Linshang Chemical
PRODUCTS
1-Chloro-2-Fluoro-6-Nitrobenzene
Linshang Chemical
|
HS Code |
881965 |
| Chemical Formula | C6H3ClFNO2 |
| Molar Mass | 177.545 g/mol |
| Appearance | Solid |
| Boiling Point | 220 - 222 °C |
| Melting Point | 34 - 36 °C |
| Density | 1.494 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents |
| Flash Point | 96 °C |
| Vapor Pressure | Low at room temperature |
| Hazard Class | Harmful if swallowed, inhaled or in contact with skin |
As an accredited 1-Chloro-2-Fluoro-6-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 2 - fluoro - 6 - nitrobenzene: Packed in 500 - gram bottles for chemical use. |
| Storage | 1 - Chloro - 2 - fluoro - 6 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and ignition sources as it may be combustible. Store in a tightly - sealed container to prevent vapor leakage. Segregate it from oxidizing agents and reducing agents to avoid potential chemical reactions. |
| Shipping | 1 - chloro - 2 - fluoro - 6 - nitrobenzene is a hazardous chemical. It must be shipped in accordance with strict regulations. Use appropriate, well - sealed containers, label clearly, and ensure compliance with transportation safety and environmental protection requirements. |
Competitive 1-Chloro-2-Fluoro-6-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Chloro-2-Fluoro-6-Nitrobenzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Chloro-2-Fluoro-6-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-2-fluoro-6-nitrobenzene?
1 - chloro - 2 - fluoro - 6 - nitrobenzene is an organic compound with a wide range of uses in the chemical industry. Its main uses are as follows:
First, it is a key intermediate in the synthesis of medicines. In many drug synthesis processes, this compound can participate in specific reactions by virtue of its own structural characteristics and help to construct the key structures of active pharmaceutical ingredients. For example, when developing new therapeutic drugs for specific diseases, the chlorine, fluorine, nitro and other functional groups it contains can be used to precisely dock with other organic molecules through a series of chemical reactions, and then obtain drug molecules with specific pharmacological activities.
Second, it is an important raw material for the preparation of pesticides. In the field of pesticide synthesis, its unique structure can impart specific biological activities to pesticides. For example, by reacting with other organic compounds, a new type of pesticide can be generated that has a high-efficiency toxic effect on pests and has a small impact on the environment. The halogen atoms and nitro groups in its structure can enhance the ability of the compound to bind to specific biological targets in pests, thereby enhancing the insecticidal effect of pesticides.
Third, it also has applications in materials science. It can be used as a starting material for the synthesis of functional materials. For example, by introducing it into the structure of polymer materials through appropriate chemical reactions, it can impart special properties such as UV resistance and chemical corrosion resistance to the material. This modified material can be used to make outdoor products, building materials, etc., to improve the durability and stability of the material.
Fourth, in the study of organic synthesis chemistry, 1-chloro-2-fluoro-6-nitrobenzene, as a compound with various functional groups, is often used to explore new organic reaction pathways and reaction mechanisms. Researchers use its rich reaction check points to carry out various chemical reaction studies, hoping to discover novel and efficient organic synthesis methods, providing new ideas and methods for the development of organic synthesis chemistry.
First, it is a key intermediate in the synthesis of medicines. In many drug synthesis processes, this compound can participate in specific reactions by virtue of its own structural characteristics and help to construct the key structures of active pharmaceutical ingredients. For example, when developing new therapeutic drugs for specific diseases, the chlorine, fluorine, nitro and other functional groups it contains can be used to precisely dock with other organic molecules through a series of chemical reactions, and then obtain drug molecules with specific pharmacological activities.
Second, it is an important raw material for the preparation of pesticides. In the field of pesticide synthesis, its unique structure can impart specific biological activities to pesticides. For example, by reacting with other organic compounds, a new type of pesticide can be generated that has a high-efficiency toxic effect on pests and has a small impact on the environment. The halogen atoms and nitro groups in its structure can enhance the ability of the compound to bind to specific biological targets in pests, thereby enhancing the insecticidal effect of pesticides.
Third, it also has applications in materials science. It can be used as a starting material for the synthesis of functional materials. For example, by introducing it into the structure of polymer materials through appropriate chemical reactions, it can impart special properties such as UV resistance and chemical corrosion resistance to the material. This modified material can be used to make outdoor products, building materials, etc., to improve the durability and stability of the material.
Fourth, in the study of organic synthesis chemistry, 1-chloro-2-fluoro-6-nitrobenzene, as a compound with various functional groups, is often used to explore new organic reaction pathways and reaction mechanisms. Researchers use its rich reaction check points to carry out various chemical reaction studies, hoping to discover novel and efficient organic synthesis methods, providing new ideas and methods for the development of organic synthesis chemistry.
What are the physical properties of 1-chloro-2-fluoro-6-nitrobenzene?
1-Chloro-2-fluoro-6-nitrobenzene is one of the organic compounds. Its physical properties are quite descriptive.
First of all, its appearance, at room temperature, is mostly colorless to light yellow liquid. The characteristics of this color state are easily discernible by the naked eye and can be regarded as the evidence for preliminary identification.
Second, its boiling point is about a certain temperature range. The value of this boiling point depends on the intermolecular forces. The existence of chlorine, fluorine, nitro and other groups in its molecules makes the intermolecular forces different, so the boiling point is also characteristic. This boiling point is very important in chemical operations such as separation and purification, and can be used as a reference criterion for operating temperature.
Furthermore, the melting point is also an important physical property. The specific melting point reflects the order of its crystal structure and molecular arrangement. When it changes from solid to liquid state, it needs to absorb specific heat to overcome the lattice energy. The determination of this melting point can be one of the methods for identifying the purity of the compound. The melting point of pure products often has a fixed range. If it contains impurities, the melting point may change.
As for the density, it is larger than that of water. This characteristic makes it often sink at the bottom in the aqueous liquid system. The value of density is related to its distribution in the mixed system, and is a parameter that cannot be ignored in the fields of chemical production and environmental monitoring.
In terms of solubility, it is slightly soluble in water. Due to the large difference between the molecular polarity of the compound and the polarity of the water molecule, it is difficult to dissolve in water according to the principle of "similar miscibility". However, in organic solvents, such as ethanol, ether, etc., it has a certain solubility, which is conducive to its dissolution, separation and subsequent treatment as a reactant or product in organic synthesis reactions.
In addition, its volatility also needs attention. Although it is not very volatile, under specific temperature and pressure conditions, some molecules will still escape from the liquid phase and enter the gas phase. This volatility is related to environmental safety and operating standards during storage and use, and needs to be properly dealt with.
In summary, the physical properties of 1-chloro-2-fluoro-6-nitrobenzene are diverse and interrelated. They are of great significance in many fields such as chemical industry and scientific research. Only by understanding their properties can they be used with ease.
First of all, its appearance, at room temperature, is mostly colorless to light yellow liquid. The characteristics of this color state are easily discernible by the naked eye and can be regarded as the evidence for preliminary identification.
Second, its boiling point is about a certain temperature range. The value of this boiling point depends on the intermolecular forces. The existence of chlorine, fluorine, nitro and other groups in its molecules makes the intermolecular forces different, so the boiling point is also characteristic. This boiling point is very important in chemical operations such as separation and purification, and can be used as a reference criterion for operating temperature.
Furthermore, the melting point is also an important physical property. The specific melting point reflects the order of its crystal structure and molecular arrangement. When it changes from solid to liquid state, it needs to absorb specific heat to overcome the lattice energy. The determination of this melting point can be one of the methods for identifying the purity of the compound. The melting point of pure products often has a fixed range. If it contains impurities, the melting point may change.
As for the density, it is larger than that of water. This characteristic makes it often sink at the bottom in the aqueous liquid system. The value of density is related to its distribution in the mixed system, and is a parameter that cannot be ignored in the fields of chemical production and environmental monitoring.
In terms of solubility, it is slightly soluble in water. Due to the large difference between the molecular polarity of the compound and the polarity of the water molecule, it is difficult to dissolve in water according to the principle of "similar miscibility". However, in organic solvents, such as ethanol, ether, etc., it has a certain solubility, which is conducive to its dissolution, separation and subsequent treatment as a reactant or product in organic synthesis reactions.
In addition, its volatility also needs attention. Although it is not very volatile, under specific temperature and pressure conditions, some molecules will still escape from the liquid phase and enter the gas phase. This volatility is related to environmental safety and operating standards during storage and use, and needs to be properly dealt with.
In summary, the physical properties of 1-chloro-2-fluoro-6-nitrobenzene are diverse and interrelated. They are of great significance in many fields such as chemical industry and scientific research. Only by understanding their properties can they be used with ease.
What are the chemical properties of 1-chloro-2-fluoro-6-nitrobenzene?
1-Chloro-2-fluoro-6-nitrobenzene is also an organic compound. Its activity is due to the presence of chlorine, fluorine and nitro functional groups on the benzene ring.
The first word is nitro, which has strong electron absorption, which reduces the electron cloud density of the benzene ring, weakens the electrophilic substitution reaction activity of the benzene ring, and decreases the electron cloud density of the ortho and para-sites more than that of the meta-site, so the electrophilic reagents mostly attack the meta-site. However, in this molecule, the situation is slightly different due to the addition of chlorine and fluorine atoms.
Although chlorine and fluorine are electron-withdrawing groups, they have solitary pairs of electrons, which can be conjugated with the benzene ring, resulting in a slight increase in the density of adjacent and para-electron clouds, which affects the choice of reaction check points to a certain extent.
In this compound, chlorine and fluorine atoms can undergo nucleophilic substitution reactions. Due to the electron-withdrawing action of the nitro group, the electron cloud density of the adjacent and para-carbon atoms of the benzene ring is reduced, and it is more susceptible to attack by nucleophiles, causing chlorine and fluorine atoms to be replaced.
And because of its nitro content, it can be reduced. Generally, under suitable conditions, the nitro group can be gradually reduced to an amino group, which is an important step in organic synthesis. Amino functional groups can be introduced to prepare many organic compounds containing amino
In addition, its physical properties are also worthy of attention. At room temperature, it is mostly solid or liquid, with a certain melting point, and its solubility in organic solvents may be better than that of water due to molecular polarity. However, the specific physical properties depend on its purity and external conditions.
The first word is nitro, which has strong electron absorption, which reduces the electron cloud density of the benzene ring, weakens the electrophilic substitution reaction activity of the benzene ring, and decreases the electron cloud density of the ortho and para-sites more than that of the meta-site, so the electrophilic reagents mostly attack the meta-site. However, in this molecule, the situation is slightly different due to the addition of chlorine and fluorine atoms.
Although chlorine and fluorine are electron-withdrawing groups, they have solitary pairs of electrons, which can be conjugated with the benzene ring, resulting in a slight increase in the density of adjacent and para-electron clouds, which affects the choice of reaction check points to a certain extent.
In this compound, chlorine and fluorine atoms can undergo nucleophilic substitution reactions. Due to the electron-withdrawing action of the nitro group, the electron cloud density of the adjacent and para-carbon atoms of the benzene ring is reduced, and it is more susceptible to attack by nucleophiles, causing chlorine and fluorine atoms to be replaced.
And because of its nitro content, it can be reduced. Generally, under suitable conditions, the nitro group can be gradually reduced to an amino group, which is an important step in organic synthesis. Amino functional groups can be introduced to prepare many organic compounds containing amino
In addition, its physical properties are also worthy of attention. At room temperature, it is mostly solid or liquid, with a certain melting point, and its solubility in organic solvents may be better than that of water due to molecular polarity. However, the specific physical properties depend on its purity and external conditions.
What are 1-chloro-2-fluoro-6-nitrobenzene synthesis methods?
The synthesis methods of 1-chloro-2-fluoro-6-nitrobenzene are as follows.
First, benzene is used as the initial raw material. The benzene is first nitrified, and the mixed acid of concentrated sulfuric acid and concentrated nitric acid is used as the nitrifying reagent. At a suitable temperature, benzene can be converted into nitrobenzene. In this reaction, the proportion of mixed acid, the reaction temperature and time must be precisely controlled. After the nitrobenzene is formed, the halogenation reaction is carried out. In the presence of specific catalysts, such as ferric chloride or iron powder, chlorine and fluorine are introduced to replace chlorine atoms and fluorine atoms at specific positions in the benzene ring, thereby obtaining 1-chloro-2-fluoro-6-nitrobenzene. This path step is relatively clear, but the regioselectivity control of the halogenation reaction is slightly difficult, and the reaction conditions need to be optimized to improve the yield of the target product.
Second, it can be started from o-fluorochlorobenzene. First, nitrate o-fluorochlorobenzene with a suitable nitrifying agent. Such as the use of a mixed system of nitric acid and sulfuric acid, according to the structural characteristics of o-fluorochlorobenzene, the concentration, reaction temperature and time of the nitrification reagent are reasonably adjusted to promote the selective introduction of nitro groups into the 6-position of the benzene ring to generate 1-chloro-2-fluoro-6-nitrobenzene. The starting material of this method is highly selective, and after optimizing the nitrification reaction conditions, it is expected to obtain the target product with higher yield and purity.
Third, 2-fluoro-6-nitroaniline is used as the raw material. Through the diazotization reaction, the amino group is converted into a diazonium salt, and sodium nitrite is often reacted with hydrochloric acid or sulfuric acid at low temperature. After the formation of diazonium salts, the Sandmaier reaction occurs with cuprous chloride as a catalyst, the diazonium group is replaced by chlorine atoms, and then 1-chloro-2-fluoro-6-nitrobenzene is obtained. Although this approach is a little complicated, it requires higher control of the reaction conditions, but it can better realize the conversion and substitution of specific functional groups, and ideal results can be obtained under suitable conditions.
All these synthesis methods have advantages and disadvantages. In practical application, according to the availability of raw materials, cost considerations, product purity requirements and many other factors, the appropriate synthesis path needs to be carefully selected, and the reaction conditions of each step can be carefully adjusted to obtain satisfactory yield and purity.
First, benzene is used as the initial raw material. The benzene is first nitrified, and the mixed acid of concentrated sulfuric acid and concentrated nitric acid is used as the nitrifying reagent. At a suitable temperature, benzene can be converted into nitrobenzene. In this reaction, the proportion of mixed acid, the reaction temperature and time must be precisely controlled. After the nitrobenzene is formed, the halogenation reaction is carried out. In the presence of specific catalysts, such as ferric chloride or iron powder, chlorine and fluorine are introduced to replace chlorine atoms and fluorine atoms at specific positions in the benzene ring, thereby obtaining 1-chloro-2-fluoro-6-nitrobenzene. This path step is relatively clear, but the regioselectivity control of the halogenation reaction is slightly difficult, and the reaction conditions need to be optimized to improve the yield of the target product.
Second, it can be started from o-fluorochlorobenzene. First, nitrate o-fluorochlorobenzene with a suitable nitrifying agent. Such as the use of a mixed system of nitric acid and sulfuric acid, according to the structural characteristics of o-fluorochlorobenzene, the concentration, reaction temperature and time of the nitrification reagent are reasonably adjusted to promote the selective introduction of nitro groups into the 6-position of the benzene ring to generate 1-chloro-2-fluoro-6-nitrobenzene. The starting material of this method is highly selective, and after optimizing the nitrification reaction conditions, it is expected to obtain the target product with higher yield and purity.
Third, 2-fluoro-6-nitroaniline is used as the raw material. Through the diazotization reaction, the amino group is converted into a diazonium salt, and sodium nitrite is often reacted with hydrochloric acid or sulfuric acid at low temperature. After the formation of diazonium salts, the Sandmaier reaction occurs with cuprous chloride as a catalyst, the diazonium group is replaced by chlorine atoms, and then 1-chloro-2-fluoro-6-nitrobenzene is obtained. Although this approach is a little complicated, it requires higher control of the reaction conditions, but it can better realize the conversion and substitution of specific functional groups, and ideal results can be obtained under suitable conditions.
All these synthesis methods have advantages and disadvantages. In practical application, according to the availability of raw materials, cost considerations, product purity requirements and many other factors, the appropriate synthesis path needs to be carefully selected, and the reaction conditions of each step can be carefully adjusted to obtain satisfactory yield and purity.
What are the precautions in storage and transportation of 1-chloro-2-fluoro-6-nitrobenzene?
1-Chloro-2-fluoro-6-nitrobenzene is also an organic compound. When storing and transporting, it is necessary to pay attention to many matters.
It has certain toxicity and irritation. When storing, it should be placed in a cool and ventilated warehouse. Keep away from fire and heat sources to prevent danger. The temperature of the warehouse should not be too high, and it should usually be controlled within a specific range to avoid changes in material properties. Because it is harmful to the human body, the storage area should be strictly prohibited from unrelated personnel, and there should be obvious warning signs.
Furthermore, it should be stored separately from oxidants, food chemicals, etc., and should not be mixed. This is because of its active chemical properties. If it is improperly contacted with other substances, it may cause severe chemical reactions and cause serious consequences such as combustion and explosion. At the same time, the storage container must be well sealed to prevent leakage. Regularly check the integrity of the container. If there is any damage, it needs to be dealt with in time.
When transporting, caution is also required. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. Summer transportation should be carried out in the morning and evening to avoid high temperature periods, because high temperature may increase its danger. During transportation, ensure that the container does not leak, collapse, fall, or damage.
When loading and unloading, the operator must wear suitable protective equipment and handle it lightly. It is strictly forbidden to drop, heavy pressure, and friction to prevent leakage caused by damage to packaging and containers. In short, the storage and transportation of 1-chloro-2-fluoro-6-nitrobenzene must be carried out in strict accordance with regulations to ensure the safety of personnel and the environment.
It has certain toxicity and irritation. When storing, it should be placed in a cool and ventilated warehouse. Keep away from fire and heat sources to prevent danger. The temperature of the warehouse should not be too high, and it should usually be controlled within a specific range to avoid changes in material properties. Because it is harmful to the human body, the storage area should be strictly prohibited from unrelated personnel, and there should be obvious warning signs.
Furthermore, it should be stored separately from oxidants, food chemicals, etc., and should not be mixed. This is because of its active chemical properties. If it is improperly contacted with other substances, it may cause severe chemical reactions and cause serious consequences such as combustion and explosion. At the same time, the storage container must be well sealed to prevent leakage. Regularly check the integrity of the container. If there is any damage, it needs to be dealt with in time.
When transporting, caution is also required. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. Summer transportation should be carried out in the morning and evening to avoid high temperature periods, because high temperature may increase its danger. During transportation, ensure that the container does not leak, collapse, fall, or damage.
When loading and unloading, the operator must wear suitable protective equipment and handle it lightly. It is strictly forbidden to drop, heavy pressure, and friction to prevent leakage caused by damage to packaging and containers. In short, the storage and transportation of 1-chloro-2-fluoro-6-nitrobenzene must be carried out in strict accordance with regulations to ensure the safety of personnel and the environment.
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