging materials must be able to withstand a certain amount of external force to prevent package damage and material leakage due to bumps and collisions during transportation. During transportation, fire and heat sources should also be kept away, and transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. Drivers and escorts need to be professionally trained and familiar with the nature of the chemical and emergency treatment methods. During driving, it is necessary to protect against sun exposure, rain exposure and high temperature. If transported by rail, the assembly should be strictly in accordance with the dangerous goods assembly table in the "Dangerous Goods Transport Rules" of the Ministry of Railways.
In this way, the above points should be carefully followed during the storage and transportation of 1-chloro-2-fluoro-4-methylbenzene to ensure safety.
What are the effects of 1-chloro-2-fluoro-4-methylbenzene on the environment and human health?
1-Chloro-2-fluoro-4-methylbenzene is one of the organic compounds. Its impact on the environment and human health cannot be ignored.
In terms of the environment, if 1-chloro-2-fluoro-4-methylbenzene is released in nature, it is difficult to degrade quickly because of its certain chemical stability. It may accumulate in soil and water, causing soil and water pollution. In soil, it may affect the community structure and function of soil microorganisms, or interfere with many biochemical reactions in soil, damage soil fertility, endanger plant root growth and nutrient absorption. In water bodies, it may cause toxicity to aquatic organisms and interfere with the balance of aquatic ecosystems. For aquatic animals such as fish, exposure to this compound may cause physiological disorders, and even affect their reproduction, growth and survival.
As for personal health, 1-chloro-2-fluoro-4-methylbenzene can invade the human body through respiratory tract, skin contact or accidental ingestion. Inhaled through the respiratory tract, it may irritate the mucosa of the respiratory tract, causing symptoms such as cough, asthma, and shortness of breath. Long-term exposure to this environment may cause persistent damage to the lungs and increase the risk of respiratory diseases. If exposed through skin, it may cause allergic reactions to the skin, such as redness, swelling, itching, and rashes. Accidentally ingesting this compound may cause serious irritation and damage to the digestive system, nausea, vomiting, abdominal pain, diarrhea and other symptoms. In severe cases, it may damage the function of important organs such as the liver and kidneys. Because of its metabolism in the body, toxic metabolites may be generated, affecting the normal operation of organs.
In summary, 1-chloro-2-fluoro-4-methylbenzene poses potential hazards to the environment and human health. During its production, use and disposal, due care should be taken to implement proper protective and management measures to reduce its adverse effects on the environment and human body.
In terms of the environment, if 1-chloro-2-fluoro-4-methylbenzene is released in nature, it is difficult to degrade quickly because of its certain chemical stability. It may accumulate in soil and water, causing soil and water pollution. In soil, it may affect the community structure and function of soil microorganisms, or interfere with many biochemical reactions in soil, damage soil fertility, endanger plant root growth and nutrient absorption. In water bodies, it may cause toxicity to aquatic organisms and interfere with the balance of aquatic ecosystems. For aquatic animals such as fish, exposure to this compound may cause physiological disorders, and even affect their reproduction, growth and survival.
As for personal health, 1-chloro-2-fluoro-4-methylbenzene can invade the human body through respiratory tract, skin contact or accidental ingestion. Inhaled through the respiratory tract, it may irritate the mucosa of the respiratory tract, causing symptoms such as cough, asthma, and shortness of breath. Long-term exposure to this environment may cause persistent damage to the lungs and increase the risk of respiratory diseases. If exposed through skin, it may cause allergic reactions to the skin, such as redness, swelling, itching, and rashes. Accidentally ingesting this compound may cause serious irritation and damage to the digestive system, nausea, vomiting, abdominal pain, diarrhea and other symptoms. In severe cases, it may damage the function of important organs such as the liver and kidneys. Because of its metabolism in the body, toxic metabolites may be generated, affecting the normal operation of organs.
In summary, 1-chloro-2-fluoro-4-methylbenzene poses potential hazards to the environment and human health. During its production, use and disposal, due care should be taken to implement proper protective and management measures to reduce its adverse effects on the environment and human body.
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