Linshang Chemical
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1-Chloro-3,4-Dibromo-5-Fluorobenzene
Linshang Chemical
|
HS Code |
153586 |
| Chemical Formula | C6H2Br2ClF |
| Molar Mass | 292.34 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Approx. 220 - 230 °C |
| Solubility In Water | Insoluble (organic halide, non - polar) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Vapor Pressure | Low (as it is a relatively high - boiling liquid) |
As an accredited 1-Chloro-3,4-Dibromo-5-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 3,4 - dibromo - 5 - fluorobenzene in 100 - gram bottles for chemical packaging. |
| Storage | 1 - Chloro - 3,4 - dibromo - 5 - fluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and incompatible substances like strong oxidizers. Store it in a tightly sealed container to prevent leakage and vapor release. Label the container clearly for easy identification and safety compliance. |
| Shipping | 1 - Chloro - 3,4 - dibromo - 5 - fluorobenzene is a chemical. Shipping requires proper packaging in sealed, corrosion - resistant containers. It must comply with hazardous material regulations, labeled clearly for safe transport. |
Competitive 1-Chloro-3,4-Dibromo-5-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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1-Chloro-3, what are the chemical properties of 4-dibromo-5-fluorobenzene
1-Chloro-3,4-dibromo-5-fluorobenzene is one of the organohalogenated aromatic hydrocarbons. Its unique chemical properties are derived from its halogen atoms.
The first part of its nucleophilic substitution reaction is one of its important properties. Edge chlorine, bromine and fluorine atoms all have electron-absorbing properties, which reduce the electron cloud density of the benzene ring, especially the electron cloud density of the ortho-para-position. Therefore, nucleophiles are prone to attack the benzene ring and replace the halogen atom. For example, when an aqueous sodium hydroxide solution is used as a nucleophilic reagent, the hydroxyl group can replace the chlorine atom under heating conditions to form the corresponding phenolic compound. The reaction mechanism is that the lone pair electron of the nucleophilic reagent attacks the benzene ring, and the halogen atom leaves through the transition state of the intermediate, and finally forms the replacement product.
Furthermore, this compound can participate in the electrophilic substitution reaction. Although the halogen atom is an ortho-para locator, its electron-absorbing properties will make the electrophilic substitution reaction of the benzene ring lower than that of benzene. However, under appropriate conditions, it can still occur. If iron bromide is used as a catalyst and reacts with bromine, the positive ion of bromine will attack the benzene ring and replace it at a position with a relatively high electron cloud density. Usually, due to steric resistance and electronic effects, the substituent tends to enter the ortho-para-position of the halogen atom to form poly
Because it contains multiple halogen atoms, it can participate in metal-catalyzed coupling reactions. For example, under palladium catalysis, Suzuki coupling reaction with organic boric acid can form new carbon-carbon bonds and construct more complex organic molecular structures. This reaction is of great significance for organic synthesis chemistry and can be used to prepare key intermediates in the fields of drugs and materials.
In addition, the chemical properties of 1-chloro-3,4-dibromo-5-fluorobenzene are also affected by the type and location of halogen atoms. The departure ability of different halogen atoms is different. Although fluorine atoms have high electronegativity, their C-F bond energy is large and it is difficult to leave; while bromine and chlorine atoms leave relatively easily. This difference affects the reaction conditions and product selectivity in nucleophilic substitution and other reactions. At the same time, the different positions of halogen atoms will also change the electron cloud density distribution at each position of the benzene ring, which in turn affects the reaction activity and selectivity.
The first part of its nucleophilic substitution reaction is one of its important properties. Edge chlorine, bromine and fluorine atoms all have electron-absorbing properties, which reduce the electron cloud density of the benzene ring, especially the electron cloud density of the ortho-para-position. Therefore, nucleophiles are prone to attack the benzene ring and replace the halogen atom. For example, when an aqueous sodium hydroxide solution is used as a nucleophilic reagent, the hydroxyl group can replace the chlorine atom under heating conditions to form the corresponding phenolic compound. The reaction mechanism is that the lone pair electron of the nucleophilic reagent attacks the benzene ring, and the halogen atom leaves through the transition state of the intermediate, and finally forms the replacement product.
Furthermore, this compound can participate in the electrophilic substitution reaction. Although the halogen atom is an ortho-para locator, its electron-absorbing properties will make the electrophilic substitution reaction of the benzene ring lower than that of benzene. However, under appropriate conditions, it can still occur. If iron bromide is used as a catalyst and reacts with bromine, the positive ion of bromine will attack the benzene ring and replace it at a position with a relatively high electron cloud density. Usually, due to steric resistance and electronic effects, the substituent tends to enter the ortho-para-position of the halogen atom to form poly
Because it contains multiple halogen atoms, it can participate in metal-catalyzed coupling reactions. For example, under palladium catalysis, Suzuki coupling reaction with organic boric acid can form new carbon-carbon bonds and construct more complex organic molecular structures. This reaction is of great significance for organic synthesis chemistry and can be used to prepare key intermediates in the fields of drugs and materials.
In addition, the chemical properties of 1-chloro-3,4-dibromo-5-fluorobenzene are also affected by the type and location of halogen atoms. The departure ability of different halogen atoms is different. Although fluorine atoms have high electronegativity, their C-F bond energy is large and it is difficult to leave; while bromine and chlorine atoms leave relatively easily. This difference affects the reaction conditions and product selectivity in nucleophilic substitution and other reactions. At the same time, the different positions of halogen atoms will also change the electron cloud density distribution at each position of the benzene ring, which in turn affects the reaction activity and selectivity.
1-Chloro-3, what are the physical properties of 4-dibromo-5-fluorobenzene
1-Chloro-3,4-dibromo-5-fluorobenzene is also an organic compound. Its physical properties are worth exploring.
Looking at its phase state, it is mostly liquid at room temperature and pressure. This state of intermolecular force keeps it flowing under this condition. Its color is usually colorless to light yellow, like many halogenated aromatic hydrocarbons. When pure, it is colorless, but it may be slightly yellow due to impurities or light.
Smell it, it has a special aromatic smell, which is inherent in the structure of the benzene ring. However, the addition of halogen atoms makes it taste different from mono-pure benzene, and it has a special smell of halogenated substances.
When it comes to the boiling point, the boiling point is significantly higher than that of benzene due to the introduction of chlorine, bromine and fluorine atoms in the molecule, which increases the intermolecular force. Its exact boiling point value needs to be accurately determined according to experiments, but it is roughly tens of degrees Celsius higher than that of benzene. Due to the large electronegativity of halogen atoms, the polarity of molecules is enhanced. In addition to the van der Waals force, there is a dipole-dipole force between molecules, which makes the molecules bond more tightly and requires more energy for gasification.
The melting point is also affected by the halogen atom, which is higher than that of benzene. The distribution of halogen atoms at specific positions in the benzene ring affects the molecular lattice arrangement, making the molecular stacking more regular and tight, increasing the lattice energy
In terms of solubility, because it is a non-polar molecule, it has good solubility in organic solvents such as ether, dichloromethane, carbon tetrachloride, etc., and is miscible or easily soluble. This is based on the principle of "similar phase dissolution". Organic solvents are mostly non-polar or weakly polar, and have similar forces to 1-chloro-3,4-dibromo-5-fluorobenzene molecules, so they are well soluble. In water, because it is difficult to form hydrogen bonds with water molecules, and the polarity difference is large, the solubility is extremely low and almost insoluble. The density of
is higher than that of water. Due to the large atomic weight of halogen atoms, the molecular weight increases, and the molecular structure is compact, and the mass per unit volume increases. Therefore, in the coexistence system of water and this compound, it sinks to the bottom of the water.
Looking at its phase state, it is mostly liquid at room temperature and pressure. This state of intermolecular force keeps it flowing under this condition. Its color is usually colorless to light yellow, like many halogenated aromatic hydrocarbons. When pure, it is colorless, but it may be slightly yellow due to impurities or light.
Smell it, it has a special aromatic smell, which is inherent in the structure of the benzene ring. However, the addition of halogen atoms makes it taste different from mono-pure benzene, and it has a special smell of halogenated substances.
When it comes to the boiling point, the boiling point is significantly higher than that of benzene due to the introduction of chlorine, bromine and fluorine atoms in the molecule, which increases the intermolecular force. Its exact boiling point value needs to be accurately determined according to experiments, but it is roughly tens of degrees Celsius higher than that of benzene. Due to the large electronegativity of halogen atoms, the polarity of molecules is enhanced. In addition to the van der Waals force, there is a dipole-dipole force between molecules, which makes the molecules bond more tightly and requires more energy for gasification.
The melting point is also affected by the halogen atom, which is higher than that of benzene. The distribution of halogen atoms at specific positions in the benzene ring affects the molecular lattice arrangement, making the molecular stacking more regular and tight, increasing the lattice energy
In terms of solubility, because it is a non-polar molecule, it has good solubility in organic solvents such as ether, dichloromethane, carbon tetrachloride, etc., and is miscible or easily soluble. This is based on the principle of "similar phase dissolution". Organic solvents are mostly non-polar or weakly polar, and have similar forces to 1-chloro-3,4-dibromo-5-fluorobenzene molecules, so they are well soluble. In water, because it is difficult to form hydrogen bonds with water molecules, and the polarity difference is large, the solubility is extremely low and almost insoluble. The density of
is higher than that of water. Due to the large atomic weight of halogen atoms, the molecular weight increases, and the molecular structure is compact, and the mass per unit volume increases. Therefore, in the coexistence system of water and this compound, it sinks to the bottom of the water.
What are the common uses of 1-chloro-3, 4-dibromo-5-fluorobenzene
1-Chloro-3,4-dibromo-5-fluorobenzene is also an organic compound. Its common uses cover the following ends.
First, in the field of pharmaceutical chemistry, it is often used as an intermediary for the synthesis of drugs. Because of its unique structure, it has halogen atoms, which can be introduced into specific functional groups through various chemical reactions to form molecules with specific pharmacological activities. Taking the preparation of antibacterial drugs as an example, the activity of halogen atoms can be used to react with reagents containing heteroatoms such as nitrogen and oxygen to construct complex structures with antibacterial properties.
Second, in the field of materials science, or involved in the synthesis of organic optoelectronic materials. Because halogen atoms can affect the electron cloud distribution of molecules, thereby regulating the optical and electrical properties of materials. Or used to make organic Light Emitting Diode (OLED) materials, through rational molecular design, to improve their luminous efficiency and stability.
Third, it also has potential uses in pesticide chemistry. It can be used as a starting material for the synthesis of high-efficiency and low-toxicity pesticides. With the reactivity of halogen atoms, it can interact with various nucleophiles to synthesize compounds with insecticidal, bactericidal or herbicidal activities, escorting agricultural production.
Fourth, it is an important building block in the field of organic synthetic chemistry. Due to its structure containing different halogen atoms, halogen atoms can be selectively initiated to participate in the reaction according to different reaction conditions and reagents, and complex organic frameworks can be constructed, providing organic synthesis chemists with a variety of synthesis strategies and possibilities.
First, in the field of pharmaceutical chemistry, it is often used as an intermediary for the synthesis of drugs. Because of its unique structure, it has halogen atoms, which can be introduced into specific functional groups through various chemical reactions to form molecules with specific pharmacological activities. Taking the preparation of antibacterial drugs as an example, the activity of halogen atoms can be used to react with reagents containing heteroatoms such as nitrogen and oxygen to construct complex structures with antibacterial properties.
Second, in the field of materials science, or involved in the synthesis of organic optoelectronic materials. Because halogen atoms can affect the electron cloud distribution of molecules, thereby regulating the optical and electrical properties of materials. Or used to make organic Light Emitting Diode (OLED) materials, through rational molecular design, to improve their luminous efficiency and stability.
Third, it also has potential uses in pesticide chemistry. It can be used as a starting material for the synthesis of high-efficiency and low-toxicity pesticides. With the reactivity of halogen atoms, it can interact with various nucleophiles to synthesize compounds with insecticidal, bactericidal or herbicidal activities, escorting agricultural production.
Fourth, it is an important building block in the field of organic synthetic chemistry. Due to its structure containing different halogen atoms, halogen atoms can be selectively initiated to participate in the reaction according to different reaction conditions and reagents, and complex organic frameworks can be constructed, providing organic synthesis chemists with a variety of synthesis strategies and possibilities.
What is the synthesis method of 1-chloro-3, 4-dibromo-5-fluorobenzene
To prepare 1-chloro-3,4-dibromo-5-fluorobenzene, the method is as follows:
First take benzene as the starting material, use ferric chloride as the catalyst, and make it electrophilically substituted with chlorine to obtain chlorobenzene. In this step, the chlorine atom is an ortho-site group, and although ortho-site products are also formed, they can be separated by fractional distillation and other methods to obtain para-chlorobenzene.
Next, take chlorobenzene as the substrate and react with bromine in a suitable solvent under the catalysis of iron bromide. At this time, chlorine is an ortho-site group, and bromine preferentially enters the ortho-site of chlorine to obtain 3-bromo-4-chlorobenzene Due to steric hindrance and electronic effects, bromine is more inclined to enter a specific location and be separated and purified to obtain pure 3-bromo-4-chlorobenzene.
Then, 3-bromo-4-chlorobenzene is used as raw material, and special fluorine-containing reagents, such as Selectfluor, are used under suitable conditions for fluorination. This reagent has suitable activity, allowing fluorine atoms to replace hydrogen at a specific position on the benzene ring to obtain 1-chloro-3-bromo-5-fluorobenzene. After the reaction, the product is purified by extraction, drying, distillation and other processes.
Finally, 1-chloro-3-bromo-5-fluorobenzene is reacted with bromine to control the reaction conditions, such as temperature, catalyst dosage, etc. Due to the positioning effect of substituents on the benzene ring, bromine atoms will enter the designated position to generate 1-chloro-3,4-dibromo-5-fluorobenzene. Then a series of separation and purification operations, such as column chromatography, are performed to obtain a high-purity target product. Careful separation and identification are required after each step of the reaction to ensure the purity of the product and the desired direction of the reaction.
First take benzene as the starting material, use ferric chloride as the catalyst, and make it electrophilically substituted with chlorine to obtain chlorobenzene. In this step, the chlorine atom is an ortho-site group, and although ortho-site products are also formed, they can be separated by fractional distillation and other methods to obtain para-chlorobenzene.
Next, take chlorobenzene as the substrate and react with bromine in a suitable solvent under the catalysis of iron bromide. At this time, chlorine is an ortho-site group, and bromine preferentially enters the ortho-site of chlorine to obtain 3-bromo-4-chlorobenzene Due to steric hindrance and electronic effects, bromine is more inclined to enter a specific location and be separated and purified to obtain pure 3-bromo-4-chlorobenzene.
Then, 3-bromo-4-chlorobenzene is used as raw material, and special fluorine-containing reagents, such as Selectfluor, are used under suitable conditions for fluorination. This reagent has suitable activity, allowing fluorine atoms to replace hydrogen at a specific position on the benzene ring to obtain 1-chloro-3-bromo-5-fluorobenzene. After the reaction, the product is purified by extraction, drying, distillation and other processes.
Finally, 1-chloro-3-bromo-5-fluorobenzene is reacted with bromine to control the reaction conditions, such as temperature, catalyst dosage, etc. Due to the positioning effect of substituents on the benzene ring, bromine atoms will enter the designated position to generate 1-chloro-3,4-dibromo-5-fluorobenzene. Then a series of separation and purification operations, such as column chromatography, are performed to obtain a high-purity target product. Careful separation and identification are required after each step of the reaction to ensure the purity of the product and the desired direction of the reaction.
1-chloro-3, 4-dibromo-5-fluorobenzene what are the precautions during storage and transportation
1-Chloro-3,4-dibromo-5-fluorobenzene is also an organic compound. When storing and transporting, there are a number of important items to pay attention to.
Bear the brunt. When storing, it should be placed in a cool, dry and well-ventilated place. This compound is heat-resistant, and high temperature can easily cause changes in its properties, or even cause dangerous reactions. Therefore, it is necessary to avoid direct sunlight and stay away from heat and fire sources, just like the old saying "prevent problems before they occur". This is the main rule to ensure its safety.
Furthermore, because of its certain chemical activity, it should be separated from oxidants, reducing agents, alkalis and other substances. Just like soldiers in their positions, they should not be intrusive, otherwise, once they come into contact with each other, they may react violently and cause safety risks.
When transporting, the packaging must be sturdy and tight. Appropriate packaging materials must be selected in accordance with relevant regulations to enable them to withstand the bumps and vibrations during transportation without damage and leakage. And the transportation vehicle should also be clean and free of other residues that may react with it.
In addition, operators must wear appropriate protective equipment during storage and transportation. Such as wearing protective gloves, goggles, protective clothing, etc., this is to protect their own safety and to protect the compound from external factors.
In short, during the storage and transportation of 1-chloro-3,4-dibromo-5-fluorobenzene, care should be taken and scientific laws and regulations should be followed.
Bear the brunt. When storing, it should be placed in a cool, dry and well-ventilated place. This compound is heat-resistant, and high temperature can easily cause changes in its properties, or even cause dangerous reactions. Therefore, it is necessary to avoid direct sunlight and stay away from heat and fire sources, just like the old saying "prevent problems before they occur". This is the main rule to ensure its safety.
Furthermore, because of its certain chemical activity, it should be separated from oxidants, reducing agents, alkalis and other substances. Just like soldiers in their positions, they should not be intrusive, otherwise, once they come into contact with each other, they may react violently and cause safety risks.
When transporting, the packaging must be sturdy and tight. Appropriate packaging materials must be selected in accordance with relevant regulations to enable them to withstand the bumps and vibrations during transportation without damage and leakage. And the transportation vehicle should also be clean and free of other residues that may react with it.
In addition, operators must wear appropriate protective equipment during storage and transportation. Such as wearing protective gloves, goggles, protective clothing, etc., this is to protect their own safety and to protect the compound from external factors.
In short, during the storage and transportation of 1-chloro-3,4-dibromo-5-fluorobenzene, care should be taken and scientific laws and regulations should be followed.
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