Linshang Chemical
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1-Chloro-3-Fluoro-2-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
573158 |
| Chemical Formula | C7H3ClF4 |
| Molecular Weight | 200.545 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 153 - 155 °C |
| Density | 1.424 g/cm³ |
| Solubility | Insoluble in water, soluble in organic solvents |
| Flash Point | 45.8 °C |
| Refractive Index | 1.429 |
As an accredited 1-Chloro-3-Fluoro-2-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500 - gram bottle packaging for 1 - chloro - 3 - fluoro - 2 - (trifluoromethyl)benzene. |
| Storage | 1 - Chloro - 3 - fluoro - 2 - (trifluoromethyl)benzene should be stored in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, acids, and bases to prevent potential reactions. Avoid storing in areas prone to high humidity. |
| Shipping | 1 - Chloro - 3 - fluoro - 2 - (trifluoromethyl)benzene is shipped in specialized, leak - proof containers. Due to its chemical nature, it's transported following strict safety regulations, ensuring secure handling during transit. |
Competitive 1-Chloro-3-Fluoro-2-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 1-Chloro-3-Fluoro-2-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-3-fluoro-2- (trifluoromethyl) benzene?
1-Chloro-3-fluoro-2 - (trifluoromethyl) benzene, an organic compound, has important uses in many fields.
One is in the field of medicinal chemistry, which is often used as a key intermediate. Due to the special structure of this compound, it contains functional groups such as chlorine, fluorine and trifluoromethyl, giving it unique physical and chemical properties. With these properties, it can be converted into molecules with specific biological activities through a series of organic synthesis reactions, which can be used to develop new drugs. For example, some fluorinated drugs have excellent performance in metabolic stability and fat solubility in the body, which helps to improve the efficacy and bioavailability of drugs. This compound may be used as a starting material to build the core skeleton of drug molecules through multi-step reactions, laying the foundation for the creation of new antibacterial, anticancer, antiviral and other drugs.
Second, in the field of materials science, 1-chloro-3-fluoro-2 - (trifluoromethyl) benzene also has important applications. Due to the presence of fluorine-containing groups, the properties of materials can be significantly improved. For example, introducing it into polymer materials can enhance the weather resistance, chemical corrosion resistance and surface hydrophobicity of materials. In this way, high-performance materials suitable for special environments can be prepared, such as protective coating materials for aerospace applications, or materials with excellent insulation properties and chemical stability in electronic devices.
Furthermore, in the field of pesticide chemistry, this compound also plays an important role. Fluorinated pesticides often have many advantages such as high efficiency, low toxicity, and environmental friendliness. 1-Chloro-3-fluoro-2 - (trifluoromethyl) benzene can be used as a key intermediate in the synthesis of new pesticides. After rational design and reaction, pesticides with high selective killing effect on specific pests or weeds can be prepared, which helps to improve the efficiency and quality of agricultural production while reducing the adverse impact on the environment.
To sum up, 1-chloro-3-fluoro-2 - (trifluoromethyl) benzene, with its unique structure and properties, has shown important application value in many fields such as medicine, materials, and pesticides, promoting the sustainable development and progress of related fields.
One is in the field of medicinal chemistry, which is often used as a key intermediate. Due to the special structure of this compound, it contains functional groups such as chlorine, fluorine and trifluoromethyl, giving it unique physical and chemical properties. With these properties, it can be converted into molecules with specific biological activities through a series of organic synthesis reactions, which can be used to develop new drugs. For example, some fluorinated drugs have excellent performance in metabolic stability and fat solubility in the body, which helps to improve the efficacy and bioavailability of drugs. This compound may be used as a starting material to build the core skeleton of drug molecules through multi-step reactions, laying the foundation for the creation of new antibacterial, anticancer, antiviral and other drugs.
Second, in the field of materials science, 1-chloro-3-fluoro-2 - (trifluoromethyl) benzene also has important applications. Due to the presence of fluorine-containing groups, the properties of materials can be significantly improved. For example, introducing it into polymer materials can enhance the weather resistance, chemical corrosion resistance and surface hydrophobicity of materials. In this way, high-performance materials suitable for special environments can be prepared, such as protective coating materials for aerospace applications, or materials with excellent insulation properties and chemical stability in electronic devices.
Furthermore, in the field of pesticide chemistry, this compound also plays an important role. Fluorinated pesticides often have many advantages such as high efficiency, low toxicity, and environmental friendliness. 1-Chloro-3-fluoro-2 - (trifluoromethyl) benzene can be used as a key intermediate in the synthesis of new pesticides. After rational design and reaction, pesticides with high selective killing effect on specific pests or weeds can be prepared, which helps to improve the efficiency and quality of agricultural production while reducing the adverse impact on the environment.
To sum up, 1-chloro-3-fluoro-2 - (trifluoromethyl) benzene, with its unique structure and properties, has shown important application value in many fields such as medicine, materials, and pesticides, promoting the sustainable development and progress of related fields.
What are the physical properties of 1-chloro-3-fluoro-2- (trifluoromethyl) benzene
1-Chloro-3-fluoro-2- (trifluoromethyl) benzene is one of the organic compounds. It has unique physical properties and is widely used in the chemical industry.
Looking at its properties, it is usually a colorless to light yellow transparent liquid with a special odor. This odor can be used as the basis for preliminary identification. Its boiling point is related to practical application, about a certain temperature range. At this temperature, the substance changes from liquid to gaseous state. This property is very critical in separation operations such as distillation. The melting point is also an important parameter, which determines its physical state at a specific temperature. If the temperature is lower than the melting point, it will be solid.
Furthermore, its density has a fixed number, and it is indispensable to consider the density in the process of chemical production. In terms of solubility, it can show good solubility in organic solvents such as certain aromatics and halogenated hydrocarbons, but it has poor solubility in water. This feature helps to select suitable solvents for reaction or separation and purification.
In addition, the vapor pressure of 1-chloro-3-fluoro-2 - (trifluoromethyl) benzene is also an important physical property. The vapor pressure reflects the difficulty of evaporation at a certain temperature. If the vapor pressure is high, it is relatively volatile. Safety factors such as ventilation should be considered when storing and using.
In summary, the various physical properties of 1-chloro-3-fluoro-2 - (trifluoromethyl) benzene, such as their properties, boiling point, melting point, density, solubility, and vapor pressure, have a profound impact on their chemical production, storage, and application. All these properties are interrelated and together determine their behavior and use in various chemical processes.
Looking at its properties, it is usually a colorless to light yellow transparent liquid with a special odor. This odor can be used as the basis for preliminary identification. Its boiling point is related to practical application, about a certain temperature range. At this temperature, the substance changes from liquid to gaseous state. This property is very critical in separation operations such as distillation. The melting point is also an important parameter, which determines its physical state at a specific temperature. If the temperature is lower than the melting point, it will be solid.
Furthermore, its density has a fixed number, and it is indispensable to consider the density in the process of chemical production. In terms of solubility, it can show good solubility in organic solvents such as certain aromatics and halogenated hydrocarbons, but it has poor solubility in water. This feature helps to select suitable solvents for reaction or separation and purification.
In addition, the vapor pressure of 1-chloro-3-fluoro-2 - (trifluoromethyl) benzene is also an important physical property. The vapor pressure reflects the difficulty of evaporation at a certain temperature. If the vapor pressure is high, it is relatively volatile. Safety factors such as ventilation should be considered when storing and using.
In summary, the various physical properties of 1-chloro-3-fluoro-2 - (trifluoromethyl) benzene, such as their properties, boiling point, melting point, density, solubility, and vapor pressure, have a profound impact on their chemical production, storage, and application. All these properties are interrelated and together determine their behavior and use in various chemical processes.
What are the chemical properties of 1-chloro-3-fluoro-2- (trifluoromethyl) benzene
1-Chloro-3-fluoro-2- (trifluoromethyl) benzene is one of the organic compounds. Its chemical properties are unique, related to many reaction characteristics, and it has a wide range of uses in the field of organic synthesis.
First describes its halogen atom properties. Both chlorine and fluorine atoms have the common properties of halogen atoms and can undergo nucleophilic substitution reactions. In this reaction, halogen atoms can be replaced by nucleophilic reagents. Because fluorine atoms are extremely electronegative and have a large carbon-fluorine bond energy, their substitution reactions are relatively difficult to occur; while chlorine atoms have relatively small carbon-chlorine bond energy and are easier to be attacked by nucleophilic reagents. Common nucleophilic reagents such as hydroxyl (-OH) and amino (-NH ²) can undergo nucleophilic substitution with the chlorine atom in the compound to form corresponding derivatives containing hydroxyl or amino groups.
Furthermore, the properties of its benzene ring. The benzene ring is aromatic and can undergo electrophilic substitution reaction. Since there are substituents such as chlorine, fluorine and trifluoromethyl on the benzene ring, these substituents will affect the electron cloud density distribution of the benzene ring. Chlorine and fluorine are electron-withdrawing groups, and trifluoromethyl is also a strong electron-withdrawing group, which reduces the electron cloud density of the benzene ring, and the activity of electrophilic substitution reaction is decreased compared with that of benzene. However, electrophilic substitution reactions can still occur, and the substitution positions are affected by the localization effect Chlorine and fluorine are ortho-para-sites, and trifluoromethyl is an meta-site. Under the combined action, electrophilic reagents are more inclined to attack specific positions on the benzene ring.
In addition, the presence of trifluoromethyl also has a great influence on the properties of the compound. Trifluoromethyl has strong electron absorption, which can enhance the polarity of the molecule and affect the physical properties of the compound, such as boiling point and solubility. At the same time, in chemical reactions, it can affect the activity and selectivity of the reaction. In redox reactions, trifluoromethyl can affect the distribution of electron clouds in other parts of the molecule, which in turn affects the difficulty of the reaction and the structure of the product.
This compound is rich in chemical properties and has important research and application value in the fields of organic synthesis, medicinal chemistry, etc. It can build a variety of organic compound structures by virtue of its unique properties.
First describes its halogen atom properties. Both chlorine and fluorine atoms have the common properties of halogen atoms and can undergo nucleophilic substitution reactions. In this reaction, halogen atoms can be replaced by nucleophilic reagents. Because fluorine atoms are extremely electronegative and have a large carbon-fluorine bond energy, their substitution reactions are relatively difficult to occur; while chlorine atoms have relatively small carbon-chlorine bond energy and are easier to be attacked by nucleophilic reagents. Common nucleophilic reagents such as hydroxyl (-OH) and amino (-NH ²) can undergo nucleophilic substitution with the chlorine atom in the compound to form corresponding derivatives containing hydroxyl or amino groups.
Furthermore, the properties of its benzene ring. The benzene ring is aromatic and can undergo electrophilic substitution reaction. Since there are substituents such as chlorine, fluorine and trifluoromethyl on the benzene ring, these substituents will affect the electron cloud density distribution of the benzene ring. Chlorine and fluorine are electron-withdrawing groups, and trifluoromethyl is also a strong electron-withdrawing group, which reduces the electron cloud density of the benzene ring, and the activity of electrophilic substitution reaction is decreased compared with that of benzene. However, electrophilic substitution reactions can still occur, and the substitution positions are affected by the localization effect Chlorine and fluorine are ortho-para-sites, and trifluoromethyl is an meta-site. Under the combined action, electrophilic reagents are more inclined to attack specific positions on the benzene ring.
In addition, the presence of trifluoromethyl also has a great influence on the properties of the compound. Trifluoromethyl has strong electron absorption, which can enhance the polarity of the molecule and affect the physical properties of the compound, such as boiling point and solubility. At the same time, in chemical reactions, it can affect the activity and selectivity of the reaction. In redox reactions, trifluoromethyl can affect the distribution of electron clouds in other parts of the molecule, which in turn affects the difficulty of the reaction and the structure of the product.
This compound is rich in chemical properties and has important research and application value in the fields of organic synthesis, medicinal chemistry, etc. It can build a variety of organic compound structures by virtue of its unique properties.
What are the synthesis methods of 1-chloro-3-fluoro-2- (trifluoromethyl) benzene
There are several common methods for synthesizing 1-chloro-3-fluoro-2- (trifluoromethyl) benzene. One is to use halogenated aromatics as the starting material and obtain it through multi-step reaction.
First, benzene containing an appropriate substituent is used as the substrate, and chlorine atoms are first introduced. Suitable chlorinated reagents, such as chlorine gas and sulfoxide chloride, can be selected. Under specific reaction conditions, such as suitable temperature and catalyst, the chlorine atom replaces the hydrogen atom on the benzene ring to obtain the chlorine-containing benzene derivative.
Then fluorine atoms are introduced. Nucleophilic substitution reaction can be used to select suitable fluorination reagents, such as potassium fluoride, etc. Under appropriate solvent system and reaction conditions, fluorine atoms are substituted for halogen atoms at specific positions or other suitable leaving groups, so fluorine atoms are introduced.
As for the introduction of trifluoromethyl, the common method is to react with reagents containing trifluoromethyl. If a trifluoromethylation reagent can be selected, under specific catalyst and reaction conditions, trifluoromethyl is substituted for the group at the corresponding position on the benzene ring to obtain 1-chloro-3-fluoro-2- (trifluoromethyl) benzene.
In addition, there are other synthesis routes, or starting from different starting materials, with different reaction mechanisms, such as the reaction of aryl diazonium salts, etc., through multi-step ingenious transformation, the synthesis of this target product can also be achieved. However, no matter what method, the reaction conditions need to be carefully adjusted, and the selectivity, yield and other factors of each step of the reaction need to be considered in order to achieve the purpose of efficient and high-quality synthesis.
First, benzene containing an appropriate substituent is used as the substrate, and chlorine atoms are first introduced. Suitable chlorinated reagents, such as chlorine gas and sulfoxide chloride, can be selected. Under specific reaction conditions, such as suitable temperature and catalyst, the chlorine atom replaces the hydrogen atom on the benzene ring to obtain the chlorine-containing benzene derivative.
Then fluorine atoms are introduced. Nucleophilic substitution reaction can be used to select suitable fluorination reagents, such as potassium fluoride, etc. Under appropriate solvent system and reaction conditions, fluorine atoms are substituted for halogen atoms at specific positions or other suitable leaving groups, so fluorine atoms are introduced.
As for the introduction of trifluoromethyl, the common method is to react with reagents containing trifluoromethyl. If a trifluoromethylation reagent can be selected, under specific catalyst and reaction conditions, trifluoromethyl is substituted for the group at the corresponding position on the benzene ring to obtain 1-chloro-3-fluoro-2- (trifluoromethyl) benzene.
In addition, there are other synthesis routes, or starting from different starting materials, with different reaction mechanisms, such as the reaction of aryl diazonium salts, etc., through multi-step ingenious transformation, the synthesis of this target product can also be achieved. However, no matter what method, the reaction conditions need to be carefully adjusted, and the selectivity, yield and other factors of each step of the reaction need to be considered in order to achieve the purpose of efficient and high-quality synthesis.
What are the precautions for 1-chloro-3-fluoro-2- (trifluoromethyl) benzene during use?
1 - chloro - 3 - fluoro - 2 - (trifluoromethyl) benzene is a chemical commonly used in organic synthesis. When using it, many things need to be paid attention to.
First safety protection. This substance is toxic and irritating to a certain extent, and may cause damage to the human body. When operating, be sure to wear protective clothing, protective gloves and goggles to prevent skin contact and splashing into the eyes. In case of inadvertent contact, rinse with plenty of water immediately and seek medical treatment according to the specific situation. At the same time, it needs to be operated in a well-ventilated environment, preferably in a fume hood, to avoid inhaling its volatile gases. Because the volatile vapor may irritate the respiratory tract, long-term inhalation may have adverse effects on the respiratory system.
Furthermore, pay attention to storage conditions. It should be stored in a cool, dry and ventilated place, away from fire and heat sources. Because it is a flammable substance, it is dangerous to encounter open flames, hot topics or combustion and explosion. When storing, it needs to be stored separately from oxidants, acids, and bases. Do not mix storage to prevent chemical reactions and cause safety accidents.
In addition, during use, it is essential to precisely control the dosage and reaction conditions. The chemical reactions in which this substance participates have strict requirements on the dosage. Improper dosage or poor reaction effect, or side reactions, affecting the purity and yield of the product. The reaction temperature, time, solvent and other conditions also need to be precisely controlled. Under different reaction conditions, the reaction process and product may be significantly different. For example, if the temperature is too high or the reaction is too violent, it is difficult to control; if the temperature is too low, the reaction rate will be slow and take a long time.
At the same time, the treatment of its waste should not be underestimated. The remaining substances and reaction waste after use cannot be discarded at will, and must be properly disposed of in accordance with relevant environmental protection regulations. Because of its certain toxicity, it can be discharged at will or cause pollution to the environment, which endangers the ecological balance. Appropriate treatment methods, such as chemical treatment, recycling, etc. should be adopted according to the characteristics of the substance to minimize the impact on the environment.
First safety protection. This substance is toxic and irritating to a certain extent, and may cause damage to the human body. When operating, be sure to wear protective clothing, protective gloves and goggles to prevent skin contact and splashing into the eyes. In case of inadvertent contact, rinse with plenty of water immediately and seek medical treatment according to the specific situation. At the same time, it needs to be operated in a well-ventilated environment, preferably in a fume hood, to avoid inhaling its volatile gases. Because the volatile vapor may irritate the respiratory tract, long-term inhalation may have adverse effects on the respiratory system.
Furthermore, pay attention to storage conditions. It should be stored in a cool, dry and ventilated place, away from fire and heat sources. Because it is a flammable substance, it is dangerous to encounter open flames, hot topics or combustion and explosion. When storing, it needs to be stored separately from oxidants, acids, and bases. Do not mix storage to prevent chemical reactions and cause safety accidents.
In addition, during use, it is essential to precisely control the dosage and reaction conditions. The chemical reactions in which this substance participates have strict requirements on the dosage. Improper dosage or poor reaction effect, or side reactions, affecting the purity and yield of the product. The reaction temperature, time, solvent and other conditions also need to be precisely controlled. Under different reaction conditions, the reaction process and product may be significantly different. For example, if the temperature is too high or the reaction is too violent, it is difficult to control; if the temperature is too low, the reaction rate will be slow and take a long time.
At the same time, the treatment of its waste should not be underestimated. The remaining substances and reaction waste after use cannot be discarded at will, and must be properly disposed of in accordance with relevant environmental protection regulations. Because of its certain toxicity, it can be discharged at will or cause pollution to the environment, which endangers the ecological balance. Appropriate treatment methods, such as chemical treatment, recycling, etc. should be adopted according to the characteristics of the substance to minimize the impact on the environment.
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