Linshang Chemical
PRODUCTS
1-Chloro-2-Iodobenzene
Linshang Chemical
|
HS Code |
583993 |
| Chemical Formula | C6H4ClI |
| Molecular Weight | 238.45 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 218 - 220 °C |
| Melting Point | N/A |
| Density | 1.917 g/cm³ |
| Flash Point | 99.7 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents |
| Odor | Characteristic aromatic odor |
| Cas Number | 615 - 37 - 2 |
As an accredited 1-Chloro-2-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 2 - iodobenzene in 500 - gram bottles, well - sealed for storage. |
| Storage | 1 - Chloro - 2 - iodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. It should be kept in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, strong bases, and reactive metals to avoid potential chemical reactions. Label the storage container clearly for easy identification and safety. |
| Shipping | 1 - Chloro - 2 - iodobenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported under regulated conditions, ensuring compliance with safety regulations for handling hazardous chemicals during transit. |
Competitive 1-Chloro-2-Iodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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What are the chemical properties of 1-chloro-2-iodobenzene?
1-chloro-2-iodobenzene is an organohalogenated aromatic hydrocarbon. Its molecular structure contains chlorine atoms and iodine atoms, which give the compound unique chemical properties.
As far as nucleophilic substitution is concerned, the electron cloud density of the benzene ring decreases due to the induction effect of halogen atoms, making it more susceptible to nucleophilic attack. However, chlorine and iodine have different atomic radii and electronegativity, and have different nucleophilic substitution activities. Iodine atoms have a large atomic radius, small C-I bond energy, and are more prone to heterocracking, so iodine atoms are more likely to be replaced than chlorine atoms in nucleophilic substitution reactions. For example, when co-heated with aqueous sodium hydroxide solutions, iodine atoms may be replaced by hydroxyl groups first to form compounds containing hydroxyl
In the field of metal-organic chemistry, 1-chloro-2-iodobenzene can react with metal reagents. Like reacting with magnesium, Grignard reagents can be formed, which are highly active and can be used to construct carbon-carbon bonds. For example, by reacting with carbonyl compounds such as aldodes and ketones, alcohols can be obtained, thereby increasing the carbon chain and enriching the molecular structure.
In addition, on aromatic rings, 1-chloro-2-iodobenzene can undergo electrophilic substitution reactions. Because both chlorine and iodine are ortho-para-localizers, the electron cloud density of the benzene ring is relatively high, and electrophilic reagents are prone to attack ortho-para-sites. However, due to the electron-absorbing induction effect of chlorine and iodine, the overall electron cloud density of benzene ring is lower than that of benzene, and the electrophilic substitution reaction activity is slightly lower than that of benzene. For example, when nitration occurs, the nitro group mainly enters the ortho-para-position of chlorine and iodine.
1-chloro-2-iodobenzene has rich chemical properties and is widely used in the field of organic synthesis. A variety of organic compounds can be prepared through various reactions.
As far as nucleophilic substitution is concerned, the electron cloud density of the benzene ring decreases due to the induction effect of halogen atoms, making it more susceptible to nucleophilic attack. However, chlorine and iodine have different atomic radii and electronegativity, and have different nucleophilic substitution activities. Iodine atoms have a large atomic radius, small C-I bond energy, and are more prone to heterocracking, so iodine atoms are more likely to be replaced than chlorine atoms in nucleophilic substitution reactions. For example, when co-heated with aqueous sodium hydroxide solutions, iodine atoms may be replaced by hydroxyl groups first to form compounds containing hydroxyl
In the field of metal-organic chemistry, 1-chloro-2-iodobenzene can react with metal reagents. Like reacting with magnesium, Grignard reagents can be formed, which are highly active and can be used to construct carbon-carbon bonds. For example, by reacting with carbonyl compounds such as aldodes and ketones, alcohols can be obtained, thereby increasing the carbon chain and enriching the molecular structure.
In addition, on aromatic rings, 1-chloro-2-iodobenzene can undergo electrophilic substitution reactions. Because both chlorine and iodine are ortho-para-localizers, the electron cloud density of the benzene ring is relatively high, and electrophilic reagents are prone to attack ortho-para-sites. However, due to the electron-absorbing induction effect of chlorine and iodine, the overall electron cloud density of benzene ring is lower than that of benzene, and the electrophilic substitution reaction activity is slightly lower than that of benzene. For example, when nitration occurs, the nitro group mainly enters the ortho-para-position of chlorine and iodine.
1-chloro-2-iodobenzene has rich chemical properties and is widely used in the field of organic synthesis. A variety of organic compounds can be prepared through various reactions.
What are the common synthetic methods of 1-chloro-2-iodobenzene?
1-Chloro-2-iodobenzene is also an organic compound. There are about three common methods for its synthesis.
First, start with o-chloroaniline. O-chloroaniline is co-placed at low temperature with sodium nitrite and hydrochloric acid, and the diazotization reaction is carried out to obtain o-chlorobenzene diazonium salt. Compound it with potassium iodide, and the diazonium group is replaced by an iodine atom to obtain 1-chloro-2-iodobenzene. This way is based on the diazotization reaction, the conditions need to be strict, and low temperature operation is required to prevent the decomposition of diazonium salts.
Second, from o-chlorobenzoic acid. O-chlorobenzoic acid first reacts with phosphorus pentachloride and is carboxylated to an acyl chloride group to obtain o-chlorobenzoyl chloride. Next, a reducing agent such as lithium aluminum hydride is used to reduce the acyl chloride group to a methyl group to obtain o-chlorotoluene. Then iodine and an appropriate oxidizing agent are used to introduce an iodine atom at the ortho-position of the methyl group, and then the chlorination reaction is repeated to introduce a chlorine atom at the other ortho-position to obtain the target product. There are many steps in this way, but there are common methods for each step of the reaction.
Third, benzene is used as the initial material. Benzene is chlorinated first to obtain chlorobenzene. Chlorobenzene is co-heated with an iodine substitution reagent and a catalyst, The starting materials are easy to obtain in this way, but the control of reaction selectivity is necessary, and the catalyst and reaction conditions need to be well selected to increase the yield of ortho-products.
All these methods have advantages and disadvantages. When synthesizing, it depends on the availability of raw materials, the level of cost, the difficulty of reaction, and the amount of yield.
First, start with o-chloroaniline. O-chloroaniline is co-placed at low temperature with sodium nitrite and hydrochloric acid, and the diazotization reaction is carried out to obtain o-chlorobenzene diazonium salt. Compound it with potassium iodide, and the diazonium group is replaced by an iodine atom to obtain 1-chloro-2-iodobenzene. This way is based on the diazotization reaction, the conditions need to be strict, and low temperature operation is required to prevent the decomposition of diazonium salts.
Second, from o-chlorobenzoic acid. O-chlorobenzoic acid first reacts with phosphorus pentachloride and is carboxylated to an acyl chloride group to obtain o-chlorobenzoyl chloride. Next, a reducing agent such as lithium aluminum hydride is used to reduce the acyl chloride group to a methyl group to obtain o-chlorotoluene. Then iodine and an appropriate oxidizing agent are used to introduce an iodine atom at the ortho-position of the methyl group, and then the chlorination reaction is repeated to introduce a chlorine atom at the other ortho-position to obtain the target product. There are many steps in this way, but there are common methods for each step of the reaction.
Third, benzene is used as the initial material. Benzene is chlorinated first to obtain chlorobenzene. Chlorobenzene is co-heated with an iodine substitution reagent and a catalyst, The starting materials are easy to obtain in this way, but the control of reaction selectivity is necessary, and the catalyst and reaction conditions need to be well selected to increase the yield of ortho-products.
All these methods have advantages and disadvantages. When synthesizing, it depends on the availability of raw materials, the level of cost, the difficulty of reaction, and the amount of yield.
1-chloro-2-iodobenzene in what areas
1 - chloro - 2 - iodobenzene is an organic compound that has applications in many fields.
In the field of medicinal chemistry, it can be used as a key intermediate. The presence of chlorine and iodine atoms in its structure endows molecules with specific reactivity and properties. Through various chemical reactions, such as nucleophilic substitution reactions, other functional groups can be introduced to synthesize compounds with specific biological activities for the development of new drugs.
In the field of materials science, it also has important uses. It can participate in the synthesis of polymers and react with other monomers to form polymer materials with special properties. Due to the influence of chlorine and iodine atoms on the electronic and physical properties of materials, or can impart unique properties such as conductivity and optical properties to materials, it is used in the preparation of optoelectronic materials.
In the field of organic synthesis, 1-chloro-2-iodobenzene can participate in the construction of many complex organic molecules as a starting material. Through metal-catalyzed cross-coupling reactions, such as Suzuki reaction, Stille reaction, etc., it can react with other organic boric acids, organotin reagents, etc., to form carbon-carbon bonds and synthesize organic compounds with diverse structures, providing organic synthesis chemists with an effective tool for constructing complex molecular structures.
In dye chemistry, it can be used as a raw material for synthesizing new dyes. Using its structural characteristics, through appropriate chemical modification, chromophore and other groups are introduced to synthesize dyes with specific colors and dyeing properties to meet the needs of textile, printing and other industries.
To sum up, 1-chloro-2-iodobenzene, with its unique structure, plays an important role in the fields of medicine, materials, organic synthesis and dyes, providing a key chemical basis for the development of various fields.
In the field of medicinal chemistry, it can be used as a key intermediate. The presence of chlorine and iodine atoms in its structure endows molecules with specific reactivity and properties. Through various chemical reactions, such as nucleophilic substitution reactions, other functional groups can be introduced to synthesize compounds with specific biological activities for the development of new drugs.
In the field of materials science, it also has important uses. It can participate in the synthesis of polymers and react with other monomers to form polymer materials with special properties. Due to the influence of chlorine and iodine atoms on the electronic and physical properties of materials, or can impart unique properties such as conductivity and optical properties to materials, it is used in the preparation of optoelectronic materials.
In the field of organic synthesis, 1-chloro-2-iodobenzene can participate in the construction of many complex organic molecules as a starting material. Through metal-catalyzed cross-coupling reactions, such as Suzuki reaction, Stille reaction, etc., it can react with other organic boric acids, organotin reagents, etc., to form carbon-carbon bonds and synthesize organic compounds with diverse structures, providing organic synthesis chemists with an effective tool for constructing complex molecular structures.
In dye chemistry, it can be used as a raw material for synthesizing new dyes. Using its structural characteristics, through appropriate chemical modification, chromophore and other groups are introduced to synthesize dyes with specific colors and dyeing properties to meet the needs of textile, printing and other industries.
To sum up, 1-chloro-2-iodobenzene, with its unique structure, plays an important role in the fields of medicine, materials, organic synthesis and dyes, providing a key chemical basis for the development of various fields.
What are the physical properties of 1-chloro-2-iodobenzene?
1 - chloro - 2 - iodobenzene is an organic halogenated aromatic compound. Its physical properties are quite special, let me tell you one by one.
Looking at its properties, under room temperature and pressure, 1 - chloro - 2 - iodobenzene is mostly colorless to pale yellow liquid. This liquid, under sunlight, can be seen to be slightly flooded, as if it has a subtle splendor. Its smell is slightly irritating, but it is not very strong. If you smell it, you can feel a faint aromatic braised taste. If you smell it for a long time, you may feel a slight discomfort between the noses.
When it comes to melting and boiling points, the melting point of this compound is about -31 ° C, and the boiling point is between 217-219 ° C. The melting point is quite low, so it exists as a liquid at room temperature; the boiling point is higher, due to the presence of van der Waals forces between molecules and the enhancement of molecular polarity caused by halogen atoms. This higher boiling point makes 1-chloro-2-iodobenzene less volatile under normal heating conditions, and it needs to reach a higher temperature before it can be converted into a gaseous state.
The density of 1-chloro-2-iodobenzene is greater than that of water, which is about 2.044 g/cm ³. When it is mixed with water, it can be seen that it sinks to the bottom of the water, like a pearl falling into the abyss, with clear boundaries. This density characteristic is also closely related to its molecular structure. The relative atomic mass of halogen atoms is larger, resulting in an increase in molecular weight and thus density.
In terms of solubility, 1-chloro-2-iodobenzene is insoluble in water, because water is a polar solvent. Although 1-chloro-2-iodobenzene has a certain polarity, its aromatic ring structure and the existence of halogen atoms make it difficult to form a strong interaction with water molecules, so it is insoluble. However, it is soluble in many organic solvents, such as ethanol, ether, acetone, etc. In such organic solvents, 1-chloro-2-iodobenzene can form a similar miscible state with solvent molecules, and can be uniformly dispersed in them.
The vapor pressure of 1-chloro-2-iodobenzene is relatively low, which means that at a certain temperature, its tendency to volatilize to the gas phase is small. This property is also related to its higher boiling point and low vapor pressure, indicating that the substance is relatively stable at room temperature and is not easily lost due to volatilization.
The refractive index of 1-chloro-2-iodobenzene is about 1.635 - 1.637. When light passes through this liquid, the direction of the light will change at a specific angle. This refractive index value is a characterization of its optical properties and is of great reference value in the analysis and identification of this substance.
1-chloro-2-iodobenzene has important uses in organic synthesis, medicinal chemistry and other fields due to its unique physical properties. It is indeed a compound that cannot be ignored in the field of organic chemistry.
Looking at its properties, under room temperature and pressure, 1 - chloro - 2 - iodobenzene is mostly colorless to pale yellow liquid. This liquid, under sunlight, can be seen to be slightly flooded, as if it has a subtle splendor. Its smell is slightly irritating, but it is not very strong. If you smell it, you can feel a faint aromatic braised taste. If you smell it for a long time, you may feel a slight discomfort between the noses.
When it comes to melting and boiling points, the melting point of this compound is about -31 ° C, and the boiling point is between 217-219 ° C. The melting point is quite low, so it exists as a liquid at room temperature; the boiling point is higher, due to the presence of van der Waals forces between molecules and the enhancement of molecular polarity caused by halogen atoms. This higher boiling point makes 1-chloro-2-iodobenzene less volatile under normal heating conditions, and it needs to reach a higher temperature before it can be converted into a gaseous state.
The density of 1-chloro-2-iodobenzene is greater than that of water, which is about 2.044 g/cm ³. When it is mixed with water, it can be seen that it sinks to the bottom of the water, like a pearl falling into the abyss, with clear boundaries. This density characteristic is also closely related to its molecular structure. The relative atomic mass of halogen atoms is larger, resulting in an increase in molecular weight and thus density.
In terms of solubility, 1-chloro-2-iodobenzene is insoluble in water, because water is a polar solvent. Although 1-chloro-2-iodobenzene has a certain polarity, its aromatic ring structure and the existence of halogen atoms make it difficult to form a strong interaction with water molecules, so it is insoluble. However, it is soluble in many organic solvents, such as ethanol, ether, acetone, etc. In such organic solvents, 1-chloro-2-iodobenzene can form a similar miscible state with solvent molecules, and can be uniformly dispersed in them.
The vapor pressure of 1-chloro-2-iodobenzene is relatively low, which means that at a certain temperature, its tendency to volatilize to the gas phase is small. This property is also related to its higher boiling point and low vapor pressure, indicating that the substance is relatively stable at room temperature and is not easily lost due to volatilization.
The refractive index of 1-chloro-2-iodobenzene is about 1.635 - 1.637. When light passes through this liquid, the direction of the light will change at a specific angle. This refractive index value is a characterization of its optical properties and is of great reference value in the analysis and identification of this substance.
1-chloro-2-iodobenzene has important uses in organic synthesis, medicinal chemistry and other fields due to its unique physical properties. It is indeed a compound that cannot be ignored in the field of organic chemistry.
What are 1-chloro-2-iodobenzene storage conditions?
1-Chloro-2-iodobenzene is an organic compound, and its storage conditions are quite critical, which is related to the stability and safety of this compound. According to the concept of "Tiangong Kaiwu", the storage material should be checked for its characteristics and careful.
This compound contains chlorine and iodine atoms, and its properties are relatively active. First, it should be stored in a cool place. Due to high temperature, it is easy to cause chemical reactions, or cause decomposition and deterioration. Heat fumigation will damage its quality, so it should be placed in a cool room to avoid the harm of high temperature.
Second, it needs to be stored in a dry place. Moisture can easily lead to many disasters, and water can promote its hydrolysis reaction and change the structure of the compound. If it is in a humid place, such as a damp cellar, it will deteriorate, so it must be kept in a dry environment for a long time.
Furthermore, keep away from fire sources and oxidants. 1-chloro-2-iodobenzene is an organic substance, which is flammable and will burn in case of fire, and the oxidant can react violently with it, causing danger. Therefore, in the warehouse, the source of fire should be eliminated, and the oxidant should not coexist with it.
In addition, storage containers are also exquisite. It is appropriate to use a sealed glass bottle. The glass material is stable, and it is not easy to react with compounds. The seal can prevent air and moisture from invading. If it is stored in a container, external objects will easily disturb its properties and make it lose its original quality.
In short, the storage of 1-chloro-2-iodobenzene should be cool, dry, protected from fire and oxidizing agents, and a suitable container should be selected, so as to maintain its quality and be ready for future use.
This compound contains chlorine and iodine atoms, and its properties are relatively active. First, it should be stored in a cool place. Due to high temperature, it is easy to cause chemical reactions, or cause decomposition and deterioration. Heat fumigation will damage its quality, so it should be placed in a cool room to avoid the harm of high temperature.
Second, it needs to be stored in a dry place. Moisture can easily lead to many disasters, and water can promote its hydrolysis reaction and change the structure of the compound. If it is in a humid place, such as a damp cellar, it will deteriorate, so it must be kept in a dry environment for a long time.
Furthermore, keep away from fire sources and oxidants. 1-chloro-2-iodobenzene is an organic substance, which is flammable and will burn in case of fire, and the oxidant can react violently with it, causing danger. Therefore, in the warehouse, the source of fire should be eliminated, and the oxidant should not coexist with it.
In addition, storage containers are also exquisite. It is appropriate to use a sealed glass bottle. The glass material is stable, and it is not easy to react with compounds. The seal can prevent air and moisture from invading. If it is stored in a container, external objects will easily disturb its properties and make it lose its original quality.
In short, the storage of 1-chloro-2-iodobenzene should be cool, dry, protected from fire and oxidizing agents, and a suitable container should be selected, so as to maintain its quality and be ready for future use.
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