Linshang Chemical
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1-Chloro-3-Fluoro-2-[(Z)-2-Nitrovinyl]Benzene
Linshang Chemical
|
HS Code |
119807 |
| Chemical Formula | C8H5ClFNO2 |
| Molecular Weight | 203.58 |
As an accredited 1-Chloro-3-Fluoro-2-[(Z)-2-Nitrovinyl]Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 3 - fluoro - 2 -[(z)-2 - nitrovinyl]benzene in 100g sealed glass bottles. |
| Storage | 1 - Chloro - 3 - fluoro - 2 - [(z)-2 - nitrovinyl]benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials. Label the storage container clearly with its name, hazards, and handling instructions to prevent misidentification and ensure safety. |
| Shipping | 1 - chloro - 3 - fluoro - 2 - [(z)-2 - nitrovinyl]benzene is shipped in accordance with strict chemical regulations. It's packaged securely in appropriate containers to prevent leakage, transported by approved carriers, ensuring safety during transit. |
Competitive 1-Chloro-3-Fluoro-2-[(Z)-2-Nitrovinyl]Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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Where to Buy 1-Chloro-3-Fluoro-2-[(Z)-2-Nitrovinyl]Benzene in China?
As a trusted 1-Chloro-3-Fluoro-2-[(Z)-2-Nitrovinyl]Benzene manufacturer, we deliver:
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As a leading 1-Chloro-3-Fluoro-2-[(Z)-2-Nitrovinyl]Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
1-chloro-3-fluoro-2- the chemical properties of [ (z) -2-nitrovinyl] benzene
1-Chloro-3-fluoro-2- [ (Z) -2-nitrovinyl] benzene is a kind of organic compound. Its chemical properties are particularly important and are described in detail below.
First of all, its structure is related. In this compound, the benzene ring is the core structure, and the chlorine atom and the fluorine atom are one place each, and there are (Z) -2 -nitrovinyl groups connected to the benzene ring. This unique structure makes it have special chemical activity.
In terms of its reactivity. The electron cloud distribution of the benzene ring is special due to the substitution of chlorine, fluorine and nitrovinyl groups. Although chlorine and fluorine are halogen atoms, they have different effects on the electron cloud of the benzene ring due to their electronegativity and atomic radius. The chlorine atom can absorb electrons by induction effect, and can conjugate with the benzene ring by its lone pair electrons to supply electrons; the fluorine atom has strong electronegativity, mainly absorbs electrons by induction effect, causing the electron cloud density of the benzene ring to be different in different parts, thus affecting the activity and check point of the electrophilic substitution reaction.
(Z) -2 -nitrovinyl, the nitro group has strong electron absorption, so that the carbon-carbon double bond electron cloud is biased to one end of the nitro group, so that the density of the double bond electron cloud is reduced. This structural feature makes the compound quite active in nucleophilic addition reactions. Nucleophilic reagents are prone to attack the β-carbon of the double bond and initiate an addition reaction.
And because it contains halogen atoms, under appropriate conditions, the substitution reaction of halogen atoms can occur. When encountering nucleophilic reagents, halogen atoms can be replaced to form new compounds. And the electrophilic substitution reaction of benzene ring is also affected by the positioning effect of the substituent. Chlorine and fluorine are ortho-para-sites, while nitrovinyl is an meta-site group. The interaction of various substituents determines the main check point for electrophilic reagents to attack benzene ring.
In terms of chemical stability, due to the existence of nitro groups, the compound has higher energy and slightly less relative stability. When exposed to heat, light, or specific reagents, decomposition or rearrangement reactions may occur, and caution should be taken during storage and use.
First of all, its structure is related. In this compound, the benzene ring is the core structure, and the chlorine atom and the fluorine atom are one place each, and there are (Z) -2 -nitrovinyl groups connected to the benzene ring. This unique structure makes it have special chemical activity.
In terms of its reactivity. The electron cloud distribution of the benzene ring is special due to the substitution of chlorine, fluorine and nitrovinyl groups. Although chlorine and fluorine are halogen atoms, they have different effects on the electron cloud of the benzene ring due to their electronegativity and atomic radius. The chlorine atom can absorb electrons by induction effect, and can conjugate with the benzene ring by its lone pair electrons to supply electrons; the fluorine atom has strong electronegativity, mainly absorbs electrons by induction effect, causing the electron cloud density of the benzene ring to be different in different parts, thus affecting the activity and check point of the electrophilic substitution reaction.
(Z) -2 -nitrovinyl, the nitro group has strong electron absorption, so that the carbon-carbon double bond electron cloud is biased to one end of the nitro group, so that the density of the double bond electron cloud is reduced. This structural feature makes the compound quite active in nucleophilic addition reactions. Nucleophilic reagents are prone to attack the β-carbon of the double bond and initiate an addition reaction.
And because it contains halogen atoms, under appropriate conditions, the substitution reaction of halogen atoms can occur. When encountering nucleophilic reagents, halogen atoms can be replaced to form new compounds. And the electrophilic substitution reaction of benzene ring is also affected by the positioning effect of the substituent. Chlorine and fluorine are ortho-para-sites, while nitrovinyl is an meta-site group. The interaction of various substituents determines the main check point for electrophilic reagents to attack benzene ring.
In terms of chemical stability, due to the existence of nitro groups, the compound has higher energy and slightly less relative stability. When exposed to heat, light, or specific reagents, decomposition or rearrangement reactions may occur, and caution should be taken during storage and use.
What are the main uses of 1-chloro-3-fluoro-2- [ (z) -2-nitrovinyl] benzene
1-Chloro-3-fluoro-2-[ (Z) -2-nitrovinyl] benzene is one of the organic compounds. Its main uses are related to various fields.
In the field of pharmaceutical chemistry, or can be a key intermediate for the creation of new drugs. Due to the structure of chlorine, fluorine and nitrovinyl groups, it can be chemically modified and reacted to obtain molecules with specific pharmacological activities. For example, by reacting with other compounds containing active groups, complex drug molecular structures can be constructed to target specific disease targets, such as certain inflammatory and tumor-related targets.
In the field of materials science, it may be used to prepare special polymer materials. The unique structure of this compound can endow polymer materials with novel properties. For example, introducing it into the main chain or side chain of the polymer can change the thermal stability, optical properties or electrical properties of the material. Like in organic optoelectronic materials, it may be possible to adjust the electronic transport and absorption spectral characteristics of the material to optimize its performance in devices such as Light Emitting Diodes and solar cells.
It also has potential uses in agricultural chemistry. It may be used as a raw material for the synthesis of new pesticides. With its structural characteristics, through rational design and derivatization, pesticide products with high insecticidal, bactericidal or herbicidal activities can be prepared to assist agricultural production, prevent and control pests and diseases, and improve crop yield and quality.
The multi-faceted nature of this compound makes it have important potential value and application prospects in many chemical-related industries and scientific research fields.
In the field of pharmaceutical chemistry, or can be a key intermediate for the creation of new drugs. Due to the structure of chlorine, fluorine and nitrovinyl groups, it can be chemically modified and reacted to obtain molecules with specific pharmacological activities. For example, by reacting with other compounds containing active groups, complex drug molecular structures can be constructed to target specific disease targets, such as certain inflammatory and tumor-related targets.
In the field of materials science, it may be used to prepare special polymer materials. The unique structure of this compound can endow polymer materials with novel properties. For example, introducing it into the main chain or side chain of the polymer can change the thermal stability, optical properties or electrical properties of the material. Like in organic optoelectronic materials, it may be possible to adjust the electronic transport and absorption spectral characteristics of the material to optimize its performance in devices such as Light Emitting Diodes and solar cells.
It also has potential uses in agricultural chemistry. It may be used as a raw material for the synthesis of new pesticides. With its structural characteristics, through rational design and derivatization, pesticide products with high insecticidal, bactericidal or herbicidal activities can be prepared to assist agricultural production, prevent and control pests and diseases, and improve crop yield and quality.
The multi-faceted nature of this compound makes it have important potential value and application prospects in many chemical-related industries and scientific research fields.
1-chloro-3-fluoro-2- [ (z) -2-nitrovinyl] benzene
To prepare 1-chloro-3-fluoro-2-[ (Z) -2-nitrovinyl] benzene, the following method can be used.
First, take o-chlorofluorobenzene as the starting material. Although chlorine and fluorine are ortho-site groups on the aromatic ring, the specific position activities are different due to spatial hindrance and electronic effects. The reaction of o-chlorofluorobenzene with nitromethane is carried out in a strong alkali environment, such as potassium tert-butyl alcohol as the base, in an aprotic polar solvent, such as N, N-dimethylformamide (DMF). Potassium tert-butyl alcohol grabs alpha-hydrogen from nitromethane to form a carboanion. This carboanion has strong nucleophilicity and attacks the benzene ring of o-chlorofluorobenzene. Due to electronic effects, the ortho-site is adjacent to chlorine and fluorine, and the steric barrier is large, so the carboanion mainly attacks the intermediate site. The generated intermediate is protonated to obtain a preliminary product.
However, this product is not the target and needs to be further transformed. With an appropriate oxidizing agent, such as active manganese dioxide, the hydroxide on the carbon connected to the nitro group in the product is oxidized to a hydroxyl group. Under acidic conditions, such as dilute sulfuric acid, a elimination reaction occurs. The hydroxyl group and the hydrogen on the adjacent carbon dehydrate to form a carbon- However, this step may produce two configuration isomers of E and Z. The Z-type isomer can be formed as the main product by selecting suitable reaction conditions, such as low temperature, controlling the reaction time and using a specific catalyst.
During the reaction process, the temperature, the amount of base and the reaction time need to be precisely controlled. If the temperature is too high, it is easy to cause side reactions, such as substitution of other positions on the benzene ring; if the amount of base is insufficient, the reaction is incomplete; if the time is too short, the raw material will remain; if the time is too long, the product will decompose or further react. After each step of the reaction is completed, the product is purified by conventional separation methods, such as extraction, distillation, column chromatography, etc., to obtain high purity 1-chloro-3-fluoro-2 - [ (Z) -2 -nitrovinyl] benzene.
First, take o-chlorofluorobenzene as the starting material. Although chlorine and fluorine are ortho-site groups on the aromatic ring, the specific position activities are different due to spatial hindrance and electronic effects. The reaction of o-chlorofluorobenzene with nitromethane is carried out in a strong alkali environment, such as potassium tert-butyl alcohol as the base, in an aprotic polar solvent, such as N, N-dimethylformamide (DMF). Potassium tert-butyl alcohol grabs alpha-hydrogen from nitromethane to form a carboanion. This carboanion has strong nucleophilicity and attacks the benzene ring of o-chlorofluorobenzene. Due to electronic effects, the ortho-site is adjacent to chlorine and fluorine, and the steric barrier is large, so the carboanion mainly attacks the intermediate site. The generated intermediate is protonated to obtain a preliminary product.
However, this product is not the target and needs to be further transformed. With an appropriate oxidizing agent, such as active manganese dioxide, the hydroxide on the carbon connected to the nitro group in the product is oxidized to a hydroxyl group. Under acidic conditions, such as dilute sulfuric acid, a elimination reaction occurs. The hydroxyl group and the hydrogen on the adjacent carbon dehydrate to form a carbon- However, this step may produce two configuration isomers of E and Z. The Z-type isomer can be formed as the main product by selecting suitable reaction conditions, such as low temperature, controlling the reaction time and using a specific catalyst.
During the reaction process, the temperature, the amount of base and the reaction time need to be precisely controlled. If the temperature is too high, it is easy to cause side reactions, such as substitution of other positions on the benzene ring; if the amount of base is insufficient, the reaction is incomplete; if the time is too short, the raw material will remain; if the time is too long, the product will decompose or further react. After each step of the reaction is completed, the product is purified by conventional separation methods, such as extraction, distillation, column chromatography, etc., to obtain high purity 1-chloro-3-fluoro-2 - [ (Z) -2 -nitrovinyl] benzene.
1-chloro-3-fluoro-2- the environmental impact of [ (z) -2-nitrovinyl] benzene
1-Chloro-3-fluoro-2-[ (Z) -2-nitrovinyl] benzene is one of the organic compounds. Its impact on the environment is quite complex and cannot be ignored.
First of all, its physical properties, this substance may have a specific color, taste and state, and can exist in one of the three phases of gas, liquid and solid in the environment. However, if it escapes from the environment, its structure contains chlorine, fluorine and other halogen elements and nitro and other functional groups, or it may cause multiple effects.
The properties of chlorine and fluorine are active. Chlorine atoms in the atmosphere, under specific conditions, may participate in the reaction of destroying the ozone layer. Although fluorine is not as significant as chlorine in destroying the ozone layer, its migration and transformation in the environment can also affect the ecology. If it is in an aquatic ecosystem, this substance may be soluble and interact with substances in the water, affecting the chemical balance of the water body. It may be adsorbed on suspended particles and settle to the bottom, affecting the chemical composition of sediments, and then affecting the survival of benthic organisms.
In addition, the 2 - [ (Z) -2 -nitrovinyl] structure makes this substance have a certain chemical activity. Nitro is prone to reactions such as reduction, which may affect the metabolism of soil microorganisms. Microorganisms may change their metabolic pathways due to this, affecting the circulation of nutrients in the soil, such as the nitrogen cycle. And this substance may be toxic to a certain extent, posing a potential threat to both animals and plants. After absorption by plants, or affecting their physiological metabolism, growth is blocked and development is abnormal. If animals are exposed to or ingested, or enriched in the body, it will damage organ function and even affect reproduction and inheritance.
In short, 1-chloro-3-fluoro-2 - [ (Z) -2 -nitrovinyl] benzene in the environment, due to its own structure and characteristics, can affect the atmosphere, water, soil and other environmental media, which is related to ecological balance and biological health. It needs to be treated with caution.
First of all, its physical properties, this substance may have a specific color, taste and state, and can exist in one of the three phases of gas, liquid and solid in the environment. However, if it escapes from the environment, its structure contains chlorine, fluorine and other halogen elements and nitro and other functional groups, or it may cause multiple effects.
The properties of chlorine and fluorine are active. Chlorine atoms in the atmosphere, under specific conditions, may participate in the reaction of destroying the ozone layer. Although fluorine is not as significant as chlorine in destroying the ozone layer, its migration and transformation in the environment can also affect the ecology. If it is in an aquatic ecosystem, this substance may be soluble and interact with substances in the water, affecting the chemical balance of the water body. It may be adsorbed on suspended particles and settle to the bottom, affecting the chemical composition of sediments, and then affecting the survival of benthic organisms.
In addition, the 2 - [ (Z) -2 -nitrovinyl] structure makes this substance have a certain chemical activity. Nitro is prone to reactions such as reduction, which may affect the metabolism of soil microorganisms. Microorganisms may change their metabolic pathways due to this, affecting the circulation of nutrients in the soil, such as the nitrogen cycle. And this substance may be toxic to a certain extent, posing a potential threat to both animals and plants. After absorption by plants, or affecting their physiological metabolism, growth is blocked and development is abnormal. If animals are exposed to or ingested, or enriched in the body, it will damage organ function and even affect reproduction and inheritance.
In short, 1-chloro-3-fluoro-2 - [ (Z) -2 -nitrovinyl] benzene in the environment, due to its own structure and characteristics, can affect the atmosphere, water, soil and other environmental media, which is related to ecological balance and biological health. It needs to be treated with caution.
1-chloro-3-fluoro-2- [ (z) -2-nitrovinyl] benzene what to pay attention to when storing and transporting
1-Chloro-3-fluoro-2-[ (Z) -2-nitrovinyl] benzene is also an organic compound. During storage and transportation, many matters must not be ignored.
First words storage, this compound should be placed in a cool, dry and well ventilated place. Because of its certain chemical activity, high temperature and humid environment, it is easy to cause its deterioration. For example, if the summer is very hot, if the warehouse does not have proper cooling and dehumidification facilities, the compound may decompose and polymerize, causing its quality to be damaged. Therefore, the temperature should be controlled within a specific range, such as between 15 ° C and 25 ° C, and the humidity should not exceed 60%.
Furthermore, this compound should be stored separately from oxidants, reducing agents, acids, alkalis and other substances. In terms of its chemical properties, in case of oxidants or violent oxidation reactions, it can even cause combustion and explosion; in case of acids or alkalis, it may also cause chemical reactions, resulting in structural changes and loss of its inherent properties.
As for transportation, professional packaging is required to ensure its tightness. The transportation container should be made of corrosion-resistant and pressure-resistant materials, such as special steel cans or plastic drums. And during transportation, avoid violent vibration and collision to prevent packaging damage and compound leakage.
In addition, in transportation and storage places, warning signs are essential to make relevant personnel clear about its danger. Practitioners also need to have professional training to be familiar with the characteristics of this compound and emergency treatment methods. In case of leakage, according to the established procedures, quickly evacuate personnel, seal off the scene, and absorb and clean up with appropriate materials. Don't panic.
In summary, when storing and transporting 1-chloro-3-fluoro-2-[ (Z) -2-nitrovinyl] benzene, temperature and humidity control, material isolation, packaging attention, labeling, and personnel training are all critical and cannot be slack.
First words storage, this compound should be placed in a cool, dry and well ventilated place. Because of its certain chemical activity, high temperature and humid environment, it is easy to cause its deterioration. For example, if the summer is very hot, if the warehouse does not have proper cooling and dehumidification facilities, the compound may decompose and polymerize, causing its quality to be damaged. Therefore, the temperature should be controlled within a specific range, such as between 15 ° C and 25 ° C, and the humidity should not exceed 60%.
Furthermore, this compound should be stored separately from oxidants, reducing agents, acids, alkalis and other substances. In terms of its chemical properties, in case of oxidants or violent oxidation reactions, it can even cause combustion and explosion; in case of acids or alkalis, it may also cause chemical reactions, resulting in structural changes and loss of its inherent properties.
As for transportation, professional packaging is required to ensure its tightness. The transportation container should be made of corrosion-resistant and pressure-resistant materials, such as special steel cans or plastic drums. And during transportation, avoid violent vibration and collision to prevent packaging damage and compound leakage.
In addition, in transportation and storage places, warning signs are essential to make relevant personnel clear about its danger. Practitioners also need to have professional training to be familiar with the characteristics of this compound and emergency treatment methods. In case of leakage, according to the established procedures, quickly evacuate personnel, seal off the scene, and absorb and clean up with appropriate materials. Don't panic.
In summary, when storing and transporting 1-chloro-3-fluoro-2-[ (Z) -2-nitrovinyl] benzene, temperature and humidity control, material isolation, packaging attention, labeling, and personnel training are all critical and cannot be slack.
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