Linshang Chemical
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1-Chloro-2-Isothiocyanatobenzene
Linshang Chemical
|
HS Code |
167263 |
| Chemical Formula | C7H4ClNS |
| Molecular Weight | 169.63 |
| Appearance | Solid (usually a pale - colored solid) |
| Melting Point | 46 - 48 °C |
| Solubility In Water | Insoluble in water |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Odor | Pungent, characteristic odor |
| Reactivity | Highly reactive, reacts with nucleophiles like amines, alcohols |
| Hazard Class | Corrosive, toxic |
As an accredited 1-Chloro-2-Isothiocyanatobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram vial of 1 - chloro - 2 - isothiocyanatobenzene, well - sealed for chemical storage. |
| Storage | 1 - Chloro - 2 - isothiocyanatobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent exposure to moisture and air, which could cause decomposition. Store it separately from incompatible substances like oxidizing agents, bases, and amines to avoid potential reactions. |
| Shipping | 1 - Chloro - 2 - isothiocyanatobenzene is a chemical that likely requires special shipping. It should be packaged in corrosion - resistant containers, labeled clearly with hazard warnings, and shipped in accordance with strict chemical transportation regulations. |
Competitive 1-Chloro-2-Isothiocyanatobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 1-Chloro-2-Isothiocyanatobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-2-isothiocyanatobenzene?
1-Chloro-2-isothiocyanate benzene is one of the organic compounds. It has a wide range of uses and is used in many fields.
In the field of organic synthesis, this compound is often used as a key intermediate. Due to the unique chemical activity of chlorine atoms and isothiocyanates, it can interact with many reagents through various chemical reactions to construct complex organic molecules. For example, chlorine atoms can participate in nucleophilic substitution reactions and can combine with reagents containing nucleophilic groups, such as alcohols and amines, to form ether and amine-substituted derivatives. And isothiocyanate is also active, and can react with compounds containing active hydrogen, such as phenols and amines, to form thioureas and other compounds. In this way, by virtue of such reactions, organic chemists can use 1-chloro-2-isothiocyanate synbenzene to synthesize organic compounds with specific structures required in the fields of medicine, pesticides, dyes, etc.
In the field of medicine, compounds derived from 1-chloro-2-isothiocyanate synbenzene may have potential biological activity. Some derivatives have been found to have inhibitory effects on specific disease targets, such as the growth of certain cancer cells and the reproduction of certain pathogens. Therefore, it provides an important starting material for the development of new drugs and injects vitality into the development of medicinal chemistry.
In the field of materials science, 1-chloro-2-isothiocyanate benzene can participate in the synthesis of polymer materials after being modified by chemical reaction. Its active groups can make materials have special properties, such as changing the surface properties of materials and enhancing the stability of materials, thereby broadening the application range of polymer materials in different scenarios.
In summary, 1-chloro-2-isothiocyanate benzene, with its unique chemical structure and activity, plays an important role in organic synthesis, pharmaceutical research and development, materials science and other fields, and is of great significance for promoting technological progress and innovation in various fields.
In the field of organic synthesis, this compound is often used as a key intermediate. Due to the unique chemical activity of chlorine atoms and isothiocyanates, it can interact with many reagents through various chemical reactions to construct complex organic molecules. For example, chlorine atoms can participate in nucleophilic substitution reactions and can combine with reagents containing nucleophilic groups, such as alcohols and amines, to form ether and amine-substituted derivatives. And isothiocyanate is also active, and can react with compounds containing active hydrogen, such as phenols and amines, to form thioureas and other compounds. In this way, by virtue of such reactions, organic chemists can use 1-chloro-2-isothiocyanate synbenzene to synthesize organic compounds with specific structures required in the fields of medicine, pesticides, dyes, etc.
In the field of medicine, compounds derived from 1-chloro-2-isothiocyanate synbenzene may have potential biological activity. Some derivatives have been found to have inhibitory effects on specific disease targets, such as the growth of certain cancer cells and the reproduction of certain pathogens. Therefore, it provides an important starting material for the development of new drugs and injects vitality into the development of medicinal chemistry.
In the field of materials science, 1-chloro-2-isothiocyanate benzene can participate in the synthesis of polymer materials after being modified by chemical reaction. Its active groups can make materials have special properties, such as changing the surface properties of materials and enhancing the stability of materials, thereby broadening the application range of polymer materials in different scenarios.
In summary, 1-chloro-2-isothiocyanate benzene, with its unique chemical structure and activity, plays an important role in organic synthesis, pharmaceutical research and development, materials science and other fields, and is of great significance for promoting technological progress and innovation in various fields.
What are the physical properties of 1-chloro-2-isothiocyanatobenzene?
1-Chloro-2-isothiocyanate benzene, the physical properties of this substance are quite important, and it is related to its performance in various reactions and applications.
Its appearance is often colorless to light yellow liquid, with a special smell and pungent smell. This smell is derived from the characteristics of isothiocyanate. Its boiling point, which has been investigated by predecessors, is about a specific temperature range, but the exact value varies depending on the fineness of the measurement conditions. Probably within a certain temperature range, the liquid boils and converts into a gaseous state.
As for the melting point, it is also a key physical property. At its melting point, the substance changes from a solid state to a liquid state. According to past records, the melting point is near a certain temperature value. At this temperature, the lattice structure of the substance begins to disintegrate, and the molecular motion intensifies, resulting in changes in the state of the substance.
The density of 1-chloro-2-isothiocyanate benzene is heavier than that of water. When placed in water in a liquid state, it will sink to the bottom. This density characteristic is particularly critical in operations such as separation and mixing, and corresponding processes can be designed according to it.
In terms of solubility, it exhibits good solubility in organic solvents such as ethanol, ether, etc., and can dissolve with it to form a uniform solution. However, in water, the solubility is poor, only slightly soluble, and this property also affects its reaction path and effect in different media.
In addition, its vapor pressure also has characteristics. At a specific temperature, the vapor pressure determines its volatilization difficulty. The magnitude of the vapor pressure is closely related to the temperature. When the temperature increases, the vapor pressure increases, and the volatilization rate of the substance also accelerates.
All kinds of physical properties are interrelated and jointly determine the application mode and scope of 1-chloro-2-isothiocyanate benzene in many fields such as chemical industry and materials. It is an important factor that cannot be ignored in later research and practice.
Its appearance is often colorless to light yellow liquid, with a special smell and pungent smell. This smell is derived from the characteristics of isothiocyanate. Its boiling point, which has been investigated by predecessors, is about a specific temperature range, but the exact value varies depending on the fineness of the measurement conditions. Probably within a certain temperature range, the liquid boils and converts into a gaseous state.
As for the melting point, it is also a key physical property. At its melting point, the substance changes from a solid state to a liquid state. According to past records, the melting point is near a certain temperature value. At this temperature, the lattice structure of the substance begins to disintegrate, and the molecular motion intensifies, resulting in changes in the state of the substance.
The density of 1-chloro-2-isothiocyanate benzene is heavier than that of water. When placed in water in a liquid state, it will sink to the bottom. This density characteristic is particularly critical in operations such as separation and mixing, and corresponding processes can be designed according to it.
In terms of solubility, it exhibits good solubility in organic solvents such as ethanol, ether, etc., and can dissolve with it to form a uniform solution. However, in water, the solubility is poor, only slightly soluble, and this property also affects its reaction path and effect in different media.
In addition, its vapor pressure also has characteristics. At a specific temperature, the vapor pressure determines its volatilization difficulty. The magnitude of the vapor pressure is closely related to the temperature. When the temperature increases, the vapor pressure increases, and the volatilization rate of the substance also accelerates.
All kinds of physical properties are interrelated and jointly determine the application mode and scope of 1-chloro-2-isothiocyanate benzene in many fields such as chemical industry and materials. It is an important factor that cannot be ignored in later research and practice.
Is 1-chloro-2-isothiocyanatobenzene chemically stable?
1-Chloro-2-isothiocyanate phenyl ester, the chemical properties of this substance are slightly complicated. It is either liquid at room temperature and pressure, colorless to light yellow in color, and has a special pungent odor. The smell is pungent. The reason for this odor is the characteristics of isothiocyanate groups.
When it comes to chemical activity, 1-chloro-2-isothiocyanate phenyl ester is quite active. The chlorine atom, due to the influence of benzene ring electron effect, can participate in many nucleophilic substitution reactions. When encountering nucleophiles, chlorine atoms are easily replaced, such as reacting with alcohols to form corresponding ether derivatives; reacting with amines, new compounds containing nitrogen can be formed.
And isothiocyanate groups also exhibit unique reactivity. It can rapidly react with compounds containing active hydrogen, such as alcohols, phenols, amines, etc., to form thiourea derivatives. This reaction is widely used in the field of organic synthesis and is often an effective way to construct new carbon-nitrogen, carbon-oxygen and other chemical bonds.
However, the stability of this compound is not high. Under high temperature, high humidity environment, or when encountering strong acid or alkali, decomposition reaction is prone to occur. The decomposition process or the production of harmful gases, such as hydrogen chloride, hydrogen sulfide, etc., is not only harmful to the environment, but also potentially harmful to the human body during operation.
Therefore, when storing and using 1-chloro-2-isothiocyanate phenyl ester, it should be handled with caution. It should be stored in a cool, dry and well-ventilated place, away from fire, heat and strong acid and alkali substances. When operating, appropriate protective measures should also be taken to ensure safety.
When it comes to chemical activity, 1-chloro-2-isothiocyanate phenyl ester is quite active. The chlorine atom, due to the influence of benzene ring electron effect, can participate in many nucleophilic substitution reactions. When encountering nucleophiles, chlorine atoms are easily replaced, such as reacting with alcohols to form corresponding ether derivatives; reacting with amines, new compounds containing nitrogen can be formed.
And isothiocyanate groups also exhibit unique reactivity. It can rapidly react with compounds containing active hydrogen, such as alcohols, phenols, amines, etc., to form thiourea derivatives. This reaction is widely used in the field of organic synthesis and is often an effective way to construct new carbon-nitrogen, carbon-oxygen and other chemical bonds.
However, the stability of this compound is not high. Under high temperature, high humidity environment, or when encountering strong acid or alkali, decomposition reaction is prone to occur. The decomposition process or the production of harmful gases, such as hydrogen chloride, hydrogen sulfide, etc., is not only harmful to the environment, but also potentially harmful to the human body during operation.
Therefore, when storing and using 1-chloro-2-isothiocyanate phenyl ester, it should be handled with caution. It should be stored in a cool, dry and well-ventilated place, away from fire, heat and strong acid and alkali substances. When operating, appropriate protective measures should also be taken to ensure safety.
What are 1-chloro-2-isothiocyanatobenzene synthesis methods?
The synthesis of 1-chloro-2-isothiocyanate benzene has been discussed in many ancient books. One common method is to use o-chloroaniline as the starting material. First, make o-chloroaniline and sulfur phosgene act in a suitable reaction environment. Sulphosgene has good activity and can be substituted with amino groups in o-chloroaniline. During the reaction, it is necessary to pay attention to the regulation of the reaction temperature. If the temperature is too high or too low, it can affect the formation of the product. Generally speaking, in the range of low temperature to room temperature, sulfur phosgene is slowly added dropwise to the solution of o-chloroaniline. The solvent of the solution is mostly an organic solvent, such as dichloromethane, because it has good solubility to the reactants and products, and its properties are relatively stable, so as not to interfere with the main reaction. After the dropwise addition, the temperature can be appropriately increased to make the reaction tend to be complete. During this process, the reaction process can be monitored by means of thin-layer chromatography.
Another method is to use o-chlorobenzoic acid as the starting material. First, the o-chlorobenzoic acid is converted into o-chlorobenzoyl chloride, and this step of conversion can be achieved by sulfinyl chloride and other reagents. This reaction condition is relatively mild and the yield is considerable. Then the nucleophilic substitution reaction between the o-chlorobenzoyl chloride and the thiocyanate occurs. Select a suitable thiocyanate, such as potassium thiocyanate, and react in a suitable solvent, such as DMF (N, N-dimethylformamide). DMF has strong polarity and can promote the reaction between ions and increase the reaction rate. During the reaction, it is also necessary to pay attention to the optimization of the reaction conditions, such as the ratio of reactants, reaction time and other factors, which have a significant impact on the formation of the final product 1-chloro-2-isothiocyanate benzene. After multi-step reaction and careful operation, the final product can be obtained.
Another method is to use o-chlorobenzoic acid as the starting material. First, the o-chlorobenzoic acid is converted into o-chlorobenzoyl chloride, and this step of conversion can be achieved by sulfinyl chloride and other reagents. This reaction condition is relatively mild and the yield is considerable. Then the nucleophilic substitution reaction between the o-chlorobenzoyl chloride and the thiocyanate occurs. Select a suitable thiocyanate, such as potassium thiocyanate, and react in a suitable solvent, such as DMF (N, N-dimethylformamide). DMF has strong polarity and can promote the reaction between ions and increase the reaction rate. During the reaction, it is also necessary to pay attention to the optimization of the reaction conditions, such as the ratio of reactants, reaction time and other factors, which have a significant impact on the formation of the final product 1-chloro-2-isothiocyanate benzene. After multi-step reaction and careful operation, the final product can be obtained.
1-chloro-2-isothiocyanatobenzene need to pay attention to when storing and transporting
1-Chloro-2-isothiocyanate benzene is a highly toxic product. When storing and transporting, many matters must be carefully paid attention to.
Bear the brunt, and the storage place must be cool and dry. This substance is highly susceptible to moisture and humid air. After deliquescence, it will not only reduce its purity, but also cause chemical reactions to generate substances with greater danger. If stored at high temperatures, its stability will also be greatly affected, or dangerous conditions such as decomposition will occur.
Furthermore, this substance has very high packaging requirements. It must be packed in a container with good sealing performance to prevent it from evaporating into the air, polluting the environment, and preventing it from reacting with external substances. Packaging materials must also have corrosion resistance, because 1-chloro-2-isothiocyanate benzene may have a corrosive effect on some materials. If the packaging is damaged by corrosion, the consequences will be disastrous.
When transporting, ensure that the means of transportation are clean and dry, and do not mix with other substances that may react with it. If the goods that will react violently in contact with water are transported with them, once the packaging is damaged, it will cause serious accidents in contact with water. The transportation process should be as smooth as possible to avoid bumps and vibrations to prevent damage to the packaging.
People who handle and come into contact with this substance must take protective measures. Wear professional protective clothing, gas masks, protective gloves, etc., to prevent it from contacting the skin and respiratory tract, because it is highly irritating and toxic to the human body.
In short, the storage and transportation of 1-chloro-2-isothiocyanate benzene should be handled with caution and in strict accordance with regulations to ensure the safety of personnel and the environment.
Bear the brunt, and the storage place must be cool and dry. This substance is highly susceptible to moisture and humid air. After deliquescence, it will not only reduce its purity, but also cause chemical reactions to generate substances with greater danger. If stored at high temperatures, its stability will also be greatly affected, or dangerous conditions such as decomposition will occur.
Furthermore, this substance has very high packaging requirements. It must be packed in a container with good sealing performance to prevent it from evaporating into the air, polluting the environment, and preventing it from reacting with external substances. Packaging materials must also have corrosion resistance, because 1-chloro-2-isothiocyanate benzene may have a corrosive effect on some materials. If the packaging is damaged by corrosion, the consequences will be disastrous.
When transporting, ensure that the means of transportation are clean and dry, and do not mix with other substances that may react with it. If the goods that will react violently in contact with water are transported with them, once the packaging is damaged, it will cause serious accidents in contact with water. The transportation process should be as smooth as possible to avoid bumps and vibrations to prevent damage to the packaging.
People who handle and come into contact with this substance must take protective measures. Wear professional protective clothing, gas masks, protective gloves, etc., to prevent it from contacting the skin and respiratory tract, because it is highly irritating and toxic to the human body.
In short, the storage and transportation of 1-chloro-2-isothiocyanate benzene should be handled with caution and in strict accordance with regulations to ensure the safety of personnel and the environment.
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