Linshang Chemical
PRODUCTS
1-Chloro-2-Methyl-4-Nitrobenzene
Linshang Chemical
|
HS Code |
605237 |
| Name | 1-Chloro-2-Methyl-4-Nitrobenzene |
| Molecular Formula | C7H6ClNO2 |
| Molecular Weight | 171.58 |
| Appearance | Yellow solid |
| Melting Point | 43 - 45 °C |
| Boiling Point | 254 - 256 °C |
| Density | 1.348 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 113 °C |
| Odor | Characteristic aromatic odor |
As an accredited 1-Chloro-2-Methyl-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 2 - methyl - 4 - nitrobenzene: Packed in 1 - kg containers for safe storage and transport. |
| Storage | 1 - Chloro - 2 - methyl - 4 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in tightly sealed containers, preferably made of corrosion - resistant materials. Label containers clearly. This storage approach helps prevent decomposition, fires, and potential reactions that could pose safety risks. |
| Shipping | 1 - chloro - 2 - methyl - 4 - nitrobenzene, a hazardous chemical, must be shipped in accordance with strict regulations. Use appropriate packaging to prevent leakage. Label containers clearly and transport via approved carriers following safety protocols. |
Competitive 1-Chloro-2-Methyl-4-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 1-Chloro-2-Methyl-4-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-chloro-2-methyl-4-nitrobenzene?
1-Chloro-2-methyl-4-nitrobenzene is also an organic compound. It has many chemical properties, which are described in detail below.
First of all, its nucleophilic substitution reaction properties. Because of the nitro group attached to the benzene ring, which is a strong electron-absorbing group, it can reduce the electron cloud density of the benzene ring, especially the electron cloud density of the carbon position connected to the chlorine atom, so that the activity of the chlorine atom is greatly increased, and it is easy to be attacked by nucleophilic reagents, and then nucleophilic substitution reactions occur. For example, when a nucleophilic reagent such as sodium oxide is used to heat it, the chlorine atom can be replaced by an alkoxy group to produce corresponding ether compounds.
The quality of its reduction The nitro group in the molecule can be reduced under suitable conditions. If iron and hydrochloric acid are used as reducing agents, the nitro group can be gradually reduced to an amino group to obtain 1-chloro-2-methyl-4-aminobenzene. This product is widely used in dyes, pharmaceutical synthesis and other fields.
Furthermore, 1-chloro-2-methyl-4-nitrobenzene has the properties of halogenated hydrocarbons. Chlorine atoms can undergo hydrolysis under basic conditions. Although hydrolysis is more difficult than aliphatic halogenated hydrocarbons due to the conjugation effect of benzene rings, under severe conditions such as high temperature and strong alkali, chlorine atoms can be replaced by hydroxyl groups to obtain 2-methyl-4-nitrophenol.
And because it contains methyl, it is affected by the benzene ring, and the methyl group has a certain activity. Under the action of appropriate oxidants, the methyl group can be oxidized. If oxidized in an acidic potassium permanganate solution, the methyl group can be converted into a carboxyl group to obtain 1-chloro-4-nitro-2-benzoic acid.
In addition, the compound has some properties of aromatic hydrocarbons due to the benzene ring, and can undergo electrophilic substitution reaction. However, since nitro is an meta-site group, methyl is an o-para-site group, and nitro has strong electron absorption, the electrophilic substitution reaction mainly occurs in the nitro meta-site.
First of all, its nucleophilic substitution reaction properties. Because of the nitro group attached to the benzene ring, which is a strong electron-absorbing group, it can reduce the electron cloud density of the benzene ring, especially the electron cloud density of the carbon position connected to the chlorine atom, so that the activity of the chlorine atom is greatly increased, and it is easy to be attacked by nucleophilic reagents, and then nucleophilic substitution reactions occur. For example, when a nucleophilic reagent such as sodium oxide is used to heat it, the chlorine atom can be replaced by an alkoxy group to produce corresponding ether compounds.
The quality of its reduction The nitro group in the molecule can be reduced under suitable conditions. If iron and hydrochloric acid are used as reducing agents, the nitro group can be gradually reduced to an amino group to obtain 1-chloro-2-methyl-4-aminobenzene. This product is widely used in dyes, pharmaceutical synthesis and other fields.
Furthermore, 1-chloro-2-methyl-4-nitrobenzene has the properties of halogenated hydrocarbons. Chlorine atoms can undergo hydrolysis under basic conditions. Although hydrolysis is more difficult than aliphatic halogenated hydrocarbons due to the conjugation effect of benzene rings, under severe conditions such as high temperature and strong alkali, chlorine atoms can be replaced by hydroxyl groups to obtain 2-methyl-4-nitrophenol.
And because it contains methyl, it is affected by the benzene ring, and the methyl group has a certain activity. Under the action of appropriate oxidants, the methyl group can be oxidized. If oxidized in an acidic potassium permanganate solution, the methyl group can be converted into a carboxyl group to obtain 1-chloro-4-nitro-2-benzoic acid.
In addition, the compound has some properties of aromatic hydrocarbons due to the benzene ring, and can undergo electrophilic substitution reaction. However, since nitro is an meta-site group, methyl is an o-para-site group, and nitro has strong electron absorption, the electrophilic substitution reaction mainly occurs in the nitro meta-site.
What are the physical properties of 1-chloro-2-methyl-4-nitrobenzene?
1-Chloro-2-methyl-4-nitrobenzene is one of the organic compounds. It has unique physical properties and has far-reaching effects on chemical, pharmaceutical and other fields.
Looking at its appearance, 1-chloro-2-methyl-4-nitrobenzene is in a light yellow to light brown crystalline shape, with stable morphology. Under room temperature and pressure, it is like a quiet solid-state elf. Its melting point is about 42-44 ° C, just like the critical melting point of ice and snow in the warm sun in spring. At this temperature, the solid state begins to gradually transform into a liquid state, opening a different state. The boiling point is about 277 ° C, and it needs to be forced by high temperature to make it rise in a gaseous state, showing a tough state and resisting easy gasification.
When it comes to density, it is about 1.37 g/cm ³, which is heavier than water. It is like a stable person who sinks down in the world of water. And it is insoluble in water, like an estranged guest in water, and it is difficult to blend with water. However, in the realm of organic solvents, such as ethanol, ether, acetone, etc., it can be intimately close to it and easily dissolve with each other, just like someone else knows it, showing unique solubility.
Smell its odor, which is irritating. If you get close to it accidentally, it will stimulate people's sense of smell, like a warning signal, warning everyone of the particularity of its existence. Its vapor density is greater than that of air, like a thick curtain, easy to accumulate in low places, and special attention should be paid when using it to prevent hidden dangers.
The physical properties of 1-chloro-2-methyl-4-nitrobenzene are of great significance in industrial synthesis and drug development. In the synthesis path, its melting point, boiling point and other properties provide guidance for the control of reaction conditions; solubility affects the steps of separation and purification. In the field of drug development, its properties may be related to key properties such as drug permeability and stability. Due to its unique physical properties, this compound plays an indispensable role in many fields.
Looking at its appearance, 1-chloro-2-methyl-4-nitrobenzene is in a light yellow to light brown crystalline shape, with stable morphology. Under room temperature and pressure, it is like a quiet solid-state elf. Its melting point is about 42-44 ° C, just like the critical melting point of ice and snow in the warm sun in spring. At this temperature, the solid state begins to gradually transform into a liquid state, opening a different state. The boiling point is about 277 ° C, and it needs to be forced by high temperature to make it rise in a gaseous state, showing a tough state and resisting easy gasification.
When it comes to density, it is about 1.37 g/cm ³, which is heavier than water. It is like a stable person who sinks down in the world of water. And it is insoluble in water, like an estranged guest in water, and it is difficult to blend with water. However, in the realm of organic solvents, such as ethanol, ether, acetone, etc., it can be intimately close to it and easily dissolve with each other, just like someone else knows it, showing unique solubility.
Smell its odor, which is irritating. If you get close to it accidentally, it will stimulate people's sense of smell, like a warning signal, warning everyone of the particularity of its existence. Its vapor density is greater than that of air, like a thick curtain, easy to accumulate in low places, and special attention should be paid when using it to prevent hidden dangers.
The physical properties of 1-chloro-2-methyl-4-nitrobenzene are of great significance in industrial synthesis and drug development. In the synthesis path, its melting point, boiling point and other properties provide guidance for the control of reaction conditions; solubility affects the steps of separation and purification. In the field of drug development, its properties may be related to key properties such as drug permeability and stability. Due to its unique physical properties, this compound plays an indispensable role in many fields.
What are the main uses of 1-chloro-2-methyl-4-nitrobenzene?
1-Chloro-2-methyl-4-nitrobenzene is also an organic compound. It has a wide range of uses and is involved in various fields of chemical industry.
First, in the synthesis of dyes, this compound is often used as a key intermediate. Due to its unique molecular structure, it can be converted into dyes of various colors through specific chemical reactions to meet the color needs of textile, printing and dyeing industries. For example, through a series of condensation and coupling reactions, dyes suitable for dyeing cotton, linen and other fabrics can be prepared, giving fabrics a lasting and gorgeous color.
Second, it also plays an important role in the field of medicine. Chemists use it as a starting material and modify it through multi-step reactions to synthesize compounds with specific pharmacological activities. Some drugs made on this basis have significant therapeutic or preventive effects on certain diseases. For example, in the research and development of antibacterial and anti-inflammatory drugs, derivatives of 1-chloro-2-methyl-4-nitrobenzene are often a research hotspot.
Furthermore, pesticide manufacturing is also indispensable. Using this as a raw material, a variety of high-efficiency pesticides can be synthesized. Such pesticides can effectively control crop pests and pathogens, and contribute greatly to ensuring agricultural harvests and improving the yield and quality of agricultural products. Such as the synthesis of some organophosphorus pesticides, 1-chloro-2-methyl-4-nitrobenzene is an important starting material.
In addition, in the study of organic synthetic chemistry, due to its special substituent positions and properties, it is often used as a model compound to help chemists deeply explore the reaction mechanism, optimize the synthesis route, and promote the development of organic synthetic chemistry.
First, in the synthesis of dyes, this compound is often used as a key intermediate. Due to its unique molecular structure, it can be converted into dyes of various colors through specific chemical reactions to meet the color needs of textile, printing and dyeing industries. For example, through a series of condensation and coupling reactions, dyes suitable for dyeing cotton, linen and other fabrics can be prepared, giving fabrics a lasting and gorgeous color.
Second, it also plays an important role in the field of medicine. Chemists use it as a starting material and modify it through multi-step reactions to synthesize compounds with specific pharmacological activities. Some drugs made on this basis have significant therapeutic or preventive effects on certain diseases. For example, in the research and development of antibacterial and anti-inflammatory drugs, derivatives of 1-chloro-2-methyl-4-nitrobenzene are often a research hotspot.
Furthermore, pesticide manufacturing is also indispensable. Using this as a raw material, a variety of high-efficiency pesticides can be synthesized. Such pesticides can effectively control crop pests and pathogens, and contribute greatly to ensuring agricultural harvests and improving the yield and quality of agricultural products. Such as the synthesis of some organophosphorus pesticides, 1-chloro-2-methyl-4-nitrobenzene is an important starting material.
In addition, in the study of organic synthetic chemistry, due to its special substituent positions and properties, it is often used as a model compound to help chemists deeply explore the reaction mechanism, optimize the synthesis route, and promote the development of organic synthetic chemistry.
What is 1-chloro-2-methyl-4-nitrobenzene synthesis method?
The synthesis of 1-chloro-2-methyl-4-nitrobenzene is an important topic in organic synthetic chemistry. To prepare this compound, common methods include toluene as the starting material.
First, toluene is used as the group, and it is heated with a mixed acid of nitric acid and sulfuric acid to carry out a nitrification reaction. Because methyl is an ortho-and para-site group, nitro is mostly introduced into the ortho-and para-sites of methyl to obtain 2-methyl-4-nitrotoluene. In this reaction, nitric acid provides the nitro group, and sulfuric acid acts as the catalyst to promote the smooth progress of the reaction.
After 2-methyl-4-nitrotoluene is obtained, it is reacted with chlorine under the condition of light or the presence of a catalyst. The methyl group is affected by the benzene ring, and its α-hydrogen has a certain activity. The chlorine atom can replace α-hydrogen to form 1-chloro-2-methyl-4-nitrobenzene. Light or catalyst can initiate the splitting of chlorine molecules into chlorine free radicals, and then the radical substitution reaction occurs with 2-methyl-4-nitrotoluene.
There are also p-nitrotoluene as the starting material. Shilling p-nitrotoluene reacts with chlorine under appropriate conditions. Due to the localization effect of methyl, chlorine atoms preferentially replace hydrogen at the ortho-methyl position to obtain 1-chloro-2-methyl-4-nitrobenzene. The control of this reaction condition is very critical. Temperature, light intensity, and the proportion of reactants all affect the yield and purity of the reaction product.
During the synthesis process, attention should be paid to the precise control of the reaction conditions. The proportion of reactants, temperature, and reaction time are all related to the quality and yield of the product. And after each step of the reaction, it often needs to be separated and purified to remove impurities to obtain pure 1-chloro-2-methyl-4-nitrobenzene. Commonly used purification methods include distillation, recrystallization, column chromatography, etc., which can be selected according to the characteristics of the product and the nature of impurities.
First, toluene is used as the group, and it is heated with a mixed acid of nitric acid and sulfuric acid to carry out a nitrification reaction. Because methyl is an ortho-and para-site group, nitro is mostly introduced into the ortho-and para-sites of methyl to obtain 2-methyl-4-nitrotoluene. In this reaction, nitric acid provides the nitro group, and sulfuric acid acts as the catalyst to promote the smooth progress of the reaction.
After 2-methyl-4-nitrotoluene is obtained, it is reacted with chlorine under the condition of light or the presence of a catalyst. The methyl group is affected by the benzene ring, and its α-hydrogen has a certain activity. The chlorine atom can replace α-hydrogen to form 1-chloro-2-methyl-4-nitrobenzene. Light or catalyst can initiate the splitting of chlorine molecules into chlorine free radicals, and then the radical substitution reaction occurs with 2-methyl-4-nitrotoluene.
There are also p-nitrotoluene as the starting material. Shilling p-nitrotoluene reacts with chlorine under appropriate conditions. Due to the localization effect of methyl, chlorine atoms preferentially replace hydrogen at the ortho-methyl position to obtain 1-chloro-2-methyl-4-nitrobenzene. The control of this reaction condition is very critical. Temperature, light intensity, and the proportion of reactants all affect the yield and purity of the reaction product.
During the synthesis process, attention should be paid to the precise control of the reaction conditions. The proportion of reactants, temperature, and reaction time are all related to the quality and yield of the product. And after each step of the reaction, it often needs to be separated and purified to remove impurities to obtain pure 1-chloro-2-methyl-4-nitrobenzene. Commonly used purification methods include distillation, recrystallization, column chromatography, etc., which can be selected according to the characteristics of the product and the nature of impurities.
What are the precautions in storage and transportation of 1-chloro-2-methyl-4-nitrobenzene?
1-Chloro-2-methyl-4-nitrobenzene is also an organic compound. During storage and transportation, many matters must be paid attention to.
Bear the brunt, when storing, it must be placed in a cool and ventilated place. Because 1-chloro-2-methyl-4-nitrobenzene is dangerous when heated, its stability can be guaranteed in a cool environment. Ventilation is also essential to avoid the accumulation of volatile gases and prevent the risk of explosion.
Furthermore, it must be stored in isolation from oxidants, reducing agents, alkalis, etc. This is because 1-chloro-2-methyl-4-nitrobenzene is chemically active. When encountering the above substances, it is easy to cause violent chemical reactions, causing fires and explosions.
Packaging should not be ignored. Packaging must be tight to ensure that there is no risk of leakage. The packaging materials used should be corrosion-resistant and can resist the erosion of 1-chloro-2-methyl-4-nitrobenzene.
When transporting, it is essential to follow relevant regulations and standards. Vehicles must be marked with corresponding warning signs to inform everyone of their danger. Transport personnel should also be professionally trained to be familiar with their characteristics and emergency response methods.
On the way, be careful to avoid collision and friction. Violent collision and friction may cause package damage and cause leakage. And during transportation, temperature and humidity also need to be controlled to avoid deterioration due to environmental factors.
In short, the storage and transportation of 1-chloro-2-methyl-4-nitrobenzene, all details are related to safety, and must be treated with caution and must not be slack in the slightest.
Bear the brunt, when storing, it must be placed in a cool and ventilated place. Because 1-chloro-2-methyl-4-nitrobenzene is dangerous when heated, its stability can be guaranteed in a cool environment. Ventilation is also essential to avoid the accumulation of volatile gases and prevent the risk of explosion.
Furthermore, it must be stored in isolation from oxidants, reducing agents, alkalis, etc. This is because 1-chloro-2-methyl-4-nitrobenzene is chemically active. When encountering the above substances, it is easy to cause violent chemical reactions, causing fires and explosions.
Packaging should not be ignored. Packaging must be tight to ensure that there is no risk of leakage. The packaging materials used should be corrosion-resistant and can resist the erosion of 1-chloro-2-methyl-4-nitrobenzene.
When transporting, it is essential to follow relevant regulations and standards. Vehicles must be marked with corresponding warning signs to inform everyone of their danger. Transport personnel should also be professionally trained to be familiar with their characteristics and emergency response methods.
On the way, be careful to avoid collision and friction. Violent collision and friction may cause package damage and cause leakage. And during transportation, temperature and humidity also need to be controlled to avoid deterioration due to environmental factors.
In short, the storage and transportation of 1-chloro-2-methyl-4-nitrobenzene, all details are related to safety, and must be treated with caution and must not be slack in the slightest.
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