Linshang Chemical
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1-Chloro-3,5-Bis(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
223318 |
| Chemical Formula | C7H3ClF6 |
| Molecular Weight | 230.54 |
| Appearance | Colorless liquid |
| Boiling Point | 115 - 117 °C |
| Melting Point | N/A |
| Density | 1.486 g/mL at 25 °C |
| Vapor Pressure | N/A |
| Solubility | Insoluble in water, soluble in organic solvents |
| Flash Point | 24 °C |
| Refractive Index | 1.3895 at 20 °C |
| Stability | Stable under normal conditions |
| Odor | Characteristic odor |
As an accredited 1-Chloro-3,5-Bis(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 3,5 - bis(trifluoromethyl)benzene in 500 - mL glass bottles, 10 bottles per case. |
| Storage | 1 - Chloro - 3,5 - bis(trifluoromethyl)benzene should be stored in a cool, well - ventilated area, away from heat sources and open flames. Keep it in a tightly closed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive chemicals. Suitable storage temperature is typically around 2 - 8°C in a dedicated chemical storage cabinet for proper containment and safety. |
| Shipping | 1 - Chloro - 3,5 - bis(trifluoromethyl)benzene is shipped in specialized, well - sealed containers. Due to its chemical nature, it follows strict hazardous materials shipping regulations to ensure safe transportation. |
Competitive 1-Chloro-3,5-Bis(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 1-Chloro-3,5-Bis(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-chloro-3,5-bis (trifluoromethyl) benzene
1-Chloro-3,5-bis (trifluoromethyl) benzene is one of the organic compounds. Its chemical properties are particularly important and are related to many chemical reactions and industrial uses.
In terms of its physical properties, this compound may be liquid at room temperature and has a special odor. Its physical constants such as boiling point and melting point are affected by the presence of chlorine atoms and trifluoromethyl groups in the molecular structure. Trifluoromethyl has strong electronegativity, which changes the polarity of the molecule, which in turn affects its melting and boiling point.
In terms of chemical properties, chlorine atoms are quite active. Because chlorine atoms are connected to benzene rings, the distribution of electron clouds in benzene rings is affected by them. This chlorine atom can participate in nucleophilic substitution reactions. In the case of nucleophilic reagents, chlorine atoms can be replaced to form new organic compounds. For example, if reacted with sodium alcohol, chlorine atoms may be replaced by alkoxy groups to obtain corresponding ether compounds.
Furthermore, trifluoromethyl also gives this compound unique chemical properties. Trifluoromethyl has strong electron absorption, which can reduce the electron cloud density of the benzene ring and reduce the activity of the benzene ring electrophilic substitution reaction. However, under certain conditions, electrophilic substitution can still occur, but the reaction check point is different from that of ordinary benzene derivatives. Due to its electron absorption effect, the reaction may prefer to occur at a relatively high electron cloud density.
In addition, the chemical stability of this compound is relatively good, due to the special structure of trifluoromethyl. Trifluoromethyl has a high carbon-fluorine bond energy and is difficult to break, so the whole molecule resists external chemical action to a certain extent, and can maintain its own structure and properties in specific environments.
In summary, the existence of 1-chloro-3,5-bis (trifluoromethyl) benzene chloride atoms and trifluoromethyl groups has unique physical and chemical properties and may have important applications in organic synthesis, materials science and other fields.
In terms of its physical properties, this compound may be liquid at room temperature and has a special odor. Its physical constants such as boiling point and melting point are affected by the presence of chlorine atoms and trifluoromethyl groups in the molecular structure. Trifluoromethyl has strong electronegativity, which changes the polarity of the molecule, which in turn affects its melting and boiling point.
In terms of chemical properties, chlorine atoms are quite active. Because chlorine atoms are connected to benzene rings, the distribution of electron clouds in benzene rings is affected by them. This chlorine atom can participate in nucleophilic substitution reactions. In the case of nucleophilic reagents, chlorine atoms can be replaced to form new organic compounds. For example, if reacted with sodium alcohol, chlorine atoms may be replaced by alkoxy groups to obtain corresponding ether compounds.
Furthermore, trifluoromethyl also gives this compound unique chemical properties. Trifluoromethyl has strong electron absorption, which can reduce the electron cloud density of the benzene ring and reduce the activity of the benzene ring electrophilic substitution reaction. However, under certain conditions, electrophilic substitution can still occur, but the reaction check point is different from that of ordinary benzene derivatives. Due to its electron absorption effect, the reaction may prefer to occur at a relatively high electron cloud density.
In addition, the chemical stability of this compound is relatively good, due to the special structure of trifluoromethyl. Trifluoromethyl has a high carbon-fluorine bond energy and is difficult to break, so the whole molecule resists external chemical action to a certain extent, and can maintain its own structure and properties in specific environments.
In summary, the existence of 1-chloro-3,5-bis (trifluoromethyl) benzene chloride atoms and trifluoromethyl groups has unique physical and chemical properties and may have important applications in organic synthesis, materials science and other fields.
What are the main uses of 1-chloro-3,5-bis (trifluoromethyl) benzene
1-Chloro-3,5-bis (trifluoromethyl) benzene, this substance has a wide range of uses and is found in various fields of chemical industry.
In the process of material synthesis, it is a key raw material for the preparation of special polymer materials. Due to its fluorine-containing group properties, the material has excellent chemical stability, weather resistance and low surface energy. If it is made of high-performance fluoropolymers, it can be used in coatings and coated on the surface of objects, which can increase its corrosion resistance and wear resistance. It can also maintain good performance in harsh environments for a long time. It is also used in the production of special plastics, which are widely used in electronics and aerospace fields. Due to its excellent electrical insulation and thermal stability, it can meet the strict requirements of high-end equipment for materials.
In the field of medicinal chemistry, 1-chloro-3,5-bis (trifluoromethyl) benzene also plays an important role. It is often used as a synthetic drug intermediate, and its unique structure can introduce drug molecules to change the physicochemical properties and biological activities of drugs. Through its participation in the reaction, drugs with specific physiological activities can be prepared for the treatment of various diseases, such as the development of new antibacterial and antiviral drugs, which contribute to human health.
It also plays a key role in the creation of pesticides. Pesticides with high insecticidal, bactericidal and herbicidal activities can be synthesized from this raw material. The fluorine-containing structure endows pesticides with high activity and selectivity, which can precisely act on target organisms, reduce the impact on non-target organisms, and have low environmental residues. It is in line with the development trend of modern green pesticides and contributes to the sustainable development of agriculture.
In addition, in the study of organic synthetic chemistry, 1-chloro-3,5-bis (trifluoromethyl) benzene is often used as a reaction substrate to explore new synthesis methods and reaction mechanisms. Chemists expand organic synthesis methodologies by studying the chemical reactions they participate in, providing new ideas and new ways for organic compound synthesis, and promoting the continuous development of organic chemistry.
In the process of material synthesis, it is a key raw material for the preparation of special polymer materials. Due to its fluorine-containing group properties, the material has excellent chemical stability, weather resistance and low surface energy. If it is made of high-performance fluoropolymers, it can be used in coatings and coated on the surface of objects, which can increase its corrosion resistance and wear resistance. It can also maintain good performance in harsh environments for a long time. It is also used in the production of special plastics, which are widely used in electronics and aerospace fields. Due to its excellent electrical insulation and thermal stability, it can meet the strict requirements of high-end equipment for materials.
In the field of medicinal chemistry, 1-chloro-3,5-bis (trifluoromethyl) benzene also plays an important role. It is often used as a synthetic drug intermediate, and its unique structure can introduce drug molecules to change the physicochemical properties and biological activities of drugs. Through its participation in the reaction, drugs with specific physiological activities can be prepared for the treatment of various diseases, such as the development of new antibacterial and antiviral drugs, which contribute to human health.
It also plays a key role in the creation of pesticides. Pesticides with high insecticidal, bactericidal and herbicidal activities can be synthesized from this raw material. The fluorine-containing structure endows pesticides with high activity and selectivity, which can precisely act on target organisms, reduce the impact on non-target organisms, and have low environmental residues. It is in line with the development trend of modern green pesticides and contributes to the sustainable development of agriculture.
In addition, in the study of organic synthetic chemistry, 1-chloro-3,5-bis (trifluoromethyl) benzene is often used as a reaction substrate to explore new synthesis methods and reaction mechanisms. Chemists expand organic synthesis methodologies by studying the chemical reactions they participate in, providing new ideas and new ways for organic compound synthesis, and promoting the continuous development of organic chemistry.
What are the synthesis methods of 1-chloro-3,5-bis (trifluoromethyl) benzene
The synthesis method of 1-chloro-3,5-bis (trifluoromethyl) benzene, let me explain in detail.
One method can be started from 3,5-bis (trifluoromethyl) aniline. First, 3,5-bis (trifluoromethyl) aniline is mixed with hydrochloric acid and sodium nitrite, and the diazotization reaction is carried out at low temperature to generate diazonium salts. Then, copper salts such as cuprous chloride are added, and a Sandmeyer reaction occurs. The diazo group is replaced by a chlorine atom, and then 1-chloro-3,5-bis (trifluoromethyl) benzene is obtained. In this method, the conditions for the diazotization reaction are quite critical, and the low temperature needs to be precisely controlled to prevent the decomposition of diazonium salts and affect the yield of the product.
The second method uses 3,5-bis (trifluoromethyl) benzoic acid as the starting material. First, it is converted into acid chloride, which can be reacted with dichlorosulfoxide. Then, under the action of reducing agents such as lithium aluminum hydride, the acid chloride is reduced to alcohol. After that, the alcohol is treated with halogenating reagents such as sulfoxide chloride or phosphorus trichloride, and the hydroxyl group is replaced by chlorine atoms, and the final product can be obtained. However, this path has a little more steps, and each step of the reaction needs to be carefully operated to ensure the complete reaction and reduce the occurrence of
In addition, suitable benzene derivatives are used as substrates and synthesized by Friedel-Crafts reaction. Under the catalysis of Lewis acids such as aluminum trichloride, benzene derivatives are reacted with reagents containing chlorine and trifluoromethyl. However, the selectivity of the Fu-gram reaction needs to be carefully regulated, and the reaction conditions need to be carefully optimized to increase the proportion of the target product.
All synthesis methods have advantages and disadvantages. In actual operation, when considering factors such as the availability of raw materials, cost, reaction conditions, and requirements for product purity, careful decisions should be made.
One method can be started from 3,5-bis (trifluoromethyl) aniline. First, 3,5-bis (trifluoromethyl) aniline is mixed with hydrochloric acid and sodium nitrite, and the diazotization reaction is carried out at low temperature to generate diazonium salts. Then, copper salts such as cuprous chloride are added, and a Sandmeyer reaction occurs. The diazo group is replaced by a chlorine atom, and then 1-chloro-3,5-bis (trifluoromethyl) benzene is obtained. In this method, the conditions for the diazotization reaction are quite critical, and the low temperature needs to be precisely controlled to prevent the decomposition of diazonium salts and affect the yield of the product.
The second method uses 3,5-bis (trifluoromethyl) benzoic acid as the starting material. First, it is converted into acid chloride, which can be reacted with dichlorosulfoxide. Then, under the action of reducing agents such as lithium aluminum hydride, the acid chloride is reduced to alcohol. After that, the alcohol is treated with halogenating reagents such as sulfoxide chloride or phosphorus trichloride, and the hydroxyl group is replaced by chlorine atoms, and the final product can be obtained. However, this path has a little more steps, and each step of the reaction needs to be carefully operated to ensure the complete reaction and reduce the occurrence of
In addition, suitable benzene derivatives are used as substrates and synthesized by Friedel-Crafts reaction. Under the catalysis of Lewis acids such as aluminum trichloride, benzene derivatives are reacted with reagents containing chlorine and trifluoromethyl. However, the selectivity of the Fu-gram reaction needs to be carefully regulated, and the reaction conditions need to be carefully optimized to increase the proportion of the target product.
All synthesis methods have advantages and disadvantages. In actual operation, when considering factors such as the availability of raw materials, cost, reaction conditions, and requirements for product purity, careful decisions should be made.
What are the precautions for 1-chloro-3,5-bis (trifluoromethyl) benzene during storage and transportation?
1-Chloro-3,5-bis (trifluoromethyl) benzene is an organic chemical. When storing and transporting, many things must be paid attention to.
First, its properties. This substance is toxic and corrosive to a certain extent, and may be harmful to the human body and the environment. Because of its chemical activity, it is necessary to know its physical and chemical properties in detail before storing and transporting specific substances.
When storing, choose a cool, dry and well-ventilated warehouse. Keep away from fire and heat sources, and the storage temperature should not exceed 30 ° C. Because it is corrosive to some materials, it should avoid contact with corrosive materials, and choose suitable containers, such as corrosion-resistant glass bottles or special plastic containers, and seal tightly to prevent leakage. Different chemicals have compatibility taboos, and 1-chloro-3,5-bis (trifluoromethyl) benzene is no exception. Do not mix with oxidants, strong alkalis, etc., to avoid dangerous reactions.
The transportation process is also critical. When handling, be sure to pack and unload lightly to prevent leakage caused by damage to packaging and containers. Transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment. During driving, drivers should drive slowly to avoid high temperature and open flame environments. If passing through densely populated areas or water sources, more caution is required. Transportation enterprises and personnel must have corresponding qualifications and operate in strict accordance with regulations to ensure transportation safety.
In short, the storage and transportation of 1-chloro-3,5-bis (trifluoromethyl) benzene must be handled in strict accordance with relevant regulations, from the environment, containers, compatibility, operation and other aspects, in order to prevent accidents and ensure the safety of personnel and the environment.
First, its properties. This substance is toxic and corrosive to a certain extent, and may be harmful to the human body and the environment. Because of its chemical activity, it is necessary to know its physical and chemical properties in detail before storing and transporting specific substances.
When storing, choose a cool, dry and well-ventilated warehouse. Keep away from fire and heat sources, and the storage temperature should not exceed 30 ° C. Because it is corrosive to some materials, it should avoid contact with corrosive materials, and choose suitable containers, such as corrosion-resistant glass bottles or special plastic containers, and seal tightly to prevent leakage. Different chemicals have compatibility taboos, and 1-chloro-3,5-bis (trifluoromethyl) benzene is no exception. Do not mix with oxidants, strong alkalis, etc., to avoid dangerous reactions.
The transportation process is also critical. When handling, be sure to pack and unload lightly to prevent leakage caused by damage to packaging and containers. Transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment. During driving, drivers should drive slowly to avoid high temperature and open flame environments. If passing through densely populated areas or water sources, more caution is required. Transportation enterprises and personnel must have corresponding qualifications and operate in strict accordance with regulations to ensure transportation safety.
In short, the storage and transportation of 1-chloro-3,5-bis (trifluoromethyl) benzene must be handled in strict accordance with relevant regulations, from the environment, containers, compatibility, operation and other aspects, in order to prevent accidents and ensure the safety of personnel and the environment.
What are the effects of 1-chloro-3,5-bis (trifluoromethyl) benzene on the environment and human health?
1-Chloro-3,5-bis (trifluoromethyl) benzene is also an organic compound. The impact of this substance on the environment and human health cannot be ignored.
At one end of the environment, 1-chloro-3,5-bis (trifluoromethyl) benzene is quite stable, difficult to degrade naturally, and easy to remain in the environment. If released into the atmosphere, it can migrate with airflow and spread to distant places. Falling into the soil may cause soil pollution, damage soil microbial communities, and hinder the balance and material cycle of soil ecosystems. Entering water bodies can affect aquatic organisms. Or cause algae growth to be inhibited and destroy aquatic food chains. And because of its fat solubility, it is easy to enrich aquatic organisms and pass along the food chain, endangering more advanced organisms.
As for human health, 1-chloro-3,5-bis (trifluoromethyl) benzene or through breathing, skin contact, dietary intake, etc. into the human body. Inhalation through the respiratory tract can irritate the mucosa of the respiratory tract, causing cough, asthma, breathing difficulties and other diseases. Long-term exposure may damage lung function and increase the risk of respiratory diseases. If exposed through skin contact, it can cause skin allergies, itching, redness and swelling. Entering the body, or affecting the nervous system, causing headaches, dizziness, fatigue, insomnia and other neurological symptoms. It may also interfere with the endocrine system, affect hormone balance, and have adverse effects on physiological processes such as reproduction and development. And some halogenated aromatic hydrocarbons have potential carcinogenicity. Although the carcinogenicity of 1-chloro-3,5-bis (trifluoromethyl) benzene has not been conclusively determined, there is still a latent risk due to its structural characteristics.
Therefore, the production, use and disposal of 1-chloro-3,5-bis (trifluoromethyl) benzene should be carefully protected and managed to reduce its harm to the environment and human health.
At one end of the environment, 1-chloro-3,5-bis (trifluoromethyl) benzene is quite stable, difficult to degrade naturally, and easy to remain in the environment. If released into the atmosphere, it can migrate with airflow and spread to distant places. Falling into the soil may cause soil pollution, damage soil microbial communities, and hinder the balance and material cycle of soil ecosystems. Entering water bodies can affect aquatic organisms. Or cause algae growth to be inhibited and destroy aquatic food chains. And because of its fat solubility, it is easy to enrich aquatic organisms and pass along the food chain, endangering more advanced organisms.
As for human health, 1-chloro-3,5-bis (trifluoromethyl) benzene or through breathing, skin contact, dietary intake, etc. into the human body. Inhalation through the respiratory tract can irritate the mucosa of the respiratory tract, causing cough, asthma, breathing difficulties and other diseases. Long-term exposure may damage lung function and increase the risk of respiratory diseases. If exposed through skin contact, it can cause skin allergies, itching, redness and swelling. Entering the body, or affecting the nervous system, causing headaches, dizziness, fatigue, insomnia and other neurological symptoms. It may also interfere with the endocrine system, affect hormone balance, and have adverse effects on physiological processes such as reproduction and development. And some halogenated aromatic hydrocarbons have potential carcinogenicity. Although the carcinogenicity of 1-chloro-3,5-bis (trifluoromethyl) benzene has not been conclusively determined, there is still a latent risk due to its structural characteristics.
Therefore, the production, use and disposal of 1-chloro-3,5-bis (trifluoromethyl) benzene should be carefully protected and managed to reduce its harm to the environment and human health.
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