Linshang Chemical
PRODUCTS
1-Chloro-3,4-Difluorobenzene
Linshang Chemical
|
HS Code |
786062 |
| Chemical Formula | C6H3ClF2 |
| Molar Mass | 148.54 g/mol |
| Appearance | Colorless to light yellow liquid |
| Odor | Characteristic aromatic odor |
| Boiling Point | 143 - 145 °C |
| Density | 1.34 g/cm³ (approximate) |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, ether |
| Flash Point | 37 °C (closed cup, approximate) |
As an accredited 1-Chloro-3,4-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 3,4 - difluorobenzene in 5 - liter containers, well - sealed for protection. |
| Storage | 1 - Chloro - 3,4 - difluorobenzene should be stored in a cool, well - ventilated area, away from heat, sparks, and open flames as it is flammable. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, strong acids, and bases to avoid reactions. Ensure storage areas comply with safety regulations for handling hazardous chemicals. |
| Shipping | 1 - Chloro - 3,4 - difluorobenzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict hazardous chemical shipping regulations, ensuring secure transportation to prevent leakage and environmental or safety risks. |
Competitive 1-Chloro-3,4-Difluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Chloro-3,4-Difluorobenzene in China?
As a trusted 1-Chloro-3,4-Difluorobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Chloro-3,4-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-3,4-difluorobenzene?
1-Chloro-3,4-difluorobenzene is one of the organic compounds. It has a wide range of main uses and is widely used in the chemical industry.
One of them is often a key intermediate in pharmaceutical synthesis. Due to the unique properties of halogen atoms on the benzene ring, other functional groups can be introduced through various chemical reactions, and then complex drug molecular structures can be constructed. Taking the synthesis of a new type of antibacterial drug as an example, 1-chloro-3,4-difluorobenzene can first undergo nucleophilic substitution reaction with specific amine compounds to form nitrogen-containing intermediates, and then further cyclization and modification steps can finally obtain antibacterial active drugs.
Second, it also plays an important role in the creation of pesticides. Pesticides need to have high-efficiency killing or inhibitory effects on specific pests or pathogens. The structural characteristics of 1-chloro-3,4-difluorobenzene enable them to derive compounds with such effects. For example, when preparing new insecticides, this is used as a starting material. By reacting with reagents containing sulfur, phosphorus and other elements, insecticidal ingredients with unique mechanisms of action can be synthesized, which have good control effects on crop pests and have relatively little impact on the environment.
Third, it is also used in the field of materials science. Because it can participate in polymerization reactions to generate polymer materials with special properties. The prepared materials may have good heat resistance and chemical corrosion resistance, and can be used as engineering plastics, coatings, etc. in special environments. For example, in the electronics industry, some parts that need to resist high temperature and chemical attack are coated with materials derived from polymers synthesized from 1-chloro-3,4-difluorobenzene.
One of them is often a key intermediate in pharmaceutical synthesis. Due to the unique properties of halogen atoms on the benzene ring, other functional groups can be introduced through various chemical reactions, and then complex drug molecular structures can be constructed. Taking the synthesis of a new type of antibacterial drug as an example, 1-chloro-3,4-difluorobenzene can first undergo nucleophilic substitution reaction with specific amine compounds to form nitrogen-containing intermediates, and then further cyclization and modification steps can finally obtain antibacterial active drugs.
Second, it also plays an important role in the creation of pesticides. Pesticides need to have high-efficiency killing or inhibitory effects on specific pests or pathogens. The structural characteristics of 1-chloro-3,4-difluorobenzene enable them to derive compounds with such effects. For example, when preparing new insecticides, this is used as a starting material. By reacting with reagents containing sulfur, phosphorus and other elements, insecticidal ingredients with unique mechanisms of action can be synthesized, which have good control effects on crop pests and have relatively little impact on the environment.
Third, it is also used in the field of materials science. Because it can participate in polymerization reactions to generate polymer materials with special properties. The prepared materials may have good heat resistance and chemical corrosion resistance, and can be used as engineering plastics, coatings, etc. in special environments. For example, in the electronics industry, some parts that need to resist high temperature and chemical attack are coated with materials derived from polymers synthesized from 1-chloro-3,4-difluorobenzene.
What are the physical properties of 1-chloro-3,4-difluorobenzene?
1-Chloro-3,4-difluorobenzene is one of the organic compounds. Its physical properties are quite worthy of investigation.
Looking at its properties, under room temperature and pressure, it is mostly a colorless to light yellow transparent liquid. This color state is clearly recognizable, like morning dew reflecting the sun, smooth and transparent. It has a special smell, but this smell is neither fragrant nor odorous, and it is unique. If you smell it, you can feel that it is different from ordinary things.
When it comes to the boiling point, it is between 140 ° C and 150 ° C. When the temperature reaches the boiling point, it liquefies into gas, such as clouds rising. This property is quite useful in separation and purification. Its melting point cannot be ignored, roughly in the range of -20 ° C to -10 ° C. Under low temperatures, it can condense into a solid state, like ice on a cold night, with a hard texture.
Furthermore, the density is related to its floating and sinking distribution in various media. The density of 1-chloro-3,4-difluorobenzene is about 1.35g/cm ³, which is heavier than water, so if placed in water, it will sink at the bottom of the water, like a stone falling into the abyss.
In terms of solubility, it is miscible in organic solvents such as ethanol, ether, acetone, etc., just like water emulsion, difficult to distinguish from each other; however, in water, the solubility is extremely low, like oil droplets entering water and floating on the surface, the two are clearly defined. This difference in solubility is a key basis for the separation and extraction of substances in chemical experiments and industrial production.
Vapor pressure is also one of the important properties. At a certain temperature, the value of its vapor pressure affects its volatilization rate. When the temperature increases, the vapor pressure increases, and the volatilization accelerates. Like water in summer, evaporation is rapid. This property needs to be carefully considered when storing and using the compound to prevent volatilization loss and potential safety hazards.
In addition, the refractive index also has its specific value, which reflects its characteristics of light refraction. Accurate determination of the refractive index can help to identify the purity of the compound, just like measuring a ruler, with accuracy.
In summary, the physical properties of 1-chloro-3,4-difluorobenzene vary from chromatic state, melting point, density, solubility to vapor pressure, refractive index, etc., and are related to each other. It is of crucial significance in the research of organic chemistry and industrial production.
Looking at its properties, under room temperature and pressure, it is mostly a colorless to light yellow transparent liquid. This color state is clearly recognizable, like morning dew reflecting the sun, smooth and transparent. It has a special smell, but this smell is neither fragrant nor odorous, and it is unique. If you smell it, you can feel that it is different from ordinary things.
When it comes to the boiling point, it is between 140 ° C and 150 ° C. When the temperature reaches the boiling point, it liquefies into gas, such as clouds rising. This property is quite useful in separation and purification. Its melting point cannot be ignored, roughly in the range of -20 ° C to -10 ° C. Under low temperatures, it can condense into a solid state, like ice on a cold night, with a hard texture.
Furthermore, the density is related to its floating and sinking distribution in various media. The density of 1-chloro-3,4-difluorobenzene is about 1.35g/cm ³, which is heavier than water, so if placed in water, it will sink at the bottom of the water, like a stone falling into the abyss.
In terms of solubility, it is miscible in organic solvents such as ethanol, ether, acetone, etc., just like water emulsion, difficult to distinguish from each other; however, in water, the solubility is extremely low, like oil droplets entering water and floating on the surface, the two are clearly defined. This difference in solubility is a key basis for the separation and extraction of substances in chemical experiments and industrial production.
Vapor pressure is also one of the important properties. At a certain temperature, the value of its vapor pressure affects its volatilization rate. When the temperature increases, the vapor pressure increases, and the volatilization accelerates. Like water in summer, evaporation is rapid. This property needs to be carefully considered when storing and using the compound to prevent volatilization loss and potential safety hazards.
In addition, the refractive index also has its specific value, which reflects its characteristics of light refraction. Accurate determination of the refractive index can help to identify the purity of the compound, just like measuring a ruler, with accuracy.
In summary, the physical properties of 1-chloro-3,4-difluorobenzene vary from chromatic state, melting point, density, solubility to vapor pressure, refractive index, etc., and are related to each other. It is of crucial significance in the research of organic chemistry and industrial production.
What are the chemical properties of 1-chloro-3,4-difluorobenzene?
1-Chloro-3,4-difluorobenzene is one of the organic compounds. Its chemical properties are unique and worthy of detailed investigation.
In terms of its reactivity, the presence of halogen atoms shows a certain reactivity. Chlorine atoms and difluorine atoms are on the benzene ring, which affects the electron cloud distribution of the benzene ring. Fluorine atoms have strong electronegativity, which reduces the electron cloud density of the benzene ring. Although the electronegativity of chlorine atoms is slightly weaker than that of fluorine, it also has an effect on the electronic structure of the benzene ring. The change of this electron cloud changes the activity of the electrophilic substitution reaction of the benzene ring compared with that of benzene. Usually, the activity of the electrophilic substitution reaction will be reduced, because the reduction of the electron cloud density of the benzene ring is not conducive to the attack of
This compound also has certain characteristics in nucleophilic substitution reactions. Halogen atoms can be used as leaving groups, and nucleophilic substitution reactions can occur under appropriate nucleophilic reagents and reaction conditions. For example, in the case of reagents with strong nucleophilic properties, chlorine atoms or fluorine atoms may be substituted. However, due to the high bond energy of fluorine atoms C-F, it is relatively difficult to be substituted, while the substitution of chlorine atoms is relatively easy to occur.
In addition, the chemical properties of 1-chloro-3,4-difluorobenzene are also significantly affected by reaction conditions. Factors such as temperature, solvent, catalyst, etc. can change the rate and direction of the reaction. At high temperatures or in the presence of specific catalysts, the reaction activity may increase and the reaction path may also change.
Because of its fluorine, chlorine and other halogen atoms, in some reactions, conversion reactions between halogen atoms may occur, or participate in the construction of new carbon-halogen bonds, carbon-carbon bonds and other reactions, showing a variety of chemical conversion possibilities, providing valuable raw materials and intermediates for the field of organic synthesis.
In terms of its reactivity, the presence of halogen atoms shows a certain reactivity. Chlorine atoms and difluorine atoms are on the benzene ring, which affects the electron cloud distribution of the benzene ring. Fluorine atoms have strong electronegativity, which reduces the electron cloud density of the benzene ring. Although the electronegativity of chlorine atoms is slightly weaker than that of fluorine, it also has an effect on the electronic structure of the benzene ring. The change of this electron cloud changes the activity of the electrophilic substitution reaction of the benzene ring compared with that of benzene. Usually, the activity of the electrophilic substitution reaction will be reduced, because the reduction of the electron cloud density of the benzene ring is not conducive to the attack of
This compound also has certain characteristics in nucleophilic substitution reactions. Halogen atoms can be used as leaving groups, and nucleophilic substitution reactions can occur under appropriate nucleophilic reagents and reaction conditions. For example, in the case of reagents with strong nucleophilic properties, chlorine atoms or fluorine atoms may be substituted. However, due to the high bond energy of fluorine atoms C-F, it is relatively difficult to be substituted, while the substitution of chlorine atoms is relatively easy to occur.
In addition, the chemical properties of 1-chloro-3,4-difluorobenzene are also significantly affected by reaction conditions. Factors such as temperature, solvent, catalyst, etc. can change the rate and direction of the reaction. At high temperatures or in the presence of specific catalysts, the reaction activity may increase and the reaction path may also change.
Because of its fluorine, chlorine and other halogen atoms, in some reactions, conversion reactions between halogen atoms may occur, or participate in the construction of new carbon-halogen bonds, carbon-carbon bonds and other reactions, showing a variety of chemical conversion possibilities, providing valuable raw materials and intermediates for the field of organic synthesis.
What is the production method of 1-chloro-3,4-difluorobenzene?
1-Chloro-3,4-difluorobenzene is also an organic compound. The method of its preparation depends on the technique of chemical synthesis in the past.
One method is often to use benzene as the initial raw material. The benzene and chlorine are replaced by a hydrogen atom on the benzene ring under specific reaction conditions, such as suitable temperature, pressure and catalyst. Under specific reaction conditions, the chlorine atom replaces one of the hydrogen atoms on the benzene ring to obtain chlorobenzene. In this reaction, the temperature is very important. If it is too high, the side reactions will increase, and if it is too low, the reaction rate will be delayed.
Then, the obtained chlorobenzene is reacted with fluoride. This step requires special fluorination reagents and is carried out in a strict anhydrous environment. Due to the presence of water, the reaction is often In the fluorination reaction, the ratio of fluorinated reagent to chlorobenzene, the reaction time and other factors all affect the yield and purity of the product. After this reaction, the fluorine atom gradually replaces the hydrogen atom at a specific position on the benzene ring, and finally 1-chloro-3,4-difluorobenzene can be obtained.
There is also another method, which uses other compounds containing benzene rings as starting materials, and is obtained by multi-step reaction. For example, benzene derivatives containing specific substituents are first prepared, and then chlorine atoms and fluorine atoms are gradually introduced through the conversion and substitution of functional groups to achieve the purpose of preparing 1-chloro-3,4-difluorobenzene. Although this approach may be complicated, it can be flexibly selected according to the availability of raw materials and the controllability of the reaction.
During the preparation process, the steps of separation and purification are also indispensable. After the reaction, the product is often mixed with unreacted raw materials and by-products. 1-chloro-3,4-difluorobenzene is separated from the mixture by distillation, extraction, recrystallization and other methods to improve its purity and meet the standards required by industry or experiments.
One method is often to use benzene as the initial raw material. The benzene and chlorine are replaced by a hydrogen atom on the benzene ring under specific reaction conditions, such as suitable temperature, pressure and catalyst. Under specific reaction conditions, the chlorine atom replaces one of the hydrogen atoms on the benzene ring to obtain chlorobenzene. In this reaction, the temperature is very important. If it is too high, the side reactions will increase, and if it is too low, the reaction rate will be delayed.
Then, the obtained chlorobenzene is reacted with fluoride. This step requires special fluorination reagents and is carried out in a strict anhydrous environment. Due to the presence of water, the reaction is often In the fluorination reaction, the ratio of fluorinated reagent to chlorobenzene, the reaction time and other factors all affect the yield and purity of the product. After this reaction, the fluorine atom gradually replaces the hydrogen atom at a specific position on the benzene ring, and finally 1-chloro-3,4-difluorobenzene can be obtained.
There is also another method, which uses other compounds containing benzene rings as starting materials, and is obtained by multi-step reaction. For example, benzene derivatives containing specific substituents are first prepared, and then chlorine atoms and fluorine atoms are gradually introduced through the conversion and substitution of functional groups to achieve the purpose of preparing 1-chloro-3,4-difluorobenzene. Although this approach may be complicated, it can be flexibly selected according to the availability of raw materials and the controllability of the reaction.
During the preparation process, the steps of separation and purification are also indispensable. After the reaction, the product is often mixed with unreacted raw materials and by-products. 1-chloro-3,4-difluorobenzene is separated from the mixture by distillation, extraction, recrystallization and other methods to improve its purity and meet the standards required by industry or experiments.
What are the precautions for using 1-chloro-3,4-difluorobenzene?
For 1-chlorine-3,4-difluorobenzene, there are many precautions when using it.
First, this product has certain toxicity and irritation. Its smell is pungent, and it is dangerous to the eyes, respiratory tract and skin. Therefore, when using, protective gear is indispensable. In front of protective clothing, strictly select those with tough materials and good airtightness to prevent them from contacting the skin. Wear protective gloves, choose those that are resistant to chemical corrosion, fit tightly to the wrist, and do not leave gaps. It is also necessary to wear protective glasses or masks to ensure that the eyes are fully protected from its harm.
Second, 1-chlorine-3,4-difluorobenzene is flammable. Where stored and used, the source of fire must be kept away. Electrical equipment should also be explosion-proof to prevent accidents caused by electric sparks. Fire extinguishing equipment on site must be complete, such as dry powder fire extinguishers, carbon dioxide fire extinguishers, etc., and placed in a convenient place to use. Everyone should be familiar with their usage.
Third, ventilation of the operating environment is extremely important. It should be performed in a well-ventilated place. If conditions permit, install local ventilation devices, which can quickly discharge volatile gases, reduce the concentration in the air, and protect people's safety. If operating in a confined space, be more cautious. Use testing equipment to measure its concentration first. After reaching the standard, you can enter it. Continuous monitoring is also required during operation.
Fourth, proper disposal after use cannot be ignored. The remaining materials should not be discarded at will, and should be handed over to a professional organization for processing in accordance with relevant regulations. The utensils used, such as containers, pipes, etc., must be thoroughly cleaned to remove residues to prevent reactions during the next use.
In short, when using 1-chloro-3,4-difluorobenzene, be careful and keep all precautions in mind to ensure safe operation.
First, this product has certain toxicity and irritation. Its smell is pungent, and it is dangerous to the eyes, respiratory tract and skin. Therefore, when using, protective gear is indispensable. In front of protective clothing, strictly select those with tough materials and good airtightness to prevent them from contacting the skin. Wear protective gloves, choose those that are resistant to chemical corrosion, fit tightly to the wrist, and do not leave gaps. It is also necessary to wear protective glasses or masks to ensure that the eyes are fully protected from its harm.
Second, 1-chlorine-3,4-difluorobenzene is flammable. Where stored and used, the source of fire must be kept away. Electrical equipment should also be explosion-proof to prevent accidents caused by electric sparks. Fire extinguishing equipment on site must be complete, such as dry powder fire extinguishers, carbon dioxide fire extinguishers, etc., and placed in a convenient place to use. Everyone should be familiar with their usage.
Third, ventilation of the operating environment is extremely important. It should be performed in a well-ventilated place. If conditions permit, install local ventilation devices, which can quickly discharge volatile gases, reduce the concentration in the air, and protect people's safety. If operating in a confined space, be more cautious. Use testing equipment to measure its concentration first. After reaching the standard, you can enter it. Continuous monitoring is also required during operation.
Fourth, proper disposal after use cannot be ignored. The remaining materials should not be discarded at will, and should be handed over to a professional organization for processing in accordance with relevant regulations. The utensils used, such as containers, pipes, etc., must be thoroughly cleaned to remove residues to prevent reactions during the next use.
In short, when using 1-chloro-3,4-difluorobenzene, be careful and keep all precautions in mind to ensure safe operation.
Scan to WhatsApp
