Linshang Chemical
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1-Chloro-2-Methoxy-3-Nitrobenzene
Linshang Chemical
|
HS Code |
818896 |
| Chemical Formula | C7H6ClNO3 |
| Molar Mass | 187.58 g/mol |
| Appearance | Yellow solid (usually) |
| Odor | May have a characteristic aromatic odor |
| Melting Point | Typically in a certain temperature range (data needed for exact value) |
| Boiling Point | Specific boiling point value pending data |
| Density | Data required for density value |
| Solubility In Water | Low solubility in water |
| Solubility In Organic Solvents | Soluble in some common organic solvents like dichloromethane |
| Flash Point | Data needed for flash point value |
| Stability | Stable under normal conditions but can react with strong oxidizing agents |
| Hazard Class | May be classified as a hazardous substance due to toxicity or other hazards (more data for exact class) |
As an accredited 1-Chloro-2-Methoxy-3-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 2 - methoxy - 3 - nitrobenzene packaged in 1 - kg bottles for secure storage. |
| Storage | 1 - Chloro - 2 - methoxy - 3 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container, preferably in a dedicated chemical storage cabinet. This helps prevent decomposition, leakage, and potential chemical reactions that could pose safety risks. |
| Shipping | 1 - Chloro - 2 - methoxy - 3 - nitrobenzene is shipped in tightly sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, with proper labeling and documentation to ensure safe transport. |
Competitive 1-Chloro-2-Methoxy-3-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 1-Chloro-2-Methoxy-3-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemistry of 1-chloro-2-methoxy-3-nitrobenzene?
1-Chloro-2-methoxy-3-nitrobenzene has unique chemical properties and has attracted much attention in the field of organic chemistry. This compound contains chlorine atoms, methoxy groups and nitro groups, and various functional groups interact to give it a variety of reactivity.
Let's talk about the chlorine atom first, which has the activity of nucleophilic substitution. Due to the high electronegativity of the chlorine atom, the carbon-chlorine bond is polar, making the carbon atom vulnerable to attack by nucleophilic reagents. When encountering nucleophilic reagents such as sodium alcohol and amines, the chlorine atom can be replaced to generate corresponding ether or amine derivatives. The electron cloud density of the benzene ring can be enhanced by methoxy group as the power supply group, and the electron cloud density of the benzene ring is relatively higher. This electronic effect makes the benzene ring more prone to electrophilic substitution, and the localization effect of methoxy group will guide the electrophilic reagents to mainly attack the adjacent and para-position of the benzene ring.
Nitro is a strong electron-absorbing group, which greatly reduces the electron cloud density of the benzene ring and makes the electrophilic substitution activity of the benzene ring significantly decrease. At the same time, the presence of nitro affects the reactivity of other parts of the molecule. Under reduction conditions, nitro can be reduced to amino groups, and a variety of amino-containing compounds can be derived.
1-chloro-2-methoxy-3-nitrophenyl functional groups interact with each other, their chemical properties are complex and diverse, and they are widely used in the field of organic synthesis. Various organic compounds can be prepared through different reaction paths.
Let's talk about the chlorine atom first, which has the activity of nucleophilic substitution. Due to the high electronegativity of the chlorine atom, the carbon-chlorine bond is polar, making the carbon atom vulnerable to attack by nucleophilic reagents. When encountering nucleophilic reagents such as sodium alcohol and amines, the chlorine atom can be replaced to generate corresponding ether or amine derivatives. The electron cloud density of the benzene ring can be enhanced by methoxy group as the power supply group, and the electron cloud density of the benzene ring is relatively higher. This electronic effect makes the benzene ring more prone to electrophilic substitution, and the localization effect of methoxy group will guide the electrophilic reagents to mainly attack the adjacent and para-position of the benzene ring.
Nitro is a strong electron-absorbing group, which greatly reduces the electron cloud density of the benzene ring and makes the electrophilic substitution activity of the benzene ring significantly decrease. At the same time, the presence of nitro affects the reactivity of other parts of the molecule. Under reduction conditions, nitro can be reduced to amino groups, and a variety of amino-containing compounds can be derived.
1-chloro-2-methoxy-3-nitrophenyl functional groups interact with each other, their chemical properties are complex and diverse, and they are widely used in the field of organic synthesis. Various organic compounds can be prepared through different reaction paths.
What are the main uses of 1-chloro-2-methoxy-3-nitrobenzene?
1 - chloro - 2 - methoxy - 3 - nitrobenzene is also an organic compound. It has a wide range of uses and has important applications in many fields.
Bearing the brunt, in the field of pharmaceutical synthesis, this compound is often used as a key intermediate. Due to the characteristics of chlorine, methoxy and nitro groups in its structure, it can build complex drug molecular structures through various chemical reactions. For example, through nucleophilic substitution, chlorine atoms can be replaced by a variety of heteroatom groups containing nitrogen, oxygen and other heteroatoms, and then derived compounds with specific pharmacological activities, or used to develop antibacterial, antiviral and even anti-cancer drugs.
Furthermore, in the field of pesticides, 1-chloro-2-methoxy-3-nitrobenzene also plays an important role. It can be chemically modified to create pesticide varieties that have high efficacy in killing pests and have little impact on the environment. For example, using its strong electron absorption of nitro groups to enhance the affinity and biological activity of the compound to specific targets in pests, achieving good insecticidal effect.
The compound is also indispensable in the dye industry. Its structure can be adjusted and optimized to give the dye its unique color and stability. By introducing different substituents, the electron cloud distribution can be changed, and the light absorption and emission characteristics of dyes can be regulated, resulting in bright and long-lasting dye products, which are widely used in textiles, printing and dyeing industries.
In addition, in the field of materials science, 1-chloro-2-methoxy-3-nitrobenzene can be used as a precursor for the synthesis of special functional materials. Materials with specific electrical, optical or thermal properties are prepared by polymerization or reaction with other organic or inorganic compounds, such as for the manufacture of organic semiconductor materials and used in new electronic devices.
In conclusion, 1-chloro-2-methoxy-3-nitrobenzene has shown important application value in many fields such as medicine, pesticides, dyes and materials science due to its unique chemical structure, and has contributed greatly to the development of related industries.
Bearing the brunt, in the field of pharmaceutical synthesis, this compound is often used as a key intermediate. Due to the characteristics of chlorine, methoxy and nitro groups in its structure, it can build complex drug molecular structures through various chemical reactions. For example, through nucleophilic substitution, chlorine atoms can be replaced by a variety of heteroatom groups containing nitrogen, oxygen and other heteroatoms, and then derived compounds with specific pharmacological activities, or used to develop antibacterial, antiviral and even anti-cancer drugs.
Furthermore, in the field of pesticides, 1-chloro-2-methoxy-3-nitrobenzene also plays an important role. It can be chemically modified to create pesticide varieties that have high efficacy in killing pests and have little impact on the environment. For example, using its strong electron absorption of nitro groups to enhance the affinity and biological activity of the compound to specific targets in pests, achieving good insecticidal effect.
The compound is also indispensable in the dye industry. Its structure can be adjusted and optimized to give the dye its unique color and stability. By introducing different substituents, the electron cloud distribution can be changed, and the light absorption and emission characteristics of dyes can be regulated, resulting in bright and long-lasting dye products, which are widely used in textiles, printing and dyeing industries.
In addition, in the field of materials science, 1-chloro-2-methoxy-3-nitrobenzene can be used as a precursor for the synthesis of special functional materials. Materials with specific electrical, optical or thermal properties are prepared by polymerization or reaction with other organic or inorganic compounds, such as for the manufacture of organic semiconductor materials and used in new electronic devices.
In conclusion, 1-chloro-2-methoxy-3-nitrobenzene has shown important application value in many fields such as medicine, pesticides, dyes and materials science due to its unique chemical structure, and has contributed greatly to the development of related industries.
What is 1-chloro-2-methoxy-3-nitrobenzene synthesis method?
The synthesis method of 1-chloro-2-methoxy-3-nitrobenzene can follow the following steps.
First, o-methoxyaniline is used as the starting material, and it is reacted with acetyl chloride in order to protect the amino group and generate N-acetyl-o-methoxyaniline. This reaction needs to be carried out at a suitable temperature and under the action of a catalyst. If it is cooled in an ice bath and catalyzed by pyridine, the two are slowly mixed, so that the reaction can occur smoothly, and the acetyl group replaces the hydrogen atom of the amino group to form a protective structure.
Then, the nitration reaction of N-acetyl-o-methoxyaniline is carried out. Using the mixed acid of concentrated nitric acid and concentrated sulfuric acid as the nitrifying reagent, under low temperature conditions, such as 0-5 ° C, carefully adding the mixed acid dropwise, the nitro group can be accurately introduced into the ortho-position of the amino group to obtain N-acetyl-2-methoxy-3-nitroaniline. This process must be strictly controlled to prevent the growth of side reactions. Due to high temperature, it is easy to cause the formation of polynitroylated products.
Subsequently, the product is hydrolyzed. Using dilute hydrochloric acid or dilute sulfuric acid as the hydrolysis reagent and heating to reflux, the N-acetyl group can be separated and 2-methoxy-3-nitroaniline can be obtained. The key to this hydrolysis step is to control the reaction time and temperature. If the time is too short or the temperature is too low, the hydrolysis will not last; otherwise, it may affect other groups.
Finally, the 2-methoxy-3-nitroaniline is reacted with a chlorinated reagent, such as phosphorus oxychloride or phosphorus pentachloride, in a suitable solvent. This reaction usually requires heating, and the solvent can be selected from dichloromethane. After this step, the amino group is replaced by a chlorine atom, and the final product is 1-chloro-2-methoxy-3-nitrobenzene. The entire synthesis process requires strict control of the reaction conditions at each step, such as temperature, reagent ratio, reaction time, etc., and the product should be properly separated and purified after each step to ensure the purity and yield of the final product.
First, o-methoxyaniline is used as the starting material, and it is reacted with acetyl chloride in order to protect the amino group and generate N-acetyl-o-methoxyaniline. This reaction needs to be carried out at a suitable temperature and under the action of a catalyst. If it is cooled in an ice bath and catalyzed by pyridine, the two are slowly mixed, so that the reaction can occur smoothly, and the acetyl group replaces the hydrogen atom of the amino group to form a protective structure.
Then, the nitration reaction of N-acetyl-o-methoxyaniline is carried out. Using the mixed acid of concentrated nitric acid and concentrated sulfuric acid as the nitrifying reagent, under low temperature conditions, such as 0-5 ° C, carefully adding the mixed acid dropwise, the nitro group can be accurately introduced into the ortho-position of the amino group to obtain N-acetyl-2-methoxy-3-nitroaniline. This process must be strictly controlled to prevent the growth of side reactions. Due to high temperature, it is easy to cause the formation of polynitroylated products.
Subsequently, the product is hydrolyzed. Using dilute hydrochloric acid or dilute sulfuric acid as the hydrolysis reagent and heating to reflux, the N-acetyl group can be separated and 2-methoxy-3-nitroaniline can be obtained. The key to this hydrolysis step is to control the reaction time and temperature. If the time is too short or the temperature is too low, the hydrolysis will not last; otherwise, it may affect other groups.
Finally, the 2-methoxy-3-nitroaniline is reacted with a chlorinated reagent, such as phosphorus oxychloride or phosphorus pentachloride, in a suitable solvent. This reaction usually requires heating, and the solvent can be selected from dichloromethane. After this step, the amino group is replaced by a chlorine atom, and the final product is 1-chloro-2-methoxy-3-nitrobenzene. The entire synthesis process requires strict control of the reaction conditions at each step, such as temperature, reagent ratio, reaction time, etc., and the product should be properly separated and purified after each step to ensure the purity and yield of the final product.
1-chloro-2-methoxy-3-nitrobenzene What are the precautions during storage and transportation?
1-Chloro-2-methoxy-3-nitrobenzene is an organic compound. When storing and transporting, many matters must be paid attention to.
First words storage. This compound has a certain chemical activity and should be stored in a cool, dry and well-ventilated place. It is easy to cause chemical reactions due to heat and moisture, which affects the quality and may even pose a safety risk. The temperature of the storage place should be controlled within a suitable range to avoid direct sunlight to prevent decomposition caused by light. In addition, this compound should be stored separately from oxidants, reducing agents, acids, bases and other substances. Because it comes into contact with such substances, or reacts violently, it is dangerous. It is necessary to ensure that the storage container is well sealed to prevent leakage, and the container material must be compatible with the compound and not chemically react with it.
As for transportation. Before transportation, it is necessary to understand the properties of the compound in detail and formulate a comprehensive transportation plan. During transportation, the vehicles used must be equipped with complete fire equipment and leakage emergency treatment equipment. When loading the vehicle, it should be lightly loaded and unloaded, and must not be operated brutally to prevent leakage caused by damage to the container. During transportation, it should avoid high temperature periods and densely populated areas, and the driving speed should be appropriate to avoid violent operations such as sudden braking and sharp turns. If a leak occurs during transportation, emergency measures should be taken immediately to evacuate the surrounding personnel, and it is strictly forbidden to approach the fire. At the same time, it should be promptly reported to the relevant departments and properly handled according to professional guidance.
All of this should be done with due care when storing and transporting 1-chloro-2-methoxy-3-nitrobenzene to ensure safety and prevent problems before they occur.
First words storage. This compound has a certain chemical activity and should be stored in a cool, dry and well-ventilated place. It is easy to cause chemical reactions due to heat and moisture, which affects the quality and may even pose a safety risk. The temperature of the storage place should be controlled within a suitable range to avoid direct sunlight to prevent decomposition caused by light. In addition, this compound should be stored separately from oxidants, reducing agents, acids, bases and other substances. Because it comes into contact with such substances, or reacts violently, it is dangerous. It is necessary to ensure that the storage container is well sealed to prevent leakage, and the container material must be compatible with the compound and not chemically react with it.
As for transportation. Before transportation, it is necessary to understand the properties of the compound in detail and formulate a comprehensive transportation plan. During transportation, the vehicles used must be equipped with complete fire equipment and leakage emergency treatment equipment. When loading the vehicle, it should be lightly loaded and unloaded, and must not be operated brutally to prevent leakage caused by damage to the container. During transportation, it should avoid high temperature periods and densely populated areas, and the driving speed should be appropriate to avoid violent operations such as sudden braking and sharp turns. If a leak occurs during transportation, emergency measures should be taken immediately to evacuate the surrounding personnel, and it is strictly forbidden to approach the fire. At the same time, it should be promptly reported to the relevant departments and properly handled according to professional guidance.
All of this should be done with due care when storing and transporting 1-chloro-2-methoxy-3-nitrobenzene to ensure safety and prevent problems before they occur.
1-chloro-2-methoxy-3-nitrobenzene impact on the environment and human health
1-Chloro-2-methoxy-3-nitrobenzene is one of the organic compounds. This substance has an impact on both the environment and human health and cannot be ignored.
In terms of environmental impact, it has certain stability and is not easy to be degraded by natural processes. If it flows into the soil, it may cause soil pollution, affect the ecological balance of soil microorganisms, and then endanger the growth of plants. Its entry into the water body will pose a threat to aquatic organisms. If aquatic organisms are exposed to this substance for a long time, or their growth and development may be hindered and their reproductive capacity will decline, and in severe cases, the population may decrease. And because of its bioaccumulation, it will be transmitted and enriched along the food chain, which will cause potential harm to higher nutrient-level organisms.
As for the impact on human health, 1-chloro-2-methoxy-3-nitrobenzene can invade the human body through respiratory tract, skin contact and accidental ingestion. It may have irritating effects on the respiratory tract. After inhalation, people may feel throat discomfort, cough, etc. Through skin contact, it may cause skin allergies, itching, redness and swelling and other symptoms. Long-term exposure or ingestion will involve human organs. It may cause damage to important organs such as the liver and kidneys, affecting the normal function of organs. At the same time, this substance may have potential carcinogenicity. Although the exact conclusion needs more research, it has attracted great attention from the scientific community. Therefore, in the production, use and disposal of substances containing 1-chloro-2-methoxy-3-nitrobenzene, it is necessary to exercise caution and follow strict safety regulations to reduce their adverse effects on the environment and human health.
In terms of environmental impact, it has certain stability and is not easy to be degraded by natural processes. If it flows into the soil, it may cause soil pollution, affect the ecological balance of soil microorganisms, and then endanger the growth of plants. Its entry into the water body will pose a threat to aquatic organisms. If aquatic organisms are exposed to this substance for a long time, or their growth and development may be hindered and their reproductive capacity will decline, and in severe cases, the population may decrease. And because of its bioaccumulation, it will be transmitted and enriched along the food chain, which will cause potential harm to higher nutrient-level organisms.
As for the impact on human health, 1-chloro-2-methoxy-3-nitrobenzene can invade the human body through respiratory tract, skin contact and accidental ingestion. It may have irritating effects on the respiratory tract. After inhalation, people may feel throat discomfort, cough, etc. Through skin contact, it may cause skin allergies, itching, redness and swelling and other symptoms. Long-term exposure or ingestion will involve human organs. It may cause damage to important organs such as the liver and kidneys, affecting the normal function of organs. At the same time, this substance may have potential carcinogenicity. Although the exact conclusion needs more research, it has attracted great attention from the scientific community. Therefore, in the production, use and disposal of substances containing 1-chloro-2-methoxy-3-nitrobenzene, it is necessary to exercise caution and follow strict safety regulations to reduce their adverse effects on the environment and human health.
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