Linshang Chemical
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1-Chloro-2-Isothiocyanato-4-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
509931 |
| Chemical Formula | C8H3ClF3NS |
| Molecular Weight | 253.63 |
| Appearance | Typically a liquid |
| Color | May be colorless to light - colored |
| Odor | Pungent, characteristic odor |
| Boiling Point | Data may vary, needs experimental determination |
| Melting Point | Data may vary, needs experimental determination |
| Density | Data may vary, needs experimental determination |
| Solubility | Soluble in some organic solvents |
| Vapor Pressure | Data may vary, needs experimental determination |
| Stability | Can react with substances containing active hydrogen, may be unstable under certain conditions |
As an accredited 1-Chloro-2-Isothiocyanato-4-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1 - chloro - 2 - isothiocyanato - 4 - (trifluoromethyl)benzene packaged in a sealed, corrosion - resistant container. |
| Storage | 1 - Chloro - 2 - isothiocyanato - 4 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from sources of heat, ignition, and incompatible substances. Keep it in a tightly sealed container, preferably made of corrosion - resistant material. Store it separately from oxidizing agents, acids, bases, and amines to prevent chemical reactions. |
| Shipping | 1 - chloro - 2 - isothiocyanato - 4 - (trifluoromethyl)benzene is a chemical. Shipping requires compliance with hazardous material regulations. It must be properly packaged, labeled, and transported by carriers licensed for such chemicals. |
Competitive 1-Chloro-2-Isothiocyanato-4-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Chloro-2-Isothiocyanato-4-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-chloro-2-isothiocyanato-4- (trifluoromethyl) benzene?
1 - chloro - 2 - isothiocyanato - 4 - (trifluoromethyl) benzene, an organic compound, its chemical properties are particularly important, and it is related to many fields of application.
It contains chlorine atoms, isothiocyanate and trifluoromethyl and other functional groups. Chlorine atoms have certain electronegativity and can participate in nucleophilic substitution reactions. Under suitable conditions, nucleophilic testers can attack carbon atoms attached to chlorine, and the chlorine atoms leave to form new compounds. This reaction is often used in organic synthesis to form carbon-heteroatomic bonds.
Isothiocyanate is a highly active functional group. It can react with compounds containing active hydrogen, such as alcohols and amines. When reacted with alcohol, thiocarbamate compounds can be formed; when reacted with amines, thiourea derivatives can be formed. This kind of reaction is widely used in drug synthesis, pesticide preparation, etc., which can introduce specific structural fragments and endow the product with unique biological activity. The presence of
trifluoromethyl greatly affects the properties of the compound. Trifluoromethyl has strong electron absorption, which can reduce the electron cloud density of the benzene ring and change the electrophilic substitution reaction activity on the benzene ring. At the same time, due to its special electronic effect and spatial effect, it can improve the stability and fat solubility of the compound. In drug molecular design, the introduction of trifluoromethyl can often improve the bioavailability, metabolic stability and binding ability of the drug to the target.
1 - chloro - 2 - isothiocyanato - 4 - (trifluoromethyl) benzene is rich and diverse in chemical properties, providing broad application prospects for organic synthesis, drug research and development, materials science and other fields. With the characteristics of each functional group, various chemical reactions and functional regulation can be realized.
It contains chlorine atoms, isothiocyanate and trifluoromethyl and other functional groups. Chlorine atoms have certain electronegativity and can participate in nucleophilic substitution reactions. Under suitable conditions, nucleophilic testers can attack carbon atoms attached to chlorine, and the chlorine atoms leave to form new compounds. This reaction is often used in organic synthesis to form carbon-heteroatomic bonds.
Isothiocyanate is a highly active functional group. It can react with compounds containing active hydrogen, such as alcohols and amines. When reacted with alcohol, thiocarbamate compounds can be formed; when reacted with amines, thiourea derivatives can be formed. This kind of reaction is widely used in drug synthesis, pesticide preparation, etc., which can introduce specific structural fragments and endow the product with unique biological activity. The presence of
trifluoromethyl greatly affects the properties of the compound. Trifluoromethyl has strong electron absorption, which can reduce the electron cloud density of the benzene ring and change the electrophilic substitution reaction activity on the benzene ring. At the same time, due to its special electronic effect and spatial effect, it can improve the stability and fat solubility of the compound. In drug molecular design, the introduction of trifluoromethyl can often improve the bioavailability, metabolic stability and binding ability of the drug to the target.
1 - chloro - 2 - isothiocyanato - 4 - (trifluoromethyl) benzene is rich and diverse in chemical properties, providing broad application prospects for organic synthesis, drug research and development, materials science and other fields. With the characteristics of each functional group, various chemical reactions and functional regulation can be realized.
What are the physical properties of 1-chloro-2-isothiocyanato-4- (trifluoromethyl) benzene?
1-Chloro-2-isothiocyanate-4- (trifluoromethyl) benzene is a kind of organic compound. Its physical properties are particularly important, and it is related to the performance of this compound in various chemical processes and applications.
First of all, its appearance, under normal temperature and pressure, is often colorless to light yellow liquid form. This morphological feature is easy to observe and operate. In many chemical processes, the fluidity of liquids makes mixing, transportation and other operations easier.
As for its melting point and boiling point, the melting point is about -15 ° C, and the boiling point is between 225-227 ° C. The lower melting point indicates that the compound can be converted from solid to liquid in a relatively mild low temperature environment, while the higher boiling point means that a higher temperature is required to make it gaseous. This property can be used in the process of separation and purification. By distillation, the purpose of separation can be achieved according to the difference in boiling points between it and others.
Furthermore, its density is about 1.45 g/cm ³, which is heavier than water. This density property is crucial in experiments and industrial processes involving stratification and extraction. According to different densities, it can be stratified with water or other liquids of different densities to achieve separation or enrichment.
Its solubility cannot be ignored, slightly soluble in water, but soluble in common organic solvents such as ethanol, ether, dichloromethane, etc. This solubility characteristic is due to the ratio of polar to non-polar parts of its molecular structure, which makes it more likely to interact with organic solvents with similar polarities, but less likely to interact with water. This property is often used in organic synthesis, and organic solvents can provide a suitable medium for the reaction to promote the smooth progress of the reaction.
In addition, 1-chloro-2-isothiocyanate-4- (trifluoromethyl) benzene is volatile to a certain extent, and in an open system, it will slowly evaporate into the air. This characteristic requires that during storage and use, attention should be paid to closed operation to prevent its dissipation, and ventilation should also be paid to avoid its accumulation in a limited space to prevent potential safety risks.
In summary, the physical properties of 1-chloro-2-isothiocyanate-4 - (trifluoromethyl) benzene, such as appearance, melting point, density, solubility, and volatility, are of great significance in many fields such as chemical research and chemical production. Only by understanding and making good use of these properties can we better control various processes related to them.
First of all, its appearance, under normal temperature and pressure, is often colorless to light yellow liquid form. This morphological feature is easy to observe and operate. In many chemical processes, the fluidity of liquids makes mixing, transportation and other operations easier.
As for its melting point and boiling point, the melting point is about -15 ° C, and the boiling point is between 225-227 ° C. The lower melting point indicates that the compound can be converted from solid to liquid in a relatively mild low temperature environment, while the higher boiling point means that a higher temperature is required to make it gaseous. This property can be used in the process of separation and purification. By distillation, the purpose of separation can be achieved according to the difference in boiling points between it and others.
Furthermore, its density is about 1.45 g/cm ³, which is heavier than water. This density property is crucial in experiments and industrial processes involving stratification and extraction. According to different densities, it can be stratified with water or other liquids of different densities to achieve separation or enrichment.
Its solubility cannot be ignored, slightly soluble in water, but soluble in common organic solvents such as ethanol, ether, dichloromethane, etc. This solubility characteristic is due to the ratio of polar to non-polar parts of its molecular structure, which makes it more likely to interact with organic solvents with similar polarities, but less likely to interact with water. This property is often used in organic synthesis, and organic solvents can provide a suitable medium for the reaction to promote the smooth progress of the reaction.
In addition, 1-chloro-2-isothiocyanate-4- (trifluoromethyl) benzene is volatile to a certain extent, and in an open system, it will slowly evaporate into the air. This characteristic requires that during storage and use, attention should be paid to closed operation to prevent its dissipation, and ventilation should also be paid to avoid its accumulation in a limited space to prevent potential safety risks.
In summary, the physical properties of 1-chloro-2-isothiocyanate-4 - (trifluoromethyl) benzene, such as appearance, melting point, density, solubility, and volatility, are of great significance in many fields such as chemical research and chemical production. Only by understanding and making good use of these properties can we better control various processes related to them.
What are the main applications of 1-chloro-2-isothiocyanato-4- (trifluoromethyl) benzene?
1-Chloro-2-isothiocyanate-4- (trifluoromethyl) benzene has a wide range of uses and has its presence in various fields.
In the field of pharmaceutical and chemical industry, this compound can be used as a key intermediate. In the medical system, with its unique chemical structure, it can be used to create new drugs. Because of its chlorine atoms, isothiocyanate and trifluoromethyl functional groups, it has the potential to interact with biological macromolecules. It can help synthesize drugs with antibacterial, anti-tumor, anti-viral and other effects by binding with specific receptors or interfering with biochemical reaction pathways in cells, opening up new ways for the treatment of various diseases.
is also of great value in the field of materials science. It can be used to prepare polymer materials with special properties. By polymerizing with other monomers, its unique functional groups can be introduced into the polymer chain, thereby imparting properties such as chemical resistance, heat resistance and special optical properties to the material. For example, the prepared polymer materials may be applied to the packaging of electronic devices, with their excellent corrosion resistance and thermal stability, to ensure stable operation of electronic components in complex environments.
In the field of agriculture, it may also be useful. Due to its structural properties, it may be developed into a new type of pesticide. By interfering with the physiological and metabolic processes of pests, or inhibiting the growth and reproduction of harmful microorganisms, the purpose of insecticide and sterilization can be achieved, and compared with traditional pesticides, it may have higher selectivity and environmental friendliness, and contribute to ensuring the harvest of crops and maintaining the balance of agricultural ecology.
In summary, 1-chloro-2-isothiocyanate-4 - (trifluoromethyl) benzene has shown important application potential in many fields such as medicine and chemical industry, materials science, agriculture, etc. With the development of science and technology, its application prospects may be broader.
In the field of pharmaceutical and chemical industry, this compound can be used as a key intermediate. In the medical system, with its unique chemical structure, it can be used to create new drugs. Because of its chlorine atoms, isothiocyanate and trifluoromethyl functional groups, it has the potential to interact with biological macromolecules. It can help synthesize drugs with antibacterial, anti-tumor, anti-viral and other effects by binding with specific receptors or interfering with biochemical reaction pathways in cells, opening up new ways for the treatment of various diseases.
is also of great value in the field of materials science. It can be used to prepare polymer materials with special properties. By polymerizing with other monomers, its unique functional groups can be introduced into the polymer chain, thereby imparting properties such as chemical resistance, heat resistance and special optical properties to the material. For example, the prepared polymer materials may be applied to the packaging of electronic devices, with their excellent corrosion resistance and thermal stability, to ensure stable operation of electronic components in complex environments.
In the field of agriculture, it may also be useful. Due to its structural properties, it may be developed into a new type of pesticide. By interfering with the physiological and metabolic processes of pests, or inhibiting the growth and reproduction of harmful microorganisms, the purpose of insecticide and sterilization can be achieved, and compared with traditional pesticides, it may have higher selectivity and environmental friendliness, and contribute to ensuring the harvest of crops and maintaining the balance of agricultural ecology.
In summary, 1-chloro-2-isothiocyanate-4 - (trifluoromethyl) benzene has shown important application potential in many fields such as medicine and chemical industry, materials science, agriculture, etc. With the development of science and technology, its application prospects may be broader.
What is the synthesis method of 1-chloro-2-isothiocyanato-4- (trifluoromethyl) benzene?
The synthesis of 1-chloro-2-isothiocyanate-4- (trifluoromethyl) benzene is a significant issue in the field of organic synthesis. To synthesize this substance, several ways can be achieved.
First, it can be started by a benzene derivative containing the corresponding substituent. First, a suitable halogenation reagent, such as thionyl chloride or phosphorus trichloride, is used to halogenate the specific position on the benzene ring and introduce chlorine atoms. This step requires selecting suitable reaction conditions, such as reaction temperature, time and solvent, to ensure that the chlorine atoms are precisely positioned at the target position.
Subsequently, for the introduction of isothiocyanate groups, thiocyanate-containing reagents can be used to introduce them through nucleophilic substitution reactions. In this process, thiocyanate ions act as nucleophiles to attack specific activity check points on the benzene ring. Only by carefully regulating the reaction conditions can the target isothiocyanate-based substitutions be efficiently generated.
At the same time, for the introduction of trifluoromethyl groups, special trifluoromethylation reagents can be used. There are many such reagents available, such as some metal-organic reagents containing trifluoromethyl groups or specific fluorohalogen exchange reagents. When using such reagents, their reactivity, selectivity and compatibility with other substituents need to be fully considered.
During the reaction process, the choice of solvent is also crucial. Suitable solvents can not only promote the dissolution and mixing of the reactants, but also affect the reaction rate and selectivity. Commonly used organic solvents, such as dichloromethane, N, N-dimethylformamide, etc., need to be carefully selected according to the characteristics of specific reaction steps.
Furthermore, the treatment after the reaction cannot be ignored. Usually, the product needs to be purified by means of extraction, washing, drying and column chromatography to obtain high-purity 1-chloro-2-isothiocyanate-4 - (trifluoromethyl) benzene. In this way, the target product can be obtained through a series of carefully designed and operated reaction steps.
First, it can be started by a benzene derivative containing the corresponding substituent. First, a suitable halogenation reagent, such as thionyl chloride or phosphorus trichloride, is used to halogenate the specific position on the benzene ring and introduce chlorine atoms. This step requires selecting suitable reaction conditions, such as reaction temperature, time and solvent, to ensure that the chlorine atoms are precisely positioned at the target position.
Subsequently, for the introduction of isothiocyanate groups, thiocyanate-containing reagents can be used to introduce them through nucleophilic substitution reactions. In this process, thiocyanate ions act as nucleophiles to attack specific activity check points on the benzene ring. Only by carefully regulating the reaction conditions can the target isothiocyanate-based substitutions be efficiently generated.
At the same time, for the introduction of trifluoromethyl groups, special trifluoromethylation reagents can be used. There are many such reagents available, such as some metal-organic reagents containing trifluoromethyl groups or specific fluorohalogen exchange reagents. When using such reagents, their reactivity, selectivity and compatibility with other substituents need to be fully considered.
During the reaction process, the choice of solvent is also crucial. Suitable solvents can not only promote the dissolution and mixing of the reactants, but also affect the reaction rate and selectivity. Commonly used organic solvents, such as dichloromethane, N, N-dimethylformamide, etc., need to be carefully selected according to the characteristics of specific reaction steps.
Furthermore, the treatment after the reaction cannot be ignored. Usually, the product needs to be purified by means of extraction, washing, drying and column chromatography to obtain high-purity 1-chloro-2-isothiocyanate-4 - (trifluoromethyl) benzene. In this way, the target product can be obtained through a series of carefully designed and operated reaction steps.
What are the precautions for 1-chloro-2-isothiocyanato-4- (trifluoromethyl) benzene in storage and transportation?
1-Chloro-2-isothiocyanate-4- (trifluoromethyl) benzene is also an organic compound. During storage and transportation, many important items should not be ignored.
First words storage. This material should be placed in a cool, dry and well-ventilated place. Cover its nature or be affected by temperature and humidity, high temperature and humid place, fear of deterioration. Keep away from fires and heat sources to prevent fires. Because of its certain chemical activity, it is easy to react with oxidants, alkalis and other substances, so it should be stored separately and must not be mixed. The storage area should also be equipped with suitable materials to contain possible leakage.
On transportation. When transporting, make sure that the container is well sealed to prevent leakage. Transportation vehicles need to be equipped with corresponding fire equipment and leakage emergency treatment equipment. During driving, drivers should drive carefully to avoid bumps and collisions to prevent packaging damage. This compound may be harmful to the environment. If there is a leak during transportation, proper measures should be taken to collect and clean it up in time, so as not to pollute the environment. Transportation personnel must also be familiar with its physical and chemical properties and emergency treatment methods. In case of emergencies, they can deal with it calmly.
All of these are things that should be taken into account when storing and transporting 1-chloro-2-isothiocyanate-4 - (trifluoromethyl) benzene, and must not be negligent to avoid harm.
First words storage. This material should be placed in a cool, dry and well-ventilated place. Cover its nature or be affected by temperature and humidity, high temperature and humid place, fear of deterioration. Keep away from fires and heat sources to prevent fires. Because of its certain chemical activity, it is easy to react with oxidants, alkalis and other substances, so it should be stored separately and must not be mixed. The storage area should also be equipped with suitable materials to contain possible leakage.
On transportation. When transporting, make sure that the container is well sealed to prevent leakage. Transportation vehicles need to be equipped with corresponding fire equipment and leakage emergency treatment equipment. During driving, drivers should drive carefully to avoid bumps and collisions to prevent packaging damage. This compound may be harmful to the environment. If there is a leak during transportation, proper measures should be taken to collect and clean it up in time, so as not to pollute the environment. Transportation personnel must also be familiar with its physical and chemical properties and emergency treatment methods. In case of emergencies, they can deal with it calmly.
All of these are things that should be taken into account when storing and transporting 1-chloro-2-isothiocyanate-4 - (trifluoromethyl) benzene, and must not be negligent to avoid harm.
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