1-Chloro-3,4-Difluoro-5-Nitrobenzene
Linshang Chemical
HS Code |
898419 |
Chemical Formula | C6H2ClF2NO2 |
Molar Mass | 195.536 g/mol |
Appearance | Solid (Typical description, actual may vary) |
Solubility In Water | Low (Aromatic nitro - halide compounds generally have low water solubility) |
Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform (Based on general properties of aromatic compounds) |
Vapor Pressure | Low (High - molecular - weight, non - volatile compound) |
Stability | Stable under normal conditions, but may react with strong reducing agents, bases, etc. |
As an accredited 1-Chloro-3,4-Difluoro-5-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
Packing | 1 - chloro - 3,4 - difluoro - 5 - nitrobenzene: Packed in 500g bottles for safe storage. |
Storage | 1 - Chloro - 3,4 - difluoro - 5 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials, to prevent leakage and exposure to air or moisture which could lead to chemical degradation or dangerous reactions. |
Shipping | 1 - Chloro - 3,4 - difluoro - 5 - nitrobenzene is shipped in sealed, corrosion - resistant containers. It's transported under regulated conditions to prevent spills, with proper labeling indicating its hazardous nature. |
Competitive 1-Chloro-3,4-Difluoro-5-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com


As a leading 1-Chloro-3,4-Difluoro-5-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
First, this compound is often used as an intermediate in the synthesis of many fine chemicals. In the process of pharmaceutical synthesis, it can be converted into drug molecules with specific pharmacological activities through specific chemical reactions. Because its molecular structure contains functional groups such as chlorine, fluorine, and nitro, it can interact with other compounds through organic synthesis to form new chemical bonds and achieve the synthesis of complex drug molecules.
Furthermore, it also plays an important role in the field of pesticide synthesis. Due to its special chemical structure, synthetic pesticides can be endowed with unique biological activities, or have insecticidal, bactericidal, weeding and other effects. After rational molecular design and synthesis process, new pesticides with high efficiency, low toxicity and environmental friendliness can be prepared.
In addition, in the field of materials science, 1-chloro-3,4-difluoro-5-nitrobenzene can be used to synthesize special polymer materials. Its functional groups can participate in polymerization reactions, introducing special properties for polymer materials, such as improving heat resistance and corrosion resistance of materials. The materials prepared from this may be widely used in high-end fields such as aerospace, electronics and electrical appliances.
In summary, although 1-chloro-3,4-difluoro-5-nitrobenzene is a small organic molecule, it has shown important application value in many fields such as medicine, pesticides, materials, etc., promoting the development and progress of the chemical industry.
First of all, under normal temperature, 1-chloro-3,4-difluoro-5-nitrobenzene is often in a solid state. The formation of this solid form is closely related to the intermolecular forces. There are Van der Waals forces and other effects between molecules, which cause them to aggregate into a solid structure at room temperature.
The melting point of this compound is also an important physical property. After many experiments and studies, its melting point has a specific numerical range. The level of melting point reflects the firmness of the binding between molecules. The presence of atoms or groups such as chlorine, fluorine, and nitro in the molecular structure affects the intermolecular force, which in turn affects the melting point. The introduction of chlorine atoms changes the polarity of molecules; fluorine atoms have strong electronegativity and strengthen the intermolecular force; the existence of nitro groups also contributes to the intermolecular interaction, and many factors are intertwined to determine its melting point.
Furthermore, the color of 1-chloro-3,4-difluoro-5-nitrobenzene is mostly colorless to light yellow. The appearance of this color is related to the absorption and reflection characteristics of the molecular structure to light. The electron cloud distribution and transition in the molecular structure make it absorb different wavelengths of light, thus showing a specific color.
When it comes to solubility, it has a certain solubility in organic solvents. For example, common organic solvents, such as dichloromethane, chloroform, etc., have good solubility to 1-chloro-3,4-difluoro-5-nitrobenzene. This is due to the principle of similarity compatibility. The molecular structure of the compound has a certain degree of compatibility with the molecular structure of the organic solvent in terms of polarity, etc., so that the solute molecules can be better dispersed between the solvent molecules to achieve dissolution.
The density of 1-chloro-3,4-difluoro-5-nitrobenzene is also an important property. Its density value indicates the mass of the substance per unit volume and is closely related to the molecular structure. The weight of each atom in the molecule and the arrangement of the molecular space all affect the density. The relative mass and atomic radius of chlorine and fluorine atoms act on the molecular density comprehensively.
In summary, the physical properties of 1-chloro-3,4-difluoro-5-nitrobenzene, such as morphology, melting point, color, solubility, density, etc., are determined by its molecular structure, and have significance in chemical synthesis, material preparation and other fields.
The first method is to use benzene as the starting material. The benzene is first nitrified, and the mixed acid of concentrated sulfuric acid and concentrated nitric acid is used as the nitrifying reagent. Under suitable temperature conditions, nitro groups are introduced into the benzene ring to generate nitrobenzene. This step requires careful control of temperature to prevent the occurrence of polynitroylation side reactions. The obtained nitrobenzene is then halogenated, and chlorine and fluorine can be used. In the presence of specific catalysts, chlorine atoms and fluorine atoms are introduced at specific positions in the benzene ring. In this process, the choice and amount of catalyst, as well as the temperature, pressure and other conditions of the reaction, all have a significant impact on the selectivity and yield of the product.
Furthermore, halogenated benzene can also be used as the starting material. If a suitable chlorobenzene or fluorobenzene is selected, the nitro group is introduced first, and then the other halogen atoms are introduced. For example, using chlorobenzene as the raw material, the nitro group is introduced through the nitration reaction, and then the fluorine atom is introduced at the desired position through a specific fluorination reaction. In the fluorination reaction, the choice of fluorination reagents is quite important. For example, the choice of nucleophilic fluorination reagents can achieve the purpose of replacing the chlorine atom on the benzene ring with the fluorine atom under the action of the phase transfer catalyst.
Or, it can be achieved by the functional group conversion of aromatic hydrocarbon derivatives. First prepare aromatic hydrocarbon derivatives with suitable substituents, and then gradually introduce chlorine, fluorine and nitro groups through various chemical reactions, such as nucleophilic substitution, electrophilic substitution, etc. This path requires a deep understanding of the mechanism of each step of the reaction in order to accurately control the reaction process and product structure.
In short, the synthesis of 1-chloro-3,4-difluoro-5-nitrobenzene requires comprehensive consideration of the availability of raw materials, the difficulty of controlling the reaction conditions, the purity and yield of the product, and many other factors, and carefully design the synthesis route to achieve the purpose of efficient and economical synthesis.
First words storage. This compound should be stored in a cool and ventilated warehouse. The cover is dangerous due to heat. If the temperature of the warehouse is too high, it may cause a chemical reaction, causing the material to deteriorate, or even risk fire and explosion. And it must be kept away from fire and heat sources. Open flames and hot topics are dangerous reasons. It should be stored separately from oxidizing agents, reducing agents, alkalis, etc., and cannot be mixed. Due to its active chemical properties, it is easy to trigger violent chemical reactions when mixed with other substances. In the warehouse, it is also necessary to have suitable containment materials to prevent timely response in the event of an accident.
Times and transportation. When transporting, the packaging must be tight to ensure that there is no leakage. The selected transportation vehicle should meet the standards for the transportation of hazardous chemicals. During transportation, it should be protected from exposure to the sun, rain, and avoid high temperature and humid environment. When driving, drivers should be cautious, follow the established route, and do not stop in densely populated areas and traffic arteries. If a leak occurs during transportation, emergency measures should be taken immediately to evacuate the surrounding people, prevent the spread of toxic gases, and notify professionals to deal with it.
In short, the storage and transportation of 1-chloro-3,4-difluoro-5-nitrobenzene is a matter of safety and should not be underestimated. All links should be carried out in accordance with regulations to ensure safety.
When it comes to the impact on the environment, it degrades slowly in the natural environment and can remain for a long time. If it is released into the soil, it may cause soil pollution, affect the soil quality, and then endanger plant growth. If it enters the water body, it may cause water quality to deteriorate and threaten the survival of aquatic organisms. It may migrate with water flow and wind, expanding the scope of pollution.
As for the impact on human health, it can enter the human body through inhalation, ingestion or skin contact. This compound may irritate the respiratory tract, causing cough, asthma, breathing difficulties and other symptoms. Long-term exposure, or damage lung function. If ingested orally, or irritate the gastrointestinal tract, cause nausea, vomiting, abdominal pain and other discomfort. Skin contact, or cause skin redness, itching, burning. In particular, it may be potentially carcinogenic, long-term exposure or increase the risk of cancer.
In summary, 1-chloro-3,4-difluoro-5-nitrobenzene is harmful to the environment and human health. During production and use, strict protective measures and proper handling measures should be taken to reduce its adverse effects on the environment and human body.

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