Linshang Chemical
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1-Chloro-2-Nitro-3-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
842118 |
| Chemical Formula | C7H3ClF3NO2 |
| Molecular Weight | 225.55 |
| Appearance | Liquid (usually) |
| Solubility In Water | Low (organic nature) |
| Solubility In Organic Solvents | Good (organic nature) |
As an accredited 1-Chloro-2-Nitro-3-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1 - chloro - 2 - nitro - 3 - (trifluoromethyl)benzene in sealed, labeled bottles. |
| Storage | 1 - Chloro - 2 - nitro - 3 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container made of compatible materials, like corrosion - resistant metal or high - density polyethylene, to prevent leakage and ensure safety. |
| Shipping | 1 - Chloro - 2 - nitro - 3 - (trifluoromethyl)benzene is a chemical. Shipping requires compliance with hazardous material regulations. It should be properly packaged in suitable containers to prevent leakage during transit. |
Competitive 1-Chloro-2-Nitro-3-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 1-Chloro-2-Nitro-3-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 1-chloro-2-nitro-3- (trifluoromethyl) benzene?
1-Chloro-2-nitro-3- (trifluoromethyl) benzene is an important member of organic compounds. It has a wide range of uses and plays a key role in many fields.
First and in the field of pharmaceutical chemistry, this compound is often used as a key intermediate. When it comes to the synthesis of specific drugs, its unique chemical structure endows the reaction with unique activity and selectivity. Well-designed chemical reactions can be cleverly combined with other organic molecules to build complex drug molecular structures, thus providing the possibility for the development of new drugs. For example, in the creation of drugs for certain diseases, the properties of 1-chloro-2-nitro-3- (trifluoromethyl) benzene can help chemists precisely control the activity check point and pharmacological properties of drugs to achieve better therapeutic effects.
and the field of materials science. This compound can participate in the synthesis process of polymer materials. Because it contains special functional groups, it can affect the physical and chemical properties of polymers. When preparing high-performance engineering plastics, the introduction of this compound can improve the heat resistance, chemical resistance and mechanical properties of the material. For example, in the special materials used in the aerospace field, by adding monomers containing 1-chloro-2-nitro-3- (trifluoromethyl) benzene structure, the comprehensive properties of the materials can be improved to meet the strict environmental requirements.
Furthermore, it also has its influence in the field of agricultural chemistry. Or it can be used as an important raw material for the synthesis of pesticides. After a series of reaction transformations, pesticide products with high insecticidal, bactericidal or herbicidal properties are generated. Due to its structural characteristics, the synthesized pesticides may be highly targeted and active to specific pests or weeds, and have good degradation characteristics in the environment, which is conducive to achieving green and efficient agricultural production goals.
In addition, in the study of organic synthetic chemistry, 1-chloro-2-nitro-3- (trifluoromethyl) benzene is often used as a model compound. Chemists explore new reaction mechanisms and synthesis methods by studying various reactions in which it participates, providing a theoretical and practical basis for the development of organic synthetic chemistry.
In summary, 1-chloro-2-nitro-3- (trifluoromethyl) benzene plays an indispensable role in many fields such as medicine, materials, agriculture and chemical research, and is of great significance to promote the development of related fields.
First and in the field of pharmaceutical chemistry, this compound is often used as a key intermediate. When it comes to the synthesis of specific drugs, its unique chemical structure endows the reaction with unique activity and selectivity. Well-designed chemical reactions can be cleverly combined with other organic molecules to build complex drug molecular structures, thus providing the possibility for the development of new drugs. For example, in the creation of drugs for certain diseases, the properties of 1-chloro-2-nitro-3- (trifluoromethyl) benzene can help chemists precisely control the activity check point and pharmacological properties of drugs to achieve better therapeutic effects.
and the field of materials science. This compound can participate in the synthesis process of polymer materials. Because it contains special functional groups, it can affect the physical and chemical properties of polymers. When preparing high-performance engineering plastics, the introduction of this compound can improve the heat resistance, chemical resistance and mechanical properties of the material. For example, in the special materials used in the aerospace field, by adding monomers containing 1-chloro-2-nitro-3- (trifluoromethyl) benzene structure, the comprehensive properties of the materials can be improved to meet the strict environmental requirements.
Furthermore, it also has its influence in the field of agricultural chemistry. Or it can be used as an important raw material for the synthesis of pesticides. After a series of reaction transformations, pesticide products with high insecticidal, bactericidal or herbicidal properties are generated. Due to its structural characteristics, the synthesized pesticides may be highly targeted and active to specific pests or weeds, and have good degradation characteristics in the environment, which is conducive to achieving green and efficient agricultural production goals.
In addition, in the study of organic synthetic chemistry, 1-chloro-2-nitro-3- (trifluoromethyl) benzene is often used as a model compound. Chemists explore new reaction mechanisms and synthesis methods by studying various reactions in which it participates, providing a theoretical and practical basis for the development of organic synthetic chemistry.
In summary, 1-chloro-2-nitro-3- (trifluoromethyl) benzene plays an indispensable role in many fields such as medicine, materials, agriculture and chemical research, and is of great significance to promote the development of related fields.
What are the physical properties of 1-chloro-2-nitro-3- (trifluoromethyl) benzene
1-Chloro-2-nitro-3- (trifluoromethyl) benzene is a kind of organic compound. Its physical properties are worth exploring.
Looking at its appearance, it is mostly colorless to light yellow liquid at room temperature and pressure, with a clear and specific quality. Its odor may be irritating, and the smell can make the senses feel it. When operating, pay attention to precautions.
When it comes to boiling point, it is about a certain temperature range. This value is related to the phase transition of substances. It is an important parameter in operations such as distillation and separation. The characteristics of boiling point are determined by factors such as intermolecular forces and structures. The presence of chlorine atoms, nitro groups and trifluoromethyl groups in the molecule affects the interaction between molecules, causing its boiling point to be different from other substances.
Melting point is also one of its important physical properties. The melting point of this compound is at a specific temperature, which characterizes the critical transformation of solid and liquid states. The melting point is also restricted by molecular structure and force. The electronic and spatial effects of functional groups such as nitro groups and trifluoromethyl groups all affect the melting point.
In terms of density, it has a certain value, which is a mass measure per unit volume. Density characteristics play a key role in mixing, delamination and other processes. Compared with common solvents such as water, due to density differences, they show different distributions in coexisting systems.
In terms of solubility, 1-chloro-2-nitro-3- (trifluoromethyl) benzene may have better solubility in organic solvents, such as common aromatic hydrocarbons and halogenated hydrocarbon solvents. However, in water, the solubility is poor. This difference in solubility is due to the polar characteristics of its molecules. Nitro is a strongly polar group, but the presence of trifluoromethyl and chlorine atoms changes the overall polarity of the molecule, making it weak in interaction with water and strong in interaction with non-polar or weakly polar organic solvents.
In addition, its volatility cannot be ignored. Under certain temperature and environmental conditions, some of this compound will change from liquid to gaseous and escape. Volatility is related to properties such as boiling point and vapor pressure. When operating, it is necessary to take into account the possible safety and environmental effects.
In summary, the physical properties of 1-chloro-2-nitro-3- (trifluoromethyl) benzene have their own reasons, and are of great significance in many fields such as chemical experiments and industrial production. In order to properly handle and use this substance, its various properties must be carefully investigated.
Looking at its appearance, it is mostly colorless to light yellow liquid at room temperature and pressure, with a clear and specific quality. Its odor may be irritating, and the smell can make the senses feel it. When operating, pay attention to precautions.
When it comes to boiling point, it is about a certain temperature range. This value is related to the phase transition of substances. It is an important parameter in operations such as distillation and separation. The characteristics of boiling point are determined by factors such as intermolecular forces and structures. The presence of chlorine atoms, nitro groups and trifluoromethyl groups in the molecule affects the interaction between molecules, causing its boiling point to be different from other substances.
Melting point is also one of its important physical properties. The melting point of this compound is at a specific temperature, which characterizes the critical transformation of solid and liquid states. The melting point is also restricted by molecular structure and force. The electronic and spatial effects of functional groups such as nitro groups and trifluoromethyl groups all affect the melting point.
In terms of density, it has a certain value, which is a mass measure per unit volume. Density characteristics play a key role in mixing, delamination and other processes. Compared with common solvents such as water, due to density differences, they show different distributions in coexisting systems.
In terms of solubility, 1-chloro-2-nitro-3- (trifluoromethyl) benzene may have better solubility in organic solvents, such as common aromatic hydrocarbons and halogenated hydrocarbon solvents. However, in water, the solubility is poor. This difference in solubility is due to the polar characteristics of its molecules. Nitro is a strongly polar group, but the presence of trifluoromethyl and chlorine atoms changes the overall polarity of the molecule, making it weak in interaction with water and strong in interaction with non-polar or weakly polar organic solvents.
In addition, its volatility cannot be ignored. Under certain temperature and environmental conditions, some of this compound will change from liquid to gaseous and escape. Volatility is related to properties such as boiling point and vapor pressure. When operating, it is necessary to take into account the possible safety and environmental effects.
In summary, the physical properties of 1-chloro-2-nitro-3- (trifluoromethyl) benzene have their own reasons, and are of great significance in many fields such as chemical experiments and industrial production. In order to properly handle and use this substance, its various properties must be carefully investigated.
What are the chemical properties of 1-chloro-2-nitro-3- (trifluoromethyl) benzene
1 - chloro - 2 - nitro - 3 - (trifluoromethyl) benzene is an organic compound with unique chemical properties and is widely used in chemical, pharmaceutical and other fields.
This compound has halogenated hydrocarbon properties because it contains chlorine atoms. Chlorine atoms have considerable activity and can participate in many chemical reactions. In nucleophilic substitution reactions, chlorine atoms can be replaced by various nucleophilic reagents. For example, when reacted with sodium alcohol, chlorine atoms will be replaced by alkoxy groups to generate corresponding ether compounds; when reacted with ammonia or amines, nitrogen-containing derivatives can be formed. This is because chlorine atoms are connected to the benzene ring, which is affected by the electronic effect of the benzene ring, and its carbon-chlorine bond polarity is enhanced, making it more vulnerable to attack by nucleophilic reagents.
The presence of nitro groups makes the compound highly oxidizing. Nitro is an electron-absorbing group, which can reduce the electron cloud density of the benzene ring and increase the difficulty of electrophilic substitution reaction on the benzene ring. However, under certain conditions, electrophilic substitution can still occur, but the reaction check point is different from that without nitro, and it mostly occurs in the interposition of nitro groups. In addition, nitro groups can be reduced to amino groups under the action of appropriate reducing agents, which is used in the preparation of amino-containing compounds in organic synthesis.
And trifluoromethyl is also a strong electron-absorbing group, which has a significant impact on the electron cloud density of the benzene ring. The presence of trifluoromethyl not only changes the reactivity of the benzene ring, but also has an effect on the physical properties of the compound. Due to the large number of fluorine atoms, the compound has a certain fat solubility, which affects its solubility in different solvents. At the same time, the strong electron-absorbing property of trifluoromethyl changes the molecular polarity, which affects the stability of the compound and the interaction with other molecules.
1-chloro-2-nitro-3 - (trifluoromethyl) benzene has various functional groups that interact with each other, making it rich and diverse in chemical properties. It plays an important role in organic synthesis and other fields, providing a basis for the preparation of various functional compounds.
This compound has halogenated hydrocarbon properties because it contains chlorine atoms. Chlorine atoms have considerable activity and can participate in many chemical reactions. In nucleophilic substitution reactions, chlorine atoms can be replaced by various nucleophilic reagents. For example, when reacted with sodium alcohol, chlorine atoms will be replaced by alkoxy groups to generate corresponding ether compounds; when reacted with ammonia or amines, nitrogen-containing derivatives can be formed. This is because chlorine atoms are connected to the benzene ring, which is affected by the electronic effect of the benzene ring, and its carbon-chlorine bond polarity is enhanced, making it more vulnerable to attack by nucleophilic reagents.
The presence of nitro groups makes the compound highly oxidizing. Nitro is an electron-absorbing group, which can reduce the electron cloud density of the benzene ring and increase the difficulty of electrophilic substitution reaction on the benzene ring. However, under certain conditions, electrophilic substitution can still occur, but the reaction check point is different from that without nitro, and it mostly occurs in the interposition of nitro groups. In addition, nitro groups can be reduced to amino groups under the action of appropriate reducing agents, which is used in the preparation of amino-containing compounds in organic synthesis.
And trifluoromethyl is also a strong electron-absorbing group, which has a significant impact on the electron cloud density of the benzene ring. The presence of trifluoromethyl not only changes the reactivity of the benzene ring, but also has an effect on the physical properties of the compound. Due to the large number of fluorine atoms, the compound has a certain fat solubility, which affects its solubility in different solvents. At the same time, the strong electron-absorbing property of trifluoromethyl changes the molecular polarity, which affects the stability of the compound and the interaction with other molecules.
1-chloro-2-nitro-3 - (trifluoromethyl) benzene has various functional groups that interact with each other, making it rich and diverse in chemical properties. It plays an important role in organic synthesis and other fields, providing a basis for the preparation of various functional compounds.
What are the synthesis methods of 1-chloro-2-nitro-3- (trifluoromethyl) benzene
The synthesis of 1-chloro-2-nitro-3- (trifluoromethyl) benzene has many different paths. The common one is to start with m-trifluoromethylaniline. Shilling m-trifluoromethylaniline is reacted with sodium nitrite and hydrochloric acid at low temperature to form diazonium salt. After that, the diazonium salt is reacted with cuprous chloride to obtain m-trifluoromethylchlorobenzene. Then, m-trifluoromethylchlorobenzene is treated with mixed acid (sulfuric acid and nitric acid). At a suitable temperature, the nitrate group attacks the benzene ring to obtain 1-chloro-2-nitro-3- (trifluoromethyl) benzene.
Another way is to use m-trifluoromethylbenzoic acid as the starting material. First, m-trifluoromethylbenzoic acid is converted into acyl chloride, and then amidation and Huffman degradation reactions can obtain m-trifluoromethylaniline. The subsequent steps are similar to the previous method by m-trifluoromethylaniline initiator, and m-trifluoromethylchlorobenzene is obtained by diazotization and Sandmeier reaction, and then the target product is obtained by nitration.
There are also m-trifluoromethylbenzene as the starting material. It is directly nitrified with a mixed acid, and the nitro group is selectively introduced into a specific position through controlled reaction conditions to obtain 1-chloro-2-nitro-3- (trifluoromethyl) benzene. However, this approach requires fine regulation of the reaction conditions, because there are both chlorine atoms and trifluoromethyl groups on the benzene ring, both of which have an impact on the activity and localization effect of the benzene ring, and it is necessary to ensure the introduction of nitro groups into the desired position. Each method has its own advantages and disadvantages. In practical application, it should be selected according to factors such as raw material availability, cost, and ease of control of reaction conditions.
Another way is to use m-trifluoromethylbenzoic acid as the starting material. First, m-trifluoromethylbenzoic acid is converted into acyl chloride, and then amidation and Huffman degradation reactions can obtain m-trifluoromethylaniline. The subsequent steps are similar to the previous method by m-trifluoromethylaniline initiator, and m-trifluoromethylchlorobenzene is obtained by diazotization and Sandmeier reaction, and then the target product is obtained by nitration.
There are also m-trifluoromethylbenzene as the starting material. It is directly nitrified with a mixed acid, and the nitro group is selectively introduced into a specific position through controlled reaction conditions to obtain 1-chloro-2-nitro-3- (trifluoromethyl) benzene. However, this approach requires fine regulation of the reaction conditions, because there are both chlorine atoms and trifluoromethyl groups on the benzene ring, both of which have an impact on the activity and localization effect of the benzene ring, and it is necessary to ensure the introduction of nitro groups into the desired position. Each method has its own advantages and disadvantages. In practical application, it should be selected according to factors such as raw material availability, cost, and ease of control of reaction conditions.
What are the precautions for 1-chloro-2-nitro-3- (trifluoromethyl) benzene during storage and transportation?
1-Chloro-2-nitro-3- (trifluoromethyl) benzene is also an organic compound. During storage and transportation, extra attention should be paid to everything to ensure safety.
When storing, first choose a cool, dry and well-ventilated place. This compound is prone to danger when heated, so it must be avoided from open flames and hot topics. If it is in a high temperature environment, it may react violently and cause explosions and other disasters.
Furthermore, it should be stored in isolation from oxidants, reducing agents, alkalis, etc. Because of its special chemical properties, it can react chemically with various substances, such as meeting with oxidants, or promoting combustion and explosion.
Storage containers must also be carefully selected and must be tightly sealed to prevent leakage. And corrosion-resistant materials should be used to cover the compound or corrode ordinary containers, resulting in material loss and endangering the surrounding environment and personal safety.
As for transportation, the transportation vehicle must be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. During driving, drivers and escorts must pay close attention to the condition of the goods and must not leave their posts without authorization.
When handling, be sure to load and unload lightly, and do not drop or pressure. Due to its sensitive nature, rough handling or package damage will cause leakage.
The planning of transportation routes should not be ignored, and densely populated areas and important facilities should be avoided to prevent the expansion of hazards in the event of an accident.
In short, during the storage and transportation of 1-chloro-2-nitro-3- (trifluoromethyl) benzene, it is necessary to strictly observe safety regulations and operate cautiously to avoid accidents and ensure the safety of all parties.
When storing, first choose a cool, dry and well-ventilated place. This compound is prone to danger when heated, so it must be avoided from open flames and hot topics. If it is in a high temperature environment, it may react violently and cause explosions and other disasters.
Furthermore, it should be stored in isolation from oxidants, reducing agents, alkalis, etc. Because of its special chemical properties, it can react chemically with various substances, such as meeting with oxidants, or promoting combustion and explosion.
Storage containers must also be carefully selected and must be tightly sealed to prevent leakage. And corrosion-resistant materials should be used to cover the compound or corrode ordinary containers, resulting in material loss and endangering the surrounding environment and personal safety.
As for transportation, the transportation vehicle must be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. During driving, drivers and escorts must pay close attention to the condition of the goods and must not leave their posts without authorization.
When handling, be sure to load and unload lightly, and do not drop or pressure. Due to its sensitive nature, rough handling or package damage will cause leakage.
The planning of transportation routes should not be ignored, and densely populated areas and important facilities should be avoided to prevent the expansion of hazards in the event of an accident.
In short, during the storage and transportation of 1-chloro-2-nitro-3- (trifluoromethyl) benzene, it is necessary to strictly observe safety regulations and operate cautiously to avoid accidents and ensure the safety of all parties.
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