Linshang Chemical
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1-Chloro-3-(Chloromethyl)-Benzene
Linshang Chemical
|
HS Code |
984251 |
| Chemical Formula | C8H8Cl2 |
| Molar Mass | 175.055 g/mol |
| Appearance | Colorless to pale - yellow liquid |
| Boiling Point | 219 - 221 °C |
| Density | 1.18 g/cm³ (approximate) |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether, etc. |
| Odor | Pungent, aromatic odor |
| Flash Point | 97 °C (closed cup) |
As an accredited 1-Chloro-3-(Chloromethyl)-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 3 - (chloromethyl) - benzene: Packed in 500 - mL glass bottles, 10 bottles per carton. |
| Storage | 1 - chloro - 3 - (chloromethyl) - benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. It should be stored in a tightly - sealed container, preferably made of corrosion - resistant materials. Keep it separate from oxidizing agents, bases, and reactive chemicals to prevent unwanted reactions. Follow local safety regulations for chemical storage. |
| Shipping | 1 - chloro - 3 - (chloromethyl) - benzene is shipped in tightly sealed, corrosion - resistant containers. Shipment follows strict hazardous chemical regulations, ensuring proper labeling and safe handling during transit to prevent leaks and risks. |
Competitive 1-Chloro-3-(Chloromethyl)-Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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What are the physical properties of 1-chloro-3- (chloromethyl) -benzene?
1-Chloro-3- (chloromethyl) -benzene, the physical properties of this substance are as follows:
It is mostly colorless to light yellow liquid under normal temperature and pressure. Looking at its shape, it is clearly recognizable and has a pure texture. Smell it, there is a specific aromatic smell, but this smell is not pleasant, but rather irritating.
When it comes to the melting point, the melting point is relatively low, about -15 ° C. Such a low melting point makes it difficult to form a solid state under normal low temperature environments. The boiling point is about 220-222 ° C. A higher boiling point indicates that it needs to supply more heat to vaporize it.
Its density is greater than that of water, about 1.26g/cm ³. When placed in one place with water, it can be seen that it sinks to the bottom of the water and is insoluble with water. And because of its volatility, it can slowly evaporate into the air in an open environment.
In terms of solubility, 1-chloro-3- (chloromethyl) -benzene is soluble in many organic solvents, such as ethanol, ether, acetone, etc. In such organic solvents, it can be well dispersed and dissolved, showing good mutual solubility. However, it is almost insoluble with water, and this property is closely related to the properties of the groups contained in the molecular structure.
In addition, the substance has a certain refractive index, which will produce a specific refractive phenomenon when light passes through. Its refractive index is about 1.552 - 1.554. This parameter is also an important basis for identifying and identifying the substance. Overall, the physical properties of 1-chloro-3- (chloromethyl) -benzene are unique, and their applications in chemical industry, scientific research and other fields often rely on these properties.
It is mostly colorless to light yellow liquid under normal temperature and pressure. Looking at its shape, it is clearly recognizable and has a pure texture. Smell it, there is a specific aromatic smell, but this smell is not pleasant, but rather irritating.
When it comes to the melting point, the melting point is relatively low, about -15 ° C. Such a low melting point makes it difficult to form a solid state under normal low temperature environments. The boiling point is about 220-222 ° C. A higher boiling point indicates that it needs to supply more heat to vaporize it.
Its density is greater than that of water, about 1.26g/cm ³. When placed in one place with water, it can be seen that it sinks to the bottom of the water and is insoluble with water. And because of its volatility, it can slowly evaporate into the air in an open environment.
In terms of solubility, 1-chloro-3- (chloromethyl) -benzene is soluble in many organic solvents, such as ethanol, ether, acetone, etc. In such organic solvents, it can be well dispersed and dissolved, showing good mutual solubility. However, it is almost insoluble with water, and this property is closely related to the properties of the groups contained in the molecular structure.
In addition, the substance has a certain refractive index, which will produce a specific refractive phenomenon when light passes through. Its refractive index is about 1.552 - 1.554. This parameter is also an important basis for identifying and identifying the substance. Overall, the physical properties of 1-chloro-3- (chloromethyl) -benzene are unique, and their applications in chemical industry, scientific research and other fields often rely on these properties.
What are the chemical properties of 1-chloro-3- (chloromethyl) -benzene
1 - chloro - 3 - (chloromethyl) - benzene is m-chlorobenzyl chloride, which is an organic compound with the following chemical properties:
1. ** Nucleophilic Substitution Reaction **: In this compound, the chlorine atom of chloromethyl is extremely active. It is affected by the electron-absorbing effect of the benzene ring and the chlorine atom, which reduces the electron cloud density of the carbon atom and makes it vulnerable to nucleophilic attack. If co-heated with an aqueous solution of sodium hydroxide, the hydroxyl nucleophilic reagent will replace the chlorine atom of chloromethyl to form m-chlorobenzyl alcohol; if reacted with sodium cyanide in a suitable solvent, the cyano group will replace the chlorine atom, and can be converted into m-chlorobenzoic acid after hydrolysis ** Electrophilic Substitution Reaction of Benzene Ring **: The benzene ring has electron-rich properties and can undergo electrophilic substitution reaction. In view of the fact that the chlorine atom is an ortho-and para-site group, in the presence of catalysts such as iron trichloride, bromine atoms mainly enter the ortho-and para-site of the chlorine atom to generate products such as 3-chloro-5- (chloromethyl) -bromobenzene; when heated with mixed acids of concentrated sulfuric acid and concentrated nitric acid, nitrification can occur to generate m-chloro-3- (chloromethyl) -nitrobenzene, etc.
3. ** Elimination reaction of halogenated hydrocarbons **: Although m-chlorobenzyl chloride mainly undergoes nucleophilic substitution reaction, under specific conditions, such as in alcohol solutions of ethanol and potassium, chlorine atoms of chloromethyl groups can be eliminated with ortho-hydrogen atoms to form unsaturated compounds containing carbon-carbon double bonds.
4. ** Reaction with metals **: It can react with metals such as magnesium in anhydrous ether and other solvents to form Grignard reagents. This Grignard reagent is an extremely important intermediate in organic synthesis and can react with carbonyl compounds, etc., to increase the carbon chain and build new carbon-carbon bonds.
1. ** Nucleophilic Substitution Reaction **: In this compound, the chlorine atom of chloromethyl is extremely active. It is affected by the electron-absorbing effect of the benzene ring and the chlorine atom, which reduces the electron cloud density of the carbon atom and makes it vulnerable to nucleophilic attack. If co-heated with an aqueous solution of sodium hydroxide, the hydroxyl nucleophilic reagent will replace the chlorine atom of chloromethyl to form m-chlorobenzyl alcohol; if reacted with sodium cyanide in a suitable solvent, the cyano group will replace the chlorine atom, and can be converted into m-chlorobenzoic acid after hydrolysis ** Electrophilic Substitution Reaction of Benzene Ring **: The benzene ring has electron-rich properties and can undergo electrophilic substitution reaction. In view of the fact that the chlorine atom is an ortho-and para-site group, in the presence of catalysts such as iron trichloride, bromine atoms mainly enter the ortho-and para-site of the chlorine atom to generate products such as 3-chloro-5- (chloromethyl) -bromobenzene; when heated with mixed acids of concentrated sulfuric acid and concentrated nitric acid, nitrification can occur to generate m-chloro-3- (chloromethyl) -nitrobenzene, etc.
3. ** Elimination reaction of halogenated hydrocarbons **: Although m-chlorobenzyl chloride mainly undergoes nucleophilic substitution reaction, under specific conditions, such as in alcohol solutions of ethanol and potassium, chlorine atoms of chloromethyl groups can be eliminated with ortho-hydrogen atoms to form unsaturated compounds containing carbon-carbon double bonds.
4. ** Reaction with metals **: It can react with metals such as magnesium in anhydrous ether and other solvents to form Grignard reagents. This Grignard reagent is an extremely important intermediate in organic synthesis and can react with carbonyl compounds, etc., to increase the carbon chain and build new carbon-carbon bonds.
What are the industrial uses of 1-chloro-3- (chloromethyl) -benzene?
1-chloro-3- (chloromethyl) -benzene, that is, m-chlorobenzyl chloride, is widely used in industry.
One of them can be used as a key intermediate in organic synthesis. Because its molecules contain chlorine atoms and chloromethyl groups, they have high reactivity and can interact with many nucleophilic reagents, such as alcohols, amines, mercaptans, etc., to generate a series of valuable organic compounds. For example, when reacted with alcohols, ether compounds can be prepared; when reacted with amines, amine-substituted derivatives can be formed. These products are crucial in the fields of medicine, pesticides, dyes, etc.
Second, in the field of pesticides, m-chlorobenzyl chloride can be converted into high-efficiency pesticides through specific chemical reactions. Some chlorine-containing pesticides synthesized by multi-step reaction with m-chlorobenzyl chloride as a starting material have excellent contact-killing, gastric toxicity and endosorption effects on pests, can effectively prevent and control crop pests, and ensure crop yield and quality.
Third, it also plays an important role in the synthesis of medicines. Through rational chemical transformation, it can be constructed into complex drug molecular structures, giving drugs specific biological activities and pharmacological properties. In the process of drug development, m-chlorobenzyl chloride will be used to introduce key structural fragments to optimize the performance of drugs.
Fourth, in the field of materials science, m-chlorobenzyl chloride can participate in the preparation of polymer materials with special functions. By polymerizing with suitable monomers, polymer materials can be endowed with unique physical and chemical properties, such as improving the heat resistance and chemical corrosion resistance of materials, and expanding the application range of materials.
With its unique chemical structure and reactivity, m-chlorobenzyl chloride plays an indispensable role in many fields of industry, promoting the development and progress of organic synthesis, pesticides, medicine and materials.
One of them can be used as a key intermediate in organic synthesis. Because its molecules contain chlorine atoms and chloromethyl groups, they have high reactivity and can interact with many nucleophilic reagents, such as alcohols, amines, mercaptans, etc., to generate a series of valuable organic compounds. For example, when reacted with alcohols, ether compounds can be prepared; when reacted with amines, amine-substituted derivatives can be formed. These products are crucial in the fields of medicine, pesticides, dyes, etc.
Second, in the field of pesticides, m-chlorobenzyl chloride can be converted into high-efficiency pesticides through specific chemical reactions. Some chlorine-containing pesticides synthesized by multi-step reaction with m-chlorobenzyl chloride as a starting material have excellent contact-killing, gastric toxicity and endosorption effects on pests, can effectively prevent and control crop pests, and ensure crop yield and quality.
Third, it also plays an important role in the synthesis of medicines. Through rational chemical transformation, it can be constructed into complex drug molecular structures, giving drugs specific biological activities and pharmacological properties. In the process of drug development, m-chlorobenzyl chloride will be used to introduce key structural fragments to optimize the performance of drugs.
Fourth, in the field of materials science, m-chlorobenzyl chloride can participate in the preparation of polymer materials with special functions. By polymerizing with suitable monomers, polymer materials can be endowed with unique physical and chemical properties, such as improving the heat resistance and chemical corrosion resistance of materials, and expanding the application range of materials.
With its unique chemical structure and reactivity, m-chlorobenzyl chloride plays an indispensable role in many fields of industry, promoting the development and progress of organic synthesis, pesticides, medicine and materials.
What are the synthesis methods of 1-chloro-3- (chloromethyl) -benzene?
1-Chloro-3- (chloromethyl) benzene, also known as m-chlorobenzyl chloride, has various synthesis methods. The following is your detailed description.
First, m-cresol is used as the starting material. First, m-cresol is interacted with thionyl chloride. In this step, the sulfur atom in thionyl chloride is nucleophilic and attacks the phenolic hydroxyl oxygen atom. The phenolic hydroxyl group is replaced by the chlorine atom to form m-chlorotoluene. Subsequently, in the presence of light or initiator, m-chlorotoluene undergoes a free radical substitution reaction with chlorine gas. Due to the influence of the benzene ring on the methyl group, α-hydrogen has high activity. Chlorine radicals in the chlorine gas capture α-hydrogen to form 1-chloro-3- (chloromethyl) benzene. The raw materials of this method are relatively easy to obtain, the reaction conditions of each step are relatively mild, and it is widely used in the field of organic synthesis.
Second, m-xylene is used as the starting material. First, through selective chlorination reaction, chlorine gas can be used to react with m-xylene under the action of a specific catalyst. Due to the fact that methyl is an ortho-para-site group and the influence of steric hindrance and other factors, chlorine atoms can be selectively introduced into the ortho-site of one of the methyl groups to generate 3-chloro-1,2- Then, using a suitable oxidant, such as a mixed system of manganese dioxide and sulfuric acid, the unchlorinated methyl is oxidized to chloromethyl to obtain the target product 1-chloro-3- (chloromethyl) benzene. This route has relatively many steps, but it is also a feasible method for the rich resources of m-xylene.
Third, benzene is used as the starting material. First, benzene and chloromethane are alkylated by Fu-g under the catalysis of anhydrous aluminum trichloride to produce toluene. Then toluene and chlorine are side-chain chlorinated under the action of light or initiator to generate benzyl chloride. Then benzyl chloride is chlorinated with chlorine on the benzene ring catalyzed by Lewis acid (such as ferric trichloride). Because benzyl is an ortho-para-position group, chlorine atoms can be introduced into the meta-position, and finally 1-chloro-3- (chloromethyl) benzene is obtained. This method has simple raw materials, but there are many reaction steps, and there may be side reactions such as polyalkylation in the Fu-gram alkylation reaction, and the reaction conditions need to be carefully controlled.
First, m-cresol is used as the starting material. First, m-cresol is interacted with thionyl chloride. In this step, the sulfur atom in thionyl chloride is nucleophilic and attacks the phenolic hydroxyl oxygen atom. The phenolic hydroxyl group is replaced by the chlorine atom to form m-chlorotoluene. Subsequently, in the presence of light or initiator, m-chlorotoluene undergoes a free radical substitution reaction with chlorine gas. Due to the influence of the benzene ring on the methyl group, α-hydrogen has high activity. Chlorine radicals in the chlorine gas capture α-hydrogen to form 1-chloro-3- (chloromethyl) benzene. The raw materials of this method are relatively easy to obtain, the reaction conditions of each step are relatively mild, and it is widely used in the field of organic synthesis.
Second, m-xylene is used as the starting material. First, through selective chlorination reaction, chlorine gas can be used to react with m-xylene under the action of a specific catalyst. Due to the fact that methyl is an ortho-para-site group and the influence of steric hindrance and other factors, chlorine atoms can be selectively introduced into the ortho-site of one of the methyl groups to generate 3-chloro-1,2- Then, using a suitable oxidant, such as a mixed system of manganese dioxide and sulfuric acid, the unchlorinated methyl is oxidized to chloromethyl to obtain the target product 1-chloro-3- (chloromethyl) benzene. This route has relatively many steps, but it is also a feasible method for the rich resources of m-xylene.
Third, benzene is used as the starting material. First, benzene and chloromethane are alkylated by Fu-g under the catalysis of anhydrous aluminum trichloride to produce toluene. Then toluene and chlorine are side-chain chlorinated under the action of light or initiator to generate benzyl chloride. Then benzyl chloride is chlorinated with chlorine on the benzene ring catalyzed by Lewis acid (such as ferric trichloride). Because benzyl is an ortho-para-position group, chlorine atoms can be introduced into the meta-position, and finally 1-chloro-3- (chloromethyl) benzene is obtained. This method has simple raw materials, but there are many reaction steps, and there may be side reactions such as polyalkylation in the Fu-gram alkylation reaction, and the reaction conditions need to be carefully controlled.
What are the effects of 1-chloro-3- (chloromethyl) -benzene on the environment and the human body?
1-Chloro-3- (chloromethyl) benzene, this is an organic compound. It has an impact on both the environment and the human body, as detailed below:
In terms of the environment, this compound has a certain persistence. If it enters the soil, due to its own nature, it is difficult to be rapidly decomposed by soil microorganisms, or cause long-term residues, affecting soil ecology. If it enters the water body, it will deteriorate the water quality, because of its toxicity, or cause toxicity to aquatic organisms. After contact with aquatic organisms, growth and development may be hindered, reproduction capacity may decrease, etc., destroying the balance of aquatic ecosystems. Moreover, this compound may evaporate into the atmosphere and participate in photochemical reactions, which will have adverse effects on the atmospheric environment and affect air quality.
As for the effects on the human body, 1-chloro-3- (chloromethyl) benzene is irritating. If human skin comes into contact with it, it can cause symptoms such as redness, itching, pain, etc. In severe cases, it may cause skin burns. If it is not accidentally entered into the eyes, it will cause strong irritation to the eyes, which can damage the eye tissue and affect vision. If inhaled, its volatilized vapor in the air will irritate the respiratory tract, causing cough, asthma, breathing difficulties, etc. Long-term inhalation or increase the risk of respiratory diseases. In addition, this compound may be potentially carcinogenic. Long-term exposure to the environment containing this substance will damage the DNA of human cells or increase the probability of genetic mutations, thereby increasing the risk of cancer.
In summary, 1-chloro-3- (chloromethyl) benzene has many adverse effects on the environment and human body. During production, use and disposal, it is necessary to treat it with caution and take protective and treatment measures to reduce its harm.
In terms of the environment, this compound has a certain persistence. If it enters the soil, due to its own nature, it is difficult to be rapidly decomposed by soil microorganisms, or cause long-term residues, affecting soil ecology. If it enters the water body, it will deteriorate the water quality, because of its toxicity, or cause toxicity to aquatic organisms. After contact with aquatic organisms, growth and development may be hindered, reproduction capacity may decrease, etc., destroying the balance of aquatic ecosystems. Moreover, this compound may evaporate into the atmosphere and participate in photochemical reactions, which will have adverse effects on the atmospheric environment and affect air quality.
As for the effects on the human body, 1-chloro-3- (chloromethyl) benzene is irritating. If human skin comes into contact with it, it can cause symptoms such as redness, itching, pain, etc. In severe cases, it may cause skin burns. If it is not accidentally entered into the eyes, it will cause strong irritation to the eyes, which can damage the eye tissue and affect vision. If inhaled, its volatilized vapor in the air will irritate the respiratory tract, causing cough, asthma, breathing difficulties, etc. Long-term inhalation or increase the risk of respiratory diseases. In addition, this compound may be potentially carcinogenic. Long-term exposure to the environment containing this substance will damage the DNA of human cells or increase the probability of genetic mutations, thereby increasing the risk of cancer.
In summary, 1-chloro-3- (chloromethyl) benzene has many adverse effects on the environment and human body. During production, use and disposal, it is necessary to treat it with caution and take protective and treatment measures to reduce its harm.
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