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1-Chloro-2-Methoxy-4-Nitrobenzene
Linshang Chemical
|
HS Code |
935216 |
| Name | 1-Chloro-2-Methoxy-4-Nitrobenzene |
| Molecular Formula | C7H6ClNO3 |
| Molecular Weight | 187.58 g/mol |
| Appearance | Yellow - solid |
| Melting Point | 57 - 60 °C |
| Boiling Point | 284.2 °C at 760 mmHg |
| Density | 1.388 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone |
| Flash Point | 125.7 °C |
| Vapor Pressure | 0.00251 mmHg at 25 °C |
As an accredited 1-Chloro-2-Methoxy-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1 - chloro - 2 - methoxy - 4 - nitrobenzene in a sealed chemical - resistant bottle. |
| Storage | 1 - Chloro - 2 - methoxy - 4 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames as it may be flammable or reactive under high temperatures. Keep it in a tightly - sealed container to prevent leakage and exposure to air or moisture, which could potentially initiate chemical reactions. Store it separately from incompatible substances like oxidizing agents. |
| Shipping | 1 - Chloro - 2 - methoxy - 4 - nitrobenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported by ground or sea, adhering to strict chemical shipping regulations to ensure safety during transit. |
Competitive 1-Chloro-2-Methoxy-4-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
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As a leading 1-Chloro-2-Methoxy-4-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-2-methoxy-4-nitrobenzene?
1 - chloro - 2 - methoxy - 4 - nitrobenzene is an organic compound with a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. This compound can be converted into other organic molecules with different functions through specific chemical reactions.
In the manufacture of dyes, or participate in the synthesis of dyes with specific colors and properties. Due to its structure containing chlorine, methoxy and nitro groups, these groups can affect the color, stability and affinity of dyes. After rational design and reaction, dyes suitable for dyeing of different fiber materials can be prepared.
In the field of medicine, it may also have important uses. Its structural properties enable it to be used as a starting material to synthesize bioactive compounds through a series of reactions. Nitro, methoxy and other groups play a key role in the molecular design of drugs, or affect the ability of drugs to bind to targets, pharmacokinetic properties, etc. For example, after modification, it may become a drug with therapeutic effects on specific diseases.
In the field of pesticides, 1-chloro-2-methoxy-4-nitrobenzene may also exhibit effects. Through chemical reactions, it can be converted into pesticide ingredients with insecticidal, bactericidal or herbicidal activities. The groups in its structure may affect the activity, selectivity and environmental compatibility of pesticides, helping to develop efficient and low-toxic pesticide products. In conclusion, 1-chloro-2-methoxy-4-nitrobenzene has important uses in many fields such as organic synthesis, dyes, medicine, and pesticides due to its unique chemical structure, providing a key basis for the preparation of many functional compounds.
In the manufacture of dyes, or participate in the synthesis of dyes with specific colors and properties. Due to its structure containing chlorine, methoxy and nitro groups, these groups can affect the color, stability and affinity of dyes. After rational design and reaction, dyes suitable for dyeing of different fiber materials can be prepared.
In the field of medicine, it may also have important uses. Its structural properties enable it to be used as a starting material to synthesize bioactive compounds through a series of reactions. Nitro, methoxy and other groups play a key role in the molecular design of drugs, or affect the ability of drugs to bind to targets, pharmacokinetic properties, etc. For example, after modification, it may become a drug with therapeutic effects on specific diseases.
In the field of pesticides, 1-chloro-2-methoxy-4-nitrobenzene may also exhibit effects. Through chemical reactions, it can be converted into pesticide ingredients with insecticidal, bactericidal or herbicidal activities. The groups in its structure may affect the activity, selectivity and environmental compatibility of pesticides, helping to develop efficient and low-toxic pesticide products. In conclusion, 1-chloro-2-methoxy-4-nitrobenzene has important uses in many fields such as organic synthesis, dyes, medicine, and pesticides due to its unique chemical structure, providing a key basis for the preparation of many functional compounds.
What are the physical properties of 1-chloro-2-methoxy-4-nitrobenzene?
1-Chloro-2-methoxy-4-nitrobenzene is one of the organic compounds. Its physical properties are crucial and related to many practical applications.
First of all, its appearance is usually a light yellow to yellow crystalline powder. Under sunlight, it resembles the aggregation of shiny particles, emitting a unique luster. This color state is easy to identify, and it is one of the important characteristics for the identification of this substance in many chemical and experimental scenarios.
As for the melting point, it is about a specific range, and this value has a great impact on its physical morphology transformation at different temperatures. When heated to near the melting point, this substance gradually melts from the solid state to the liquid state. This process follows the thermal principle and provides an important reference for many heating and fusion processes involving this substance.
Boiling point is also an important property. When a specific boiling point is reached, 1-chloro-2-methoxy-4-nitrobenzene in the liquid state will be converted into a gaseous state. This property plays a key role in the effective purification and separation of this substance in chemical operations such as distillation and separation.
In terms of solubility, it has good solubility in organic solvents, such as ethanol, ether and other common organic solvents, which can dissolve it. However, the solubility in water is poor, and this difference requires careful consideration when selecting solvents for chemical production and experimental operations to achieve the best reaction or separation effect.
Density is also a physical property that cannot be ignored. The specific density value endows this substance with unique sedimentation or floating characteristics in the mixing system, which is of great significance in the operation of material mixing and delamination in the chemical process.
In summary, the physical properties of 1-chloro-2-methoxy-4-nitrobenzene are a key consideration in many fields such as chemical industry and experiment, which deeply affects its application and treatment methods.
First of all, its appearance is usually a light yellow to yellow crystalline powder. Under sunlight, it resembles the aggregation of shiny particles, emitting a unique luster. This color state is easy to identify, and it is one of the important characteristics for the identification of this substance in many chemical and experimental scenarios.
As for the melting point, it is about a specific range, and this value has a great impact on its physical morphology transformation at different temperatures. When heated to near the melting point, this substance gradually melts from the solid state to the liquid state. This process follows the thermal principle and provides an important reference for many heating and fusion processes involving this substance.
Boiling point is also an important property. When a specific boiling point is reached, 1-chloro-2-methoxy-4-nitrobenzene in the liquid state will be converted into a gaseous state. This property plays a key role in the effective purification and separation of this substance in chemical operations such as distillation and separation.
In terms of solubility, it has good solubility in organic solvents, such as ethanol, ether and other common organic solvents, which can dissolve it. However, the solubility in water is poor, and this difference requires careful consideration when selecting solvents for chemical production and experimental operations to achieve the best reaction or separation effect.
Density is also a physical property that cannot be ignored. The specific density value endows this substance with unique sedimentation or floating characteristics in the mixing system, which is of great significance in the operation of material mixing and delamination in the chemical process.
In summary, the physical properties of 1-chloro-2-methoxy-4-nitrobenzene are a key consideration in many fields such as chemical industry and experiment, which deeply affects its application and treatment methods.
What is the chemistry of 1-chloro-2-methoxy-4-nitrobenzene?
1-Chloro-2-methoxy-4-nitrobenzene is one of the organic compounds. Its chemical properties are interesting and worth exploring in detail.
In this compound, the chlorine atom, methoxy group and nitro group each show unique properties and interact with each other to co-shape its overall chemical behavior. Chlorine atoms have certain electronegativity, and can be used as leaving groups in nucleophilic substitution reactions, causing nucleophiles to attack benzene rings and replace chlorine atoms. For example, when encountering strong nucleophilic reagents such as hydroxyl negative ions, nucleophilic substitution can occur, and the chlorine atom is replaced by a hydroxyl group to produce corresponding phenolic derivatives. The electron cloud density of the benzene ring can be increased by the conjugation effect, especially for the ortho and para-sites. This property makes the ortho and para-sites of the benzene ring more susceptible to attack by electrophilic reagents, and electrophilic substitution reactions occur. However, in this compound, because the nitro group is also on the benzene ring, and the nitro group is a strong electron-withdrawing group, its influence cannot be ignored. The strong electron-withdrawing property of the
nitro group greatly reduces the electron cloud density of the benzene ring, making the electrophilic substitution reaction difficult to occur, but making the nucleophilic substitution reaction easier to proceed. Under reduction conditions, nitro groups can be reduced to amino groups, which is a common conversion step in organic synthesis. With suitable reducing agents, such as iron and hydrochloric acid, or catalytic hydrogenation, nitro can be gradually converted into amino groups to obtain amino-containing benzene derivatives, which are widely used in dyes, pharmaceutical synthesis and other fields.
1-chloro-2-methoxy-4-nitrobenzene The synergistic and antagonistic effects of each substituent present rich chemical properties. It is an important intermediate for the preparation of diverse functional benzene derivatives in the stage of organic synthesis.
In this compound, the chlorine atom, methoxy group and nitro group each show unique properties and interact with each other to co-shape its overall chemical behavior. Chlorine atoms have certain electronegativity, and can be used as leaving groups in nucleophilic substitution reactions, causing nucleophiles to attack benzene rings and replace chlorine atoms. For example, when encountering strong nucleophilic reagents such as hydroxyl negative ions, nucleophilic substitution can occur, and the chlorine atom is replaced by a hydroxyl group to produce corresponding phenolic derivatives. The electron cloud density of the benzene ring can be increased by the conjugation effect, especially for the ortho and para-sites. This property makes the ortho and para-sites of the benzene ring more susceptible to attack by electrophilic reagents, and electrophilic substitution reactions occur. However, in this compound, because the nitro group is also on the benzene ring, and the nitro group is a strong electron-withdrawing group, its influence cannot be ignored. The strong electron-withdrawing property of the
nitro group greatly reduces the electron cloud density of the benzene ring, making the electrophilic substitution reaction difficult to occur, but making the nucleophilic substitution reaction easier to proceed. Under reduction conditions, nitro groups can be reduced to amino groups, which is a common conversion step in organic synthesis. With suitable reducing agents, such as iron and hydrochloric acid, or catalytic hydrogenation, nitro can be gradually converted into amino groups to obtain amino-containing benzene derivatives, which are widely used in dyes, pharmaceutical synthesis and other fields.
1-chloro-2-methoxy-4-nitrobenzene The synergistic and antagonistic effects of each substituent present rich chemical properties. It is an important intermediate for the preparation of diverse functional benzene derivatives in the stage of organic synthesis.
What are 1-chloro-2-methoxy-4-nitrobenzene synthesis methods?
The common methods for synthesizing 1-chloro-2-methoxy-4-nitrobenzene are as follows.
First, p-nitrophenol is used as the starting material. First, it is reacted with dimethyl sulfate in an alkaline environment. In this process, bases such as potassium carbonate can promote the formation of oxygen anions of the phenolic hydroxyl group of p-nitrophenol, and then nucleophilic substitution with dimethyl sulfate to form p-nitrobenzene. Then, chlorine gas or chlorine-containing reagents are used to chlorinate the phenyl ring under a suitable catalyst such as ferric chloride, so that 1-chloro-2-methoxy-4-nitrobenzene can be obtained. The reaction mechanism is that the phenyl ring of phenol ether is jointly affected by methoxy and nitro. Methoxy is an ortho-para-site group, and nitro is an meta-site group. The combined effect of the two makes the chlorination reaction more likely to occur at the methoxy ortho-site, and the target product is obtained.
Second, 2-methoxy-4-nitroaniline is used as the starting material. First, it is made into a diazo salt. Generally, sodium nitrite is reacted with hydrochloric acid at low temperature to convert the amino group into a diazo group. Subsequently, copper salt catalysts such as cuprous chloride are added, and the diazo group is replaced by a chlorine atom to achieve the synthesis of 1-chloro-2-methoxy-4-nitrobenzene. This is a classic Sandmeier reaction. The diazonium salt is active, and the substitution reaction can be effectively carried out by the catalyst of copper salt. The reaction conditions are relatively mild and the yield is relatively impressive.
Third, 1-chloro-4-nitrobenzene is used as the raw material. React with sodium methoxide, the chlorine atom is replaced by methoxy to generate 1-chloro-2-methoxy-4-nitrobenzene. This reaction is based on the nucleophilic substitution mechanism. The alkoxy negative ion in sodium methoxide has strong nucleophilicity, which can attack the carbon atom connected to the chlorine on the benzene ring, and the chlorine atom leaves to complete the introduction of the methoxy group.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider various factors such as raw material availability, reaction conditions, cost and yield to choose the optimal synthesis path.
First, p-nitrophenol is used as the starting material. First, it is reacted with dimethyl sulfate in an alkaline environment. In this process, bases such as potassium carbonate can promote the formation of oxygen anions of the phenolic hydroxyl group of p-nitrophenol, and then nucleophilic substitution with dimethyl sulfate to form p-nitrobenzene. Then, chlorine gas or chlorine-containing reagents are used to chlorinate the phenyl ring under a suitable catalyst such as ferric chloride, so that 1-chloro-2-methoxy-4-nitrobenzene can be obtained. The reaction mechanism is that the phenyl ring of phenol ether is jointly affected by methoxy and nitro. Methoxy is an ortho-para-site group, and nitro is an meta-site group. The combined effect of the two makes the chlorination reaction more likely to occur at the methoxy ortho-site, and the target product is obtained.
Second, 2-methoxy-4-nitroaniline is used as the starting material. First, it is made into a diazo salt. Generally, sodium nitrite is reacted with hydrochloric acid at low temperature to convert the amino group into a diazo group. Subsequently, copper salt catalysts such as cuprous chloride are added, and the diazo group is replaced by a chlorine atom to achieve the synthesis of 1-chloro-2-methoxy-4-nitrobenzene. This is a classic Sandmeier reaction. The diazonium salt is active, and the substitution reaction can be effectively carried out by the catalyst of copper salt. The reaction conditions are relatively mild and the yield is relatively impressive.
Third, 1-chloro-4-nitrobenzene is used as the raw material. React with sodium methoxide, the chlorine atom is replaced by methoxy to generate 1-chloro-2-methoxy-4-nitrobenzene. This reaction is based on the nucleophilic substitution mechanism. The alkoxy negative ion in sodium methoxide has strong nucleophilicity, which can attack the carbon atom connected to the chlorine on the benzene ring, and the chlorine atom leaves to complete the introduction of the methoxy group.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider various factors such as raw material availability, reaction conditions, cost and yield to choose the optimal synthesis path.
1-chloro-2-methoxy-4-nitrobenzene What are the precautions during storage and transportation?
1-Chloro-2-methoxy-4-nitrobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
First words storage, this compound should be stored in a cool, dry and well-ventilated place. Cover because of its certain chemical activity, high temperature and humid environment, may cause deterioration or cause dangerous reactions. Be sure to keep away from fires and heat sources to prevent fires. In addition, it should be stored separately from oxidizing agents, acids, bases, etc., because it can react chemically with such substances, causing safety concerns. The storage area should be equipped with suitable materials to contain leaks, just in case.
As for transportation, relevant regulations and standards must be followed. Transportation vehicles should ensure that they are in good condition and have safety facilities such as fire prevention and explosion protection. The handling process must be light and light to prevent material leakage due to damaged packaging. During transportation, close attention should be paid to changes in temperature and humidity. In case of bad weather, proper protective measures should be taken. And transportation personnel need professional training, familiar with the characteristics of the compound and emergency treatment methods. In the event of leakage and other accidents, they can respond in a timely and effective manner to ensure the safety of personnel and the environment.
First words storage, this compound should be stored in a cool, dry and well-ventilated place. Cover because of its certain chemical activity, high temperature and humid environment, may cause deterioration or cause dangerous reactions. Be sure to keep away from fires and heat sources to prevent fires. In addition, it should be stored separately from oxidizing agents, acids, bases, etc., because it can react chemically with such substances, causing safety concerns. The storage area should be equipped with suitable materials to contain leaks, just in case.
As for transportation, relevant regulations and standards must be followed. Transportation vehicles should ensure that they are in good condition and have safety facilities such as fire prevention and explosion protection. The handling process must be light and light to prevent material leakage due to damaged packaging. During transportation, close attention should be paid to changes in temperature and humidity. In case of bad weather, proper protective measures should be taken. And transportation personnel need professional training, familiar with the characteristics of the compound and emergency treatment methods. In the event of leakage and other accidents, they can respond in a timely and effective manner to ensure the safety of personnel and the environment.
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