Linshang Chemical
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1-Chloro-3-Fluoro-2-Nitrobenzene
Linshang Chemical
|
HS Code |
479898 |
| Chemical Formula | C6H3ClFNO2 |
| Molar Mass | 177.545 g/mol |
| Appearance | Colorless to yellow liquid |
| Boiling Point | 216 - 217 °C |
| Density | 1.49 g/cm³ |
| Solubility In Water | Insoluble |
| Flash Point | 94 °C |
| Vapor Pressure | Low |
| Odor | Pungent |
As an accredited 1-Chloro-3-Fluoro-2-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1 - chloro - 3 - fluoro - 2 - nitrobenzene packaged in a sealed glass bottle. |
| Storage | 1 - Chloro - 3 - fluoro - 2 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be stored in tightly sealed containers, preferably made of corrosion - resistant materials. Keep it separated from oxidizing agents, reducing agents, and bases to prevent chemical reactions. Store in a dedicated chemical storage facility, following all safety regulations. |
| Shipping | 1 - Chloro - 3 - fluoro - 2 - nitrobenzene is a hazardous chemical. It should be shipped in well - sealed, corrosion - resistant containers. Adhere to strict regulations, using appropriate labeling and transport with carriers specialized in hazardous substances. |
Competitive 1-Chloro-3-Fluoro-2-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Chloro-3-Fluoro-2-Nitrobenzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Chloro-3-Fluoro-2-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-3-fluoro-2-nitrobenzene?
1-Chloro-3-fluoro-2-nitrobenzene is an important member of organic compounds. It has a wide range of uses and plays a key role in many fields.
It is first applied in the field of medicinal chemistry. This compound is often a key intermediate in the synthesis of drugs. Functional groups such as chlorine, fluorine and nitro on the benzene ring can be modified and transformed by chemical means, thereby constructing complex molecular structures with specific pharmacological activities. When a doctor wants to develop a new type of antibacterial, antiviral or anti-tumor drug, 1-chloro-3-fluoro-2-nitrobenzene can be used as a starting material. After a series of chemical reactions, the required pharmacoactive group is gradually constructed, so as to obtain a drug with excellent efficacy.
In addition, it also plays a crucial role in pesticide chemistry. It can be used as an important cornerstone for the synthesis of high-efficiency pesticides. Nowadays, the world attaches great importance to crop protection, and there is a growing demand for high-efficiency, low-toxicity and environmentally friendly pesticides. 1-chloro-3-fluoro-2-nitrobenzene can be converted into pesticide active ingredients that can effectively control pests, weeds and plant diseases through an ingenious chemical synthesis path. Its unique chemical structure endows the prepared pesticides with good biological activity and selectivity, which can not only kill pests with precision, but also have little impact on the environment and non-target organisms.
In addition, in the field of materials science, 1-chloro-3-fluoro-2-nitrobenzene has also emerged. Can participate in the synthesis of special polymers. By polymerizing with other monomers, its unique functional groups are introduced into the main chain or side chain of the polymer, thereby giving the polymer special properties, such as excellent thermal stability, chemical stability or electrical properties. These special polymers are widely used in high-end fields such as aerospace and electronic information, and can provide solid material support for technological development in related fields.
In conclusion, although 1-chloro-3-fluoro-2-nitrobenzene is a small organic molecule, it plays an extraordinary role in many fields such as medicine, pesticides and materials science, promoting technological progress and development in various fields.
It is first applied in the field of medicinal chemistry. This compound is often a key intermediate in the synthesis of drugs. Functional groups such as chlorine, fluorine and nitro on the benzene ring can be modified and transformed by chemical means, thereby constructing complex molecular structures with specific pharmacological activities. When a doctor wants to develop a new type of antibacterial, antiviral or anti-tumor drug, 1-chloro-3-fluoro-2-nitrobenzene can be used as a starting material. After a series of chemical reactions, the required pharmacoactive group is gradually constructed, so as to obtain a drug with excellent efficacy.
In addition, it also plays a crucial role in pesticide chemistry. It can be used as an important cornerstone for the synthesis of high-efficiency pesticides. Nowadays, the world attaches great importance to crop protection, and there is a growing demand for high-efficiency, low-toxicity and environmentally friendly pesticides. 1-chloro-3-fluoro-2-nitrobenzene can be converted into pesticide active ingredients that can effectively control pests, weeds and plant diseases through an ingenious chemical synthesis path. Its unique chemical structure endows the prepared pesticides with good biological activity and selectivity, which can not only kill pests with precision, but also have little impact on the environment and non-target organisms.
In addition, in the field of materials science, 1-chloro-3-fluoro-2-nitrobenzene has also emerged. Can participate in the synthesis of special polymers. By polymerizing with other monomers, its unique functional groups are introduced into the main chain or side chain of the polymer, thereby giving the polymer special properties, such as excellent thermal stability, chemical stability or electrical properties. These special polymers are widely used in high-end fields such as aerospace and electronic information, and can provide solid material support for technological development in related fields.
In conclusion, although 1-chloro-3-fluoro-2-nitrobenzene is a small organic molecule, it plays an extraordinary role in many fields such as medicine, pesticides and materials science, promoting technological progress and development in various fields.
What are the physical properties of 1-chloro-3-fluoro-2-nitrobenzene?
1 - chloro - 3 - fluoro - 2 - nitrobenzene, this is an organic compound with special physical properties. At room temperature, it is mostly in a liquid state, and it has a certain fluidity. Due to the molecular structure, it often has a specific smell. However, this smell is not fragrant or pungent.
When it comes to density, this compound is denser than water. If it is placed in the same place as water, it can be seen that it sinks to the bottom of the water. And because its molecules contain chlorine, fluorine, nitro and other groups, its boiling point also has characteristics. Intermolecular forces are enhanced by these groups, so the boiling point is relatively high, and a certain amount of heat is required to convert it from liquid to gas.
In terms of solubility, 1-chloro-3-fluoro-2-nitrobenzene is insoluble in water. Because water is a polar molecule, and the molecular polarity of this compound is quite different from that of water, it is difficult for the two to dissolve each other according to the principle of "similar miscibility". However, it is soluble in some organic solvents, such as ethanol, ether, etc., because these organic solvents are adapted to the intermolecular forces of the compound and can be miscible with each other.
In addition, 1-chloro-3-fluoro-2-nitrobenzene has a certain chemical activity due to its nitro and halogen atoms, and is often used as an important raw material or intermediate in organic synthesis and other fields. The physical properties of this compound have a great influence on its application and treatment methods. In actual operation, it is necessary to properly separate, purify and react according to its density, solubility, boiling point and other properties.
When it comes to density, this compound is denser than water. If it is placed in the same place as water, it can be seen that it sinks to the bottom of the water. And because its molecules contain chlorine, fluorine, nitro and other groups, its boiling point also has characteristics. Intermolecular forces are enhanced by these groups, so the boiling point is relatively high, and a certain amount of heat is required to convert it from liquid to gas.
In terms of solubility, 1-chloro-3-fluoro-2-nitrobenzene is insoluble in water. Because water is a polar molecule, and the molecular polarity of this compound is quite different from that of water, it is difficult for the two to dissolve each other according to the principle of "similar miscibility". However, it is soluble in some organic solvents, such as ethanol, ether, etc., because these organic solvents are adapted to the intermolecular forces of the compound and can be miscible with each other.
In addition, 1-chloro-3-fluoro-2-nitrobenzene has a certain chemical activity due to its nitro and halogen atoms, and is often used as an important raw material or intermediate in organic synthesis and other fields. The physical properties of this compound have a great influence on its application and treatment methods. In actual operation, it is necessary to properly separate, purify and react according to its density, solubility, boiling point and other properties.
What are the chemical properties of 1-chloro-3-fluoro-2-nitrobenzene?
1-Chloro-3-fluoro-2-nitrobenzene is one of the organic compounds. It has unique chemical properties, which are described in detail by you today.
First of all, its halogen atomic properties. This compound contains chlorine and fluorine dihalogen atoms. The activity of chlorine atoms is quite high. Although the nucleophilic substitution reaction is more difficult than that of halogenated alkanes due to the conjugation effect of benzene ring, it can still react with nucleophilic reagents under suitable conditions. In case of strong nucleophilic reagents, chlorine atoms can be replaced to form new compounds. Fluorine atoms have high electronegativity, which decreases the electron cloud density of benzene ring, especially the density of ortho and para-position electron clouds, resulting in lower electrophilic substitution activity than benzene. At the same time, the fluorine atom also affects the physical properties of the molecule, which can change the boiling point and melting point of the compound.
Furthermore, the nitro group is a strong electron-absorbing group. Its existence greatly reduces the electron cloud density of the benzene ring, making it extremely difficult for the electrophilic substitution reaction to occur, and reduces the density of the o and para-electron clouds even more than the meta-position. Therefore, the electrophilic substitution reaction mainly occurs in the meta-position. However, under certain specific conditions, the nitro group can also participate in the reaction. For example, the nitro group can be reduced to an amino group, which is an important conversion step in organic synthesis.
In addition, 1-chloro-3-fluoro-2-nitrobenzene contains a variety of functional groups, and the functional groups interact with each other. The conjugation and induction effects of halogen atoms and nitro groups are intertwined, which affect the reactivity and selectivity of compounds. This compound has a wide range of uses in the field of organic synthesis, and can be used as an intermediate to prepare many high-value-added organic compounds through different chemical reaction paths.
In short, 1-chloro-3-fluoro-2-nitrobenzene presents unique chemical properties due to its structure containing halogen atoms and nitro groups, and occupies an important position in the research and synthesis of organic chemistry.
First of all, its halogen atomic properties. This compound contains chlorine and fluorine dihalogen atoms. The activity of chlorine atoms is quite high. Although the nucleophilic substitution reaction is more difficult than that of halogenated alkanes due to the conjugation effect of benzene ring, it can still react with nucleophilic reagents under suitable conditions. In case of strong nucleophilic reagents, chlorine atoms can be replaced to form new compounds. Fluorine atoms have high electronegativity, which decreases the electron cloud density of benzene ring, especially the density of ortho and para-position electron clouds, resulting in lower electrophilic substitution activity than benzene. At the same time, the fluorine atom also affects the physical properties of the molecule, which can change the boiling point and melting point of the compound.
Furthermore, the nitro group is a strong electron-absorbing group. Its existence greatly reduces the electron cloud density of the benzene ring, making it extremely difficult for the electrophilic substitution reaction to occur, and reduces the density of the o and para-electron clouds even more than the meta-position. Therefore, the electrophilic substitution reaction mainly occurs in the meta-position. However, under certain specific conditions, the nitro group can also participate in the reaction. For example, the nitro group can be reduced to an amino group, which is an important conversion step in organic synthesis.
In addition, 1-chloro-3-fluoro-2-nitrobenzene contains a variety of functional groups, and the functional groups interact with each other. The conjugation and induction effects of halogen atoms and nitro groups are intertwined, which affect the reactivity and selectivity of compounds. This compound has a wide range of uses in the field of organic synthesis, and can be used as an intermediate to prepare many high-value-added organic compounds through different chemical reaction paths.
In short, 1-chloro-3-fluoro-2-nitrobenzene presents unique chemical properties due to its structure containing halogen atoms and nitro groups, and occupies an important position in the research and synthesis of organic chemistry.
What are 1-chloro-3-fluoro-2-nitrobenzene synthesis methods?
There are several methods for synthesizing 1-chloro-3-fluoro-2-nitrobenzene.
First, benzene is used as the starting material. First, benzene is nitrified. The mixed acid of concentrated sulfuric acid and concentrated nitric acid is used as the nitrifying reagent. At an appropriate temperature, nitro groups are introduced into the benzene ring to generate nitrobenzene. Then, nitrobenzene is halogenated. In the presence of a specific catalyst, such as iron or its halides, chlorine gas is introduced to introduce chlorine atoms at specific positions on the benzene ring to obtain an intermediate containing nitro and chlorine atoms. Finally, using fluorinated reagents, such as potassium fluoride, under suitable reaction conditions, such as high temperature and suitable solvents, the halogen in the intermediate is replaced by fluorine atoms to obtain 1-chloro-3-fluoro-2-nitrobenzene.
Second, o-nitroaniline is used as the starting material. First, o-nitroaniline is reacted with sodium nitrite and hydrochloric acid through diazotization to generate diazonium salts. After that, under the catalysis of cuprous chloride, it reacts with hydrogen chloride to achieve the substitution of diazonium groups with chlorine atoms to obtain o-nitrochlorobenzene. Then, the fluorination reaction of o-nitrochlorobenzene is carried out, and the appropriate fluorination reagent and reaction conditions are selected to introduce fluorine atoms at specific positions in the benzene ring, and the final product is 1-chloro-3-fluoro-2-nitrobenzene.
Third, m-fluorobenzene is used as raw material. Let m-fluorobenzene react with nitrifying reagents, such as mixed acids of nitric acid and sulfuric acid, and control the reaction conditions to selectively introduce nitro groups into specific positions in the benzene ring to obtain 1-chloro-3-fluoro-2-nitrobenzene. This process requires fine regulation of reaction conditions to ensure the selectivity of nitro introduction sites.
The above synthesis methods each have their own advantages and disadvantages. In practical applications, it is necessary to choose an appropriate synthesis path based on various factors such as the availability of raw materials, cost, difficulty in controlling reaction conditions, and purity requirements of the target product.
First, benzene is used as the starting material. First, benzene is nitrified. The mixed acid of concentrated sulfuric acid and concentrated nitric acid is used as the nitrifying reagent. At an appropriate temperature, nitro groups are introduced into the benzene ring to generate nitrobenzene. Then, nitrobenzene is halogenated. In the presence of a specific catalyst, such as iron or its halides, chlorine gas is introduced to introduce chlorine atoms at specific positions on the benzene ring to obtain an intermediate containing nitro and chlorine atoms. Finally, using fluorinated reagents, such as potassium fluoride, under suitable reaction conditions, such as high temperature and suitable solvents, the halogen in the intermediate is replaced by fluorine atoms to obtain 1-chloro-3-fluoro-2-nitrobenzene.
Second, o-nitroaniline is used as the starting material. First, o-nitroaniline is reacted with sodium nitrite and hydrochloric acid through diazotization to generate diazonium salts. After that, under the catalysis of cuprous chloride, it reacts with hydrogen chloride to achieve the substitution of diazonium groups with chlorine atoms to obtain o-nitrochlorobenzene. Then, the fluorination reaction of o-nitrochlorobenzene is carried out, and the appropriate fluorination reagent and reaction conditions are selected to introduce fluorine atoms at specific positions in the benzene ring, and the final product is 1-chloro-3-fluoro-2-nitrobenzene.
Third, m-fluorobenzene is used as raw material. Let m-fluorobenzene react with nitrifying reagents, such as mixed acids of nitric acid and sulfuric acid, and control the reaction conditions to selectively introduce nitro groups into specific positions in the benzene ring to obtain 1-chloro-3-fluoro-2-nitrobenzene. This process requires fine regulation of reaction conditions to ensure the selectivity of nitro introduction sites.
The above synthesis methods each have their own advantages and disadvantages. In practical applications, it is necessary to choose an appropriate synthesis path based on various factors such as the availability of raw materials, cost, difficulty in controlling reaction conditions, and purity requirements of the target product.
1-chloro-3-fluoro-2-nitrobenzene What are the precautions during storage and transportation?
1-Chloro-3-fluoro-2-nitrobenzene is one of the organic compounds. During storage and transportation, many matters need to be paid attention to.
Safety first. This compound is toxic and irritating. When storing, it must be placed in a cool and ventilated place, away from fire and heat sources, to prevent accidents. The warehouse temperature should be controlled within an appropriate range to avoid excessive temperature that will disturb its stability and cause dangerous chemical reactions. And it should be stored separately from oxidants, edible chemicals, etc., and must not be mixed, otherwise it may cause violent reactions.
Furthermore, the packaging should be tight. Before transportation, ensure that the packaging is intact, and the packaging materials used must be able to effectively prevent leakage. If the packaging is damaged, the leakage of 1-chloro-3-fluoro-2-nitrobenzene will not only pollute the environment, but also pose a threat to the safety of surrounding personnel. During transportation, care should also be taken to avoid collision, vibration and friction to prevent damage to the packaging.
Repeat, the logo should be clear. Clear hazard signs, such as toxic, irritating and other warning words, should be posted on the storage place and the transportation vehicle, so that the contact can be seen at a glance, so that appropriate protective measures can be taken.
In addition, the protection of relevant personnel cannot be ignored. Those involved in storage and transportation must be equipped with appropriate protective equipment, such as gas masks, protective gloves, protective clothing, etc., to avoid direct contact with this material and endanger health. In the event of a leak or other accident, the surrounding personnel should be evacuated quickly, emergency plans should be activated, and effective measures should be taken to reduce the harm. In short, when storing and transporting 1-chloro-3-fluoro-2-nitrobenzene, all aspects need to be treated with caution to ensure safety.
Safety first. This compound is toxic and irritating. When storing, it must be placed in a cool and ventilated place, away from fire and heat sources, to prevent accidents. The warehouse temperature should be controlled within an appropriate range to avoid excessive temperature that will disturb its stability and cause dangerous chemical reactions. And it should be stored separately from oxidants, edible chemicals, etc., and must not be mixed, otherwise it may cause violent reactions.
Furthermore, the packaging should be tight. Before transportation, ensure that the packaging is intact, and the packaging materials used must be able to effectively prevent leakage. If the packaging is damaged, the leakage of 1-chloro-3-fluoro-2-nitrobenzene will not only pollute the environment, but also pose a threat to the safety of surrounding personnel. During transportation, care should also be taken to avoid collision, vibration and friction to prevent damage to the packaging.
Repeat, the logo should be clear. Clear hazard signs, such as toxic, irritating and other warning words, should be posted on the storage place and the transportation vehicle, so that the contact can be seen at a glance, so that appropriate protective measures can be taken.
In addition, the protection of relevant personnel cannot be ignored. Those involved in storage and transportation must be equipped with appropriate protective equipment, such as gas masks, protective gloves, protective clothing, etc., to avoid direct contact with this material and endanger health. In the event of a leak or other accident, the surrounding personnel should be evacuated quickly, emergency plans should be activated, and effective measures should be taken to reduce the harm. In short, when storing and transporting 1-chloro-3-fluoro-2-nitrobenzene, all aspects need to be treated with caution to ensure safety.
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