Linshang Chemical
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1-Chloro-2-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
557621 |
| Chemical Formula | C7H4ClF3 |
| Molar Mass | 180.55 g/mol |
| Appearance | Colorless liquid |
| Odor | Characteristic odor |
| Boiling Point | 142 - 144 °C |
| Density | 1.32 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents |
| Flash Point | 38 °C |
| Refractive Index | 1.436 (20 °C) |
As an accredited 1-Chloro-2-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 2 - (trifluoromethyl)benzene: Packaged in 500 - mL glass bottles, 10 bottles per carton. |
| Storage | 1 - Chloro - 2 - (trifluoromethyl)benzene should be stored in a cool, well - ventilated area, away from direct sunlight and heat sources. Keep it in a tightly - sealed container to prevent evaporation and leakage. Store it separately from oxidizing agents, strong acids, and bases to avoid potential chemical reactions. Ensure the storage location has proper spill - containment measures. |
| Shipping | 1 - chloro - 2 - (trifluoromethyl)benzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict hazardous chemical shipping regulations, ensuring secure transportation to prevent leakage and environmental risks. |
Competitive 1-Chloro-2-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 1-Chloro-2-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 1-chloro-2- (trifluoromethyl) benzene?
1-Chloro-2 - (trifluoromethyl) benzene, also known as o-chloro-trifluorotoluene, is a very important organic compound in the field of organic chemistry. Its main uses are wide and it plays a key role in many fields.
Bearing the brunt, in the field of pharmaceutical synthesis, this compound is an important intermediate. Due to its unique chemical structure, it contains chlorine atoms and trifluoromethyl groups, giving it specific physical and chemical properties. The construction of many drug molecules requires its participation in reactions to introduce key structural fragments, thereby endowing the drug with specific biological activities and pharmacological properties. For example, in the synthesis of some antibacterial drugs and antiviral drugs, 1-chloro-2 - (trifluoromethyl) benzene is often used as a starting material or key intermediate. Through a series of chemical reactions, complex drug molecular structures with therapeutic effects are gradually constructed.
Furthermore, in the field of pesticides, it is also an important synthetic raw material. The development of pesticides requires high efficiency, low toxicity and environmental friendliness. The special functional group of 1-chloro-2 - (trifluoromethyl) benzene can be used to synthesize a variety of high-efficiency pesticides. By reacting with other compounds, the resulting pesticides can exhibit excellent control effects on specific pests and pathogens. Such as the synthesis of some new insecticides and fungicides, the application of this compound can effectively improve the activity and selectivity of pesticides, reduce the impact on non-target organisms, and conform to the development trend of modern green pesticides.
In addition, in the field of materials science, 1-chloro-2 - (trifluoromethyl) benzene also has important applications. When synthesizing polymer materials with special properties, it can be introduced into the polymer chain as a functional monomer. In this way, the synthesized polymer materials can have special properties such as excellent corrosion resistance, weather resistance, and low surface energy. Such polymer materials are widely used in coatings, plastics and other fields, such as the preparation of high-performance anti-corrosion coatings, which can significantly improve the coating's resistance to harsh environments and prolong the service life of materials.
In summary, 1-chloro-2 - (trifluoromethyl) benzene, with its unique structure and properties, plays an indispensable role in the fields of medicine, pesticides and materials science, and is of great significance to promote the development of related industries.
Bearing the brunt, in the field of pharmaceutical synthesis, this compound is an important intermediate. Due to its unique chemical structure, it contains chlorine atoms and trifluoromethyl groups, giving it specific physical and chemical properties. The construction of many drug molecules requires its participation in reactions to introduce key structural fragments, thereby endowing the drug with specific biological activities and pharmacological properties. For example, in the synthesis of some antibacterial drugs and antiviral drugs, 1-chloro-2 - (trifluoromethyl) benzene is often used as a starting material or key intermediate. Through a series of chemical reactions, complex drug molecular structures with therapeutic effects are gradually constructed.
Furthermore, in the field of pesticides, it is also an important synthetic raw material. The development of pesticides requires high efficiency, low toxicity and environmental friendliness. The special functional group of 1-chloro-2 - (trifluoromethyl) benzene can be used to synthesize a variety of high-efficiency pesticides. By reacting with other compounds, the resulting pesticides can exhibit excellent control effects on specific pests and pathogens. Such as the synthesis of some new insecticides and fungicides, the application of this compound can effectively improve the activity and selectivity of pesticides, reduce the impact on non-target organisms, and conform to the development trend of modern green pesticides.
In addition, in the field of materials science, 1-chloro-2 - (trifluoromethyl) benzene also has important applications. When synthesizing polymer materials with special properties, it can be introduced into the polymer chain as a functional monomer. In this way, the synthesized polymer materials can have special properties such as excellent corrosion resistance, weather resistance, and low surface energy. Such polymer materials are widely used in coatings, plastics and other fields, such as the preparation of high-performance anti-corrosion coatings, which can significantly improve the coating's resistance to harsh environments and prolong the service life of materials.
In summary, 1-chloro-2 - (trifluoromethyl) benzene, with its unique structure and properties, plays an indispensable role in the fields of medicine, pesticides and materials science, and is of great significance to promote the development of related industries.
What are the physical properties of 1-chloro-2- (trifluoromethyl) benzene
1 - chloro - 2 - (trifluoromethyl) benzene is an organic compound, often referred to as o-chlorotrifluorotoluene. Its physical properties are unique and worthy of careful investigation.
Looking at its properties, under normal temperature and pressure, this substance is in the state of a colorless to light yellow transparent liquid, with a clear appearance and no visible impurities. Its smell is special and irritating. It can be smelled, but it should not be smelled close to it for too long to prevent damage to the body.
When it comes to boiling point, it is about 152 - 153 ° C. The value of this boiling point indicates that in the normal pressure environment, when the temperature rises to 152 - 153 ° C, 1 - chloro - 2 - (trifluoromethyl) benzene will change from liquid state to gaseous state. This boiling point property is of great significance when separating and purifying this compound. In related chemical processes, it can be used to achieve effective separation from other substances with different boiling points.
In addition, the melting point is about -35 ° C. This melting point indicates that in an environment below -35 ° C, 1-chloro-2 - (trifluoromethyl) benzene will condense into a solid state. Knowing the melting point is crucial for storing and transporting this substance. It is necessary to ensure that the temperature is higher than the melting point to prevent it from solidifying and affecting subsequent use.
Its density is about 1.33 g/cm ³, which is heavier than water. If mixed with water, it will sink to the bottom of the water. This property needs to be taken into account when dealing with operations such as liquid-liquid separation.
In terms of solubility, 1-chloro-2- (trifluoromethyl) benzene is insoluble in water, but it can be well miscible with many organic solvents, such as ethanol, ether, acetone, etc. This solubility characteristic makes it possible to select suitable organic solvents according to the needs of the reaction in organic synthesis to provide a good medium environment for the reaction and promote the smooth progress of the reaction.
In addition, the vapor pressure of 1-chloro-2- (trifluoromethyl) benzene has a corresponding value at a specific temperature, and the vapor pressure is related to its volatilization degree in the air. At a certain temperature, the higher the vapor pressure, the stronger the tendency of the substance to volatilize into the air. This needs to be paid attention to during storage and use to prevent excessive volatilization, which may not only cause material loss, but also lead to safety and environmental problems.
In short, the many physical properties of 1-chloro-2 - (trifluoromethyl) benzene play an important role in many fields such as organic synthesis, chemical production, storage and transportation. Only by accurately grasping it can this compound be better applied.
Looking at its properties, under normal temperature and pressure, this substance is in the state of a colorless to light yellow transparent liquid, with a clear appearance and no visible impurities. Its smell is special and irritating. It can be smelled, but it should not be smelled close to it for too long to prevent damage to the body.
When it comes to boiling point, it is about 152 - 153 ° C. The value of this boiling point indicates that in the normal pressure environment, when the temperature rises to 152 - 153 ° C, 1 - chloro - 2 - (trifluoromethyl) benzene will change from liquid state to gaseous state. This boiling point property is of great significance when separating and purifying this compound. In related chemical processes, it can be used to achieve effective separation from other substances with different boiling points.
In addition, the melting point is about -35 ° C. This melting point indicates that in an environment below -35 ° C, 1-chloro-2 - (trifluoromethyl) benzene will condense into a solid state. Knowing the melting point is crucial for storing and transporting this substance. It is necessary to ensure that the temperature is higher than the melting point to prevent it from solidifying and affecting subsequent use.
Its density is about 1.33 g/cm ³, which is heavier than water. If mixed with water, it will sink to the bottom of the water. This property needs to be taken into account when dealing with operations such as liquid-liquid separation.
In terms of solubility, 1-chloro-2- (trifluoromethyl) benzene is insoluble in water, but it can be well miscible with many organic solvents, such as ethanol, ether, acetone, etc. This solubility characteristic makes it possible to select suitable organic solvents according to the needs of the reaction in organic synthesis to provide a good medium environment for the reaction and promote the smooth progress of the reaction.
In addition, the vapor pressure of 1-chloro-2- (trifluoromethyl) benzene has a corresponding value at a specific temperature, and the vapor pressure is related to its volatilization degree in the air. At a certain temperature, the higher the vapor pressure, the stronger the tendency of the substance to volatilize into the air. This needs to be paid attention to during storage and use to prevent excessive volatilization, which may not only cause material loss, but also lead to safety and environmental problems.
In short, the many physical properties of 1-chloro-2 - (trifluoromethyl) benzene play an important role in many fields such as organic synthesis, chemical production, storage and transportation. Only by accurately grasping it can this compound be better applied.
What are the chemical properties of 1-chloro-2- (trifluoromethyl) benzene?
1-Chloro-2 - (trifluoromethyl) benzene has unique chemical properties and is of great research value in the field of organic chemistry.
In this compound, the chlorine atom is connected to the benzene ring containing trifluoromethyl, and the structure endows it with special reactivity. As for the electrophilic substitution reaction, due to the strong electron absorption of trifluoromethyl, the electron cloud density of the benzene ring decreases, and the electrophilic substitution reaction activity decreases compared with benzene. The positioning effect shows that trifluoromethyl is the meta-site group, and the chlorine atom is the o and para-site group. Under the combined action of the two, the new electrophilic substitution reaction mainly occurs in the meta (relative to trifluoromethyl).
In the nucleophilic substitution However, due to the conjugation effect of the benzene ring, the carbon-chlorine bond has some double bond properties, and the ability of chlorine atoms to leave is weakened compared with aliphatic halogenated hydrocarbons. Usually, more violent reaction conditions are required before nucleophilic substitution can occur. For example, under high temperature, strong alkali and other conditions, chlorine atoms can be replaced by nucleophiles to generate corresponding replacement products.
From the perspective of redox properties, the compound is relatively stable and is not easy to be oxidized by general oxidants. However, under certain strong oxidation conditions, the benzene ring may be oxidized to open the ring, or the side chain of trifluoromethyl may undergo oxidation reactions to form fluorine-containing carboxylic acid derivatives.
The chemical properties of 1-chloro-2 - (trifluoromethyl) benzene are determined by its unique structure. It can be used as an important intermediate in organic synthesis, and various organic compounds can be constructed through different reaction paths. It has potential applications in pharmaceutical chemistry, materials science and other fields.
In this compound, the chlorine atom is connected to the benzene ring containing trifluoromethyl, and the structure endows it with special reactivity. As for the electrophilic substitution reaction, due to the strong electron absorption of trifluoromethyl, the electron cloud density of the benzene ring decreases, and the electrophilic substitution reaction activity decreases compared with benzene. The positioning effect shows that trifluoromethyl is the meta-site group, and the chlorine atom is the o and para-site group. Under the combined action of the two, the new electrophilic substitution reaction mainly occurs in the meta (relative to trifluoromethyl).
In the nucleophilic substitution However, due to the conjugation effect of the benzene ring, the carbon-chlorine bond has some double bond properties, and the ability of chlorine atoms to leave is weakened compared with aliphatic halogenated hydrocarbons. Usually, more violent reaction conditions are required before nucleophilic substitution can occur. For example, under high temperature, strong alkali and other conditions, chlorine atoms can be replaced by nucleophiles to generate corresponding replacement products.
From the perspective of redox properties, the compound is relatively stable and is not easy to be oxidized by general oxidants. However, under certain strong oxidation conditions, the benzene ring may be oxidized to open the ring, or the side chain of trifluoromethyl may undergo oxidation reactions to form fluorine-containing carboxylic acid derivatives.
The chemical properties of 1-chloro-2 - (trifluoromethyl) benzene are determined by its unique structure. It can be used as an important intermediate in organic synthesis, and various organic compounds can be constructed through different reaction paths. It has potential applications in pharmaceutical chemistry, materials science and other fields.
What are the preparation methods of 1-chloro-2- (trifluoromethyl) benzene
1-Chloro-2 - (trifluoromethyl) benzene is also an organic compound. The method of its preparation has been explored by many predecessors. Today, the number of important ones is recorded for study.
First, take o (trifluoromethyl) benzoic acid as the starting material, and first make it co-heat with sulfoxide chloride. Sulfoxide chloride has strong chlorination power. When the two are heated, the carboxyl group of benzoic acid reacts with sulfoxide chloride, and the carboxyl group is converted into an acyl chloride group to obtain o (trifluoromethyl) benzoyl chloride. This reaction needs to be carried out at an appropriate temperature and reaction time to preserve the yield. Then, o (trifluoromethyl) benzoyl chloride is treated with zinc-amalgam and concentrated hydrochloric acid. After the Clemson reduction reaction, the acyl chloride group obtains hydrogen and is converted into methyl group, and the ortho-position of the methyl group introduces chlorine atoms, and finally obtains 1-chloro-2- (trifluoromethyl) benzene. In this way, it is necessary to pay attention to the dosage of zinc-amalgam and the concentration of concentrated hydrochloric acid, which are all related to the success or failure of the reaction.
Second, the starting substance of o-chlorotoluene is to interact with the trifluoromethylation reagent in the presence of a specific catalyst. There are many trifluoromethylation reagents, and the one suitable for it is selected, such as sodium trifluorome The purpose of this reaction is to introduce trifluoromethyl into the benzene ring of o-chlorotoluene, and mainly locate in the ortho position of the chlorine atom to obtain 1-chloro-2 - (trifluoromethyl) benzene. However, in this process, the choice of catalyst is the key, and different catalysts have a great influence on the activity and selectivity of the reaction. Many tests are required to find the best one.
Third, 2-bromo-1-chlorobenzene is reacted with trifluoromethyl copper reagent. The bromine atom in 2-bromo-1-chlorobenzene has high activity, and the trifluoromethyl anion in the trifluoromethyl copper reagent can undergo nucleophilic substitution reaction with it, and the bromine atom leaves, and the trifluoromethyl replaces it to generate 1-chloro-2 - (trifluoromethyl) benzene. This reaction needs to be carried out in an anhydrous and oxygen-free environment to avoid side reactions, and the preparation of the trifluoromethyl copper reagent needs to be carefully handled to ensure its purity and activity.
All of the above preparation methods have their own advantages and disadvantages. Experimenters should choose carefully according to their own conditions and needs, and carefully consider the availability of raw materials, the difficulty of reaction, the yield, and the impact on the environment.
First, take o (trifluoromethyl) benzoic acid as the starting material, and first make it co-heat with sulfoxide chloride. Sulfoxide chloride has strong chlorination power. When the two are heated, the carboxyl group of benzoic acid reacts with sulfoxide chloride, and the carboxyl group is converted into an acyl chloride group to obtain o (trifluoromethyl) benzoyl chloride. This reaction needs to be carried out at an appropriate temperature and reaction time to preserve the yield. Then, o (trifluoromethyl) benzoyl chloride is treated with zinc-amalgam and concentrated hydrochloric acid. After the Clemson reduction reaction, the acyl chloride group obtains hydrogen and is converted into methyl group, and the ortho-position of the methyl group introduces chlorine atoms, and finally obtains 1-chloro-2- (trifluoromethyl) benzene. In this way, it is necessary to pay attention to the dosage of zinc-amalgam and the concentration of concentrated hydrochloric acid, which are all related to the success or failure of the reaction.
Second, the starting substance of o-chlorotoluene is to interact with the trifluoromethylation reagent in the presence of a specific catalyst. There are many trifluoromethylation reagents, and the one suitable for it is selected, such as sodium trifluorome The purpose of this reaction is to introduce trifluoromethyl into the benzene ring of o-chlorotoluene, and mainly locate in the ortho position of the chlorine atom to obtain 1-chloro-2 - (trifluoromethyl) benzene. However, in this process, the choice of catalyst is the key, and different catalysts have a great influence on the activity and selectivity of the reaction. Many tests are required to find the best one.
Third, 2-bromo-1-chlorobenzene is reacted with trifluoromethyl copper reagent. The bromine atom in 2-bromo-1-chlorobenzene has high activity, and the trifluoromethyl anion in the trifluoromethyl copper reagent can undergo nucleophilic substitution reaction with it, and the bromine atom leaves, and the trifluoromethyl replaces it to generate 1-chloro-2 - (trifluoromethyl) benzene. This reaction needs to be carried out in an anhydrous and oxygen-free environment to avoid side reactions, and the preparation of the trifluoromethyl copper reagent needs to be carefully handled to ensure its purity and activity.
All of the above preparation methods have their own advantages and disadvantages. Experimenters should choose carefully according to their own conditions and needs, and carefully consider the availability of raw materials, the difficulty of reaction, the yield, and the impact on the environment.
What are the precautions for using 1-chloro-2- (trifluoromethyl) benzene?
For 1-chloro-2- (trifluoromethyl) benzene, all precautions need to be paid attention to when using it.
This substance has certain toxicity and is related to personal safety, so it must be treated with caution. When operating, be prepared with protective equipment, such as gas masks, protective gloves and protective clothing, etc., to prevent its harm. Because it may invade the human body through the respiratory tract and skin, it is harmful to health, and must not be negligent.
Furthermore, 1-chloro-2- (trifluoromethyl) benzene is flammable and explodes in case of open flame, hot topic or combustion. Therefore, the site of use should prevent fire sources and properly control electrical equipment to prevent electric sparks from causing accidents. And the site needs to be well ventilated to reduce its concentration in the air to avoid its accumulation to the dangerous limit.
In addition, this substance is also harmful to the environment. During use, waste must not be discarded at will, and must be properly disposed of in accordance with relevant regulations to prevent pollution of soil and water sources.
Storage should be placed in a cool and ventilated warehouse, away from fire and heat sources, and the warehouse temperature should not be too high. And it should be stored separately from oxidants and food chemicals, and mixed storage should not be avoided.
Use 1-chloro-2- (trifluoromethyl) benzene, be sure to be familiar with various characteristics, strictly abide by operating procedures, and pay attention to safety and environmental protection, in order to achieve the expected effect and avoid the risk of accidents.
This substance has certain toxicity and is related to personal safety, so it must be treated with caution. When operating, be prepared with protective equipment, such as gas masks, protective gloves and protective clothing, etc., to prevent its harm. Because it may invade the human body through the respiratory tract and skin, it is harmful to health, and must not be negligent.
Furthermore, 1-chloro-2- (trifluoromethyl) benzene is flammable and explodes in case of open flame, hot topic or combustion. Therefore, the site of use should prevent fire sources and properly control electrical equipment to prevent electric sparks from causing accidents. And the site needs to be well ventilated to reduce its concentration in the air to avoid its accumulation to the dangerous limit.
In addition, this substance is also harmful to the environment. During use, waste must not be discarded at will, and must be properly disposed of in accordance with relevant regulations to prevent pollution of soil and water sources.
Storage should be placed in a cool and ventilated warehouse, away from fire and heat sources, and the warehouse temperature should not be too high. And it should be stored separately from oxidants and food chemicals, and mixed storage should not be avoided.
Use 1-chloro-2- (trifluoromethyl) benzene, be sure to be familiar with various characteristics, strictly abide by operating procedures, and pay attention to safety and environmental protection, in order to achieve the expected effect and avoid the risk of accidents.
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