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1-Chloro-2-(Trifluoromethoxy)Benzene
Linshang Chemical
|
HS Code |
593817 |
| Chemical Formula | C7H4ClF3O |
| Molar Mass | 196.55 g/mol |
| Appearance | Colorless liquid |
| Boiling Point | Approximately 146 - 148 °C |
| Density | Around 1.36 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | Approximately 46 °C |
| Odor | Characteristic aromatic odor |
| Stability | Stable under normal conditions |
As an accredited 1-Chloro-2-(Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 2 - (trifluoromethoxy) benzene in 500 - gram bottles for chemical packaging. |
| Storage | 1 - Chloro - 2 - (trifluoromethoxy)benzene should be stored in a cool, well - ventilated area away from heat sources and open flames. Keep it in a tightly - sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents and reactive chemicals to prevent potential reactions. Ensure storage areas comply with safety regulations. |
| Shipping | 1 - chloro - 2 - (trifluoromethoxy)benzene is shipped in specialized, leak - proof containers. It's handled with care due to its chemical nature, following strict regulations to ensure safe transportation. Temperature and handling procedures are closely monitored. |
Competitive 1-Chloro-2-(Trifluoromethoxy)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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What is the main use of 1-chloro-2- (trifluoromethoxy) benzene?
1 - chloro - 2 - (trifluoromethoxy) benzene, Chinese name 1 - chloro - 2 - (trifluoromethoxy) benzene, its main uses are as follows.
This compound is widely used in the field of organic synthesis. First, it can be used as a key intermediate to create various bioactive compounds. For example, in the synthesis of pesticides, it can participate in the construction of special molecular structures, giving pesticides unique insecticidal, bactericidal or herbicidal properties. With its chlorine atoms and trifluoromethoxy functional groups, it can be combined with other organic molecules through specific chemical reactions to generate new pesticide components with high biological activity and relatively small environmental impact.
Second, in the field of medicinal chemistry, 1-chloro-2 - (trifluoromethoxy) benzene also plays an important role. It can be used to synthesize a variety of drug molecules. The introduction of trifluoromethoxy can significantly change the physicochemical properties of drug molecules, such as lipophilic, stability, etc., and then affect the interaction between drugs and biological targets. Through rational design and reaction, this compound can be used as a starting material to synthesize high-efficiency and low-toxicity drugs for specific disease targets. For example, in the research and development of anti-tumor drugs and neurological diseases, it may participate in the construction process of drug molecules as an important structural unit.
Furthermore, in the field of materials science, it also shows certain value. When synthesizing functional organic materials, it can be used as a structural modification unit. Its unique chemical structure helps to improve the electrical properties, optical properties or thermal stability of the material. For example, in the preparation of organic optoelectronic materials, the introduction of 1-chloro-2 - (trifluoromethoxy) benzene structure may improve the absorption and conversion efficiency of the material, which can be used in solar cells, Light Emitting Diodes and other optoelectronic devices to promote the optimization and improvement of the properties of related materials.
This compound is widely used in the field of organic synthesis. First, it can be used as a key intermediate to create various bioactive compounds. For example, in the synthesis of pesticides, it can participate in the construction of special molecular structures, giving pesticides unique insecticidal, bactericidal or herbicidal properties. With its chlorine atoms and trifluoromethoxy functional groups, it can be combined with other organic molecules through specific chemical reactions to generate new pesticide components with high biological activity and relatively small environmental impact.
Second, in the field of medicinal chemistry, 1-chloro-2 - (trifluoromethoxy) benzene also plays an important role. It can be used to synthesize a variety of drug molecules. The introduction of trifluoromethoxy can significantly change the physicochemical properties of drug molecules, such as lipophilic, stability, etc., and then affect the interaction between drugs and biological targets. Through rational design and reaction, this compound can be used as a starting material to synthesize high-efficiency and low-toxicity drugs for specific disease targets. For example, in the research and development of anti-tumor drugs and neurological diseases, it may participate in the construction process of drug molecules as an important structural unit.
Furthermore, in the field of materials science, it also shows certain value. When synthesizing functional organic materials, it can be used as a structural modification unit. Its unique chemical structure helps to improve the electrical properties, optical properties or thermal stability of the material. For example, in the preparation of organic optoelectronic materials, the introduction of 1-chloro-2 - (trifluoromethoxy) benzene structure may improve the absorption and conversion efficiency of the material, which can be used in solar cells, Light Emitting Diodes and other optoelectronic devices to promote the optimization and improvement of the properties of related materials.
What are the physical properties of 1-chloro-2- (trifluoromethoxy) benzene
1-Chloro-2 - (trifluoromethoxy) benzene is one of the organic compounds. Its physical properties are quite characteristic, let me tell you in detail.
Looking at its properties, under normal temperature and pressure, this substance is mostly a colorless to light yellow transparent liquid. Its appearance is bright and eye-catching.
When it comes to boiling point, it is about 158-160 ° C. The boiling point is the temperature limit at which a substance changes from liquid to gas. This boiling point value indicates that in a specific pressure environment, when the temperature rises to 158-160 ° C, 1-chloro-2 - (trifluoromethoxy) benzene will gradually vaporize.
Besides, its melting point is about -48 ° C. The melting point is also the critical temperature for a solid substance to melt into a liquid state. When the ambient temperature is higher than -48 ° C, the substance gradually melts from a solid state to a liquid state.
As for the density, it is about 1.38g/cm ³. The density reflects the mass of a substance per unit volume. This value reflects that 1-chloro-2 - (trifluoromethoxy) benzene is denser than water. If it is mixed with water, it must sink to the bottom.
The solubility of 1-chloro-2 - (trifluoromethoxy) benzene is also considerable. It is difficult to dissolve in water because of its molecular structure and weak interaction with water molecules, so it is difficult to disperse in water. However, it is soluble in common organic solvents such as ethanol, ether, acetone, etc. This solubility characteristic has considerable application value in many fields such as organic synthesis.
In addition, its vapor pressure is also one of the important physical properties. Although the exact value varies with temperature, the existence of vapor pressure indicates that at a certain temperature, some molecules of the substance will escape from the liquid surface to form steam. This property needs to be taken into account for the storage, transportation and other processes involved in the substance.
In summary, the physical properties of 1-chloro-2 - (trifluoromethoxy) benzene are diverse and interrelated, which are of great significance for their application and treatment in organic chemistry and related industries.
Looking at its properties, under normal temperature and pressure, this substance is mostly a colorless to light yellow transparent liquid. Its appearance is bright and eye-catching.
When it comes to boiling point, it is about 158-160 ° C. The boiling point is the temperature limit at which a substance changes from liquid to gas. This boiling point value indicates that in a specific pressure environment, when the temperature rises to 158-160 ° C, 1-chloro-2 - (trifluoromethoxy) benzene will gradually vaporize.
Besides, its melting point is about -48 ° C. The melting point is also the critical temperature for a solid substance to melt into a liquid state. When the ambient temperature is higher than -48 ° C, the substance gradually melts from a solid state to a liquid state.
As for the density, it is about 1.38g/cm ³. The density reflects the mass of a substance per unit volume. This value reflects that 1-chloro-2 - (trifluoromethoxy) benzene is denser than water. If it is mixed with water, it must sink to the bottom.
The solubility of 1-chloro-2 - (trifluoromethoxy) benzene is also considerable. It is difficult to dissolve in water because of its molecular structure and weak interaction with water molecules, so it is difficult to disperse in water. However, it is soluble in common organic solvents such as ethanol, ether, acetone, etc. This solubility characteristic has considerable application value in many fields such as organic synthesis.
In addition, its vapor pressure is also one of the important physical properties. Although the exact value varies with temperature, the existence of vapor pressure indicates that at a certain temperature, some molecules of the substance will escape from the liquid surface to form steam. This property needs to be taken into account for the storage, transportation and other processes involved in the substance.
In summary, the physical properties of 1-chloro-2 - (trifluoromethoxy) benzene are diverse and interrelated, which are of great significance for their application and treatment in organic chemistry and related industries.
What are the chemical properties of 1-chloro-2- (trifluoromethoxy) benzene
1-Chloro-2 - (trifluoromethoxy) benzene is one of the organic compounds. Its chemical properties are particularly important and are often regarded as key intermediates in the field of organic synthesis.
Looking at its chemical properties, the characteristics of halogenated aromatics are first deduced. In this compound, the chlorine atom is attached to the benzene ring, and the electron cloud density of the benzene ring changes due to the certain electronegativity of the chlorine atom. The benzene ring has a tendency to electrophilic substitution reaction, but the presence of chlorine atoms affects the reaction check point and reactivity. Usually, the chlorine atom is an ortho-para-site group, which can make the electrophilic reagent more inclined to attack the position adjacent to or opposite the chlorine atom on the benzene ring.
Furthermore, the introduction of trifluoromethoxy gives the compound unique properties. In the trifluoromethoxy group, the fluorine atom is extremely negative, making the trifluoromethoxy group a strong electron-absorbing group. This strong electron-absorbing effect not only affects the electron cloud distribution of the benzene ring, but also has a significant effect on the physical and chemical properties of the whole molecule. For example, due to the strong electron-absorbing properties of the trifluoromethoxy group, it may enhance the acidity of the compound, and in some reactions, it may cause it to lose protons more easily.
In nucleophilic substitution reactions, chlorine atoms are more active and can be replaced by many nucleophiles. The nucleophilic reagent attacks the carbon atom connected to the chlorine atom by virtue of its electron-rich properties, and the chlorine atom leaves in the form of chloride ions to form new organic compounds. The key to this reaction mechanism lies in the strength of the nucleophilic reagent and the control of the reaction conditions.
In the redox reaction, the reactivity of the compound is also affected by the substituent on the benzene ring. The strong electron-absorbing trifluoromethoxy group may make the benzene ring relatively easier to oxidize, but the specific reaction process depends on the type of oxidant used in the reaction and the reaction conditions.
1-chloro-2 - (trifluoromethoxy) benzene has rich and diverse chemical properties. In the field of organic synthesis chemistry, its halogenated aromatics and special electron-absorbing substituents provide a broad path for the synthesis of various organic compounds. The research and development of many new organic materials and drugs may be achieved by the unique reaction properties of these compounds.
Looking at its chemical properties, the characteristics of halogenated aromatics are first deduced. In this compound, the chlorine atom is attached to the benzene ring, and the electron cloud density of the benzene ring changes due to the certain electronegativity of the chlorine atom. The benzene ring has a tendency to electrophilic substitution reaction, but the presence of chlorine atoms affects the reaction check point and reactivity. Usually, the chlorine atom is an ortho-para-site group, which can make the electrophilic reagent more inclined to attack the position adjacent to or opposite the chlorine atom on the benzene ring.
Furthermore, the introduction of trifluoromethoxy gives the compound unique properties. In the trifluoromethoxy group, the fluorine atom is extremely negative, making the trifluoromethoxy group a strong electron-absorbing group. This strong electron-absorbing effect not only affects the electron cloud distribution of the benzene ring, but also has a significant effect on the physical and chemical properties of the whole molecule. For example, due to the strong electron-absorbing properties of the trifluoromethoxy group, it may enhance the acidity of the compound, and in some reactions, it may cause it to lose protons more easily.
In nucleophilic substitution reactions, chlorine atoms are more active and can be replaced by many nucleophiles. The nucleophilic reagent attacks the carbon atom connected to the chlorine atom by virtue of its electron-rich properties, and the chlorine atom leaves in the form of chloride ions to form new organic compounds. The key to this reaction mechanism lies in the strength of the nucleophilic reagent and the control of the reaction conditions.
In the redox reaction, the reactivity of the compound is also affected by the substituent on the benzene ring. The strong electron-absorbing trifluoromethoxy group may make the benzene ring relatively easier to oxidize, but the specific reaction process depends on the type of oxidant used in the reaction and the reaction conditions.
1-chloro-2 - (trifluoromethoxy) benzene has rich and diverse chemical properties. In the field of organic synthesis chemistry, its halogenated aromatics and special electron-absorbing substituents provide a broad path for the synthesis of various organic compounds. The research and development of many new organic materials and drugs may be achieved by the unique reaction properties of these compounds.
What are the synthesis methods of 1-chloro-2- (trifluoromethoxy) benzene
The synthesis of 1-chloro-2 - (trifluoromethoxy) benzene has been a wonderful method in the past. The following are some common ways that Ru Chen said.
First, start with 2-chlorophenol. Mix 2-chlorophenol with a base, such as sodium hydroxide, in a suitable solvent, such as N, N-dimethylformamide (DMF), to form a phenolic salt. Then, add a trifluoromethylating agent, such as trifluoromethylsulfonyl fluoride (CF 🥰 SO 🥰 F). This reaction is carried out at a mild temperature, and the oxygen anion of the phenate attacks the trifluoromethylation reagent to obtain 1-chloro-2- (trifluoromethoxy) benzene. In this process, the nature of the solvent, the strength and dosage of the base, the reaction temperature and time all need to be carefully controlled to obtain a higher yield.
Second, 1-chloro-2-nitrobenzene is used as the starting material. First, it is reduced to 2-chloroaniline, which is commonly used as a reducing agent such as iron and hydrochloric acid, or catalytic hydrogenation. Then, 2-chloroaniline is reacted with sodium nitrite and hydrochloric acid through diazotization to form a diazonium salt. Next, a trifluoromethoxy reagent, such as potassium trifluoromethanol (CF
Third, a halogenated aromatic hydrocarbon is directly reacted with a trifluoromethoxy reagent. Select a suitable catalyst, such as a palladium catalyst, such as Pd (PPh). Taking 1-chloro-2-bromobenzene as an example, it reacts with trifluoromethoxylation reagents, such as lithium trifluoromethoxy (CF-OLi), under the action of catalysts and ligands, in appropriate solvents, such as toluene. This reaction depends on the activity and stability of the catalyst, and the coordination ability of the ligand is also greatly affected. By optimizing the reaction parameters, the halogen atom can be successfully replaced by trifluoromethoxy to achieve the synthesis of 1-chloro-2 - (trifluoromethoxy) benzene.
The above methods have their own advantages and disadvantages. In practical applications, the choice needs to be weighed according to the availability of raw materials, the ease of control of reaction conditions, cost-effectiveness and many other factors, in order to achieve the best synthesis effect.
First, start with 2-chlorophenol. Mix 2-chlorophenol with a base, such as sodium hydroxide, in a suitable solvent, such as N, N-dimethylformamide (DMF), to form a phenolic salt. Then, add a trifluoromethylating agent, such as trifluoromethylsulfonyl fluoride (CF 🥰 SO 🥰 F). This reaction is carried out at a mild temperature, and the oxygen anion of the phenate attacks the trifluoromethylation reagent to obtain 1-chloro-2- (trifluoromethoxy) benzene. In this process, the nature of the solvent, the strength and dosage of the base, the reaction temperature and time all need to be carefully controlled to obtain a higher yield.
Second, 1-chloro-2-nitrobenzene is used as the starting material. First, it is reduced to 2-chloroaniline, which is commonly used as a reducing agent such as iron and hydrochloric acid, or catalytic hydrogenation. Then, 2-chloroaniline is reacted with sodium nitrite and hydrochloric acid through diazotization to form a diazonium salt. Next, a trifluoromethoxy reagent, such as potassium trifluoromethanol (CF
Third, a halogenated aromatic hydrocarbon is directly reacted with a trifluoromethoxy reagent. Select a suitable catalyst, such as a palladium catalyst, such as Pd (PPh). Taking 1-chloro-2-bromobenzene as an example, it reacts with trifluoromethoxylation reagents, such as lithium trifluoromethoxy (CF-OLi), under the action of catalysts and ligands, in appropriate solvents, such as toluene. This reaction depends on the activity and stability of the catalyst, and the coordination ability of the ligand is also greatly affected. By optimizing the reaction parameters, the halogen atom can be successfully replaced by trifluoromethoxy to achieve the synthesis of 1-chloro-2 - (trifluoromethoxy) benzene.
The above methods have their own advantages and disadvantages. In practical applications, the choice needs to be weighed according to the availability of raw materials, the ease of control of reaction conditions, cost-effectiveness and many other factors, in order to achieve the best synthesis effect.
What should be paid attention to when storing and transporting 1-chloro-2- (trifluoromethoxy) benzene?
1-Chloro-2 - (trifluoromethoxy) benzene is also an organic compound. When storing and transporting, many matters need to be paid attention to.
Let's talk about storage first. This substance should be stored in a cool and ventilated warehouse. Because of its certain chemical activity, it is easy to cause reactions when heated, so the temperature of the warehouse should not be too high, and it should be maintained at an appropriate low temperature to prevent accidents. And keep away from fire and heat sources, both of which can cause temperature rise and cause material changes. The lighting, ventilation and other facilities of the warehouse must be explosion-proof, because if the substance encounters an open flame or a high energy source, there may be a risk of combustion and explosion. Electrical equipment also needs to meet the requirements of explosion protection to avoid the danger of electric sparks.
Furthermore, it should be stored separately from oxidants and edible chemicals, and must not be mixed. Oxidants have strong oxidizing properties, or react violently with the substance; while mixed with edible chemicals, if there is leakage, it is easy to contaminate food supplies and endanger human health. The storage area should be equipped with suitable materials to contain leaks, so that they can be dealt with in time when leaks occur to prevent the spread of pollution.
As for transportation. Before transportation, make sure that the container is well sealed and there is no danger of leakage. During transportation, make sure that the container does not collapse, fall or damage. Transportation vehicles should be equipped with corresponding varieties and quantities of fire equipment and leakage emergency treatment equipment. Summer transportation should be carried out in the morning and evening to avoid high temperature periods, because high temperature will increase the volatility of substances and increase the risk factor. During transportation, it should be protected from exposure to the sun, rain and high temperature. When transporting by road, it should be driven according to the specified route, and do not stop in residential areas and densely populated areas, so as to avoid major casualties and property losses in case of accidents. When transporting by rail, it is also necessary to follow relevant regulations to ensure transportation safety. In short, when storing and transporting 1-chloro-2 - (trifluoromethoxy) benzene, it is necessary to act with caution and operate in strict accordance with regulations to ensure safety.
Let's talk about storage first. This substance should be stored in a cool and ventilated warehouse. Because of its certain chemical activity, it is easy to cause reactions when heated, so the temperature of the warehouse should not be too high, and it should be maintained at an appropriate low temperature to prevent accidents. And keep away from fire and heat sources, both of which can cause temperature rise and cause material changes. The lighting, ventilation and other facilities of the warehouse must be explosion-proof, because if the substance encounters an open flame or a high energy source, there may be a risk of combustion and explosion. Electrical equipment also needs to meet the requirements of explosion protection to avoid the danger of electric sparks.
Furthermore, it should be stored separately from oxidants and edible chemicals, and must not be mixed. Oxidants have strong oxidizing properties, or react violently with the substance; while mixed with edible chemicals, if there is leakage, it is easy to contaminate food supplies and endanger human health. The storage area should be equipped with suitable materials to contain leaks, so that they can be dealt with in time when leaks occur to prevent the spread of pollution.
As for transportation. Before transportation, make sure that the container is well sealed and there is no danger of leakage. During transportation, make sure that the container does not collapse, fall or damage. Transportation vehicles should be equipped with corresponding varieties and quantities of fire equipment and leakage emergency treatment equipment. Summer transportation should be carried out in the morning and evening to avoid high temperature periods, because high temperature will increase the volatility of substances and increase the risk factor. During transportation, it should be protected from exposure to the sun, rain and high temperature. When transporting by road, it should be driven according to the specified route, and do not stop in residential areas and densely populated areas, so as to avoid major casualties and property losses in case of accidents. When transporting by rail, it is also necessary to follow relevant regulations to ensure transportation safety. In short, when storing and transporting 1-chloro-2 - (trifluoromethoxy) benzene, it is necessary to act with caution and operate in strict accordance with regulations to ensure safety.
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