Linshang Chemical
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1-Chloro-3-(4-Chlorophenoxy)-Benzene
Linshang Chemical
|
HS Code |
463581 |
| Chemical Formula | C12H8Cl2O |
| Molecular Weight | 241.1 |
| Appearance | Solid |
As an accredited 1-Chloro-3-(4-Chlorophenoxy)-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 3 - (4 - chlorophenoxy) - benzene in 500 - gram bottles for packaging. |
| Storage | 1 - chloro - 3 - (4 - chlorophenoxy) benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. It should be kept in a tightly sealed container to prevent leakage. Store it separately from oxidizing agents, reducing agents, and incompatible substances to avoid chemical reactions. |
| Shipping | 1 - chloro - 3 - (4 - chlorophenoxy) - benzene is shipped in sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, with proper labeling for safe and compliant transportation. |
Competitive 1-Chloro-3-(4-Chlorophenoxy)-Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 1-chloro-3- (4-chlorophenoxy) -benzene?
1-Chloro-3- (4-chlorophenoxy) benzene, this is an organic compound. In terms of physical properties, it is mostly liquid at room temperature, with a clear and transparent appearance. However, the specific properties will vary depending on the purity. Its melting point and boiling point are determined by the intermolecular force and structure. Due to the close connection of atoms in the molecule, the force is quite strong, resulting in a relatively high boiling point and can be gasified at higher temperatures.
In terms of chemical properties, chlorine atoms and phenoxy groups are the key activity check points. Chlorine atoms on the benzene ring can participate in nucleophilic substitution reactions. Because chlorine atoms have certain electronegativity, the density distribution of electron clouds in the benzene ring changes, and electron-rich reagents can attack the benzene ring, and chlorine atoms are replaced. For example, when reacting with sodium alcohol under suitable conditions, chlorine atoms can be replaced by alkoxy groups to form corresponding ether compounds.
The oxygen atoms in the phenoxy group have lone pairs of electrons, so that the phenoxy group has a certain nucleophilicity and can react with electrophilic reagents such as halogenated hydrocarbons to form new carbon-oxygen bonds. At the same time, the benzene ring of the compound can undergo electrophilic substitution reactions. Because of its electron-rich properties, it is easily attacked by electrophilic reagents. For example, under the action of a catalyst, bromine reacts with bromine and introduces bromine atoms into the benzene ring. In addition, the compound is relatively stable, but in case of extreme conditions such as strong oxidizing agents or high temperatures, its structure will also be destroyed, triggering complex reactions such as oxidation.
In terms of chemical properties, chlorine atoms and phenoxy groups are the key activity check points. Chlorine atoms on the benzene ring can participate in nucleophilic substitution reactions. Because chlorine atoms have certain electronegativity, the density distribution of electron clouds in the benzene ring changes, and electron-rich reagents can attack the benzene ring, and chlorine atoms are replaced. For example, when reacting with sodium alcohol under suitable conditions, chlorine atoms can be replaced by alkoxy groups to form corresponding ether compounds.
The oxygen atoms in the phenoxy group have lone pairs of electrons, so that the phenoxy group has a certain nucleophilicity and can react with electrophilic reagents such as halogenated hydrocarbons to form new carbon-oxygen bonds. At the same time, the benzene ring of the compound can undergo electrophilic substitution reactions. Because of its electron-rich properties, it is easily attacked by electrophilic reagents. For example, under the action of a catalyst, bromine reacts with bromine and introduces bromine atoms into the benzene ring. In addition, the compound is relatively stable, but in case of extreme conditions such as strong oxidizing agents or high temperatures, its structure will also be destroyed, triggering complex reactions such as oxidation.
What are the physical properties of 1-chloro-3- (4-chlorophenoxy) -benzene?
1 - chloro - 3 - (4 - chlorophenoxy) - benzene, this is an organic compound, often referred to as p-chlorophenoxy-m-chlorobenzene. Its physical properties are quite important, and the application of this compound in different scenarios is described as follows:
1. ** Properties **: Under normal conditions, p-chlorophenoxy-m-chlorobenzene is mostly colorless to light yellow liquid, and it is clear and transparent. This property makes it easy to observe and operate in specific reactions or mixed systems, and also facilitates its application in some industrial processes.
2. ** Melting point and boiling point **: The melting point is about -20 ° C, and the boiling point is in the range of 280-290 ° C. The lower melting point causes it to exist as a liquid at room temperature, while the higher boiling point indicates that it has good thermal stability and is not volatile at high temperatures. It can maintain its own structure and properties in chemical reactions or industrial processes that require heating.
3. ** Density **: The density is about 1.28 - 1.32 g/cm ³, which is heavier than water. This property is of great significance in chemical processes involving liquid-liquid separation. It can be separated from water or other low-density liquids by density difference to achieve purification or separation goals.
4. ** Solubility **: Slightly soluble in water, but soluble in various organic solvents such as ethanol, ether, acetone, etc. The characteristics of slight solubility in water require special means to treat wastewater containing this compound; and good organic solvent solubility lays the foundation for it to be used as a reaction medium or participate in organic synthesis reactions, because many organic reactions need to be carried out efficiently in organic solvents.
5. ** Odor **: has a special aromatic odor. However, this odor may bring discomfort to the working environment, long-term exposure or endanger human health. Proper ventilation and protective measures should be taken during use and storage.
6. ** Volatility **: The volatility is relatively low, and the volatilization rate is slow at room temperature and pressure. This characteristic allows it to reduce losses due to volatilization and environmental pollution during storage and use, and also reduce safety risks such as fire and explosion.
1. ** Properties **: Under normal conditions, p-chlorophenoxy-m-chlorobenzene is mostly colorless to light yellow liquid, and it is clear and transparent. This property makes it easy to observe and operate in specific reactions or mixed systems, and also facilitates its application in some industrial processes.
2. ** Melting point and boiling point **: The melting point is about -20 ° C, and the boiling point is in the range of 280-290 ° C. The lower melting point causes it to exist as a liquid at room temperature, while the higher boiling point indicates that it has good thermal stability and is not volatile at high temperatures. It can maintain its own structure and properties in chemical reactions or industrial processes that require heating.
3. ** Density **: The density is about 1.28 - 1.32 g/cm ³, which is heavier than water. This property is of great significance in chemical processes involving liquid-liquid separation. It can be separated from water or other low-density liquids by density difference to achieve purification or separation goals.
4. ** Solubility **: Slightly soluble in water, but soluble in various organic solvents such as ethanol, ether, acetone, etc. The characteristics of slight solubility in water require special means to treat wastewater containing this compound; and good organic solvent solubility lays the foundation for it to be used as a reaction medium or participate in organic synthesis reactions, because many organic reactions need to be carried out efficiently in organic solvents.
5. ** Odor **: has a special aromatic odor. However, this odor may bring discomfort to the working environment, long-term exposure or endanger human health. Proper ventilation and protective measures should be taken during use and storage.
6. ** Volatility **: The volatility is relatively low, and the volatilization rate is slow at room temperature and pressure. This characteristic allows it to reduce losses due to volatilization and environmental pollution during storage and use, and also reduce safety risks such as fire and explosion.
What is the main use of 1-chloro-3- (4-chlorophenoxy) -benzene?
1-Chloro-3- (4-chlorophenoxy) benzene, this is an organic compound. It has a wide range of uses and plays an important role in both industrial and scientific research fields.
In industry, it is often used as an intermediate in the synthesis of many organic materials. For example, by specific chemical reactions, it can be converted into high-molecular polymers with excellent properties. These polymers can be used in the production of plastic products to provide better mechanical properties and chemical stability, such as for the manufacture of durable pipes, sheets, etc. Furthermore, it is also used in the synthesis of various fine chemicals, such as special coatings, fragrances, etc. Taking coatings as an example, coatings based on the synthesis of 1-chloro-3- (4-chlorophenoxy) benzene may have excellent weather resistance and corrosion resistance, and can be used to protect metal surfaces, building exteriors, etc.
In the field of scientific research, it is an important chemical reagent. Chemists can explore novel organic synthesis methods and reaction mechanisms by studying its structure modification and reaction. In addition, it may play a key role in drug development. Due to its specific chemical structure, it may be used as a lead compound. After further structural optimization and activity screening, it is expected to develop new drugs with specific pharmacological activities for the treatment of various diseases.
In conclusion, 1-chloro-3- (4-chlorophenoxy) benzene plays an indispensable role in industrial production and scientific research, promoting the development and progress of related fields.
In industry, it is often used as an intermediate in the synthesis of many organic materials. For example, by specific chemical reactions, it can be converted into high-molecular polymers with excellent properties. These polymers can be used in the production of plastic products to provide better mechanical properties and chemical stability, such as for the manufacture of durable pipes, sheets, etc. Furthermore, it is also used in the synthesis of various fine chemicals, such as special coatings, fragrances, etc. Taking coatings as an example, coatings based on the synthesis of 1-chloro-3- (4-chlorophenoxy) benzene may have excellent weather resistance and corrosion resistance, and can be used to protect metal surfaces, building exteriors, etc.
In the field of scientific research, it is an important chemical reagent. Chemists can explore novel organic synthesis methods and reaction mechanisms by studying its structure modification and reaction. In addition, it may play a key role in drug development. Due to its specific chemical structure, it may be used as a lead compound. After further structural optimization and activity screening, it is expected to develop new drugs with specific pharmacological activities for the treatment of various diseases.
In conclusion, 1-chloro-3- (4-chlorophenoxy) benzene plays an indispensable role in industrial production and scientific research, promoting the development and progress of related fields.
What is the synthesis method of 1-chloro-3- (4-chlorophenoxy) -benzene?
The synthesis of 1-chloro-3- (4-chlorophenoxy) benzene is an important task in organic synthesis. The method follows a number of paths, which are described in detail below.
First, the nucleophilic substitution reaction can be carried out by m-chlorophenol and p-chlorohalobenzene under the catalysis of base. Prepare m-chlorophenol first, add an appropriate amount of base, such as potassium carbonate or sodium hydroxide, to deprotonate the phenolic hydroxyl group and form phenoxy negative ions. This negative ion has strong nucleophilicity. At the same time, take p-chlorohalogenated benzene, such as p-chlorobromobenzene or p-chloroiodobenzene, the halogen atom can be attacked by phenoxy negative ions, and the nucleophilic substitution, the halogen atom leaves to obtain the target product 1-chloro-3- (4-chlorophenoxy) benzene. This reaction requires appropriate temperature and appropriate solvents, such as N, N-dimethylformamide (DMF) or dimethyl sulfoxide (DMSO), to facilitate the reaction.
Second, m-chloroaniline can also be used as the starting material. First, through diazotization, m-chloroaniline reacts with sodium nitrite in an acidic medium at low temperature to obtain m-chloro diazonium salt. This diazonium salt is unstable and needs to react with p-chlorophenol immediately. The diazonium group is replaced by p-chlorophenoxy. After a series of transformations, 1-chloro-3- (4-chlorophenoxy) benzene can be obtained. This approach requires precise temperature control and reaction conditions to prevent the decomposition of diazonium salts.
Or an intermediate containing m-chlorophenoxy can be synthesized first, and then a 4-chloro substituent can be introduced. For example, m-chlorobromobenzene reacts with phenol under alkali catalysis to obtain m-phenoxy bromobenzene. After nucleophilic substitution of halogen atoms, 4-chlorine atoms are introduced, and the final target compound is obtained.
All these methods have advantages and disadvantages. The nucleophilic substitution method is easy to obtain and the operation is simple; although the diazotization method is a little complicated, the selectivity is good. During synthesis, the method should be carefully selected according to the requirements of raw material availability, cost, yield and purity, so as to achieve the purpose of efficient synthesis of 1-chloro-3- (4-chlorophenoxy) benzene.
First, the nucleophilic substitution reaction can be carried out by m-chlorophenol and p-chlorohalobenzene under the catalysis of base. Prepare m-chlorophenol first, add an appropriate amount of base, such as potassium carbonate or sodium hydroxide, to deprotonate the phenolic hydroxyl group and form phenoxy negative ions. This negative ion has strong nucleophilicity. At the same time, take p-chlorohalogenated benzene, such as p-chlorobromobenzene or p-chloroiodobenzene, the halogen atom can be attacked by phenoxy negative ions, and the nucleophilic substitution, the halogen atom leaves to obtain the target product 1-chloro-3- (4-chlorophenoxy) benzene. This reaction requires appropriate temperature and appropriate solvents, such as N, N-dimethylformamide (DMF) or dimethyl sulfoxide (DMSO), to facilitate the reaction.
Second, m-chloroaniline can also be used as the starting material. First, through diazotization, m-chloroaniline reacts with sodium nitrite in an acidic medium at low temperature to obtain m-chloro diazonium salt. This diazonium salt is unstable and needs to react with p-chlorophenol immediately. The diazonium group is replaced by p-chlorophenoxy. After a series of transformations, 1-chloro-3- (4-chlorophenoxy) benzene can be obtained. This approach requires precise temperature control and reaction conditions to prevent the decomposition of diazonium salts.
Or an intermediate containing m-chlorophenoxy can be synthesized first, and then a 4-chloro substituent can be introduced. For example, m-chlorobromobenzene reacts with phenol under alkali catalysis to obtain m-phenoxy bromobenzene. After nucleophilic substitution of halogen atoms, 4-chlorine atoms are introduced, and the final target compound is obtained.
All these methods have advantages and disadvantages. The nucleophilic substitution method is easy to obtain and the operation is simple; although the diazotization method is a little complicated, the selectivity is good. During synthesis, the method should be carefully selected according to the requirements of raw material availability, cost, yield and purity, so as to achieve the purpose of efficient synthesis of 1-chloro-3- (4-chlorophenoxy) benzene.
What are the precautions for using 1-chloro-3- (4-chlorophenoxy) -benzene?
1-Chloro-3- (4-chlorophenoxy) benzene, this is an organic compound, and many matters need to be paid attention to during use.
First, safety protection is the key. This compound has certain toxicity and irritation, and protective equipment must be fully worn during operation. If wearing protective gloves, avoid direct contact with the skin to prevent skin allergies, redness, swelling, itching and even burns and other symptoms; wear protective glasses to protect the eyes from its damage. If it is not carefully entered, it may cause serious consequences such as eye pain, tears, and blurred vision; wear a gas mask to prevent inhalation of its volatile gases, so as not to cause damage to the respiratory tract and cause cough, asthma, breathing difficulties and other conditions.
Second, the storage conditions should not be ignored. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Because of its flammability, it is easy to cause combustion hazards in case of open flames and hot topics. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., to avoid chemical reactions and dangerous accidents.
Third, during use, the operating specifications must be strictly followed. Operate in the fume hood to ensure that volatile gases can be discharged in time, reduce the concentration in the air, and reduce the harm to the human body. Precisely control the amount of use to avoid waste and excessive use causing environmental pollution. After use, the remaining compounds and related appliances need to be properly handled and cleaned to prevent residual substances from causing pollution.
Fourth, the transportation process is also treated with caution. Choose appropriate packaging materials to ensure good sealing and prevent leakage. During transportation, avoid violent vibration, collision and high temperature environment to prevent packaging damage from causing danger.
In short, when using 1-chloro-3- (4-chlorophenoxy) benzene, the above matters need to be carefully considered and must not be taken lightly, so as to ensure the safety of personnel and the environment from pollution.
First, safety protection is the key. This compound has certain toxicity and irritation, and protective equipment must be fully worn during operation. If wearing protective gloves, avoid direct contact with the skin to prevent skin allergies, redness, swelling, itching and even burns and other symptoms; wear protective glasses to protect the eyes from its damage. If it is not carefully entered, it may cause serious consequences such as eye pain, tears, and blurred vision; wear a gas mask to prevent inhalation of its volatile gases, so as not to cause damage to the respiratory tract and cause cough, asthma, breathing difficulties and other conditions.
Second, the storage conditions should not be ignored. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Because of its flammability, it is easy to cause combustion hazards in case of open flames and hot topics. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., to avoid chemical reactions and dangerous accidents.
Third, during use, the operating specifications must be strictly followed. Operate in the fume hood to ensure that volatile gases can be discharged in time, reduce the concentration in the air, and reduce the harm to the human body. Precisely control the amount of use to avoid waste and excessive use causing environmental pollution. After use, the remaining compounds and related appliances need to be properly handled and cleaned to prevent residual substances from causing pollution.
Fourth, the transportation process is also treated with caution. Choose appropriate packaging materials to ensure good sealing and prevent leakage. During transportation, avoid violent vibration, collision and high temperature environment to prevent packaging damage from causing danger.
In short, when using 1-chloro-3- (4-chlorophenoxy) benzene, the above matters need to be carefully considered and must not be taken lightly, so as to ensure the safety of personnel and the environment from pollution.
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