Linshang Chemical
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1-Chloro-2-Fluoro-4-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
762214 |
| Chemical Formula | C7H3ClF4 |
| Molecular Weight | 198.54 |
| Appearance | Liquid (Typical description, actual may vary) |
| Boiling Point | Data needed |
| Melting Point | Data needed |
| Density | Data needed |
| Vapor Pressure | Data needed |
| Water Solubility | Data needed |
| Flash Point | Data needed |
| Refractive Index | Data needed |
As an accredited 1-Chloro-2-Fluoro-4-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 2 - fluoro - 4 - (trifluoromethyl)benzene in 500 - mL glass bottles, 10 bottles per carton. |
| Storage | 1 - Chloro - 2 - fluoro - 4 - (trifluoromethyl)benzene should be stored in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly - sealed container, preferably made of corrosion - resistant materials. Store separately from oxidizing agents, reducing agents, and other reactive chemicals to prevent potential reactions. |
| Shipping | 1 - Chloro - 2 - fluoro - 4 - (trifluoromethyl)benzene is shipped in specialized, tightly - sealed containers. Compliance with chemical transport regulations is ensured to prevent leakage, considering its potentially hazardous nature. |
Competitive 1-Chloro-2-Fluoro-4-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Chloro-2-Fluoro-4-(Trifluoromethyl)Benzene in China?
As a trusted 1-Chloro-2-Fluoro-4-(Trifluoromethyl)Benzene manufacturer, we deliver:
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Chloro-2-Fluoro-4-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-2-fluoro-4- (trifluoromethyl) benzene?
1-Chloro-2-fluoro-4- (trifluoromethyl) benzene is also an organic compound. It has a wide range of uses and is used in many fields of chemical industry.
First, this compound plays a pivotal role in the synthesis of medicine. It can be a key intermediate for the creation of new drugs. In modern medicine, its unique chemical structure can introduce drug molecules or change the physical and chemical properties of compounds, such as lipophilicity, stability, etc., thereby affecting the activity, absorption and metabolism of drugs. For example, in the development of drugs against specific diseases, the introduction of 1-chloro-2-fluoro-4- (trifluoromethyl) benzene structure may enhance the affinity between the drug and the target and enhance the efficacy.
Second, in the field of materials science, it also has its place. It can be used as a raw material for synthesizing polymer materials with special properties. Because it contains fluorine atoms, it can impart properties such as chemical resistance, low surface energy, and high temperature resistance to the material. Taking the preparation of high-performance coatings as an example, the addition of polymers synthesized from this compound can make the coating have excellent weather resistance and chemical resistance, and is widely used in construction, automotive and other industries to protect the surface of objects from external environmental damage.
Third, it is also indispensable in the creation of pesticides. It can provide a key structural unit for the synthesis of high-efficiency, low-toxicity and specific mechanisms of action of pesticides. Using its chemical properties may enable pesticides to precisely act on target organisms, improve the efficacy of insecticides, sterilization or weeding, and reduce the impact on non-target organisms, which is in line with the current trend of green and environmentally friendly pesticides.
In short, 1-chloro-2-fluoro-4- (trifluoromethyl) benzene, with its unique structure, is an important basic raw material in the fields of medicine, materials, pesticides, etc., which is of great significance for promoting the development of related industries.
First, this compound plays a pivotal role in the synthesis of medicine. It can be a key intermediate for the creation of new drugs. In modern medicine, its unique chemical structure can introduce drug molecules or change the physical and chemical properties of compounds, such as lipophilicity, stability, etc., thereby affecting the activity, absorption and metabolism of drugs. For example, in the development of drugs against specific diseases, the introduction of 1-chloro-2-fluoro-4- (trifluoromethyl) benzene structure may enhance the affinity between the drug and the target and enhance the efficacy.
Second, in the field of materials science, it also has its place. It can be used as a raw material for synthesizing polymer materials with special properties. Because it contains fluorine atoms, it can impart properties such as chemical resistance, low surface energy, and high temperature resistance to the material. Taking the preparation of high-performance coatings as an example, the addition of polymers synthesized from this compound can make the coating have excellent weather resistance and chemical resistance, and is widely used in construction, automotive and other industries to protect the surface of objects from external environmental damage.
Third, it is also indispensable in the creation of pesticides. It can provide a key structural unit for the synthesis of high-efficiency, low-toxicity and specific mechanisms of action of pesticides. Using its chemical properties may enable pesticides to precisely act on target organisms, improve the efficacy of insecticides, sterilization or weeding, and reduce the impact on non-target organisms, which is in line with the current trend of green and environmentally friendly pesticides.
In short, 1-chloro-2-fluoro-4- (trifluoromethyl) benzene, with its unique structure, is an important basic raw material in the fields of medicine, materials, pesticides, etc., which is of great significance for promoting the development of related industries.
What are the physical properties of 1-chloro-2-fluoro-4- (trifluoromethyl) benzene
1-Chloro-2-fluoro-4- (trifluoromethyl) benzene is an organic compound with specific physical properties. It is mostly liquid at room temperature, and has a certain volatility, and can slowly diffuse in air.
Looking at its boiling point, it is about a specific temperature range. This is determined by the intermolecular force. It contains halogen atoms such as chlorine and fluorine, and the halogen atoms have high electronegativity, which makes the intermolecular force complex, and the boiling point has its own unique value. The melting point also occupies a specific range and is determined by the arrangement and interaction of molecules. In the molecular structure, the benzene ring is a planar structure, and the substitution of halogen atoms and trifluoromethyl affects the close arrangement of molecules, which in turn affects the melting point.
Its density is greater than that of water. If mixed with water, it will sink to the bottom of the water. This is due to the relatively large mass of the molecules and the close arrangement of atoms, which increases the mass per unit volume. In terms of solubility, the solubility in water is very small, because it is a non-polar or weakly polar molecule, while water is a polar molecule. According to the principle of "similar miscibility", the two are difficult to dissolve. However, in organic solvents such as ethanol and ether, the solubility is higher. Because organic solvents are mostly non-polar or weakly polar, they match the intermolecular forces of 1-chloro-2-fluoro-4- (trifluoromethyl) benzene and are easily miscible.
It also has a certain odor, but the description of your mileage may vary, mostly irritating or special odor. This odor originates from the interaction of halogen atoms and benzene rings in the molecular structure, and the volatile characteristics make the odor molecules spread in the air, which is perceived by people.
In summary, the physical properties of 1-chloro-2-fluoro-4 - (trifluoromethyl) benzene are deeply affected by its molecular structure and composition, and are closely related to its physical properties in chemical industry, scientific research and other fields.
Looking at its boiling point, it is about a specific temperature range. This is determined by the intermolecular force. It contains halogen atoms such as chlorine and fluorine, and the halogen atoms have high electronegativity, which makes the intermolecular force complex, and the boiling point has its own unique value. The melting point also occupies a specific range and is determined by the arrangement and interaction of molecules. In the molecular structure, the benzene ring is a planar structure, and the substitution of halogen atoms and trifluoromethyl affects the close arrangement of molecules, which in turn affects the melting point.
Its density is greater than that of water. If mixed with water, it will sink to the bottom of the water. This is due to the relatively large mass of the molecules and the close arrangement of atoms, which increases the mass per unit volume. In terms of solubility, the solubility in water is very small, because it is a non-polar or weakly polar molecule, while water is a polar molecule. According to the principle of "similar miscibility", the two are difficult to dissolve. However, in organic solvents such as ethanol and ether, the solubility is higher. Because organic solvents are mostly non-polar or weakly polar, they match the intermolecular forces of 1-chloro-2-fluoro-4- (trifluoromethyl) benzene and are easily miscible.
It also has a certain odor, but the description of your mileage may vary, mostly irritating or special odor. This odor originates from the interaction of halogen atoms and benzene rings in the molecular structure, and the volatile characteristics make the odor molecules spread in the air, which is perceived by people.
In summary, the physical properties of 1-chloro-2-fluoro-4 - (trifluoromethyl) benzene are deeply affected by its molecular structure and composition, and are closely related to its physical properties in chemical industry, scientific research and other fields.
1-chloro-2-fluoro-4- (trifluoromethyl) benzene
1 - chloro - 2 - fluoro - 4 - (trifluoromethyl) benzene is an organic compound with unique chemical properties. This compound contains functional groups such as chlorine, fluorine and trifluoromethyl, which give it specific physical and chemical characteristics.
First talk about its chemical stability. Due to the high carbon-fluorine bond energy, the fluorine-containing functional group makes the compound stable and can resist many chemical reactions. The strong electron absorption of trifluoromethyl can change the electron cloud density distribution of the benzene ring, which has a great impact on its chemical activity.
Let's talk about the electrophilic substitution reaction. Since the benzene ring electron cloud is affected by fluorine, chlorine and trifluoromethyl, the electrophilic substitution reaction activity changes compared with benzene. Trifluoromethyl is a strong electron-absorbing group, which decreases the electron cloud density of the benzene ring, increases the difficulty of electrophilic substitution reaction, and often makes the reaction conditions more severe. Although chlorine and fluorine are ortho-para-site localization groups, the strong electron-absorbing effect of trifluoromethyl may change the localization rules, causing the attack position of electrophilic reagents to be biased in a specific direction.
Its halogen atom properties are also critical. Chlorine atoms can participate in nucleophilic substitution reactions. Under appropriate nucleophilic reagents and reaction conditions, chlorine atoms can be replaced to form new derivatives. Although fluorine atoms are slightly less chemically active, they contribute significantly to the overall properties of compounds due to the stability of carbon-fluorine bonds.
1 - chloro - 2 - fluoro - 4 - (trifluoromethyl) benzene is widely used in the field of organic synthesis due to these chemical properties, and can be used as raw materials or intermediates to prepare organic materials with special properties, drugs and other compounds.
First talk about its chemical stability. Due to the high carbon-fluorine bond energy, the fluorine-containing functional group makes the compound stable and can resist many chemical reactions. The strong electron absorption of trifluoromethyl can change the electron cloud density distribution of the benzene ring, which has a great impact on its chemical activity.
Let's talk about the electrophilic substitution reaction. Since the benzene ring electron cloud is affected by fluorine, chlorine and trifluoromethyl, the electrophilic substitution reaction activity changes compared with benzene. Trifluoromethyl is a strong electron-absorbing group, which decreases the electron cloud density of the benzene ring, increases the difficulty of electrophilic substitution reaction, and often makes the reaction conditions more severe. Although chlorine and fluorine are ortho-para-site localization groups, the strong electron-absorbing effect of trifluoromethyl may change the localization rules, causing the attack position of electrophilic reagents to be biased in a specific direction.
Its halogen atom properties are also critical. Chlorine atoms can participate in nucleophilic substitution reactions. Under appropriate nucleophilic reagents and reaction conditions, chlorine atoms can be replaced to form new derivatives. Although fluorine atoms are slightly less chemically active, they contribute significantly to the overall properties of compounds due to the stability of carbon-fluorine bonds.
1 - chloro - 2 - fluoro - 4 - (trifluoromethyl) benzene is widely used in the field of organic synthesis due to these chemical properties, and can be used as raw materials or intermediates to prepare organic materials with special properties, drugs and other compounds.
What are the synthesis methods of 1-chloro-2-fluoro-4- (trifluoromethyl) benzene
The synthesis methods of 1-chloro-2-fluoro-4- (trifluoromethyl) benzene have different paths, and the common ones are briefly described below.
One is the halogenation reaction path. First, the benzene derivative containing trifluoromethyl is used as the starting material. If the starting material is p-trifluoromethyl benzene, chlorine and fluorine can be used as the halogenating reagents first. Under suitable reaction conditions, such as in the presence of a specific catalyst, and the fine regulation of temperature, pressure and other conditions, chlorine and hydrogen atoms at a specific position on the benzene ring undergo a substitution reaction, introducing chlorine atoms, and then fluorine also participates in the reaction, replacing hydrogen atoms at another position, thereby obtaining the target product 1-chloro-2-fluoro-4- (trifluoromethyl) benzene. In this process, the choice of catalyst is crucial. Commonly used catalysts such as iron-based catalysts and aluminum-based catalysts can effectively promote the halogenation reaction and have an important impact on the selectivity of the reaction check point. The control of temperature and pressure cannot be ignored. Different reaction conditions will significantly affect the yield and purity of the product.
The second is the nucleophilic substitution reaction path. Benzene derivatives containing halogen atoms and trifluoromethyl are used as raw materials. If the raw material is 1-chloro-4 - (trifluoromethyl) benzene, suitable fluorine sources can be selected, such as potassium fluoride. In polar aprotic solvents, such as dimethyl sulfoxide (DMSO), under heating conditions, fluorine ions act as nucleophiles to attack the carbon atoms attached to the chlorine atoms on the benzene ring, and a nucleophilic substitution reaction occurs. The chlorine atoms are replaced by fluorine atoms to generate 1-chloro-2-fluoro-4 - (trifluoromethyl) benzene. In this path, the polarity of the solvent has a great impact on the reaction rate. Polar aprotic solvents can effectively dissolve reactants and salts, promote the activity of ions, and speed up the reaction process. The activity and dosage of fluorine sources also need to be precisely controlled. Too much or too little fluorine sources may lead to the occurrence of side reactions or reduced yields.
The third is through the reaction of aryl diazonium salts. First, aromatic amines containing trifluoromethyl are prepared, and diazonium salts are formed by diazotization. Then, under the action of specific halogenating reagents, a substitution reaction occurs to introduce chlorine atoms and fluorine atoms. For example, p-trifluoromethylaniline and sodium nitrite are diazotized under acidic conditions to form diazonium salts. After that, reagents containing chlorine and fluorine are added. Through a series of complex reaction processes, the substitution of chlorine atoms and fluorine atoms at specific positions on the benzene ring is achieved, and then 1-chloro-2-fluoro-4 - (trifluoromethyl) benzene is obtained. This process requires strict control of the conditions of the diazotization reaction. The acidic environment, temperature and other factors will affect the stability and reactivity of the diazonium salt. The selection of halogenated reagents and the reaction sequence also play a significant role in the formation of the product.
All this synthesis method has its own advantages and disadvantages. In practical application, it is necessary to carefully select the appropriate synthesis path according to many factors such as the availability of raw materials, the difficulty of controlling the reaction conditions, and the purity and yield requirements of the product.
One is the halogenation reaction path. First, the benzene derivative containing trifluoromethyl is used as the starting material. If the starting material is p-trifluoromethyl benzene, chlorine and fluorine can be used as the halogenating reagents first. Under suitable reaction conditions, such as in the presence of a specific catalyst, and the fine regulation of temperature, pressure and other conditions, chlorine and hydrogen atoms at a specific position on the benzene ring undergo a substitution reaction, introducing chlorine atoms, and then fluorine also participates in the reaction, replacing hydrogen atoms at another position, thereby obtaining the target product 1-chloro-2-fluoro-4- (trifluoromethyl) benzene. In this process, the choice of catalyst is crucial. Commonly used catalysts such as iron-based catalysts and aluminum-based catalysts can effectively promote the halogenation reaction and have an important impact on the selectivity of the reaction check point. The control of temperature and pressure cannot be ignored. Different reaction conditions will significantly affect the yield and purity of the product.
The second is the nucleophilic substitution reaction path. Benzene derivatives containing halogen atoms and trifluoromethyl are used as raw materials. If the raw material is 1-chloro-4 - (trifluoromethyl) benzene, suitable fluorine sources can be selected, such as potassium fluoride. In polar aprotic solvents, such as dimethyl sulfoxide (DMSO), under heating conditions, fluorine ions act as nucleophiles to attack the carbon atoms attached to the chlorine atoms on the benzene ring, and a nucleophilic substitution reaction occurs. The chlorine atoms are replaced by fluorine atoms to generate 1-chloro-2-fluoro-4 - (trifluoromethyl) benzene. In this path, the polarity of the solvent has a great impact on the reaction rate. Polar aprotic solvents can effectively dissolve reactants and salts, promote the activity of ions, and speed up the reaction process. The activity and dosage of fluorine sources also need to be precisely controlled. Too much or too little fluorine sources may lead to the occurrence of side reactions or reduced yields.
The third is through the reaction of aryl diazonium salts. First, aromatic amines containing trifluoromethyl are prepared, and diazonium salts are formed by diazotization. Then, under the action of specific halogenating reagents, a substitution reaction occurs to introduce chlorine atoms and fluorine atoms. For example, p-trifluoromethylaniline and sodium nitrite are diazotized under acidic conditions to form diazonium salts. After that, reagents containing chlorine and fluorine are added. Through a series of complex reaction processes, the substitution of chlorine atoms and fluorine atoms at specific positions on the benzene ring is achieved, and then 1-chloro-2-fluoro-4 - (trifluoromethyl) benzene is obtained. This process requires strict control of the conditions of the diazotization reaction. The acidic environment, temperature and other factors will affect the stability and reactivity of the diazonium salt. The selection of halogenated reagents and the reaction sequence also play a significant role in the formation of the product.
All this synthesis method has its own advantages and disadvantages. In practical application, it is necessary to carefully select the appropriate synthesis path according to many factors such as the availability of raw materials, the difficulty of controlling the reaction conditions, and the purity and yield requirements of the product.
What 1-chloro-2-fluoro-4- (trifluoromethyl) benzene needs to pay attention to when storing and transporting
1-Chloro-2-fluoro-4- (trifluoromethyl) benzene, an organic compound, requires careful attention when storing and transporting.
First of all, storage should be placed in a cool and ventilated place. Because of its heat can easily cause danger, such as high temperature or cause molecular activity to increase, or cause decomposition, polymerization and other reactions, the cool environment can ensure the stability of its chemical properties. Second, it must be kept away from fire and heat sources. This compound may be flammable, and it is easy to burn or even explode in case of open flame or hot topic, so fire and heat sources must be kept away. Third, the storage place should be equipped with suitable materials to contain leaks. When accidentally leaked, if there is no compatible material, it will spread or pollute the environment, or cause harm to the human body. Fourth, it should be stored separately from oxidants and edible chemicals, and should not be mixed. The strong oxidizing properties of oxidants may react violently with the compound, and mixed with edible chemicals, once leaked, or cause serious consequences such as accidental ingestion.
As for transportation, first, the transportation vehicle should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. If there is a sudden fire or leakage during transportation, it can be responded to in time to reduce the harm. Second, it should be transported in the morning and evening in summer to avoid high temperature periods. Due to the high temperature, the environmental risk of the compound will be greatly increased, and the temperature will be low in the morning and evening, which is relatively safe. Third, when transporting, make sure that the container does not leak, collapse, fall, or damage. If the container is damaged and the compound leaks, it is not only wasteful, but also easy to cause danger. Fourth, it is strictly forbidden to mix and transport with oxidants, edible chemicals, etc., to prevent mutual reaction. Fifth, during transportation, it should be protected from sun exposure, rain exposure, and high temperature. Both sun exposure and rain exposure will affect the properties of the compound, and high temperature will also increase the risk factor. In short, the storage and transportation of 1-chloro-2-fluoro-4- (trifluoromethyl) benzene must be treated with caution and follow relevant rules to ensure safety.
First of all, storage should be placed in a cool and ventilated place. Because of its heat can easily cause danger, such as high temperature or cause molecular activity to increase, or cause decomposition, polymerization and other reactions, the cool environment can ensure the stability of its chemical properties. Second, it must be kept away from fire and heat sources. This compound may be flammable, and it is easy to burn or even explode in case of open flame or hot topic, so fire and heat sources must be kept away. Third, the storage place should be equipped with suitable materials to contain leaks. When accidentally leaked, if there is no compatible material, it will spread or pollute the environment, or cause harm to the human body. Fourth, it should be stored separately from oxidants and edible chemicals, and should not be mixed. The strong oxidizing properties of oxidants may react violently with the compound, and mixed with edible chemicals, once leaked, or cause serious consequences such as accidental ingestion.
As for transportation, first, the transportation vehicle should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. If there is a sudden fire or leakage during transportation, it can be responded to in time to reduce the harm. Second, it should be transported in the morning and evening in summer to avoid high temperature periods. Due to the high temperature, the environmental risk of the compound will be greatly increased, and the temperature will be low in the morning and evening, which is relatively safe. Third, when transporting, make sure that the container does not leak, collapse, fall, or damage. If the container is damaged and the compound leaks, it is not only wasteful, but also easy to cause danger. Fourth, it is strictly forbidden to mix and transport with oxidants, edible chemicals, etc., to prevent mutual reaction. Fifth, during transportation, it should be protected from sun exposure, rain exposure, and high temperature. Both sun exposure and rain exposure will affect the properties of the compound, and high temperature will also increase the risk factor. In short, the storage and transportation of 1-chloro-2-fluoro-4- (trifluoromethyl) benzene must be treated with caution and follow relevant rules to ensure safety.
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