Linshang Chemical
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1-Chloro-2-Methyl-3-(Methylsulfanyl)Benzene
Linshang Chemical
|
HS Code |
594926 |
| Chemical Formula | C8H9ClS |
| Molar Mass | 172.68 g/mol |
| Solubility In Water | poor solubility expected (due to non - polar nature) |
| Solubility In Organic Solvents | soluble in common organic solvents like dichloromethane, toluene |
As an accredited 1-Chloro-2-Methyl-3-(Methylsulfanyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 2 - methyl - 3 - (methylsulfanyl)benzene: Packed in 500 - mL glass bottles, 10 bottles per carton. |
| Storage | 1 - Chloro - 2 - methyl - 3 - (methylsulfanyl)benzene should be stored in a cool, dry, well - ventilated area, away from sources of heat and ignition. Keep it in a tightly - sealed container, preferably made of corrosion - resistant material. Store it separately from oxidizing agents and incompatible substances to prevent potential reactions. |
| Shipping | 1 - Chloro - 2 - methyl - 3 - (methylsulfanyl)benzene is shipped in tightly sealed, corrosion - resistant containers. Transport follows strict chemical safety regulations to prevent leakage and ensure safe transit. |
Competitive 1-Chloro-2-Methyl-3-(Methylsulfanyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 1-chloro-2-methyl-3- (methylsulfanyl) benzene
1-chloro-2-methyl-3- (methylsulfanyl) benzene, Chinese name or 1-chloro-2-methyl-3-methylthiobenzene. The chemical properties of this substance are unique, with the characteristics of aromatic hydrocarbons and sulfur-containing and chlorine functional groups.
As far as its aromatic hydrocarbon properties are concerned, the benzene ring is stable, and there is a delocalized π bond due to the existence of a conjugated system. This structure causes it to have certain aromaticity, and electrophilic substitution reactions can occur, such as halogenation, nitrification, sulfonation, etc. For example, under certain conditions, the benzene ring can be catalyzed with bromine, and the bromine atom can replace the hydrogen atom of the benzene ring to obtain
The chlorine-containing functional group makes the compound have the properties of halogenated hydrocarbons. Chlorine atoms have high electronegativity and strong carbon-chlorine bond polarity, resulting in a decrease in the electron cloud density of α-carbon atoms, which is vulnerable to nucleophilic reagents and occurs nucleophilic substitution reactions. If co-heated with sodium hydroxide aqueous solution, chlorine atoms can be replaced by hydroxyl groups to form alcohols; in case of strong bases in alcohol solution, elimination reactions may also occur to form carbon-carbon double bonds.
Containing methyl-thio functional groups also add unique properties. Sulfur atoms have lone pair electrons, which can be used as nucleophilic reagents to participate in the reaction. At the same time, methylthio has an effect on the distribution of benzene ring electron clouds, changing the reactivity of benz Under the action of appropriate oxidants, methylthio groups can be oxidized to sulfoxide or sulfone groups, transforming the properties and reactivity of compounds.
In addition, 1-chloro-2-methyl-3-methylthiobenzene contains multiple different functional groups, which interact with each other, resulting in complex and diverse chemical properties. It is widely used in the field of organic synthesis and can be used as a raw material or intermediate to construct complex organic compounds through a series of reactions.
As far as its aromatic hydrocarbon properties are concerned, the benzene ring is stable, and there is a delocalized π bond due to the existence of a conjugated system. This structure causes it to have certain aromaticity, and electrophilic substitution reactions can occur, such as halogenation, nitrification, sulfonation, etc. For example, under certain conditions, the benzene ring can be catalyzed with bromine, and the bromine atom can replace the hydrogen atom of the benzene ring to obtain
The chlorine-containing functional group makes the compound have the properties of halogenated hydrocarbons. Chlorine atoms have high electronegativity and strong carbon-chlorine bond polarity, resulting in a decrease in the electron cloud density of α-carbon atoms, which is vulnerable to nucleophilic reagents and occurs nucleophilic substitution reactions. If co-heated with sodium hydroxide aqueous solution, chlorine atoms can be replaced by hydroxyl groups to form alcohols; in case of strong bases in alcohol solution, elimination reactions may also occur to form carbon-carbon double bonds.
Containing methyl-thio functional groups also add unique properties. Sulfur atoms have lone pair electrons, which can be used as nucleophilic reagents to participate in the reaction. At the same time, methylthio has an effect on the distribution of benzene ring electron clouds, changing the reactivity of benz Under the action of appropriate oxidants, methylthio groups can be oxidized to sulfoxide or sulfone groups, transforming the properties and reactivity of compounds.
In addition, 1-chloro-2-methyl-3-methylthiobenzene contains multiple different functional groups, which interact with each other, resulting in complex and diverse chemical properties. It is widely used in the field of organic synthesis and can be used as a raw material or intermediate to construct complex organic compounds through a series of reactions.
What are the physical properties of 1-chloro-2-methyl-3- (methylsulfanyl) benzene
1-Chloro-2-methyl-3- (methylthio) benzene is one of the organic compounds. Its physical properties are considerable and important in the field of organic synthesis.
First of all, under normal temperature and pressure, this compound is often in a liquid state. It can be seen that it has a specific color and appearance, or it is a clear liquid with a slightly special smell. Although its smell is not pungent or intolerable, it also has a unique smell and can be identified.
On the melting point and boiling point, the melting point is the temperature at which a substance changes from a solid state to a liquid state. The melting point of 1-chloro-2-methyl-3- (methylthio) benzene varies slightly according to the specific experimental conditions, and is roughly in a specific temperature range. The boiling point is related to the difficulty of its gasification, and the boiling point of the compound also has its fixed number. Above this temperature, it will transform from liquid to gaseous state. Both of these are crucial indicators for the separation, purification and storage of the substance.
Furthermore, its solubility cannot be ignored. In organic solvents, such as common ethanol, ether, etc., 1-chloro-2-methyl-3 - (methylthio) benzene exhibits good solubility and can be miscible with these organic solvents. However, in water, its solubility is quite limited. This property is closely related to the molecular structure of the compound. Because the molecular structure contains sulfur atoms and methyl groups, it affects the interaction between it and water molecules.
In addition, density is also one of its important physical properties. The density of 1-chloro-2-methyl-3 - (methylthio) benzene is different from that of water, or greater than or less than water. This difference has practical application value in related chemical experiments and industrial applications.
In summary, the physical properties of 1-chloro-2-methyl-3- (methylthio) benzene, such as their properties, melting point, solubility, and density, are all indispensable factors in the study and practical application of organic chemistry, which help chemists to deeply understand the properties of this compound and carry out various experiments and production activities accordingly.
First of all, under normal temperature and pressure, this compound is often in a liquid state. It can be seen that it has a specific color and appearance, or it is a clear liquid with a slightly special smell. Although its smell is not pungent or intolerable, it also has a unique smell and can be identified.
On the melting point and boiling point, the melting point is the temperature at which a substance changes from a solid state to a liquid state. The melting point of 1-chloro-2-methyl-3- (methylthio) benzene varies slightly according to the specific experimental conditions, and is roughly in a specific temperature range. The boiling point is related to the difficulty of its gasification, and the boiling point of the compound also has its fixed number. Above this temperature, it will transform from liquid to gaseous state. Both of these are crucial indicators for the separation, purification and storage of the substance.
Furthermore, its solubility cannot be ignored. In organic solvents, such as common ethanol, ether, etc., 1-chloro-2-methyl-3 - (methylthio) benzene exhibits good solubility and can be miscible with these organic solvents. However, in water, its solubility is quite limited. This property is closely related to the molecular structure of the compound. Because the molecular structure contains sulfur atoms and methyl groups, it affects the interaction between it and water molecules.
In addition, density is also one of its important physical properties. The density of 1-chloro-2-methyl-3 - (methylthio) benzene is different from that of water, or greater than or less than water. This difference has practical application value in related chemical experiments and industrial applications.
In summary, the physical properties of 1-chloro-2-methyl-3- (methylthio) benzene, such as their properties, melting point, solubility, and density, are all indispensable factors in the study and practical application of organic chemistry, which help chemists to deeply understand the properties of this compound and carry out various experiments and production activities accordingly.
What is the main use of 1-chloro-2-methyl-3- (methylsulfanyl) benzene?
1-chloro-2-methyl-3- (methylsulfanyl) benzene, which is 1-chloro-2-methyl-3- (methylthio) benzene, is widely used. In the field of organic synthesis, it is an important starting material. Due to its molecular structure, chlorine atoms, methyl groups and methylthio groups all have unique reactivity and can participate in many organic reactions.
For example, chlorine atoms can undergo nucleophilic substitution reactions, and many nucleophilic reagents, such as alkoxides, amines, etc., can replace chlorine atoms to form new carbon-heteroatomic bonds, thereby synthesizing various compounds containing different functional groups. Methyl and methylthio groups have an effect on the electron cloud density and reactivity distribution of the benzene ring, which can guide the reaction to occur at a specific location, and help to synthesize organic molecules with complex structures and specific functions.
In the field of medicinal chemistry, using this substance as the starting material, through multi-step reactions, some bioactive compounds can be prepared, or further optimized as lead compounds, laying the foundation for the development of new drugs. In the field of materials science, the organic compounds involved in the synthesis can be used to prepare materials with special properties, such as optoelectronic materials. Due to its structural properties, the synthesized products may have unique electrical and optical properties, meeting the specific needs of the field of materials science. Overall, 1-chloro-2-methyl-3- (methylthio) benzene plays an important role in many fields such as organic synthesis, medicine and materials, and has made significant contributions to the development of related fields.
For example, chlorine atoms can undergo nucleophilic substitution reactions, and many nucleophilic reagents, such as alkoxides, amines, etc., can replace chlorine atoms to form new carbon-heteroatomic bonds, thereby synthesizing various compounds containing different functional groups. Methyl and methylthio groups have an effect on the electron cloud density and reactivity distribution of the benzene ring, which can guide the reaction to occur at a specific location, and help to synthesize organic molecules with complex structures and specific functions.
In the field of medicinal chemistry, using this substance as the starting material, through multi-step reactions, some bioactive compounds can be prepared, or further optimized as lead compounds, laying the foundation for the development of new drugs. In the field of materials science, the organic compounds involved in the synthesis can be used to prepare materials with special properties, such as optoelectronic materials. Due to its structural properties, the synthesized products may have unique electrical and optical properties, meeting the specific needs of the field of materials science. Overall, 1-chloro-2-methyl-3- (methylthio) benzene plays an important role in many fields such as organic synthesis, medicine and materials, and has made significant contributions to the development of related fields.
What are the synthesis methods of 1-chloro-2-methyl-3- (methylsulfanyl) benzene
To prepare 1 - chloro - 2 - methyl - 3 - (methylsulfanyl) benzene, the number method is often followed.
First, o-methyl chlorobenzene is used as the starting material. First, o-methyl chlorobenzene interacts with butyl lithium, which is strongly alkaline and can capture hydrogen at a specific position on the aromatic ring of o-methyl chlorobenzene to form the corresponding lithium salt. Then, the lithium salt reacts with methyl sulfur chloride (CH 🥰 SCl), and the lithium atom is replaced by a methyl sulfur group to obtain the target product 1 - chloro - 2 - methyl - 3 - (methylsulfanyl) benzene. In this process, the amount of butyllithium, reaction temperature and time are all key, and precise regulation is required to obtain the best effect.
Second, 2-methyl-3-mercaptoaniline is used as the starting material. First, 2-methyl-3-mercaptoaniline is diazotized with an appropriate diazotization reagent, such as a mixture of sodium nitrite and hydrochloric acid, to form a diazosalt. Subsequently, cuprous chloride (CuCl) is added, the diazo group is replaced by the chlorine atom, and the thiol group is methylated at the same time. The carboxyl group can be converted into acyl chloride (CHI) under alkaline conditions, and finally 1-chloro-2-methyl-3- (methylsulfanyl) benzene is obtained. The diazotization reaction needs to be carried out at low temperature to prevent the decomposition of diazonium salts, and the alkali concentration and reaction time of the methylation step will also affect the yield of the product.
Third, 2-methyl-3-chlorobenzoic acid is used as the starting material. The carboxyl group is first converted into acyl chloride, and the reaction is achieved with sulfoxide chloride (SOCl ²). Next, the acid chloride is reacted with sodium methyl mercaptan (CH 🥰 SNa) to form thioesters. After that, the target compound can be obtained through reduction steps, such as reduction with lithium aluminum hydride (LiAlH). In this path, the control of reaction conditions at each step, such as reaction solvent, reactant ratio, etc., is crucial to the successful acquisition of the product.
First, o-methyl chlorobenzene is used as the starting material. First, o-methyl chlorobenzene interacts with butyl lithium, which is strongly alkaline and can capture hydrogen at a specific position on the aromatic ring of o-methyl chlorobenzene to form the corresponding lithium salt. Then, the lithium salt reacts with methyl sulfur chloride (CH 🥰 SCl), and the lithium atom is replaced by a methyl sulfur group to obtain the target product 1 - chloro - 2 - methyl - 3 - (methylsulfanyl) benzene. In this process, the amount of butyllithium, reaction temperature and time are all key, and precise regulation is required to obtain the best effect.
Second, 2-methyl-3-mercaptoaniline is used as the starting material. First, 2-methyl-3-mercaptoaniline is diazotized with an appropriate diazotization reagent, such as a mixture of sodium nitrite and hydrochloric acid, to form a diazosalt. Subsequently, cuprous chloride (CuCl) is added, the diazo group is replaced by the chlorine atom, and the thiol group is methylated at the same time. The carboxyl group can be converted into acyl chloride (CHI) under alkaline conditions, and finally 1-chloro-2-methyl-3- (methylsulfanyl) benzene is obtained. The diazotization reaction needs to be carried out at low temperature to prevent the decomposition of diazonium salts, and the alkali concentration and reaction time of the methylation step will also affect the yield of the product.
Third, 2-methyl-3-chlorobenzoic acid is used as the starting material. The carboxyl group is first converted into acyl chloride, and the reaction is achieved with sulfoxide chloride (SOCl ²). Next, the acid chloride is reacted with sodium methyl mercaptan (CH 🥰 SNa) to form thioesters. After that, the target compound can be obtained through reduction steps, such as reduction with lithium aluminum hydride (LiAlH). In this path, the control of reaction conditions at each step, such as reaction solvent, reactant ratio, etc., is crucial to the successful acquisition of the product.
1-chloro-2-methyl-3- (methylsulfanyl) benzene during storage and transportation
When storing and transporting 1-chloro-2-methyl-3- (methylthio) benzene, it is necessary to pay attention to many key matters.
Bear the brunt of it. When storing, you must find a cool, dry and well-ventilated place. This substance is quite sensitive to heat and open flames. If placed near high temperatures or fire sources, it may cause hazards such as combustion or even explosion. And the warehouse temperature should not be too high to prevent its chemical properties from changing and causing deterioration.
Furthermore, it needs to be strictly separated from oxidants, acids and other substances. Due to the characteristics of its chemical structure, when it encounters with oxidants, it is easy to cause violent chemical reactions, or cause combustion and explosion; when it comes into contact with acids, it may also cause adverse chemical reactions, affect its quality, and even produce harmful gases.
Packaging should also not be sloppy. Appropriate packaging materials should be selected to ensure that the packaging is tight and does not leak. Common such as metal drums or special plastic containers, it is necessary to ensure that the material is stable, does not react with the substance, and has certain resistance to pressure and corrosion.
During transportation, relevant regulations must be strictly followed. Transportation vehicles must be equipped with corresponding varieties and quantities of fire equipment and leakage emergency treatment equipment. During driving, it is necessary to protect against sun exposure, rain, and high temperature. The trough (tank) car used during transportation should have a grounding chain, and holes can be set in the trough to reduce shock and generate static electricity to prevent fire or explosion accidents caused by static electricity.
The loading and unloading process also needs to be handled with caution. Operators should wear appropriate protective equipment, such as gas masks, chemical protective clothing, etc., to avoid direct contact with the substance to prevent damage to the body. Loading and unloading should be handled lightly to prevent damage to packaging and containers, resulting in leakage.
1-chloro-2-methyl-3 - (methylthio) benzene In storage and transportation, every step is related to safety and quality. Do not be negligent, and must strictly follow the corresponding specifications and requirements.
Bear the brunt of it. When storing, you must find a cool, dry and well-ventilated place. This substance is quite sensitive to heat and open flames. If placed near high temperatures or fire sources, it may cause hazards such as combustion or even explosion. And the warehouse temperature should not be too high to prevent its chemical properties from changing and causing deterioration.
Furthermore, it needs to be strictly separated from oxidants, acids and other substances. Due to the characteristics of its chemical structure, when it encounters with oxidants, it is easy to cause violent chemical reactions, or cause combustion and explosion; when it comes into contact with acids, it may also cause adverse chemical reactions, affect its quality, and even produce harmful gases.
Packaging should also not be sloppy. Appropriate packaging materials should be selected to ensure that the packaging is tight and does not leak. Common such as metal drums or special plastic containers, it is necessary to ensure that the material is stable, does not react with the substance, and has certain resistance to pressure and corrosion.
During transportation, relevant regulations must be strictly followed. Transportation vehicles must be equipped with corresponding varieties and quantities of fire equipment and leakage emergency treatment equipment. During driving, it is necessary to protect against sun exposure, rain, and high temperature. The trough (tank) car used during transportation should have a grounding chain, and holes can be set in the trough to reduce shock and generate static electricity to prevent fire or explosion accidents caused by static electricity.
The loading and unloading process also needs to be handled with caution. Operators should wear appropriate protective equipment, such as gas masks, chemical protective clothing, etc., to avoid direct contact with the substance to prevent damage to the body. Loading and unloading should be handled lightly to prevent damage to packaging and containers, resulting in leakage.
1-chloro-2-methyl-3 - (methylthio) benzene In storage and transportation, every step is related to safety and quality. Do not be negligent, and must strictly follow the corresponding specifications and requirements.
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