Linshang Chemical
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1-Chloro-3,5-Difluorobenzene
Linshang Chemical
|
HS Code |
466409 |
| Chemical Formula | C6H3ClF2 |
| Molecular Weight | 148.54 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 127 - 129 °C |
| Density | 1.346 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents |
| Flash Point | 27 °C |
| Refractive Index | 1.455 - 1.457 |
As an accredited 1-Chloro-3,5-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 3,5 - difluorobenzene in 500 - ml glass bottles, 10 bottles per carton. |
| Storage | 1 - Chloro - 3,5 - difluorobenzene should be stored in a cool, well - ventilated area away from heat sources and open flames. It should be kept in a tightly closed container to prevent vapor leakage. Store it separately from oxidizing agents, strong acids, and bases. Use a storage location with proper containment to handle potential spills, as it is a hazardous chemical. |
| Shipping | 1 - Chloro - 3,5 - difluorobenzene is shipped in specialized containers designed for hazardous chemicals. These containers ensure safe transport, protecting against leakage and environmental exposure during transit. |
Competitive 1-Chloro-3,5-Difluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Chloro-3,5-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-3,5-difluorobenzene?
1-Alkane-3,5-diene benzene is one of the organic compounds. It has a wide range of main uses and is mostly used as an important raw material in the field of chemical synthesis. Due to the specific carbon-carbon double bond and benzene ring structure in its molecular structure, it is endowed with unique chemical activity and reactivity. Therefore, it can participate in many organic synthesis reactions. Through ingenious reaction paths, complex organic molecular structures can be constructed, and then a variety of high-value-added fine chemicals can be synthesized.
In the field of materials science, 1-alkane-3,5-diene benzene also plays an important role. It can be used as a monomer to participate in polymerization reactions to prepare polymer materials with unique properties. Due to its special structure, the prepared polymer may have good thermal stability, mechanical properties and optical properties, etc., and has great application potential in high-end fields such as aerospace, electronics and electrical appliances.
In addition, in the field of medicinal chemistry, the structure of 1-alkane-3,5-dienobenzene may be used as an important part of pharmacophore. After reasonable modification and modification, it is expected to develop new drug molecules and contribute to human health.
This compound has shown important uses in many fields due to its unique structure, providing rich possibilities and broad development space for chemical research and industrial production.
In the field of materials science, 1-alkane-3,5-diene benzene also plays an important role. It can be used as a monomer to participate in polymerization reactions to prepare polymer materials with unique properties. Due to its special structure, the prepared polymer may have good thermal stability, mechanical properties and optical properties, etc., and has great application potential in high-end fields such as aerospace, electronics and electrical appliances.
In addition, in the field of medicinal chemistry, the structure of 1-alkane-3,5-dienobenzene may be used as an important part of pharmacophore. After reasonable modification and modification, it is expected to develop new drug molecules and contribute to human health.
This compound has shown important uses in many fields due to its unique structure, providing rich possibilities and broad development space for chemical research and industrial production.
What are the physical properties of 1-chloro-3,5-difluorobenzene?
The physical properties of 1-% deuterium-3,5-di-tert-butyl are as follows:
This substance is solid under normal conditions. Its melting temperature is special, and it is around [X] ° C. The melting value makes it appear different physical properties in a specific temperature environment. At lower temperatures, it is solid, and once the temperature rises above the melting temperature, it is difficult to melt.
Its boiling temperature is also one of the important physical properties, and it is greater than [Y] ° C. The first characteristic of the boiling process determines that in the addition process, the density of this substance is determined from the boundary of the liquid reaction and the external environment. Furthermore, its solubility cannot be ignored. In multi-soluble solutions, 1-% deuterium-3,5-di-tert-butyl exhibits a certain solubility. For example, in some non-soluble solutions such as n-hexane and toluene, it can be well dissolved and can be uniformly dispersed to form a stable solution; however, in a soluble solution such as water, it can be dissolved and the two repel each other, and the solubility depends on the properties of its molecules.
In addition, the crystals of 1-% deuterium-3,5-di-tert-butyl also have physical properties. The crystals of the crystals can be further explored and clarified due to the specific external shape and atomic arrangement of the atoms in the solid, which affect the hardness and optical properties of the crystals.
This substance is solid under normal conditions. Its melting temperature is special, and it is around [X] ° C. The melting value makes it appear different physical properties in a specific temperature environment. At lower temperatures, it is solid, and once the temperature rises above the melting temperature, it is difficult to melt.
Its boiling temperature is also one of the important physical properties, and it is greater than [Y] ° C. The first characteristic of the boiling process determines that in the addition process, the density of this substance is determined from the boundary of the liquid reaction and the external environment. Furthermore, its solubility cannot be ignored. In multi-soluble solutions, 1-% deuterium-3,5-di-tert-butyl exhibits a certain solubility. For example, in some non-soluble solutions such as n-hexane and toluene, it can be well dissolved and can be uniformly dispersed to form a stable solution; however, in a soluble solution such as water, it can be dissolved and the two repel each other, and the solubility depends on the properties of its molecules.
In addition, the crystals of 1-% deuterium-3,5-di-tert-butyl also have physical properties. The crystals of the crystals can be further explored and clarified due to the specific external shape and atomic arrangement of the atoms in the solid, which affect the hardness and optical properties of the crystals.
Is 1-chloro-3,5-difluorobenzene chemically stable?
For 1-% -3,5-difluorobenzene, its chemical properties are determined. In this compound, the introduction of fluorine atoms has greatly improved its properties. Fluorine atoms have chemical properties, which can rearrange the density of molecules and increase their qualitative properties.
There is no reason to change it, carbon-fluorine. In terms of total energy, carbon-fluorine energy is very high, and it takes a lot of energy to do so. In 1-% -3,5-difluorobenzene, the carbon-fluorine formation is usually solid, and the external components are easy to crack, which is a major reason for the determination of its chemical properties.
Furthermore, the fluorine atom is effective. As a result, the activity of benzene substitution for anti-benzene is weak. benzene substitutes for anti-benzene to attract anti-benzene. Now the density of benzene sub-clouds decreases, and the anti-benzene is generated, which also makes 1-%-3,5-difluorobenzene more stable.
In addition, the space resistance of the fluorine atom is not large, but the substitution of benzene at a specific position still results in a certain space effect. This space resistance can prevent other molecules from getting close to 1-%-3,5-difluorobenzene molecules, so that the anti-benzene can be reacted and the reaction can be improved.
In addition, the chemical properties of 1-%-3,5-difluorobenzene are determined by factors such as carbon-fluorine, fluorine atom, and space resistance.
There is no reason to change it, carbon-fluorine. In terms of total energy, carbon-fluorine energy is very high, and it takes a lot of energy to do so. In 1-% -3,5-difluorobenzene, the carbon-fluorine formation is usually solid, and the external components are easy to crack, which is a major reason for the determination of its chemical properties.
Furthermore, the fluorine atom is effective. As a result, the activity of benzene substitution for anti-benzene is weak. benzene substitutes for anti-benzene to attract anti-benzene. Now the density of benzene sub-clouds decreases, and the anti-benzene is generated, which also makes 1-%-3,5-difluorobenzene more stable.
In addition, the space resistance of the fluorine atom is not large, but the substitution of benzene at a specific position still results in a certain space effect. This space resistance can prevent other molecules from getting close to 1-%-3,5-difluorobenzene molecules, so that the anti-benzene can be reacted and the reaction can be improved.
In addition, the chemical properties of 1-%-3,5-difluorobenzene are determined by factors such as carbon-fluorine, fluorine atom, and space resistance.
What are the preparation methods of 1-chloro-3,5-difluorobenzene?
1-Bromo-3,5-difluorobenzene is an important organic compound, which is widely used in medicine, pesticides, materials and other fields. Its preparation methods are various and are described in ancient methods today.
First, 3,5-difluoroaniline is used as the starting material. First, it reacts with sodium nitrite and hydrochloric acid by diazotization. In a low temperature environment, carefully control the temperature, so that the two slowly react to form 3,5-difluorobenzene diazonium salt. This step needs to be handled with caution, because the diazonium salt is active and easy to explode when heated or vibrated. Then, the diazonium salt is mixed with cuprous bromide and hydrobromic acid, and the Sandmeier reaction occurs. 1-Bromo-3,5-difluorobenzene is obtained by substituting the diazo group with the bromine atom. However, the reagents used in this process are quite toxic, and the operation needs to be fine. If there is a little carelessness, it will be dangerous.
Second, 3,5-difluorobenzoic acid is used as the starting material. First, it is esterified with methanol under the catalysis of concentrated sulfuric acid to form 3,5-difluorobenzoate methyl ester. This reaction needs to be heated and refluxed to make the reaction sufficient. After that, it is reduced with lithium aluminum hydride to obtain 3,5-difluorobenzyl alcohol. Then phosphorus tribromide is reacted with it, and the hydroxyl group is replaced by bromine atoms, and the final target product is 1-bromo-3,5-difluorobenzene. There are many steps in this route, but each step is relatively mild and easy to control.
Third, 1,3,5-trifluorobenzene is used as the raw material. In the presence of a suitable catalyst, an electrophilic substitution reaction occurs with the brominating reagent. This process requires precise control of the reaction conditions, such as temperature and catalyst dosage. Due to the influence of fluorine atoms on the benzene ring, the selectivity of the reaction check point needs to be carefully adjusted, so that the bromine atom can accurately replace one fluorine atom to obtain 1-bromo-3,5-difluorobenzene. The raw materials of this method are relatively easy to obtain, but the reaction conditions are strict and the technical difficulty is high.
First, 3,5-difluoroaniline is used as the starting material. First, it reacts with sodium nitrite and hydrochloric acid by diazotization. In a low temperature environment, carefully control the temperature, so that the two slowly react to form 3,5-difluorobenzene diazonium salt. This step needs to be handled with caution, because the diazonium salt is active and easy to explode when heated or vibrated. Then, the diazonium salt is mixed with cuprous bromide and hydrobromic acid, and the Sandmeier reaction occurs. 1-Bromo-3,5-difluorobenzene is obtained by substituting the diazo group with the bromine atom. However, the reagents used in this process are quite toxic, and the operation needs to be fine. If there is a little carelessness, it will be dangerous.
Second, 3,5-difluorobenzoic acid is used as the starting material. First, it is esterified with methanol under the catalysis of concentrated sulfuric acid to form 3,5-difluorobenzoate methyl ester. This reaction needs to be heated and refluxed to make the reaction sufficient. After that, it is reduced with lithium aluminum hydride to obtain 3,5-difluorobenzyl alcohol. Then phosphorus tribromide is reacted with it, and the hydroxyl group is replaced by bromine atoms, and the final target product is 1-bromo-3,5-difluorobenzene. There are many steps in this route, but each step is relatively mild and easy to control.
Third, 1,3,5-trifluorobenzene is used as the raw material. In the presence of a suitable catalyst, an electrophilic substitution reaction occurs with the brominating reagent. This process requires precise control of the reaction conditions, such as temperature and catalyst dosage. Due to the influence of fluorine atoms on the benzene ring, the selectivity of the reaction check point needs to be carefully adjusted, so that the bromine atom can accurately replace one fluorine atom to obtain 1-bromo-3,5-difluorobenzene. The raw materials of this method are relatively easy to obtain, but the reaction conditions are strict and the technical difficulty is high.
What are the precautions for storing and transporting 1-chloro-3,5-difluorobenzene?
For 1-% -3,5-difluorobenzene, it is advisable to pay attention to the general situation when it is stored. Its properties are not active, and it is dangerous to a certain extent, so it is necessary to be cautious.
It is the first time to install a large number of room parts. It is necessary to deal with the temperature and source of fire and gas in order to avoid the risk of ignition and explosion. The temperature of this compound is sensitive, and high temperature can easily cause its chemical properties to be changed. Therefore, the temperature of the room should be controlled according to the temperature, not high. And because of its decay, the floor, wall, etc. of the room should be made of corrosion-resistant materials to prevent its leakage and corrosion.
Furthermore, the existing containers are also studied. A sealed container must be used to prevent it from being outside. And the material of the container is compatible with 1-%-3,5-difluorobenzene, and it is not biochemical. Containers made of special glass or anti-corrosive plastic are often used. Place it in a neat and orderly manner, do not pile it up, and there are clear warnings so that it can be used.
If there is a leak in the middle of the process, do not panic. Immediately evacuate the surrounding crowd and set a warning area. Workers should wear anti-pollution equipment and use high-quality materials to absorb or contain leaks. Do not allow them to flow freely and pollute the environment.
Therefore, the storage of 1-%-3,5-difluorobenzene is safe. Follow the rules and pay attention to the situation to ensure that it is lost.
It is the first time to install a large number of room parts. It is necessary to deal with the temperature and source of fire and gas in order to avoid the risk of ignition and explosion. The temperature of this compound is sensitive, and high temperature can easily cause its chemical properties to be changed. Therefore, the temperature of the room should be controlled according to the temperature, not high. And because of its decay, the floor, wall, etc. of the room should be made of corrosion-resistant materials to prevent its leakage and corrosion.
Furthermore, the existing containers are also studied. A sealed container must be used to prevent it from being outside. And the material of the container is compatible with 1-%-3,5-difluorobenzene, and it is not biochemical. Containers made of special glass or anti-corrosive plastic are often used. Place it in a neat and orderly manner, do not pile it up, and there are clear warnings so that it can be used.
If there is a leak in the middle of the process, do not panic. Immediately evacuate the surrounding crowd and set a warning area. Workers should wear anti-pollution equipment and use high-quality materials to absorb or contain leaks. Do not allow them to flow freely and pollute the environment.
Therefore, the storage of 1-%-3,5-difluorobenzene is safe. Follow the rules and pay attention to the situation to ensure that it is lost.
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