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1-Chloro-2-Methyl-4-(Trifluoromethoxy)Benzene
|
HS Code |
569527 |
| Chemical Formula | C8H6ClF3O |
| Molar Mass | 210.58 g/mol |
| Appearance | liquid (usually) |
| Odor | characteristic organic odor |
| Density | data - dependent on conditions |
| Boiling Point | data - dependent on pressure |
| Melting Point | data - specific to the compound |
| Solubility In Water | low (organic compound) |
| Solubility In Organic Solvents | soluble in common organic solvents |
| Vapor Pressure | data - temperature - dependent |
| Flash Point | data - characteristic of the flammability |
As an accredited 1-Chloro-2-Methyl-4-(Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 2 - methyl - 4 - (trifluoromethoxy) benzene, 500g in sealed, corrosion - resistant container. |
| Storage | 1 - chloro - 2 - methyl - 4 - (trifluoromethoxy)benzene should be stored in a cool, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly - sealed container to prevent leakage. Store it separately from oxidizing agents, acids, and bases. The storage area should be dry to avoid potential reactions with moisture. |
| Shipping | 1 - chloro - 2 - methyl - 4 - (trifluoromethoxy)benzene is shipped in specialized, tightly - sealed containers. Transport follows strict chemical safety regulations, ensuring protection from environmental factors and preventing any leakage during transit. |
Competitive 1-Chloro-2-Methyl-4-(Trifluoromethoxy)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 1-chloro-2-methyl-4- (trifluoromethoxy) benzene
1-Chloro-2-methyl-4- (trifluoromethoxy) benzene, this is an organic compound. Its physical properties are mostly colorless to light yellow liquids with a special odor. The boiling point is about 170-180 ° C, the density is about 1.3-1.4 g/cm ³, which is insoluble in water, but easily soluble in organic solvents such as ethanol, ether, dichloromethane, etc.
In terms of chemical properties, the chlorine atom in this compound is quite active. In nucleophilic substitution reactions, chlorine atoms are easily attacked by various nucleophilic reagents, and then new organic compounds are formed. For example, when reacted with sodium alcohol, corresponding ether compounds can be formed; when reacted with amines, amino substitution products can be formed.
The trifluoromethoxy group gives the compound a unique electronic effect. Because of its strong electron absorption ability, the electron cloud density on the benzene ring will decrease, so the electrophilic substitution activity of the benzene ring will decrease. However, once the electrophilic substitution reaction occurs, the substituent group will preferentially enter the position on the benzene ring that is less affected by the trifluoromethoxy group.
In addition, the methyl group in this compound is relatively stable, but under certain conditions, such as the action of strong oxidants, the methyl group may be oxidized to other functional groups such as carboxyl groups. In conclusion, 1-chloro-2-methyl-4-trifluoromethoxy benzene is chemically active and widely used in the field of organic synthesis, which can be used to prepare a variety of drugs, pesticides and other organic materials.
In terms of chemical properties, the chlorine atom in this compound is quite active. In nucleophilic substitution reactions, chlorine atoms are easily attacked by various nucleophilic reagents, and then new organic compounds are formed. For example, when reacted with sodium alcohol, corresponding ether compounds can be formed; when reacted with amines, amino substitution products can be formed.
The trifluoromethoxy group gives the compound a unique electronic effect. Because of its strong electron absorption ability, the electron cloud density on the benzene ring will decrease, so the electrophilic substitution activity of the benzene ring will decrease. However, once the electrophilic substitution reaction occurs, the substituent group will preferentially enter the position on the benzene ring that is less affected by the trifluoromethoxy group.
In addition, the methyl group in this compound is relatively stable, but under certain conditions, such as the action of strong oxidants, the methyl group may be oxidized to other functional groups such as carboxyl groups. In conclusion, 1-chloro-2-methyl-4-trifluoromethoxy benzene is chemically active and widely used in the field of organic synthesis, which can be used to prepare a variety of drugs, pesticides and other organic materials.
What are the physical properties of 1-chloro-2-methyl-4- (trifluoromethoxy) benzene
1-Chloro-2-methyl-4- (trifluoromethoxy) benzene, this is an organic compound. Its physical properties are very important, and it is related to many chemical processes and practical applications.
First, the appearance is usually colorless to light yellow transparent liquid, which is clear in appearance and has no significant impurities. This color state characteristic can be used as a basis for preliminary identification and observation of the reaction system.
When talking about the boiling point, it is about a specific temperature range, which is determined by the intermolecular forces. The molecule contains chlorine atoms, methyl groups and trifluoromethoxy groups, and the structure causes its boiling point to be in the corresponding range. Accurate boiling point data is of great significance for the separation and purification of this compound. In distillation and other operations, it can be effectively separated from the mixture according to the boiling point.
Melting point is also a key property, reflecting the molecular lattice arrangement and interaction. The specific melting point makes the compound have a clear temperature limit when it transitions from solid to liquid, and has a guiding role in setting storage and transportation conditions.
In terms of density, it is relatively stable. This parameter is indispensable in solution preparation, measurement and determination of its position in a multiphase system. Knowing the density, the compound can be accurately measured to ensure the accuracy of experiment and production.
In terms of solubility, it exhibits certain solubility in common organic solvents such as ethanol and ether, but it is difficult to dissolve in water. This characteristic is derived from the molecular structure. Trifluoromethoxy and chlorine atoms make it hydrophobic to a certain extent. Using solubility, suitable solvents can be selected for reaction, recrystallization and other operations.
Volatility, there is a certain volatility at room temperature and pressure. This requires that it be well sealed during storage and operated in a ventilated place to prevent it from evaporating in the air and causing loss or endangering the environment and human health.
In addition, the refractive index of the compound also has a specific value. The refractive index can be used to identify the purity of the compound and determine its concentration. It has important applications in the fields of quality control and analytical chemistry.
In summary, these physical properties of 1-chloro-2-methyl-4 - (trifluoromethoxy) benzene are interrelated and play a key role in chemical synthesis, analytical testing, product storage and transportation, etc. Only by deeply understanding and making good use of these properties can we better control various chemical activities related to them.
First, the appearance is usually colorless to light yellow transparent liquid, which is clear in appearance and has no significant impurities. This color state characteristic can be used as a basis for preliminary identification and observation of the reaction system.
When talking about the boiling point, it is about a specific temperature range, which is determined by the intermolecular forces. The molecule contains chlorine atoms, methyl groups and trifluoromethoxy groups, and the structure causes its boiling point to be in the corresponding range. Accurate boiling point data is of great significance for the separation and purification of this compound. In distillation and other operations, it can be effectively separated from the mixture according to the boiling point.
Melting point is also a key property, reflecting the molecular lattice arrangement and interaction. The specific melting point makes the compound have a clear temperature limit when it transitions from solid to liquid, and has a guiding role in setting storage and transportation conditions.
In terms of density, it is relatively stable. This parameter is indispensable in solution preparation, measurement and determination of its position in a multiphase system. Knowing the density, the compound can be accurately measured to ensure the accuracy of experiment and production.
In terms of solubility, it exhibits certain solubility in common organic solvents such as ethanol and ether, but it is difficult to dissolve in water. This characteristic is derived from the molecular structure. Trifluoromethoxy and chlorine atoms make it hydrophobic to a certain extent. Using solubility, suitable solvents can be selected for reaction, recrystallization and other operations.
Volatility, there is a certain volatility at room temperature and pressure. This requires that it be well sealed during storage and operated in a ventilated place to prevent it from evaporating in the air and causing loss or endangering the environment and human health.
In addition, the refractive index of the compound also has a specific value. The refractive index can be used to identify the purity of the compound and determine its concentration. It has important applications in the fields of quality control and analytical chemistry.
In summary, these physical properties of 1-chloro-2-methyl-4 - (trifluoromethoxy) benzene are interrelated and play a key role in chemical synthesis, analytical testing, product storage and transportation, etc. Only by deeply understanding and making good use of these properties can we better control various chemical activities related to them.
What is the main use of 1-chloro-2-methyl-4- (trifluoromethoxy) benzene?
1 - chloro - 2 - methyl - 4 - (trifluoromethoxy) benzene, Chinese name 1 - chloro - 2 - methyl - 4 - (trifluoromethoxy) benzene, this substance has a wide range of uses and is widely involved in the field of chemical synthesis.
First, it is often a key intermediate in the synthesis of medicine. It can be constructed through a series of chemical reactions to construct a specific drug molecular structure. For example, some compounds with special physiological activities need to introduce functional groups such as chlorine atoms, methyl and trifluoromethoxy by virtue of their unique chemical structure to achieve the required pharmacological efficacy, or enhance the affinity of the drug to specific targets, or improve the pharmacokinetic properties of the drug metabolism.
Second, it also plays an important role in the creation of pesticides. With this as the starting material, the well-designed synthesis route can prepare many high-efficiency pesticides. Because its structure endows the molecule with specific physical and chemical properties, or makes the pesticide more fat-soluble, which is conducive to penetrating the epidermis of insects or the stratum corneum of plants, improving the efficacy; or enhancing its selectivity to specific pests or pathogens, reducing the impact on beneficial organisms, and achieving the effect of green environmental protection.
Third, it is also useful in the field of materials science. It can be used as a functional monomer to participate in the synthesis of polymer materials. After polymerization, its unique functional groups are introduced into the main chain or side chain of the polymer to endow the material with special properties, such as improving the material's chemical resistance and thermal stability, or endowing the material with special optical and electrical properties to meet the needs of high-performance materials in the fields of electronics and optics.
In summary, 1-chloro-2-methyl-4 - (trifluoromethoxy) benzene, with its unique structure, plays an important role in many fields such as medicine, pesticides, materials, etc., providing a key chemical basis for the development of various fields.
First, it is often a key intermediate in the synthesis of medicine. It can be constructed through a series of chemical reactions to construct a specific drug molecular structure. For example, some compounds with special physiological activities need to introduce functional groups such as chlorine atoms, methyl and trifluoromethoxy by virtue of their unique chemical structure to achieve the required pharmacological efficacy, or enhance the affinity of the drug to specific targets, or improve the pharmacokinetic properties of the drug metabolism.
Second, it also plays an important role in the creation of pesticides. With this as the starting material, the well-designed synthesis route can prepare many high-efficiency pesticides. Because its structure endows the molecule with specific physical and chemical properties, or makes the pesticide more fat-soluble, which is conducive to penetrating the epidermis of insects or the stratum corneum of plants, improving the efficacy; or enhancing its selectivity to specific pests or pathogens, reducing the impact on beneficial organisms, and achieving the effect of green environmental protection.
Third, it is also useful in the field of materials science. It can be used as a functional monomer to participate in the synthesis of polymer materials. After polymerization, its unique functional groups are introduced into the main chain or side chain of the polymer to endow the material with special properties, such as improving the material's chemical resistance and thermal stability, or endowing the material with special optical and electrical properties to meet the needs of high-performance materials in the fields of electronics and optics.
In summary, 1-chloro-2-methyl-4 - (trifluoromethoxy) benzene, with its unique structure, plays an important role in many fields such as medicine, pesticides, materials, etc., providing a key chemical basis for the development of various fields.
What are the synthesis methods of 1-chloro-2-methyl-4- (trifluoromethoxy) benzene
The synthesis methods of 1-chloro-2-methyl-4 - (trifluoromethoxy) benzene are described in ancient books, and there are about several ends.
First, the phenolic compound is used as the starting material. First, the phenolic compound is interacted with an appropriate halogenating agent to convert the phenolic hydroxyl group into a halogen atom, and then the chlorine atom is introduced into the benzene ring. Subsequently, the halogenated phenol derivative is co-placed with the trifluoromethylated reagent, such as trifluoromethyl halide or trifluoromethylated salt, under suitable reaction conditions, or a specific catalyst and base are required to participate, so that the trifluoromethoxy group is successfully connected to the designated position of the benzene ring. At the same time, the methyl group can be pre-existing on the benzene ring of the starting phenolic compound, or in the subsequent reaction steps, it can be introduced by alkylation reaction, such as the use of halogenated methane and the corresponding base, in a suitable solvent, to achieve the purpose of methylation.
Second, it can be started from halogenated benzene derivatives. Compounds with suitable halogen atoms (such as bromine atoms or iodine atoms) and methyl groups on the benzene ring are first selected, and are connected to trifluoromethoxylation reagents by metal-catalyzed coupling reactions, such as palladium-catalyzed reaction systems. During the reaction, the type and amount of palladium catalyst, ligand and base should be carefully selected, and the reaction temperature and time should be precisely adjusted to ensure that the trifluoromethoxy group is oriented into the specific position of the benzene ring, while retaining the chlorine atom in the predetermined position.
Third, direct fluorination and subsequent derivatization paths via aromatic hydrocarbons can also be considered. First, the aromatic hydrocarbons containing methyl and chlorine atoms are selectively fluorinated to prepare fluorine-containing intermediates, and then the fluorine atoms are converted into trifluoromethoxy groups. This process often requires specific fluorination reagents and conditions to ensure the selectivity of fluorination check points. The subsequent conversion to trifluoromethoxy also requires precise control of the reaction conditions in order to efficiently synthesize the target product 1-chloro-2-methyl-4 - (trifluoromethoxy) benzene.
First, the phenolic compound is used as the starting material. First, the phenolic compound is interacted with an appropriate halogenating agent to convert the phenolic hydroxyl group into a halogen atom, and then the chlorine atom is introduced into the benzene ring. Subsequently, the halogenated phenol derivative is co-placed with the trifluoromethylated reagent, such as trifluoromethyl halide or trifluoromethylated salt, under suitable reaction conditions, or a specific catalyst and base are required to participate, so that the trifluoromethoxy group is successfully connected to the designated position of the benzene ring. At the same time, the methyl group can be pre-existing on the benzene ring of the starting phenolic compound, or in the subsequent reaction steps, it can be introduced by alkylation reaction, such as the use of halogenated methane and the corresponding base, in a suitable solvent, to achieve the purpose of methylation.
Second, it can be started from halogenated benzene derivatives. Compounds with suitable halogen atoms (such as bromine atoms or iodine atoms) and methyl groups on the benzene ring are first selected, and are connected to trifluoromethoxylation reagents by metal-catalyzed coupling reactions, such as palladium-catalyzed reaction systems. During the reaction, the type and amount of palladium catalyst, ligand and base should be carefully selected, and the reaction temperature and time should be precisely adjusted to ensure that the trifluoromethoxy group is oriented into the specific position of the benzene ring, while retaining the chlorine atom in the predetermined position.
Third, direct fluorination and subsequent derivatization paths via aromatic hydrocarbons can also be considered. First, the aromatic hydrocarbons containing methyl and chlorine atoms are selectively fluorinated to prepare fluorine-containing intermediates, and then the fluorine atoms are converted into trifluoromethoxy groups. This process often requires specific fluorination reagents and conditions to ensure the selectivity of fluorination check points. The subsequent conversion to trifluoromethoxy also requires precise control of the reaction conditions in order to efficiently synthesize the target product 1-chloro-2-methyl-4 - (trifluoromethoxy) benzene.
What are the precautions for 1-chloro-2-methyl-4- (trifluoromethoxy) benzene in storage and transportation?
1-Chloro-2-methyl-4- (trifluoromethoxy) benzene is an organic chemical. When storing and transporting, many matters must be paid attention to.
First of all, this substance may be hazardous to the environment and should be stored in a special chemical storage area. The area must be dry, cool and well ventilated to prevent its properties from changing due to environmental factors. And keep away from fires and heat sources, because it is flammable, in case of open flames, hot topics or hazards such as combustion or even explosion.
When storing, it must be stored separately from oxidants, acids, alkalis, etc., because of its active chemical properties, contact with these substances, or violent chemical reactions, resulting in serious consequences such as leakage and explosion. There are also requirements for storage containers, which must be tightly sealed to prevent them from volatilizing, polluting the environment and harming the human body. Regular inspections of the storage area are also required to check whether the containers are damaged or leaking.
As for transportation, it is necessary to ensure that the packaging is complete and the loading is secure before transportation. Packaging materials should be able to withstand a certain amount of external force to prevent package damage caused by collision, vibration and extrusion. During transportation, it is also necessary to keep away from fire and heat sources, and the transportation vehicle should be equipped with corresponding fire equipment. Transportation personnel need to undergo professional training and be familiar with the chemical characteristics and emergency treatment methods.
During transportation, avoid exposure to the sun, rain, high temperature, humid environment or affect its stability. Different regions have regulations on the transportation of hazardous chemicals, which must be strictly followed. If you drive according to the designated route, do not stop in densely populated areas or important places. If there is an accident such as leakage during transportation, transportation personnel should immediately take emergency measures, evacuate the crowd, call the police and cooperate with relevant departments to deal with it.
First of all, this substance may be hazardous to the environment and should be stored in a special chemical storage area. The area must be dry, cool and well ventilated to prevent its properties from changing due to environmental factors. And keep away from fires and heat sources, because it is flammable, in case of open flames, hot topics or hazards such as combustion or even explosion.
When storing, it must be stored separately from oxidants, acids, alkalis, etc., because of its active chemical properties, contact with these substances, or violent chemical reactions, resulting in serious consequences such as leakage and explosion. There are also requirements for storage containers, which must be tightly sealed to prevent them from volatilizing, polluting the environment and harming the human body. Regular inspections of the storage area are also required to check whether the containers are damaged or leaking.
As for transportation, it is necessary to ensure that the packaging is complete and the loading is secure before transportation. Packaging materials should be able to withstand a certain amount of external force to prevent package damage caused by collision, vibration and extrusion. During transportation, it is also necessary to keep away from fire and heat sources, and the transportation vehicle should be equipped with corresponding fire equipment. Transportation personnel need to undergo professional training and be familiar with the chemical characteristics and emergency treatment methods.
During transportation, avoid exposure to the sun, rain, high temperature, humid environment or affect its stability. Different regions have regulations on the transportation of hazardous chemicals, which must be strictly followed. If you drive according to the designated route, do not stop in densely populated areas or important places. If there is an accident such as leakage during transportation, transportation personnel should immediately take emergency measures, evacuate the crowd, call the police and cooperate with relevant departments to deal with it.
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