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1-Chloro-2-Fluoro-5-Nitro-3-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
235504 |
| Chemical Formula | C7H2ClF4NO2 |
| Molar Mass | 245.54 g/mol |
| Appearance | Solid (presumably, based on common aromatic halonitro compounds) |
| Solubility In Water | Low (due to non - polar aromatic and fluorinated structure) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform (due to non - polar nature) |
| Vapor Pressure | Low (due to its solid nature, but exact value needs research) |
| Stability | Stable under normal conditions, but may react with strong reducing agents or bases |
As an accredited 1-Chloro-2-Fluoro-5-Nitro-3-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1 - chloro - 2 - fluoro - 5 - nitro - 3 - (trifluoromethyl)benzene in a sealed chemical - grade bottle. |
| Storage | 1 - chloro - 2 - fluoro - 5 - nitro - 3 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and bases to prevent potential chemical reactions. |
| Shipping | 1 - chloro - 2 - fluoro - 5 - nitro - 3 - (trifluoromethyl)benzene is a chemical. Shipping requires proper packaging in accordance with hazardous material regulations, with labels indicating its nature, and transport via approved carriers for safe transit. |
Competitive 1-Chloro-2-Fluoro-5-Nitro-3-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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Where to Buy 1-Chloro-2-Fluoro-5-Nitro-3-(Trifluoromethyl)Benzene in China?
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As a leading 1-Chloro-2-Fluoro-5-Nitro-3-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-2-fluoro-5-nitro-3- (trifluoromethyl) benzene?
1-Chloro-2-fluoro-5-nitro-3- (trifluoromethyl) benzene, an organic compound, is widely used in chemical and scientific research fields.
One of them is a key intermediate in the field of organic synthesis. It can interact with nucleophilic reagents such as nitrogen, oxygen, and sulfur through many chemical reactions, such as nucleophilic substitution reactions, to build complex organic molecules. For example, it can react with amine compounds to generate new nitrogen-containing organic compounds, providing key basic substances for drug development, materials science, and other fields. Due to the coexistence of various functional groups such as chlorine, fluorine, nitro and trifluoromethyl in the molecule, it endows it with rich chemical reactivity, and can derive a wide variety of compounds according to different reaction conditions and needs, providing a broad space for organic synthesis chemists to create new compounds.
Second, in the field of materials science, its importance cannot be underestimated. Because of its special electronic properties and chemical stability, it can be used to prepare materials with special properties. For example, it can participate in polymerization reactions as monomers to synthesize fluorine-containing polymer materials. Such materials often exhibit excellent chemical corrosion resistance, low surface energy and excellent electrical properties, and have important applications in high-end fields such as aerospace and electronic devices. For example, some components in the aerospace field need to withstand extreme environments, and polymer materials derived from this compound can meet this demand; in the insulating materials of electronic devices, such fluorinated materials can also improve the performance of devices by virtue of their electrical properties.
Third, in the field of medicinal chemistry, it also plays an important role. Due to its special structure and electronic effects, it may be used as a lead compound for structural modification and optimization. Pharmaceutical chemists can develop drug molecules with specific biological activities based on the structure of this compound by adjusting functional groups and exploring its interaction with biological targets. In the development process of some anticancer drugs and antibacterial drugs, it may be used as a starting material to optimize the structure through multi-step reactions to obtain drugs with better curative effects and fewer side effects.
To sum up, 1-chloro-2-fluoro-5-nitro-3- (trifluoromethyl) benzene plays an indispensable role in the fields of organic synthesis, materials science and medicinal chemistry due to its unique structure and chemical properties, promoting technological progress and innovation in various fields.
One of them is a key intermediate in the field of organic synthesis. It can interact with nucleophilic reagents such as nitrogen, oxygen, and sulfur through many chemical reactions, such as nucleophilic substitution reactions, to build complex organic molecules. For example, it can react with amine compounds to generate new nitrogen-containing organic compounds, providing key basic substances for drug development, materials science, and other fields. Due to the coexistence of various functional groups such as chlorine, fluorine, nitro and trifluoromethyl in the molecule, it endows it with rich chemical reactivity, and can derive a wide variety of compounds according to different reaction conditions and needs, providing a broad space for organic synthesis chemists to create new compounds.
Second, in the field of materials science, its importance cannot be underestimated. Because of its special electronic properties and chemical stability, it can be used to prepare materials with special properties. For example, it can participate in polymerization reactions as monomers to synthesize fluorine-containing polymer materials. Such materials often exhibit excellent chemical corrosion resistance, low surface energy and excellent electrical properties, and have important applications in high-end fields such as aerospace and electronic devices. For example, some components in the aerospace field need to withstand extreme environments, and polymer materials derived from this compound can meet this demand; in the insulating materials of electronic devices, such fluorinated materials can also improve the performance of devices by virtue of their electrical properties.
Third, in the field of medicinal chemistry, it also plays an important role. Due to its special structure and electronic effects, it may be used as a lead compound for structural modification and optimization. Pharmaceutical chemists can develop drug molecules with specific biological activities based on the structure of this compound by adjusting functional groups and exploring its interaction with biological targets. In the development process of some anticancer drugs and antibacterial drugs, it may be used as a starting material to optimize the structure through multi-step reactions to obtain drugs with better curative effects and fewer side effects.
To sum up, 1-chloro-2-fluoro-5-nitro-3- (trifluoromethyl) benzene plays an indispensable role in the fields of organic synthesis, materials science and medicinal chemistry due to its unique structure and chemical properties, promoting technological progress and innovation in various fields.
What are the physical properties of 1-chloro-2-fluoro-5-nitro-3- (trifluoromethyl) benzene
1-Chloro-2-fluoro-5-nitro-3- (trifluoromethyl) benzene is a kind of organic compound. Its physical properties are quite characteristic, let me tell you in detail.
Looking at its appearance, under room temperature and pressure, this substance is often colorless to light yellow liquid, but the specific color state may vary slightly due to factors such as purity. Its odor may be irritating. If you smell it carelessly, it may disturb the nasal cavity and respiratory tract.
As for the melting point, the melting point is about [X] ° C, and the boiling point is about [X] ° C. The value of the melting boiling point is determined by many factors such as the intermolecular force, the relative molecular weight and the molecular structure. Its relative molecular weight is large, and the molecule contains fluorine, chlorine, nitro and other groups, which enhance the intermolecular force, so the melting boiling point is relatively high.
In terms of solubility, this compound is insoluble in water. Due to its molecular structure, benzene ring and various halogen atoms, nitro, trifluoromethyl and other groups are hydrophobic groups, making it difficult to form effective interactions with water molecules, so it has little solubility in water. However, in organic solvents, such as ethanol, ether, dichloromethane, etc., it has good solubility. This is because the organic solvent and the compound molecules can interact with each other through van der Waals forces, so as to achieve mutual solubility.
Density is also one of its important physical properties. Its density is greater than that of water, about [X] g/cm ³. This is due to the presence of halogen atoms and trifluoromethyl in the molecule, which increases the mass of the substance per unit volume, so the density is greater than that of water.
In addition, the volatility of the compound is relatively low. The strong force between molecules binds the movement of the molecule, making it difficult to volatilize into the gas phase at room temperature. This property is crucial in practical applications, and is related to its stability during storage and use.
In summary, the physical properties of 1-chloro-2-fluoro-5-nitro-3- (trifluoromethyl) benzene are restricted by its molecular structure. Understanding these properties is of great significance in studying its chemical behavior, practical application, and related safety protection.
Looking at its appearance, under room temperature and pressure, this substance is often colorless to light yellow liquid, but the specific color state may vary slightly due to factors such as purity. Its odor may be irritating. If you smell it carelessly, it may disturb the nasal cavity and respiratory tract.
As for the melting point, the melting point is about [X] ° C, and the boiling point is about [X] ° C. The value of the melting boiling point is determined by many factors such as the intermolecular force, the relative molecular weight and the molecular structure. Its relative molecular weight is large, and the molecule contains fluorine, chlorine, nitro and other groups, which enhance the intermolecular force, so the melting boiling point is relatively high.
In terms of solubility, this compound is insoluble in water. Due to its molecular structure, benzene ring and various halogen atoms, nitro, trifluoromethyl and other groups are hydrophobic groups, making it difficult to form effective interactions with water molecules, so it has little solubility in water. However, in organic solvents, such as ethanol, ether, dichloromethane, etc., it has good solubility. This is because the organic solvent and the compound molecules can interact with each other through van der Waals forces, so as to achieve mutual solubility.
Density is also one of its important physical properties. Its density is greater than that of water, about [X] g/cm ³. This is due to the presence of halogen atoms and trifluoromethyl in the molecule, which increases the mass of the substance per unit volume, so the density is greater than that of water.
In addition, the volatility of the compound is relatively low. The strong force between molecules binds the movement of the molecule, making it difficult to volatilize into the gas phase at room temperature. This property is crucial in practical applications, and is related to its stability during storage and use.
In summary, the physical properties of 1-chloro-2-fluoro-5-nitro-3- (trifluoromethyl) benzene are restricted by its molecular structure. Understanding these properties is of great significance in studying its chemical behavior, practical application, and related safety protection.
What are the chemical properties of 1-chloro-2-fluoro-5-nitro-3- (trifluoromethyl) benzene
1-Chloro-2-fluoro-5-nitro-3- (trifluoromethyl) benzene, this is an organic compound with unique chemical properties.
First talk about its halogenated hydrocarbon characteristics. Due to the presence of chlorine atoms and fluorine atoms, there is a typical reaction of halogenated hydrocarbons. In case of nucleophiles, chlorine atoms can be replaced. If co-heated with sodium hydroxide aqueous solution, chlorine atoms will be replaced by hydroxyl groups to form corresponding phenolic derivatives; when reacted with sodium alcohol, ether compounds can be formed. The activity of this substitution reaction is affected by other substituents on the benzene ring. Nitro and trifluoromethyl are electron-withdrawing groups, which reduce the electron cloud density of the benzene ring and make it easier for chlorine atoms to leave, enhancing the substitution reaction activity.
Let's talk about the influence of nitro. Nitro is a strong electron-absorbing group, which not only affects the electron cloud distribution of benzene ring, but also makes the benzene ring more prone to electrophilic substitution. However, due to the electron-absorbing action of nitro, the new electrophilic substitution reaction mainly occurs in the nitro interposition. At the same time, nitro can be reduced. Under suitable conditions, if iron and hydrochloric acid are used as reducing agents, nitro can be gradually reduced to amino groups to obtain benzene derivatives containing amino groups. This product is widely used in synthetic dyes, medicine and other fields.
Trifluoromethyl also cannot be ignored. Due to its strong electron absorption and high electronegativity, it significantly changes the electron cloud density and spatial structure of benzene ring. This not only affects the physical properties of the compound, such as boiling point and solubility, but also improves its chemical stability. The presence of trifluoromethyl makes the compound exhibit unique selectivity and activity in some chemical reactions.
In terms of solubility, this compound contains multiple polar groups, and has good solubility in polar organic solvents such as dichloromethane, N, N-dimethylformamide, but poor solubility in water. Its stability is high, and it can exist stably at room temperature and pressure, but when exposed to strong oxidants, high temperatures or specific catalysts, chemical reactions will occur.
First talk about its halogenated hydrocarbon characteristics. Due to the presence of chlorine atoms and fluorine atoms, there is a typical reaction of halogenated hydrocarbons. In case of nucleophiles, chlorine atoms can be replaced. If co-heated with sodium hydroxide aqueous solution, chlorine atoms will be replaced by hydroxyl groups to form corresponding phenolic derivatives; when reacted with sodium alcohol, ether compounds can be formed. The activity of this substitution reaction is affected by other substituents on the benzene ring. Nitro and trifluoromethyl are electron-withdrawing groups, which reduce the electron cloud density of the benzene ring and make it easier for chlorine atoms to leave, enhancing the substitution reaction activity.
Let's talk about the influence of nitro. Nitro is a strong electron-absorbing group, which not only affects the electron cloud distribution of benzene ring, but also makes the benzene ring more prone to electrophilic substitution. However, due to the electron-absorbing action of nitro, the new electrophilic substitution reaction mainly occurs in the nitro interposition. At the same time, nitro can be reduced. Under suitable conditions, if iron and hydrochloric acid are used as reducing agents, nitro can be gradually reduced to amino groups to obtain benzene derivatives containing amino groups. This product is widely used in synthetic dyes, medicine and other fields.
Trifluoromethyl also cannot be ignored. Due to its strong electron absorption and high electronegativity, it significantly changes the electron cloud density and spatial structure of benzene ring. This not only affects the physical properties of the compound, such as boiling point and solubility, but also improves its chemical stability. The presence of trifluoromethyl makes the compound exhibit unique selectivity and activity in some chemical reactions.
In terms of solubility, this compound contains multiple polar groups, and has good solubility in polar organic solvents such as dichloromethane, N, N-dimethylformamide, but poor solubility in water. Its stability is high, and it can exist stably at room temperature and pressure, but when exposed to strong oxidants, high temperatures or specific catalysts, chemical reactions will occur.
What are the synthesis methods of 1-chloro-2-fluoro-5-nitro-3- (trifluoromethyl) benzene
The synthesis methods of 1-chloro-2-fluoro-5-nitro-3- (trifluoromethyl) benzene include the following:
First, the benzene derivative containing trifluoromethyl is used as the starting material. It can be nitrified first, and the nitro group is introduced into the benzene ring. Under suitable reaction conditions, a mixed acid (a mixture of sulfuric acid and nitric acid) is used as the nitrifying reagent, and the reaction temperature, time and other factors are controlled to selectively introduce the nitro group into the target position. Then the halogenation reaction is carried out, and the chlorine atom is introduced first. Appropriate chlorination reagents, such as sulfoxide chloride and phosphorus oxychloride, can be selected to react with the reactants in the presence of suitable catalysts. Then fluorine atoms are introduced, and commonly used fluorinating reagents such as potassium fluoride are used to complete the fluorination reaction under specific solvents and reaction conditions to obtain the target product.
Second, halobenzene is used as the starting material. First, the trifluoromethylation reaction of halogenated benzene can be carried out, and suitable trifluoromethylation reagents can be selected, such as Grignard reagents such as trifluoromethyl halide magnesium, or trifluoromethyl is introduced into the benzene ring by Ullman reaction and other related methods. After that, the nitration reaction is carried out in sequence, the nitro group is introduced, and then another halogen atom substitution reaction is carried out, and the chlorine atom and fluorine atom are introduced respectively. The synthesis of the target product is achieved by carefully adjusting the reaction conditions of each step, including the proportion of reactants
Third, the strategy of gradually constructing benzene rings can also be used. First, some simple organic compounds are used as raw materials to construct benzene ring structures containing specific substituents through multi-step reactions. For example, starting from fluorine-containing, chlorine, nitro and trifluoromethyl-related small molecules, using classic organic reactions such as Fu-G reaction, gradually linking each substituent and constructing benzene rings, and finally synthesizing 1-chloro-2-fluoro-5-nitro-3- (trifluoromethyl) benzene. Although this method is complicated, it requires high control of the intermediates in each step of the reaction, but it is also a feasible synthesis path. In the actual synthesis process, it is necessary to comprehensively consider and select the most suitable synthesis method according to many factors such as the availability of starting materials, the difficulty of controlling reaction conditions, and the cost.
First, the benzene derivative containing trifluoromethyl is used as the starting material. It can be nitrified first, and the nitro group is introduced into the benzene ring. Under suitable reaction conditions, a mixed acid (a mixture of sulfuric acid and nitric acid) is used as the nitrifying reagent, and the reaction temperature, time and other factors are controlled to selectively introduce the nitro group into the target position. Then the halogenation reaction is carried out, and the chlorine atom is introduced first. Appropriate chlorination reagents, such as sulfoxide chloride and phosphorus oxychloride, can be selected to react with the reactants in the presence of suitable catalysts. Then fluorine atoms are introduced, and commonly used fluorinating reagents such as potassium fluoride are used to complete the fluorination reaction under specific solvents and reaction conditions to obtain the target product.
Second, halobenzene is used as the starting material. First, the trifluoromethylation reaction of halogenated benzene can be carried out, and suitable trifluoromethylation reagents can be selected, such as Grignard reagents such as trifluoromethyl halide magnesium, or trifluoromethyl is introduced into the benzene ring by Ullman reaction and other related methods. After that, the nitration reaction is carried out in sequence, the nitro group is introduced, and then another halogen atom substitution reaction is carried out, and the chlorine atom and fluorine atom are introduced respectively. The synthesis of the target product is achieved by carefully adjusting the reaction conditions of each step, including the proportion of reactants
Third, the strategy of gradually constructing benzene rings can also be used. First, some simple organic compounds are used as raw materials to construct benzene ring structures containing specific substituents through multi-step reactions. For example, starting from fluorine-containing, chlorine, nitro and trifluoromethyl-related small molecules, using classic organic reactions such as Fu-G reaction, gradually linking each substituent and constructing benzene rings, and finally synthesizing 1-chloro-2-fluoro-5-nitro-3- (trifluoromethyl) benzene. Although this method is complicated, it requires high control of the intermediates in each step of the reaction, but it is also a feasible synthesis path. In the actual synthesis process, it is necessary to comprehensively consider and select the most suitable synthesis method according to many factors such as the availability of starting materials, the difficulty of controlling reaction conditions, and the cost.
1-chloro-2-fluoro-5-nitro-3- (trifluoromethyl) benzene during storage and transportation
1-Chloro-2-fluoro-5-nitro-3- (trifluoromethyl) benzene is an organic compound. When storing and transporting, many matters must be paid attention to.
First words Storage. This compound should be placed in a cool, dry and well-ventilated place. Because of its chemical activity, high temperature and humid environment can easily lead to qualitative change. High temperature can cause a large increase in the active level of molecules, or trigger chemical reactions, causing it to deteriorate; in a humid environment, moisture may react with the compound, damaging its purity and quality. Therefore, choose a cool, dry and well-ventilated place to ensure its chemical stability.
In addition, when storing, it must be stored separately from oxidizing agents, reducing agents, alkalis, etc. This compound is chemically active, and it can react with oxidizing agents or cause severe oxidation reactions, and even cause combustion and explosion; it may react with reducing agents, causing chemical properties to change; it may react with alkalis, or cause acid-base neutralization and other reactions, which can damage its original characteristics.
As for packaging, it is also very important. It must be contained in a sealed, chemically resistant container. Sealing can prevent the compound from evaporating, escaping and causing environmental pollution, and prevent it from contacting with oxygen, moisture, etc. in the air; chemically resistant containers can avoid the reaction between the container and the compound, and keep their packaging intact.
The following transportation. During transportation, it is necessary to ensure that the container does not leak, collapse, fall or damage. Because of its potential danger, if the container is damaged, the compound will leak, or cause serious consequences. It can not only pollute the environment, but also pose a health threat to the transporters.
When transporting, it must also be implemented in accordance with relevant regulations and standards. Follow the specific requirements for the transportation of hazardous chemicals, and be equipped with necessary emergency treatment equipment and protective equipment. In this way, in case of emergencies, the transporters can properly dispose of it in time to reduce the damage.
In summary, when storing and transporting 1-chloro-2-fluoro-5-nitro-3- (trifluoromethyl) benzene, attention should be paid to the environment, classified storage, packaging and transportation specifications to ensure its safety and avoid dangerous accidents.
First words Storage. This compound should be placed in a cool, dry and well-ventilated place. Because of its chemical activity, high temperature and humid environment can easily lead to qualitative change. High temperature can cause a large increase in the active level of molecules, or trigger chemical reactions, causing it to deteriorate; in a humid environment, moisture may react with the compound, damaging its purity and quality. Therefore, choose a cool, dry and well-ventilated place to ensure its chemical stability.
In addition, when storing, it must be stored separately from oxidizing agents, reducing agents, alkalis, etc. This compound is chemically active, and it can react with oxidizing agents or cause severe oxidation reactions, and even cause combustion and explosion; it may react with reducing agents, causing chemical properties to change; it may react with alkalis, or cause acid-base neutralization and other reactions, which can damage its original characteristics.
As for packaging, it is also very important. It must be contained in a sealed, chemically resistant container. Sealing can prevent the compound from evaporating, escaping and causing environmental pollution, and prevent it from contacting with oxygen, moisture, etc. in the air; chemically resistant containers can avoid the reaction between the container and the compound, and keep their packaging intact.
The following transportation. During transportation, it is necessary to ensure that the container does not leak, collapse, fall or damage. Because of its potential danger, if the container is damaged, the compound will leak, or cause serious consequences. It can not only pollute the environment, but also pose a health threat to the transporters.
When transporting, it must also be implemented in accordance with relevant regulations and standards. Follow the specific requirements for the transportation of hazardous chemicals, and be equipped with necessary emergency treatment equipment and protective equipment. In this way, in case of emergencies, the transporters can properly dispose of it in time to reduce the damage.
In summary, when storing and transporting 1-chloro-2-fluoro-5-nitro-3- (trifluoromethyl) benzene, attention should be paid to the environment, classified storage, packaging and transportation specifications to ensure its safety and avoid dangerous accidents.
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