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1-Chloro-3,5-Difluorobenzene(3,5-Difluorchlorbenzol)
Linshang Chemical
|
HS Code |
949763 |
| Chemical Formula | C6H3ClF2 |
| Molar Mass | 148.54 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 131 - 133 °C |
| Density | 1.325 g/cm³ |
| Solubility In Water | Insoluble |
| Flash Point | 37 °C |
| Refractive Index | 1.472 - 1.474 |
As an accredited 1-Chloro-3,5-Difluorobenzene(3,5-Difluorchlorbenzol) factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 3,5 - difluorobenzene packaged in 5 - liter containers. |
| Storage | 1 - Chloro - 3,5 - difluorobenzene (3,5 - difluorchlorbenzol) should be stored in a cool, well - ventilated area, away from heat, sparks, and open flames. It should be kept in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents and incompatible substances to prevent potential reactions. |
| Shipping | 1 - Chloro - 3,5 - difluorobenzene (3,5 - difluorchlorbenzol) is shipped in sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations to ensure safe transportation due to its chemical nature. |
Competitive 1-Chloro-3,5-Difluorobenzene(3,5-Difluorchlorbenzol) prices that fit your budget—flexible terms and customized quotes for every order.
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What is the main use of 1-chloro-3,5-difluorobenzene (5-difluorchlorbenzol)?
1-Chloro-3,5-difluorobenzene (3,5-dichlorobenzene) is widely used in various fields of chemical industry.
First, it is a key intermediate in the synthesis of medicine. When preparing specific antibacterial drugs, the properties of fluorine and chlorine atoms in its structure can endow the drug with better lipid solubility and biological activity. By reacting with other compounds containing specific functional groups, through various organic reaction steps such as substitution and condensation, complex drug molecular structures can be constructed, which can help improve the affinity and selectivity of the drug to specific targets and improve the curative effect.
Second, it also plays an important role in the creation of pesticides. Because it contains halogen atoms, it can enhance the ability of compounds to interfere with the physiological system of pests. Using it as a starting material, through a series of synthesis and transformation, pesticides such as insecticides and fungicides can be prepared. Such pesticides can effectively control crop diseases and insect pests and ensure agricultural harvests due to their unique chemical structure, or with high efficiency, low toxicity, environmental friendliness and other characteristics.
Third, it is also useful in the field of materials science. Can participate in the synthesis of high-performance polymer materials. After polymerization reaction, its structural units are introduced into the polymer chain, which can improve the thermal stability, chemical stability and mechanical properties of the material. Such as used in the manufacture of special engineering plastics, such plastics can meet special use conditions such as high temperature and corrosion resistance in industries with strict material properties such as aerospace, electronics and electrical appliances.
Fourth, it is a commonly used reagent in organic synthesis chemistry research. Due to the difference in activity of different halogen atoms on the benzene ring, nucleophilic substitution, metal catalytic coupling and other reactions can selectively occur, providing an effective path for the synthesis of various organic compounds with complex structures and promoting the development and innovation of organic synthesis methodologies.
First, it is a key intermediate in the synthesis of medicine. When preparing specific antibacterial drugs, the properties of fluorine and chlorine atoms in its structure can endow the drug with better lipid solubility and biological activity. By reacting with other compounds containing specific functional groups, through various organic reaction steps such as substitution and condensation, complex drug molecular structures can be constructed, which can help improve the affinity and selectivity of the drug to specific targets and improve the curative effect.
Second, it also plays an important role in the creation of pesticides. Because it contains halogen atoms, it can enhance the ability of compounds to interfere with the physiological system of pests. Using it as a starting material, through a series of synthesis and transformation, pesticides such as insecticides and fungicides can be prepared. Such pesticides can effectively control crop diseases and insect pests and ensure agricultural harvests due to their unique chemical structure, or with high efficiency, low toxicity, environmental friendliness and other characteristics.
Third, it is also useful in the field of materials science. Can participate in the synthesis of high-performance polymer materials. After polymerization reaction, its structural units are introduced into the polymer chain, which can improve the thermal stability, chemical stability and mechanical properties of the material. Such as used in the manufacture of special engineering plastics, such plastics can meet special use conditions such as high temperature and corrosion resistance in industries with strict material properties such as aerospace, electronics and electrical appliances.
Fourth, it is a commonly used reagent in organic synthesis chemistry research. Due to the difference in activity of different halogen atoms on the benzene ring, nucleophilic substitution, metal catalytic coupling and other reactions can selectively occur, providing an effective path for the synthesis of various organic compounds with complex structures and promoting the development and innovation of organic synthesis methodologies.
What are the physical properties of 1-chloro-3,5-difluorobenzene (5-difluorchlorbenzol)
1-Chloro-3,5-difluorobenzene (3,5-difluorobenzene) has important physical properties and is useful in chemical engineering.
This substance is mostly liquid at room temperature. Looking at its color, it is often colorless and transparent. If placed under light, it can be seen that it is clear and has no cloudy appearance, just like water. Its smell is specific and irritating. If you smell it, you can feel pungent. If you have been in this gas for a long time, or feel unwell, your respiratory tract, eyes, etc. may be affected.
In terms of its density, it is heavier than water. When it is co-placed with water, it can be seen that it sinks to the bottom of the water, like the significant other of water, but it does not blend with it, forming a layer of its own. Its boiling point is also fixed, about a specific temperature range. When heated to this point, it can be seen boiling and turning into gaseous ascension.
In terms of solubility, 1-chloro-3,5-difluorobenzene can be mostly dissolved in organic solvents. If placed in ethanol, ether and other solvents, it will soon blend into one, as if it were naturally compatible. However, in water, its solubility is poor, and the two are difficult to dissolve. For example, oil and water are distinct.
In addition, the volatility of 1-chloro-3,5-difluorobenzene should not be underestimated. When exposed to the air, its molecules are like active spirits, gradually dissipating, and the air has its smell. This volatility needs special attention during chemical operations, which is related to safety and operation accuracy.
This substance is mostly liquid at room temperature. Looking at its color, it is often colorless and transparent. If placed under light, it can be seen that it is clear and has no cloudy appearance, just like water. Its smell is specific and irritating. If you smell it, you can feel pungent. If you have been in this gas for a long time, or feel unwell, your respiratory tract, eyes, etc. may be affected.
In terms of its density, it is heavier than water. When it is co-placed with water, it can be seen that it sinks to the bottom of the water, like the significant other of water, but it does not blend with it, forming a layer of its own. Its boiling point is also fixed, about a specific temperature range. When heated to this point, it can be seen boiling and turning into gaseous ascension.
In terms of solubility, 1-chloro-3,5-difluorobenzene can be mostly dissolved in organic solvents. If placed in ethanol, ether and other solvents, it will soon blend into one, as if it were naturally compatible. However, in water, its solubility is poor, and the two are difficult to dissolve. For example, oil and water are distinct.
In addition, the volatility of 1-chloro-3,5-difluorobenzene should not be underestimated. When exposed to the air, its molecules are like active spirits, gradually dissipating, and the air has its smell. This volatility needs special attention during chemical operations, which is related to safety and operation accuracy.
Is 1-chloro-3,5-difluorobenzene (5-difluorchlorbenzol) chemically stable?
The chemical properties of 1-chloro-3,5-difluorobenzene (3,5-dichlorobenzene) are relatively stable.
In this compound, both the chlorine atom and the difluorine atom are directly connected to the benzene ring. The benzene ring is inherently stable, and its π electron cloud forms a conjugated system, which reduces the molecular energy. Although the chlorine atom has a certain electron-withdrawing induction effect, it also has a electron-giving conjugation effect, and the two affect each other. The fluorine atom is extremely electronegative, and the electron-withdrawing induction effect is significant, which can reduce the electron cloud density of the benzene ring.
From the perspective of reactivity, because the electron cloud density of the benzene ring is affected by the fluorine atom, the electrophilic substitution reaction is more For example, halogenation reactions, nitration reactions, sulfonation reactions, and other electrophilic substitution reactions often have more harsh reaction conditions than benzene, and the reaction rate is relatively slow.
However, under certain conditions, 1-chloro-3,5-difluorobenzene can still participate in many reactions. If the catalyst and reaction conditions are suitable, nucleophilic substitution reactions can occur. At this time, the chlorine atoms on the benzene ring can be replaced by nucleophilic reagents. Because the chlorine atoms are connected to the benzene ring, the electron cloud density of the adjacent position is relatively high, and the nucleophilic reagents are more likely to attack.
And because of its fluorine-containing atoms, in some organic synthesis reactions, fluorine atoms can take advantage of special properties, such as fluorine atoms can enhance the fat solubility of compounds, etc., so as to participate in the construction of organic molecular structures with special properties. Overall, 1-chloro-3,5-difluorobenzene is chemically stable, but can participate in a variety of organic reactions under specific conditions, showing unique chemical activities.
In this compound, both the chlorine atom and the difluorine atom are directly connected to the benzene ring. The benzene ring is inherently stable, and its π electron cloud forms a conjugated system, which reduces the molecular energy. Although the chlorine atom has a certain electron-withdrawing induction effect, it also has a electron-giving conjugation effect, and the two affect each other. The fluorine atom is extremely electronegative, and the electron-withdrawing induction effect is significant, which can reduce the electron cloud density of the benzene ring.
From the perspective of reactivity, because the electron cloud density of the benzene ring is affected by the fluorine atom, the electrophilic substitution reaction is more For example, halogenation reactions, nitration reactions, sulfonation reactions, and other electrophilic substitution reactions often have more harsh reaction conditions than benzene, and the reaction rate is relatively slow.
However, under certain conditions, 1-chloro-3,5-difluorobenzene can still participate in many reactions. If the catalyst and reaction conditions are suitable, nucleophilic substitution reactions can occur. At this time, the chlorine atoms on the benzene ring can be replaced by nucleophilic reagents. Because the chlorine atoms are connected to the benzene ring, the electron cloud density of the adjacent position is relatively high, and the nucleophilic reagents are more likely to attack.
And because of its fluorine-containing atoms, in some organic synthesis reactions, fluorine atoms can take advantage of special properties, such as fluorine atoms can enhance the fat solubility of compounds, etc., so as to participate in the construction of organic molecular structures with special properties. Overall, 1-chloro-3,5-difluorobenzene is chemically stable, but can participate in a variety of organic reactions under specific conditions, showing unique chemical activities.
What is the production method of 1-chloro-3,5-difluorobenzene (5-difluorchlorbenzol)
The preparation method of 1-chloro-3,5-difluorobenzene (3,5-difluorochlorobenzene) has been recorded in many books in the past, and the methods are different. There are two common methods mentioned above.
First, 3,5-difluoroaniline is used as the starting material. First, 3,5-difluoroaniline is mixed with hydrochloric acid, and the sodium nitrite solution is added dropwise at low temperature. This is the process of diazotization. Under the catalytic action of cuprous chloride, the generated diazo salt undergoes a displacement reaction with hydrogen chloride, and the diazo group is replaced by a chlorine atom, and then 1-chloro-3,5-difluorobenzene is obtained. The advantage of this method is that the raw materials are relatively easy to obtain and the reaction conditions are relatively mild. However, the diazotization reaction needs to be strictly controlled at temperature, otherwise side reactions are prone to occur, which affects the purity and yield of the product.
Second, 3,5-difluorobenzoic acid is used as the starting material. First, it is reacted with thionyl chloride, and the carboxyl group is converted into an acyl chloride. This step is relatively fast and the yield is quite high. The obtained acyl chloride is reduced to 3,5-difluorobenzyl alcohol under the action of a reducing agent such as lithium aluminum hydride. After that, 3,5-difluorobenzyl alcohol reacts with chlorinated reagents such as phosphorus trichloride or thionyl chloride, and the hydroxyl group is replaced by a chlorine atom, and the final product is 1-chloro-3,5 This route has a little more steps, but the selectivity of each step is better, which is conducive to improving the purity of the product, but the price of reagents such as lithium aluminum hydride is higher and the cost is relatively large.
In addition, with 3,5-difluorobrobenzene as raw material, in the presence of specific catalysts and ligands, halogen exchange reaction occurs with chlorine sources such as zinc chloride, etc., 1-chloro-3,5-difluorobenzene can be obtained. This method has harsh reaction conditions and high requirements for catalysts, but it is a feasible method for some existing 3,5-difluorobrobenzene raw materials.
First, 3,5-difluoroaniline is used as the starting material. First, 3,5-difluoroaniline is mixed with hydrochloric acid, and the sodium nitrite solution is added dropwise at low temperature. This is the process of diazotization. Under the catalytic action of cuprous chloride, the generated diazo salt undergoes a displacement reaction with hydrogen chloride, and the diazo group is replaced by a chlorine atom, and then 1-chloro-3,5-difluorobenzene is obtained. The advantage of this method is that the raw materials are relatively easy to obtain and the reaction conditions are relatively mild. However, the diazotization reaction needs to be strictly controlled at temperature, otherwise side reactions are prone to occur, which affects the purity and yield of the product.
Second, 3,5-difluorobenzoic acid is used as the starting material. First, it is reacted with thionyl chloride, and the carboxyl group is converted into an acyl chloride. This step is relatively fast and the yield is quite high. The obtained acyl chloride is reduced to 3,5-difluorobenzyl alcohol under the action of a reducing agent such as lithium aluminum hydride. After that, 3,5-difluorobenzyl alcohol reacts with chlorinated reagents such as phosphorus trichloride or thionyl chloride, and the hydroxyl group is replaced by a chlorine atom, and the final product is 1-chloro-3,5 This route has a little more steps, but the selectivity of each step is better, which is conducive to improving the purity of the product, but the price of reagents such as lithium aluminum hydride is higher and the cost is relatively large.
In addition, with 3,5-difluorobrobenzene as raw material, in the presence of specific catalysts and ligands, halogen exchange reaction occurs with chlorine sources such as zinc chloride, etc., 1-chloro-3,5-difluorobenzene can be obtained. This method has harsh reaction conditions and high requirements for catalysts, but it is a feasible method for some existing 3,5-difluorobrobenzene raw materials.
Precautions for storage and transportation of 1-chloro-3,5-difluorobenzene (5-difluorchlorbenzol)
1-Chloro-3,5-difluorobenzene (3,5-dichlorobenzene) requires attention when storing and transporting.
This chemical is toxic and irritating, and poses potential hazards to both the human body and the environment. When storing, choose a suitable location first. It must be placed in a cool, well-ventilated place, away from fire and heat sources to prevent danger caused by excessive temperature. The temperature of the warehouse should be controlled within a specific range, and the humidity should also be adjusted to ensure the stability of the material.
Furthermore, the storage container must have a good seal to prevent leakage. This substance is corrosive to metals to a certain extent, so the material of the container should be corrosion-resistant, such as special plastics or metal materials treated with anti-corrosion treatment. And the storage place should be set up with obvious warning signs to indicate its danger, so that everyone who comes into contact can be alert.
When transporting, there are also many precautions. Transportation vehicles must be equipped with corresponding fire equipment and leakage emergency treatment equipment. Loading should be safe to avoid collision and vibration causing damage to the container. During transportation, drivers and escorts must pay close attention to the condition of the goods and must not leave the post without authorization. If passing through densely populated areas or sensitive areas, you need to be extra cautious and follow the specified route.
In addition, whether it is storage or transportation, it is necessary to strictly follow relevant regulations and standards. Operators should be professionally trained and familiar with their characteristics and emergency handling methods. In the event of an accident such as a leak, emergency plans should be activated quickly, surrounding personnel should be evacuated, and protective measures should be taken to properly handle the leak to avoid causing greater harm.
This chemical is toxic and irritating, and poses potential hazards to both the human body and the environment. When storing, choose a suitable location first. It must be placed in a cool, well-ventilated place, away from fire and heat sources to prevent danger caused by excessive temperature. The temperature of the warehouse should be controlled within a specific range, and the humidity should also be adjusted to ensure the stability of the material.
Furthermore, the storage container must have a good seal to prevent leakage. This substance is corrosive to metals to a certain extent, so the material of the container should be corrosion-resistant, such as special plastics or metal materials treated with anti-corrosion treatment. And the storage place should be set up with obvious warning signs to indicate its danger, so that everyone who comes into contact can be alert.
When transporting, there are also many precautions. Transportation vehicles must be equipped with corresponding fire equipment and leakage emergency treatment equipment. Loading should be safe to avoid collision and vibration causing damage to the container. During transportation, drivers and escorts must pay close attention to the condition of the goods and must not leave the post without authorization. If passing through densely populated areas or sensitive areas, you need to be extra cautious and follow the specified route.
In addition, whether it is storage or transportation, it is necessary to strictly follow relevant regulations and standards. Operators should be professionally trained and familiar with their characteristics and emergency handling methods. In the event of an accident such as a leak, emergency plans should be activated quickly, surrounding personnel should be evacuated, and protective measures should be taken to properly handle the leak to avoid causing greater harm.
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