Linshang Chemical
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1-Chloro-2-Iodo-5-(Trifluoromethoxy)Benzene
Linshang Chemical
|
HS Code |
888951 |
| Chemical Formula | C7H3ClF3IO |
| Molecular Weight | 318.45 |
| Appearance | Solid (Typical) |
| Boiling Point | Estimated based on structure - complex calculation needed for exact value |
| Melting Point | Estimated based on structure - complex calculation needed for exact value |
| Density | Estimated based on structure - complex calculation needed for exact value |
| Solubility In Water | Low solubility due to non - polar groups |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Vapor Pressure | Low vapor pressure due to relatively large and heavy molecule |
| Flash Point | Estimated based on structure - complex calculation needed for exact value |
As an accredited 1-Chloro-2-Iodo-5-(Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 2 - iodo - 5 - (trifluoromethoxy)benzene, 500g, packaged in a sealed glass bottle. |
| Storage | 1 - Chloro - 2 - iodo - 5 - (trifluoromethoxy)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics. Store it separately from oxidizing agents, reducing agents, and reactive substances to prevent potential chemical reactions. |
| Shipping | 1 - chloro - 2 - iodo - 5 - (trifluoromethoxy)benzene is shipped in sealed, specialized containers, following strict chemical transport regulations. Shipment ensures proper protection against physical damage and environmental exposure. |
Competitive 1-Chloro-2-Iodo-5-(Trifluoromethoxy)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 1-chloro-2-iodo-5- (trifluoromethoxy) benzene?
1-Chloro-2-iodine-5- (trifluoromethoxy) benzene, an organic compound, has interesting chemical properties and is of great significance in the field of organic synthesis.
Let's talk about its halogen atom properties first. Chlorine and iodine are both halogen atoms, and chlorine atoms have certain electronegativity, which changes the electron cloud density of the benzene ring. Because the electronegativity of chlorine is greater than that of carbon, it will attract benzene ring electron clouds, resulting in a relative decrease in the density of adjacent and para-potential electron clouds of the benzene ring, and a slight increase in the density of meta-potential electron clouds. This electronic effect affects the activity and localization of the electrophilic substitution reaction of the benzene ring. Although the electronegativity of iodine atoms is inferior In chemical reactions, iodine atoms are easily affected by external electric fields, and the electron cloud deforms, which makes the compound more likely to participate in nucleophilic substitution reactions. For example, under appropriate nucleophilic reagents and reaction conditions, iodine atoms can be replaced by nucleophilic reagents to generate new organic compounds, which provides an important path for organic synthesis.
Furthermore, trifluoromethoxy groups have a profound impact on the properties of compounds. The fluorine atoms in the trifluoromethoxy group are extremely electronegative, and the connection of three fluorine atoms makes the group have a strong electron-absorbing induction effect. This strong electron-absorbing effect further reduces the electron cloud density of the benzene ring, which significantly affects the reactivity of the benzene ring. Compared with ordinary methoxy groups, trifluoromethoxy groups make it more difficult for the benzene ring to undergo electrophilic substitution reactions, and their electron-absorbing However, in some nucleophilic substitution reactions, due to the reduced electron cloud density of the benzene ring, it is conducive to the attack of nucleophilic reagents.
In addition, 1-chloro-2-iodine-5 - (trifluoromethoxy) benzene may also participate in metal catalytic reactions. Halogen atoms can form complexes with transition metals, which can be activated by metal catalysis to realize the construction of carbon-carbon bonds or carbon-heteroatom bonds. For example, in palladium-catalyzed cross-coupling reactions, chlorine atoms or iodine atoms can interact with palladium catalysts to couple with carbon-containing nucleophiles, expand the molecular carbon chain structure, and enrich organic synthesis strategies.
Let's talk about its halogen atom properties first. Chlorine and iodine are both halogen atoms, and chlorine atoms have certain electronegativity, which changes the electron cloud density of the benzene ring. Because the electronegativity of chlorine is greater than that of carbon, it will attract benzene ring electron clouds, resulting in a relative decrease in the density of adjacent and para-potential electron clouds of the benzene ring, and a slight increase in the density of meta-potential electron clouds. This electronic effect affects the activity and localization of the electrophilic substitution reaction of the benzene ring. Although the electronegativity of iodine atoms is inferior In chemical reactions, iodine atoms are easily affected by external electric fields, and the electron cloud deforms, which makes the compound more likely to participate in nucleophilic substitution reactions. For example, under appropriate nucleophilic reagents and reaction conditions, iodine atoms can be replaced by nucleophilic reagents to generate new organic compounds, which provides an important path for organic synthesis.
Furthermore, trifluoromethoxy groups have a profound impact on the properties of compounds. The fluorine atoms in the trifluoromethoxy group are extremely electronegative, and the connection of three fluorine atoms makes the group have a strong electron-absorbing induction effect. This strong electron-absorbing effect further reduces the electron cloud density of the benzene ring, which significantly affects the reactivity of the benzene ring. Compared with ordinary methoxy groups, trifluoromethoxy groups make it more difficult for the benzene ring to undergo electrophilic substitution reactions, and their electron-absorbing However, in some nucleophilic substitution reactions, due to the reduced electron cloud density of the benzene ring, it is conducive to the attack of nucleophilic reagents.
In addition, 1-chloro-2-iodine-5 - (trifluoromethoxy) benzene may also participate in metal catalytic reactions. Halogen atoms can form complexes with transition metals, which can be activated by metal catalysis to realize the construction of carbon-carbon bonds or carbon-heteroatom bonds. For example, in palladium-catalyzed cross-coupling reactions, chlorine atoms or iodine atoms can interact with palladium catalysts to couple with carbon-containing nucleophiles, expand the molecular carbon chain structure, and enrich organic synthesis strategies.
What are the common uses of 1-chloro-2-iodo-5- (trifluoromethoxy) benzene?
1-Chloro-2-iodine-5- (trifluoromethoxy) benzene is an important chemical substance in the field of organic synthesis. Its common uses are mainly reflected in the following numbers.
One is often used as a key intermediate in the process of pharmaceutical research and development. The structure of the benzene ring and its specific substituents give the substance its unique chemical activity and spatial structure. With the help of organic synthesis methods, it can be transformed and modified by functional groups, and then a complex molecular structure with specific pharmacological activities can be constructed, laying the foundation for the creation of new drugs. For example, in the synthesis of some antibacterial drugs and anti-tumor drugs, 1-chloro-2-iodine-5- (trifluoromethoxy) benzene can be used as a starting material to introduce other active groups through multi-step reactions to obtain target drug molecules.
Second, in the field of materials science, it also has important value. Due to the characteristics of fluorine-containing groups, it can improve the chemical stability, thermal stability and corrosion resistance of materials. For example, when preparing high-performance polymer materials, introducing the substance into the main chain or side chain of the polymer can improve the surface properties of the polymer, making it suitable for aerospace, electronic devices and other fields that require strict material properties.
Furthermore, in the field of pesticides, there are also applications. With its unique chemical structure, pesticide compounds with high insecticidal, bactericidal or herbicidal activities can be designed and synthesized. Compared with traditional products, such pesticides may have higher biological activity and selectivity, which can ensure agricultural production while reducing the impact on the environment.
1-chloro-2-iodine-5 - (trifluoromethoxy) benzene has shown important uses and broad application prospects in many fields such as medicine, materials and pesticides due to its special structure and chemical properties. It has made great contributions to technological development and innovation in various fields.
One is often used as a key intermediate in the process of pharmaceutical research and development. The structure of the benzene ring and its specific substituents give the substance its unique chemical activity and spatial structure. With the help of organic synthesis methods, it can be transformed and modified by functional groups, and then a complex molecular structure with specific pharmacological activities can be constructed, laying the foundation for the creation of new drugs. For example, in the synthesis of some antibacterial drugs and anti-tumor drugs, 1-chloro-2-iodine-5- (trifluoromethoxy) benzene can be used as a starting material to introduce other active groups through multi-step reactions to obtain target drug molecules.
Second, in the field of materials science, it also has important value. Due to the characteristics of fluorine-containing groups, it can improve the chemical stability, thermal stability and corrosion resistance of materials. For example, when preparing high-performance polymer materials, introducing the substance into the main chain or side chain of the polymer can improve the surface properties of the polymer, making it suitable for aerospace, electronic devices and other fields that require strict material properties.
Furthermore, in the field of pesticides, there are also applications. With its unique chemical structure, pesticide compounds with high insecticidal, bactericidal or herbicidal activities can be designed and synthesized. Compared with traditional products, such pesticides may have higher biological activity and selectivity, which can ensure agricultural production while reducing the impact on the environment.
1-chloro-2-iodine-5 - (trifluoromethoxy) benzene has shown important uses and broad application prospects in many fields such as medicine, materials and pesticides due to its special structure and chemical properties. It has made great contributions to technological development and innovation in various fields.
What are the synthesis methods of 1-chloro-2-iodo-5- (trifluoromethoxy) benzene?
The synthesis of 1-chloro-2-iodine-5- (trifluoromethoxy) benzene is a subject of considerable interest in organic synthetic chemistry. The synthesis of this compound can be achieved through several different paths.
One of the methods can be to start with benzene derivatives containing trifluoromethoxy as the starting material. For example, select an appropriate trifluoromethoxy benzene and perform a halogenation reaction on it first. Under suitable reaction conditions, iodine atoms are selectively introduced into the benzene ring by iodizing a specific position of the benzene ring with an iodine substitution reagent, such as iodine elemental substance, in combination with an appropriate catalyst and an oxidizing agent. Then, through the chlorination reaction, a suitable chlorination reagent, such as thionyl chloride or other chlorination reagents, is selected to introduce a chlorine atom at another specific position to obtain the target product 1-chloro-2-iodine-5 - (trifluoromethoxy) benzene. This path requires fine regulation of the reaction conditions to ensure the selectivity and yield of the halogenation reaction.
Furthermore, halogenated benzene can also be used as the starting material. The trifluoromethoxy functional group is introduced first, and the trifluoromethoxy reagent can react with the halogenated benzene in a suitable base and solvent environment to form a halogenated benzene intermediate containing trifluoromethoxy. Then, according to the requirements, chlorination or iodation reactions are carried out successively, and chlorine and iodine atoms are introduced one by one at the designated positions of the benzene ring precisely. In this process, factors such as the choice of solvent, the strength and amount of base, as well as the reaction temperature and time all have a significant impact on the reaction process and product purity.
In addition, there are synthesis strategies based on transition metal catalysis. Transition metal catalysts, such as palladium and copper, are used to catalyze the coupling reaction between halogenated aromatics and trifluoromethoxy-containing reagents. Benzene derivatives containing trifluoromethoxy are first constructed, and then chlorine and iodine atoms are introduced in an orderly manner through halogenation reactions or further functional group conversion. This method relies on a highly efficient transition metal catalyst system, and requires consideration of catalyst loading and ligand structure to optimize reaction efficiency and selectivity to achieve effective synthesis of 1-chloro-2-iodine-5- (trifluoromethoxy) benzene. In short, the synthesis of this compound requires careful design of the synthesis route considering various factors such as the availability of starting materials, the difficulty of controlling the reaction conditions, and the purity and yield of the target product.
One of the methods can be to start with benzene derivatives containing trifluoromethoxy as the starting material. For example, select an appropriate trifluoromethoxy benzene and perform a halogenation reaction on it first. Under suitable reaction conditions, iodine atoms are selectively introduced into the benzene ring by iodizing a specific position of the benzene ring with an iodine substitution reagent, such as iodine elemental substance, in combination with an appropriate catalyst and an oxidizing agent. Then, through the chlorination reaction, a suitable chlorination reagent, such as thionyl chloride or other chlorination reagents, is selected to introduce a chlorine atom at another specific position to obtain the target product 1-chloro-2-iodine-5 - (trifluoromethoxy) benzene. This path requires fine regulation of the reaction conditions to ensure the selectivity and yield of the halogenation reaction.
Furthermore, halogenated benzene can also be used as the starting material. The trifluoromethoxy functional group is introduced first, and the trifluoromethoxy reagent can react with the halogenated benzene in a suitable base and solvent environment to form a halogenated benzene intermediate containing trifluoromethoxy. Then, according to the requirements, chlorination or iodation reactions are carried out successively, and chlorine and iodine atoms are introduced one by one at the designated positions of the benzene ring precisely. In this process, factors such as the choice of solvent, the strength and amount of base, as well as the reaction temperature and time all have a significant impact on the reaction process and product purity.
In addition, there are synthesis strategies based on transition metal catalysis. Transition metal catalysts, such as palladium and copper, are used to catalyze the coupling reaction between halogenated aromatics and trifluoromethoxy-containing reagents. Benzene derivatives containing trifluoromethoxy are first constructed, and then chlorine and iodine atoms are introduced in an orderly manner through halogenation reactions or further functional group conversion. This method relies on a highly efficient transition metal catalyst system, and requires consideration of catalyst loading and ligand structure to optimize reaction efficiency and selectivity to achieve effective synthesis of 1-chloro-2-iodine-5- (trifluoromethoxy) benzene. In short, the synthesis of this compound requires careful design of the synthesis route considering various factors such as the availability of starting materials, the difficulty of controlling the reaction conditions, and the purity and yield of the target product.
What are the precautions for storing and transporting 1-chloro-2-iodo-5- (trifluoromethoxy) benzene?
1-Chloro-2-iodine-5- (trifluoromethoxy) benzene is an organic compound, and many matters need to be paid attention to during storage and transportation.
Bear the brunt, and the storage environment is crucial. This compound should be stored in a cool, dry and well-ventilated place. High temperature and humidity can easily cause it to deteriorate or cause chemical reactions. Therefore, the warehouse temperature should be controlled within a suitable range, and humidity should also be strictly managed to prevent moisture.
Furthermore, this compound has a certain chemical activity and must be kept away from fire, heat and strong oxidants. Fire and heat sources may cause combustion or even explosion, and strong oxidizing agents come into contact with them, or trigger violent chemical reactions, endangering safety.
When transporting, the packaging must be sturdy and reliable. Choose suitable packaging materials, which can effectively resist vibration, collision and friction, and prevent compound leakage caused by container damage. And its characteristics and warning labels should be clearly marked on the outside of the package, so that transporters can understand its danger.
In addition, the transportation process must follow relevant regulations and standards. Transport personnel should be professionally trained and familiar with the characteristics of the compound and emergency treatment methods. In the event of an accident such as leakage, it can be disposed of quickly and properly to minimize the harm.
In conclusion, 1-chloro-2-iodine-5- (trifluoromethoxy) benzene cannot be ignored in terms of environmental conditions, isolation of fire sources, heat sources and oxidants, packaging conditions, and compliance with transportation regulations during storage and transportation, so as to ensure its safe storage and transportation.
Bear the brunt, and the storage environment is crucial. This compound should be stored in a cool, dry and well-ventilated place. High temperature and humidity can easily cause it to deteriorate or cause chemical reactions. Therefore, the warehouse temperature should be controlled within a suitable range, and humidity should also be strictly managed to prevent moisture.
Furthermore, this compound has a certain chemical activity and must be kept away from fire, heat and strong oxidants. Fire and heat sources may cause combustion or even explosion, and strong oxidizing agents come into contact with them, or trigger violent chemical reactions, endangering safety.
When transporting, the packaging must be sturdy and reliable. Choose suitable packaging materials, which can effectively resist vibration, collision and friction, and prevent compound leakage caused by container damage. And its characteristics and warning labels should be clearly marked on the outside of the package, so that transporters can understand its danger.
In addition, the transportation process must follow relevant regulations and standards. Transport personnel should be professionally trained and familiar with the characteristics of the compound and emergency treatment methods. In the event of an accident such as leakage, it can be disposed of quickly and properly to minimize the harm.
In conclusion, 1-chloro-2-iodine-5- (trifluoromethoxy) benzene cannot be ignored in terms of environmental conditions, isolation of fire sources, heat sources and oxidants, packaging conditions, and compliance with transportation regulations during storage and transportation, so as to ensure its safe storage and transportation.
What are the effects of 1-chloro-2-iodo-5- (trifluoromethoxy) benzene on the environment and human health?
1-Chloro-2-iodine-5- (trifluoromethoxy) benzene, its impact on the environment and human health is related to many aspects.
At the environmental end, this compound has considerable chemical stability, difficult to degrade naturally, or causes it to accumulate in the environment for a long time. It enters the water body, or affects aquatic organisms. The uptake and accumulation of aquatic organisms can be transmitted through the food chain, causing higher trophic organisms to be affected. If plankton are ingested, small fish eat plankton, and large fish eat small fish, the toxin will gradually accumulate, or cause abnormal reproduction, growth and behavior of fish, endangering the population and ecological balance.
In soil, or affect the structure and function of soil microbial community, causing changes in soil ecological processes, such as affecting soil nutrient cycling and decomposition of organic matter, and then affecting vegetation growth.
As for human health, this compound may be potentially toxic. Enter the human body through respiratory tract, skin contact or accidental ingestion. It contains halogen atoms and special functional groups, or interfere with the normal physiological and biochemical processes of the human body. Or affect the nervous system, causing headaches, dizziness, fatigue and other symptoms. Or affect the endocrine system, interfere with hormone balance, and have adverse consequences for reproduction and development. Long-term exposure, or increase the risk of cancer, because some of its structural characteristics are similar to known carcinogens. Therefore, such compounds should be treated with caution and must be strictly controlled in all aspects of production, use and discharge to protect the environment and human health.
At the environmental end, this compound has considerable chemical stability, difficult to degrade naturally, or causes it to accumulate in the environment for a long time. It enters the water body, or affects aquatic organisms. The uptake and accumulation of aquatic organisms can be transmitted through the food chain, causing higher trophic organisms to be affected. If plankton are ingested, small fish eat plankton, and large fish eat small fish, the toxin will gradually accumulate, or cause abnormal reproduction, growth and behavior of fish, endangering the population and ecological balance.
In soil, or affect the structure and function of soil microbial community, causing changes in soil ecological processes, such as affecting soil nutrient cycling and decomposition of organic matter, and then affecting vegetation growth.
As for human health, this compound may be potentially toxic. Enter the human body through respiratory tract, skin contact or accidental ingestion. It contains halogen atoms and special functional groups, or interfere with the normal physiological and biochemical processes of the human body. Or affect the nervous system, causing headaches, dizziness, fatigue and other symptoms. Or affect the endocrine system, interfere with hormone balance, and have adverse consequences for reproduction and development. Long-term exposure, or increase the risk of cancer, because some of its structural characteristics are similar to known carcinogens. Therefore, such compounds should be treated with caution and must be strictly controlled in all aspects of production, use and discharge to protect the environment and human health.
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